Rapid laminated clastic alluviation associated with increased Little Ice Age flooding co-driven by climate variability and historic land-use in the middle Severn catchment, UK

The analysis of exceptionally well-preserved visible clastic laminations in deep alluvial sediments at Kempsey, Worcestershire (UK), allows a new high-resolution analysis of late-Holocene flood-history in the largest UK catchment, as well as local human response. At the sample site over 4.5 m of sandy-silt overbank-alluvium accumulated on the floodplain and optically stimulated luminescence (OSL) dating of the upper 2.25 m demonstrates accretion from the late 14th century CE onwards. Sub-centimetre to centimetre resolution multi-proxy sediment analysis (loss on ignition, magnetic susceptibility, particle size, ITRAX and portable XRF) demonstrate clear variations in depositional history over the last millennium due to channel stability. Between c. 1380 and 1550 CE overbank sedimentation was driven by lower energy flood events, with negligible effect from climatic conditions during the Spörer Minimum (1460–1550 CE). After c. 1550 CE the magnitude of flooding events increased and by c. 1610 CE, the start of the visible sub-centimetre laminations, the accumulation rate regularly exceeded 3 mm year−1, which increased to 4.5 mm year−1 between c. 1690 and 1710 CE, and 3 and 3.5 mm year−1 between c. 1790 and 1840 CE before alluviation was altered by an embankment. The greatest extent of coarse overbank deposition and increased accumulation rate occur concurrently with periods of climatic instability associated with the Maunder (1645–1715 CE) and Dalton (1790–1820 CE) Minima, the periods of largest historical floods and during the intensification of arable cultivation across the middle Severn catchment. This data correlates well with other sites in the catchment suggesting that these are basin-wide forcing-responses. We also present evidence that this catchment-wide hydro-geomorphological history had local effects in shifting the geographical focus of an important settlement away from its historic floodplain edge location – which can be viewed as an adaptation to the flood risk

The geomorphology of the Anthropocene:emergence, status and implications

This is the peer reviewed version of the following article: BROWN, A.G. ... et al, 2017. The geomorphology of the Anthropocene: emergence, status and implications. Earth Surface Processes and Landforms, 42(1), pp.71-90., which has been published in final form at http://dx.doi.org/10.1002/esp.3943. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.The Anthropocene is proposed as a new interval of geological time in which human influence on Earth and its geological record dominates over natural processes. A major challenge in demarcating the Anthropocene is that the balance between human-influenced and natural processes varies over spatial and temporal scales owing to the inherent variability of both human activities (as associated with culture and modes of development) and natural drivers (e.g. tectonic activity and sea level variation). Against this backdrop, we consider how geomorphology might contribute towards the Anthropocene debate focussing on human impact on aeolian, fluvial, cryospheric and coastal process domains, and how evidence of this impact is preserved in landforms and sedimentary records. We also consider the evidence for an explicitly anthropogenic geomorphology that includes artificial slopes and other human-created landforms. This provides the basis for discussing the theoretical and practical contributions that geomorphology can make to defining an Anthropocene stratigraphy. It is clear that the relevance of the Anthropocene concept varies considerably amongst different branches of geomorphology, depending on the history of human actions in different process domains. For example, evidence of human dominance is more widespread in fluvial and coastal records than in aeolian and cryospheric records, so geomorphologically the Anthropocene would inevitably comprise a highly diachronous lower boundary. Even to identify this lower boundary, research would need to focus on the disambiguation of human effects on geomorphological and sedimentological signatures. This would require robust data, derived from a combination of modelling and new empirical work rather than an arbitrary ‘war of possible boundaries’ associated with convenient, but disputed, `golden spikes’. Rather than being drawn into stratigraphical debates, the primary concern of geomorphology should be with the investigation of processes and landform development, so providing the underpinning science for the study of this time of critical geological transition

