80 research outputs found
Isolating signatures of major cloud-cloud collisions using position-velocity diagrams
This article has been accepted for publication in Monthly Notices of the Royal Astronomical Society. © 2015 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society.Collisions between giant molecular clouds are a potential mechanism for triggering the formation of massive stars, or even super star clusters. The trouble is identifying this process observationally and distinguishing it from other mechanisms. We produce synthetic positionâvelocity diagrams from models of cloudâcloud collisions, non-interacting clouds along the line of sight, clouds with internal radiative feedback and a more complex cloud evolving in a galactic disc, to try and identify unique signatures of collision. We find that a broad bridge feature connecting two intensity peaks, spatially correlated but separated in velocity, is a signature of a high-velocity cloudâcloud collision. We show that the broad bridge feature is resilient to the effects of radiative feedback, at least to around 2.5 Myr after the formation of the first massive (ionizing) star. However for a head-on 10âkmâsâ1 collision, we find that this will only be observable from 20 to 30âperâcent of viewing angles. Such broadâbridge features have been identified towards M20, a very young region of massive star formation that was concluded to be a site of cloudâcloud collision by Torii et al., and also towards star formation in the outer Milky Way by Izumi et al.Peer reviewe
Response to Emerging Infection Leading to Outbreak of Linezolid-Resistant Enterococci
These bacteria have emerged as a hospital problem that appears to be caused by both linezolid exposure and patient-to-patient transmission
Cosmic microwave background constraints on the duration and timing of reionization from the South Pole Telescope
The epoch of reionization is a milestone of cosmological structure formation,
marking the birth of the first objects massive enough to yield large numbers of
ionizing photons. The mechanism and timescale of reionization remain largely
unknown. Measurements of the CMB Doppler effect from ionizing bubbles embedded
in large-scale velocity streams (the patchy kinetic Sunyaev-Zel'dovich effect)
can constrain the duration of reionization. When combined with large-scale CMB
polarization measurements, the evolution of the ionized fraction can be
inferred. Using new multi-frequency data from the South Pole Telescope (SPT),
we show that the ionized fraction evolved relatively rapidly. For our basic
foreground model, we find the kinetic Sunyaev-Zel'dovich power sourced by
reionization at l=3000 to be <= 2.1 micro K^2 at 95% CL. Using reionization
simulations, we translate this to a limit on the duration of reionization of
Delta z <= 4.4 (95% CL). We find that this constraint depends on assumptions
about the angular correlation between the thermal Sunyaev-Zel'dovich power and
the cosmic infrared background (CIB). Introducing the degree of correlation as
a free parameter, we find that the limits on kSZ power weaken to <= 4.9 micro
K^2, implying Delta z <= 7.9 (95% CL). We combine the SPT constraint on the
duration of reionization with the WMAP7 measurement of the integrated optical
depth to probe the cosmic ionization history. We find that reionization ended
with 95% CL at z > 7.2 under the assumption of no tSZ-CIB correlation, and
z>5.8 when correlations are allowed. Improved constraints from the full SPT
data set in conjunction with upcoming Herschel and Planck data should detect
extended reionization at >95% CL provided Delta z >= 4. (abbreviated)Comment: 16 pages, 13 figures, version accepted by ApJ, improved forecast of
Herschel-SPT reionization constraint
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The Simons Observatory: Science goals and forecasts
The Simons Observatory (SO) is a new cosmic microwave background experiment
being built on Cerro Toco in Chile, due to begin observations in the early
2020s. We describe the scientific goals of the experiment, motivate the design,
and forecast its performance. SO will measure the temperature and polarization
anisotropy of the cosmic microwave background in six frequency bands: 27, 39,
93, 145, 225 and 280 GHz. The initial configuration of SO will have three
small-aperture 0.5-m telescopes (SATs) and one large-aperture 6-m telescope
(LAT), with a total of 60,000 cryogenic bolometers. Our key science goals are
to characterize the primordial perturbations, measure the number of
relativistic species and the mass of neutrinos, test for deviations from a
cosmological constant, improve our understanding of galaxy evolution, and
constrain the duration of reionization. The SATs will target the largest
angular scales observable from Chile, mapping ~10% of the sky to a white noise
level of 2 K-arcmin in combined 93 and 145 GHz bands, to measure the
primordial tensor-to-scalar ratio, , at a target level of .
