Enfoque de Manejo Costero Integrado aplicado a la cuenca baja del arroyo El Potrero, Maldonado, Uruguay = The Integrated Coastal Management approach in the lower basin of the El Potrero stream, Maldonado, Uruguay

En la cuenca del arroyo El Potrero, departamento de Maldonado, confluyen una particular diversidad de ambientes, actores, intereses y problemáticas socioambientales. El objetivo de este trabajo es proponer medidas para el manejo de los conflictos, problemáticas y oportunidades socioambientales en el área, aplicando herramientas de Manejo Costero Integrado (MCI). El MCI busca un balance entre intereses sociales, ambientales y económicos en la zona costera, con un enfoque basado en ecosistemas e incorporando en el proceso a los distintos actores de una comunidad dada. A partir de revisión documental, entrevistas a 11 actores con incidencia local, talleres internos del equipo de trabajo y un taller abierto de validación se reconocieron cuatro asuntos sobre los que enfocar las propuestas de manejo: fortalecimiento de la gobernanza, fomento de la integridad ambiental de la costa balnearia, conservación del arroyo y sus márgenes y consolidación de una trama urbana de bajo impacto ambiental. Cada asunto de manejo dio origen a un programa del cual se desprenden proyectos con acciones específicas. Todos los programas se agrupan en un ”Plan integrado de manejo de la cuenca baja del arroyo El Potrero”. El espacio de intercambio entre actores diversos promovido en este estudio favoreció la generación de nuevos lazos y mostró el potencial del trabajo conjunto

AUTONOMOUS SYSTEMS & SAFETY ISSUES: THE ROADMAP TO ENABLE NEW ADVANCES IN INDUSTRIAL APPLICATIONS

The paper addresses the safety issues related to the development of new solutions based on autonomous systems for industrial applications and the necessity to develop experimental environments for investigating these cases; a set of examples is proposed in order to provide cases and challenges as well as to suggest approaches to address these problems

Author Correction: DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death (Scientific Reports, (2021), 11, 1, (16793), 10.1038/s41598-021-95976-7)

Link to the corrected article: [https://farfar.pharmacy.bg.ac.rs/handle/123456789/3944

DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death

The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16 laboratories using the comet assay between 1996 and 2016 was followed-up. Kaplan–Meier analysis indicated a worse overall survival in the medium and high tertile of DNA damage (p < 0.001). The effect of DNA damage on survival was modelled according to Cox proportional hazard regression model. The adjusted hazard ratio (HR) was 1.42 (1.06–1.90) for overall mortality, and 1.94 (1.04–3.59) for diseases of the circulatory system in subjects with the highest tertile of DNA damage. The findings of this study provide epidemiological evidence encouraging the implementation of the comet assay in preventive strategies for non-communicable diseases.This article has been corrected. Link to the correction: [https://farfar.pharmacy.bg.ac.rs/handle/123456789/3975

Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification

The multifactorial likelihood analysis method has demonstrated utility for quantitative assessment of variant pathogenicity for multiple cancer syndrome genes. Independent data types currently incorporated in the model for assessing BRCA1 and BRCA2 variants include clinically calibrated prior probability of pathogenicity based on variant location and bioinformatic prediction of variant effect, co-segregation, family cancer history profile, co-occurrence with a pathogenic variant in the same gene, breast tumor pathology, and case-control information. Research and clinical data for multifactorial likelihood analysis were collated for 1,395 BRCA1/2 predominantly intronic and missense variants, enabling classification based on posterior probability of pathogenicity for 734 variants: 447 variants were classified as (likely) benign, and 94 as (likely) pathogenic; and 248 classifications were new or considerably altered relative to ClinVar submissions. Classifications were compared with information not yet included in the likelihood model, and evidence strengths aligned to those recommended for ACMG/AMP classification codes. Altered mRNA splicing or function relative to known nonpathogenic variant controls were moderately to strongly predictive of variant pathogenicity. Variant absence in population datasets provided supporting evidence for variant pathogenicity. These findings have direct relevance for BRCA1 and BRCA2 variant evaluation, and justify the need for gene-specific calibration of evidence types used for variant classification

Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification

Abstract The multifactorial likelihood analysis method has demonstrated utility for quantitative assessment of variant pathogenicity for multiple cancer syndrome genes. Independent data types currently incorporated in the model for assessing BRCA1 and BRCA2 variants include clinically calibrated prior probability of pathogenicity based on variant location and bioinformatic prediction of variant effect, co-segregation, family cancer history profile, co-occurrence with a pathogenic variant in the same gene, breast tumor pathology, and case-control information. Research and clinical data for multifactorial likelihood analysis were collated for 1395 BRCA1/2 predominantly intronic and missense variants, enabling classification based on posterior probability of pathogenicity for 734 variants: 447 variants were classified as (likely) benign, and 94 as (likely) pathogenic; 248 classifications were new or considerably altered relative to ClinVar submissions. Classifications were compared to information not yet included in the likelihood model, and evidence strengths aligned to those recommended for ACMG/AMP classification codes. Altered mRNA splicing or function relative to known non-pathogenic variant controls were moderately to strongly predictive of variant pathogenicity. Variant absence in population datasets provided supporting evidence for variant pathogenicity. These findings have direct relevance for BRCA1 and BRCA2 variant evaluation, and justify the need for gene-specific calibration of evidence types used for variant classification. This article is protected by copyright. All rights reserved.Peer reviewe

Enfoque de Manejo Costero Integrado aplicado a la cuenca baja del arroyo El Potrero, Maldonado, Uruguay

A diversity of environments, stakeholders, interests and socioenvironmental problems converge in the basin of the El Potrero stream, Maldonado department, Uruguay. The objective of this article is to outline management proposals for conflicts, problems and socioenvironmental opportunities in this area, applying the Integrated Coastal Management (ICM) approach. The ICM promotes a balance between social, environmental, and economic interests in the coastal zone, based on an ecosystem approach and involving the different community stakeholders in the process. Based on document reviews, interviews with 11 local actors, internal team workshops, and an open validation workshop, four issues were identified to focus the management proposals: strengthening governance, promoting the environmental integrity of the seaside coast, conserving the stream and its margins, and fostering urbanization with a low environmental impact. Each management issue gave rise to a program from which projects with specific actions emerged. All programs are grouped in an "Integrated Management Plan for the Lower Basin of the El Potrero Stream". The exchange between different actors favored the relationship between stakeholders and showed the potential for working together.En la cuenca del arroyo El Potrero, departamento de Maldonado, confluyen una particular diversidad de ambientes, actores, intereses y problemáticas socioambientales. El objetivo de este trabajo es proponer medidas para el manejo de los conflictos, problemáticas y oportunidades socioambientales en el área, aplicando herramientas de Manejo Costero Integrado (MCI). El MCI busca un balance entre intereses sociales, ambientales y económicos en la zona costera, con un enfoque basado en ecosistemas e incorporando en el proceso a los distintos actores de una comunidad dada. A partir de revisión documental, entrevistas a 11 actores con incidencia local, talleres internos del equipo de trabajo y un taller abierto de validación se reconocieron cuatro asuntos sobre los que enfocar las propuestas de manejo: fortalecimiento de la gobernanza, fomento de la integridad ambiental de la costa balnearia, conservación del arroyo y sus márgenes y consolidación de una trama urbana de bajo impacto ambiental. Cada asunto de manejo dio origen a un programa del cual se desprenden proyectos con acciones específicas. Todos los programas se agrupan en un ”Plan integrado de manejo de la cuenca baja del arroyo El Potrero”. El espacio de intercambio entre actores diversos promovido en este estudio favoreció la generación de nuevos lazos y mostró el potencial del trabajo conjunto