Sulphonylurea Usage in Melioidosis Is Associated with Severe Disease and Suppressed Immune Response

10.1371/journal.pntd.0002795PLoS Neglected Tropical Diseases84

Validating the use of the shuttle walking test in healthy adult women

The Shuttle Walking Test (SWT), with its externally paced characteristics, is commonly used as an objective measure of functional capacity. The reliability and validity of the SWT has been previously shown but only in patient populations. No studies have been carried out to investigate the validity of the SWT in healthy adult women. Therefore, the primary aim of this test was to determine if the SWT is a valid field measure of cardiorespiratory fitness in healthy adult women. A secondary aim was to identify if variables, such as age, body composition and habitual physical activity influence performance on the SWT. The distance ambulated on the SWT was compared with a standard laboratory test of cardiorespiratory capacity, peak oxygen consumption ( VO2peak) determined on an Individualised Balke Treadmill Test (IBT). Thirty-four healthy adult women with an age range of 32-65 yrs completed both exercise tests. Mean (± SD) SWT distance 624.5 (148.9) m and VO2peak 29.4 (7.8) ml.kg-1.min-1 were higher than that shown in previous studies of patient populations. Pearson product moment correlation analysis indicated a moderate but significant relationship (r = 0.58, p = 0.0005) between SWT distance and VO2peak. Variability in performance on the SWT can be explained partly by age and estimated body fat. This study is the first to investigate the validity of the SWT in healthy adult women. The correlation with VO2peak from IBT was lower than that in previous studies with patient populations. The findings suggest that performance on the SWT in healthy adult women is limited by locor.10tor ability as well as cardiorespiratory fitness. Therefore, the use of SWT as a field measure of cardiorespiratory fitness in healthy adult women has limitations. The study provides the basis for further work to modify the SWT for use in a healthy adult population

Cosmological evolution of interacting dark energy in Lorentz violation

The cosmological evolution of an interacting scalar field model in which the scalar field interacts with dark matter, radiation, and baryon via Lorentz violation is investigated. We propose a model of interaction through the effective coupling $\bar{\beta}$. Using dynamical system analysis, we study the linear dynamics of an interacting model and show that the dynamics of critical points are completely controlled by two parameters. Some results can be mentioned as follows. Firstly, the sequence of radiation, the dark matter, and the scalar field dark energy exist and baryons are sub dominant. Secondly, the model also allows the possibility of having a universe in the phantom phase with constant potential. Thirdly, the effective gravitational constant varies with respect to time through $\bar{\beta}$. In particular, we consider a simple case where $\bar{\beta}$ has a quadratic form and has a good agreement with the modified $\Lambda$CDM and quintessence models. Finally, we also calculate the first post--Newtonian parameters for our model.Comment: 14 pages, published versio

Quasilinear hyperbolic Fuchsian systems and AVTD behavior in T2-symmetric vacuum spacetimes

We set up the singular initial value problem for quasilinear hyperbolic Fuchsian systems of first order and establish an existence and uniqueness theory for this problem with smooth data and smooth coefficients (and with even lower regularity). We apply this theory in order to show the existence of smooth (generally not analytic) T2-symmetric solutions to the vacuum Einstein equations, which exhibit AVTD (asymptotically velocity term dominated) behavior in the neighborhood of their singularities and are polarized or half-polarized.Comment: 78 page

Anisotropic colloids through non-trivial buckling

We present a study on buckling of colloidal particles, including experimental, theoretical and numerical developments. Oil-filled thin shells prepared by emulsion templating show buckling in mixtures of water and ethanol, due to dissolution of the core in the external medium. This leads to conformations with a single depression, either axisymmetric or polygonal depending on the geometrical features of the shells. These conformations could be theoretically and/or numerically reproduced in a model of homogeneous spherical thin shells with bending and stretching elasticity, submitted to an isotropic external pressure.Comment: submitted to EPJ

Non-minimally coupled dark matter: effective pressure and structure formation

We propose a phenomenological model in which a non-minimal coupling between gravity and dark matter is present in order to address some of the apparent small scales issues of \lcdm model. When described in a frame in which gravity dynamics is given by the standard Einstein-Hilbert action, the non-minimal coupling translates into an effective pressure for the dark matter component. We consider some phenomenological examples and describe both background and linear perturbations. We show that the presence of an effective pressure may lead these scenarios to differ from \lcdm at the scales where the non-minimal coupling (and therefore the pressure) is active. In particular two effects are present: a pressure term for the dark matter component that is able to reduce the growth of structures at galactic scales, possibly reconciling simulations and observations; an effective interaction term between dark matter and baryons that could explain observed correlations between the two components of the cosmic fluid within Tully-Fisher analysis.Comment: 18 pages, 6 figures, references added. Published in JCA