The LAT will map ~40% of the sky at arcminute angular resolution to an expected
white noise level of 6 K-arcmin in combined 93 and 145 GHz bands,
overlapping with the majority of the LSST sky region and partially with DESI.
With up to an order of magnitude lower polarization noise than maps from the
Planck satellite, the high-resolution sky maps will constrain cosmological
parameters derived from the damping tail, gravitational lensing of the
microwave background, the primordial bispectrum, and the thermal and kinematic
Sunyaev-Zel'dovich effects, and will aid in delensing the large-angle
polarization signal to measure the tensor-to-scalar ratio. The survey will also
provide a legacy catalog of 16,000 galaxy clusters and more than 20,000
extragalactic sources
CMB-S4: Forecasting Constraints on Primordial Gravitational Waves
CMB-S4---the next-generation ground-based cosmic microwave background (CMB)
experiment---is set to significantly advance the sensitivity of CMB
measurements and enhance our understanding of the origin and evolution of the
Universe, from the highest energies at the dawn of time through the growth of
structure to the present day. Among the science cases pursued with CMB-S4, the
quest for detecting primordial gravitational waves is a central driver of the
experimental design. This work details the development of a forecasting
framework that includes a power-spectrum-based semi-analytic projection tool,
targeted explicitly towards optimizing constraints on the tensor-to-scalar
ratio, , in the presence of Galactic foregrounds and gravitational lensing
of the CMB. This framework is unique in its direct use of information from the
achieved performance of current Stage 2--3 CMB experiments to robustly forecast
the science reach of upcoming CMB-polarization endeavors. The methodology
allows for rapid iteration over experimental configurations and offers a
flexible way to optimize the design of future experiments given a desired
scientific goal. To form a closed-loop process, we couple this semi-analytic
tool with map-based validation studies, which allow for the injection of
additional complexity and verification of our forecasts with several
independent analysis methods. We document multiple rounds of forecasts for
CMB-S4 using this process and the resulting establishment of the current
reference design of the primordial gravitational-wave component of the Stage-4
experiment, optimized to achieve our science goals of detecting primordial
gravitational waves for at greater than , or, in the
absence of a detection, of reaching an upper limit of at CL.Comment: 24 pages, 8 figures, 9 tables, submitted to ApJ. arXiv admin note:
text overlap with arXiv:1907.0447
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have
fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in
25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16
regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of
correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP,
while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in
Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium
(LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region.
Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant
enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the
refined data for existing association signals, we estimate that these loci now explain âŒ38.9% of the familial relative risk of PrCa,
an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of
PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent
signals within the same regio
Characterizing microscopic and submicroscopic malaria parasitaemia at three sites with varied transmission intensity in Uganda
CMB-S4: Forecasting Constraints on Primordial Gravitational Waves
Abstract: CMB-S4âthe next-generation ground-based cosmic microwave background (CMB) experimentâis set to significantly advance the sensitivity of CMB measurements and enhance our understanding of the origin and evolution of the universe. Among the science cases pursued with CMB-S4, the quest for detecting primordial gravitational waves is a central driver of the experimental design. This work details the development of a forecasting framework that includes a power-spectrum-based semianalytic projection tool, targeted explicitly toward optimizing constraints on the tensor-to-scalar ratio, r, in the presence of Galactic foregrounds and gravitational lensing of the CMB. This framework is unique in its direct use of information from the achieved performance of current Stage 2â3 CMB experiments to robustly forecast the science reach of upcoming CMB-polarization endeavors. The methodology allows for rapid iteration over experimental configurations and offers a flexible way to optimize the design of future experiments, given a desired scientific goal. To form a closed-loop process, we couple this semianalytic tool with map-based validation studies, which allow for the injection of additional complexity and verification of our forecasts with several independent analysis methods. We document multiple rounds of forecasts for CMB-S4 using this process and the resulting establishment of the current reference design of the primordial gravitational-wave component of the Stage-4 experiment, optimized to achieve our science goals of detecting primordial gravitational waves for r > 0.003 at greater than 5Ï, or in the absence of a detection, of reaching an upper limit of r < 0.001 at 95% CL
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