Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV

Peer reviewe

AXONAL TRANSPORT IN ACRYLAMIDE NEUROPATHY

The axoplasmic transport of acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) were studied in the sciatic nerves of normal rats and those with neuropathy due to acrylamide by measuring the accumulation of these enzymes proximal to single and double ligatures. Approximately 10 per cent of the enzymes were mobile. The absolute transport rate of AChE was decreased to 287 mm/24h in acrylamide neuropathy compared with 567 mm/24h in normal nerve. The absolute transport rate of ChAT was unchanged (176 and 170 mm/24h). The amount of AChE activity transported in the orthograde direction in acrylamide neuropathy was 2.03 umol/24h, which was slightly less than normal (2.6 umol/24h). The amount of ChAT transported in acrylamide neuropathy was 0.5 umol/24h which was considerably greater than normal (0.2 umol/24h). Specific colchicine binding by neurotubulin from acrylamide intoxicated rats was reduced to 40 per cent of normal though the total amount of neurotubulin appeared to be normal

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before. We report thumb and spine osteoarthritis risk variants and identify differences in genetic effects between weight-bearing and non-weight-bearing joints. We identify sex-specific and early age-at-onset osteoarthritis risk loci. We integrate functional genomics data from primary patient tissues (including articular cartilage, subchondral bone, and osteophytic cartilage) and identify high-confidence effector genes. We provide evidence for genetic correlation with phenotypes related to pain, the main disease symptom, and identify likely causal genes linked to neuronal processes. Our results provide insights into key molecular players in disease processes and highlight attractive drug targets to accelerate translation. © 2021 The Author

Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors

Estimated central systolic blood pressure (cSBP) and amplification (Brachial SBP-cSBP) are non-invasive measures potentially prognostic of cardiovascular (CV) disease. No worldwide, multiple-device reference values are available. We aimed to establish reference values for a worldwide general population standardizing between the different available methods of measurement. How these values were significantly altered by cardiovascular risk factors (CVRFs) was then investigated.AtCor Medical via an unrestricted gran