De Broglie-Bohm Guidance Equations for Arbitrary Hamiltonians

In a pilot-wave theory, an individual closed system is described by a wavefunction $\psi(q)$ and configuration $q$. The evolution of the wavefunction and configuration are respectively determined by the Schr\"odinger and guidance equations. The guidance equation states that the velocity field for the configuration is given by the quantum current divided by the density $|\psi(q)|^2$. We present the currents and associated guidance equations for any Hamiltonian given by a differential operator. These are derived directly from the Schr\"odinger equation, and also as Noether currents arising from a global phase symmetry associated with the wavefunction in configuration space.Comment: 22 pages, no figures, LaTex; v3 minor corrections; v2 minor correction

Shell model half-lives for r-process N=82 nuclei

We have performed shell-model calculations of the half-lives and neutron-branching probabilities of the r-process waiting point nuclei at the magic neutron number N=82. These new calculations use a larger model space than previous shell model studies and an improved residual interaction which is adjusted to recent spectroscopic data around A=130. Our shell-model results give a good account of all experimentally known half-lives and $Q_\beta$-values for the N=82 r-process waiting point nuclei. Our half-life predictions for the N=82 nuclei with Z=42--46 agree well with recent estimates based in the energy-density functional method

The environmental context and function of Burnt-Mounds: new studies of Irish Fulachtaí Fiadh

Burnt mounds, or fulachtaí fiadh as they are known in Ireland, are probably the most common prehistoric site type in Ireland and Britain. Typically Middle–Late Bronze Age in age (although both earlier and later examples are known), they are artefact-poor and rarely associated with settlements. The function of these sites has been much debated with the most commonly cited uses being for cooking, as steam baths or saunas, for brewing, tanning, or textile processing. A number of major infrastructural development schemes in Ireland in the years 2002–2007 revealed remarkable numbers of these mounds often associated with wood-lined troughs, many of which were extremely well-preserved. This afforded an opportunity to investigate them as landscape features using environmental techniques – specifically plant macrofossils and charcoal, pollen, beetles, and multi-element analyses. This paper summarises the results from eight sites from Ireland and compares them with burnt mound sites in Great Britain. The fulachtaí fiadh which are generally in clusters, are all groundwater-fed by springs, along floodplains and at the bases of slopes. The sites are associated with the clearance of wet woodland for fuel; most had evidence of nearby agriculture and all revealed low levels of grazing. Multi-element analysis at two sites revealed elevated heavy metal concentrations suggesting that off-site soil, ash or urine had been used in the trough. Overall the evidence suggests that the most likely function for these sites is textile production involving both cleaning and/or dyeing of wool and/or natural plant fibres and as a functionally related activity to hide cleaning and tanning. Whilst further research is clearly needed to confirm if fulachtaí fiadh are part of the ‘textile revolution’ we should also recognise their important role in the rapid deforestation of the wetter parts of primary woodland and the expansion of agriculture into marginal areas during the Irish and British Bronze Ages

Beta-decay properties of 25^{25}Si and 26^{26}P

The $\beta$-decay properties of the neutron-deficient nuclei $^{25}$Si and $^{26}$P have been investigated at the GANIL/LISE3 facility by means of charged-particle and $\gamma$-ray spectroscopy. The decay schemes obtained and the Gamow-Teller strength distributions are compared to shell-model calculations based on the USD interaction. B(GT) values derived from the absolute measurement of the $\beta$-decay branching ratios give rise to a quenching factor of the Gamow-Teller strength of 0.6. A precise half-life of 43.7 (6) ms was determined for $^{26}$P, the $\beta$- (2)p decay mode of which is described

Sedimentary ancient DNA shows terrestrial plant richness continuously increased over the Holocene in northern Fennoscandia