Observation of Scaling Violations in Scaled Momentum Distributions at HERA

Charged particle production has been measured in deep inelastic scattering (DIS) events over a large range of $x$ and $Q^2$ using the ZEUS detector. The evolution of the scaled momentum, $x_p$, with $Q^2,$ in the range 10 to 1280 $GeV^2$, has been investigated in the current fragmentation region of the Breit frame. The results show clear evidence, in a single experiment, for scaling violations in scaled momenta as a function of $Q^2$.Comment: 21 pages including 4 figures, to be published in Physics Letters B. Two references adde

D* Production in Deep Inelastic Scattering at HERA

This paper presents measurements of D^{*\pm} production in deep inelastic scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The data have been taken with the ZEUS detector at HERA. The decay channel $D^{*+}\to (D^0 \to K^- \pi^+) \pi^+$ (+ c.c.) has been used in the study. The $e^+p$ cross section for inclusive D^{*\pm} production with $5<Q^2<100 GeV^2$ and $y<0.7$ is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region {$1.3<p_T(D^{*\pm})<9.0$ GeV and $| \eta(D^{*\pm}) |<1.5$}. Differential cross sections as functions of p_T(D^{*\pm}), $\eta(D^{*\pm}), W$ and $Q^2$ are compared with next-to-leading order QCD calculations based on the photon-gluon fusion production mechanism. After an extrapolation of the cross section to the full kinematic region in p_T(D^{*\pm}) and $\eta$(D^{*\pm}), the charm contribution $F_2^{c\bar{c}}(x,Q^2)$ to the proton structure function is determined for Bjorken $x$ between 2 $\cdot$ 10$^{-4}$ and 5 $\cdot$ 10$^{-3}$.Comment: 17 pages including 4 figure

Solar Neutrinos: What We Have Learned

The four operating solar neutrino experiments confirm the hypothesis that the energy source for solar luminosity is hydrogen fusion. However, the measured rate for each of the four solar neutrino experiments differs significantly (by factors of 2.0 to 3.5) from the corresponding theoretical prediction that is based upon the standard solar model and the simplest version of the standard electroweak theory. If standard electroweak theory is correct, the energy spectrum for \b8 neutrinos created in the solar interior must be the same (to one part in $10^5$) as the known laboratory \b8 neutrino energy spectrum. Direct comparison of the chlorine and the Kamiokande experiments, both sensitive to \b8 neutrinos, suggests that the discrepancy between theory and observations depends upon neutrino energy, in conflict with standard expectations. Monte Carlo studies with 1000 implementations of the standard solar model confirm that the chlorine and the Kamiokande experiments cannot be reconciled unless new weak interaction physics changes the shape of the \b8 neutrino energy spectrum. The results of the two gallium solar neutrino experiments strengthen the conclusion that new physics is required and help determine a relatively small allowed region for the MSW neutrino parameters.Comment: LaTeX file, 19 pages. For hardcopy with figures contact [email protected]. Institute for Advanced Study number AST 93/6

Measurement of D*+/- meson production in jets from pp collisions at sqrt(s) = 7 TeV with the ATLAS detector

This paper reports a measurement of D*+/- meson production in jets from proton-proton collisions at a center-of-mass energy of sqrt(s) = 7 TeV at the CERN Large Hadron Collider. The measurement is based on a data sample recorded with the ATLAS detector with an integrated luminosity of 0.30 pb^-1 for jets with transverse momentum between 25 and 70 GeV in the pseudorapidity range |eta| < 2.5. D*+/- mesons found in jets are fully reconstructed in the decay chain: D*+ -> D0pi+, D0 -> K-pi+, and its charge conjugate. The production rate is found to be N(D*+/-)/N(jet) = 0.025 +/- 0.001(stat.) +/- 0.004(syst.) for D*+/- mesons that carry a fraction z of the jet momentum in the range 0.3 < z < 1. Monte Carlo predictions fail to describe the data at small values of z, and this is most marked at low jet transverse momentum.Comment: 10 pages plus author list (22 pages total), 5 figures, 1 table, matches published version in Physical Review