The effects of climate change on species richness are debated but can be informed by the past. Here, we generated a sedimentary ancient DNA dataset covering 10 lakes and applied novel methods for data harmonization. We assessed the impact of Holocene climate changes and nutrients on terrestrial plant richness in northern Fennoscandia. We find that richness increased steeply during the rapidly warming Early Holocene. In contrast to findings from most pollen studies, we show that richness continued to increase thereafter, although the climate was stable, with richness and the regional species pool only stabilizing during the past three millennia. Furthermore, overall increases in richness were greater in catchments with higher soil nutrient availability. We suggest that richness will increase with ongoing warming, especially at localities with high nutrient availability and assuming that human activity remains low in the region, although lags of millennia may be expected.The effects of climate change on species richness are debated but can be informed by the past. Here, we generated a sedimentary ancient DNA dataset covering 10 lakes and applied novel methods for data harmonization. We assessed the impact of Holocene climate changes and nutrients on terrestrial plant richness in northern Fennoscandia. We find that richness increased steeply during the rapidly warming Early Holocene. In contrast to findings from most pollen studies, we show that richness continued to increase thereafter, although the climate was stable, with richness and the regional species pool only stabilizing during the past three millennia. Furthermore, overall increases in richness were greater in catchments with higher soil nutrient availability. We suggest that richness will increase with ongoing warming, especially at localities with high nutrient availability and assuming that human activity remains low in the region, although lags of millennia may be expected.Peer reviewe

Postglacial species arrival and diversity buildup of northern ecosystems took millennia

What drives ecosystem buildup, diversity, and stability? We assess species arrival and ecosystem changes across 16 millennia by combining regional-scale plant sedimentary ancient DNA from Fennoscandia with near-complete DNA and trait databases. We show that postglacial arrival time varies within and between plant growth forms. Further, arrival times were mainly predicted by adaptation to temperature, disturbance, and light. Major break points in ecological trait diversity were seen between 13.9 and 10.8 calibrated thousand years before the present (cal ka BP), as well as break point in functional diversity at 12.0 cal ka BP, shifting from a state of ecosystem buildup to a state where most habitat types and biotic ecosystem components were in place. Trait and functional diversity stabilized around 8 cal ka BP, after which both remained stable, although changes in climate took place and species inflow continued. Our ecosystem reconstruction indicates a millennial-scale time phase of formation to reach stable and resilient levels of diversity and functioning.publishedVersio

Safety, Efficacy, and Biomarker Analyses of Dostarlimab in Patients with Endometrial Cancer: Interim Results of the Phase I GARNET Study.

PURPOSE: This interim report of the GARNET phase I trial presents efficacy and safety of dostarlimab in patients with advanced or recurrent endometrial cancer (EC), with an analysis of tumor biomarkers as prognostic indicators. PATIENTS AND METHODS: A total of 153 patients with mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) and 161 patients with mismatch repair proficient (MMRp)/microsatellite stable (MSS) EC were enrolled and dosed. Patients received 500 mg dostarlimab every 3 weeks for 4 cycles, then 1000 mg every 6 weeks until progression. Primary endpoints were objective response rate (ORR) and duration of response (DOR). RESULTS: A total of 143 patients with dMMR/MSI-H EC and 156 patients with MMRp/MSS EC were evaluated for efficacy. ORR was 45.5% (n = 65) and 15.4% (n = 24) for dMMR/MSI-H EC and MMRp/MSS EC, respectively. Median DOR for dMMR/MSI-H EC was not met (median follow-up, 27.6 months); median DOR for MMRp/MSS EC was 19.4 months. The ORRs by combined positive score (CPS) ≥1 status were 54.9% and 21.7% for dMMR/MSI-H EC and MMRp/MSS EC, respectively. ORRs by high tumor mutational burden (≥10 mutations/Mb) were 47.8% (43/90) and 45.5% (5/11) for dMMR/MSI-H EC and MMRp/MSS EC, respectively. ORR in TP53mut or POLεmut molecular subgroups was 18.1% (17/94) and 40.0% (2/5), respectively. The safety profile of dostarlimab was consistent with previous reports. CONCLUSIONS: Dostarlimab demonstrated durable antitumor activity and safety in patients with dMMR/MSI-H EC. Biomarkers associated with EC may identify patients likely to respond to dostarlimab. TRIAL REGISTRATION: ClinicalTrials.gov NCT02715284