Brexit and the Cultural Sector

A collaborative ebook on the effects of the Brexit vote on the UK's cultural sector and its agents: "It's not just the economy, stupid! Brexit and the Cultural Sector", edited by Gesa Stedman and Sandra van Lente. Our contributors come from a broad range of cultural and artistic practice and many of them worry about two aspects which have come to the fore in the context of Brexit: the stark social rift which separates the Leave and Remain camps, and the nasty rise of xenophobia and insularity in all its different shapes and forms. Although our authors do not intend to be read or viewed as all-encompassing, and although they differ in respect to the focus they chose for their essays, poems, or statements, one aspect unifies their utterances: passion. Passion for the multi-faceted characteristics of culture, language, exchange, dialogue, border-crossings, passion for an outward-looking approach to both Britain, its different nations, and its neighbours close and far. A passionate fear of what Britain might lose in the process of departing from the EU. And the fear of loss does not concentrate on the loss of revenue or even on the probable obstacles to travel and artistic exchange once Brexit is in place. But the loss of ambivalence and ambiguity, the loss of conflicting opinions, texts, stances, diversity, in short: everything that culture, which is free to find its own forms of expression, is valued for

The US etonogestrel implant mandatory clinical training and active monitoring programs: 6-year experience

ObjectiveThe objective was to monitor the effectiveness of the etonogestrel implant clinical training program through a voluntary active monitoring program (AMP).Study designUS health care providers underwent mandatory training by the manufacturer on etonogestrel implant insertion, localization and removal. After training, health care providers could enroll in a voluntary AMP to provide outcome data to meet a postmarketing commitment of the manufacturer with the US Food and Drug Administration (FDA). Those who volunteered completed and faxed forms to the manufacturer after implant insertion and removal detailing the procedure and device-related outcomes, including insertion-, localization- or removal-associated events. Experts reviewed outcome data quarterly, which the Sponsor then reported to the FDA.ResultsAmong 42,337 health care providers completing the training program, 4294 (10.1%) volunteered to participate in the AMP. The 26,198 forms submitted over 6.4 years included more insertion (n=20,497) forms than removal forms (n=5701). The volunteers reported 646 events on 566 (2.2%) forms related to insertion (n=197), localization (n=34), removal (n=357) and "other" (n=58). Clinically important events included noninsertion (n=4), serum etonogestrel positive but implant not found (n=1), and possible nerve (n=66) or vascular (n=5) injury. The reports did not include any insertion-, localization- or removal-associated hospitalizations. Eight (0.14%) removal reports described referral for surgical implant removal.ConclusionEvents related to insertion, localization or removal of the etonogestrel implant are uncommon among US providers who received mandatory training in the use of the implant.ImplicationsThis report presents results from the first mandatory US contraceptive training program. Health care providers volunteered to report information about etonogestrel implant insertion, localization and removal. Although the data do not demonstrate whether a mandatory program improves outcomes, they elucidate the utility and real-life experience that clinical training programs can provide

Pre-deployment verification and predicted mapping speed of MUSCAT

The Mexico-UK Submillimetre Camera for AsTronomy (MUSCAT) is a 1.1 mm receiver consisting of 1,500 lumped-element kinetic inductance detectors (LEKIDs) for the Large Millimeter Telescope (LMT; Volcán Sierra Negra in Puebla, México). MUSCAT utilises the maximum field of view of the LMT's upgraded 50-metre primary mirror and is the first México-UK collaboration to deploy a millimetre/sub-mm receiver on the Large Millimeter Telescope. Using a simplistic simulator, we estimate a predicted mapping speed for MUSCAT by combining the measured performance of MUSCAT with the observed sky conditions at the LMT. We compare this to a previously calculated bolometric-model mapping speed and find that our mapping speed is in good agreement when this is scaled by a previously reported empirical factor. Through this simulation we show that signal contamination due to sky fluctuations can be effectively removed through the use of principle component analysis. We also give an overvie

MUSCAT focal plane verification

The Mexico-UK Submillimetre Camera for Astronomy (MUSCAT) is the second-generation large-format continuum camera operating in the 1.1 mm band to be installed on the 50-m diameter Large Millimeter Telescope (LMT) in Mexico. The focal plane of the instrument is made up of 1458 horn coupled lumped-element kinetic inductance detectors (LEKID) divided equally into six channels deposited on three silicon wafers. Here we present the preliminary results of the complete characterisation in the laboratory of the MUSCAT focal plane. Through the instrument's readout system, we perform frequency sweeps of the array to identify the resonance frequencies, and continuous timestream acquisitions to measure and characterise the intrinsic noise and 1/f knee of the detectors. Subsequently, with a re-imaging lens and a blackbody point source, the beams of every detector are mapped, obtaining a mean FWHM size of ~3.27 mm, close to the expected 3.1 mm. Then, by varying the intensity of a beam filling blackbody source, we measure the responsivity and noise power spectral density (PSD) for each detector under an optical load of 300 K, obtaining the noise equivalent power (NEP), with which we verify that the majority of the detectors are photon noise limited. Finally, using a Fourier Transform Spectrometer (FTS), we measure the spectral response of the instrument, which indicate a bandwidth of 1.0-1.2 mm centred on 1.1 mm, as expected

Design and characterization of the MUSCAT detectors

MUSCAT is a second-generation continuum camera for the Large Millimeter Telescope (LMT) 'Alfonso Serrano', to observe at the 1.1 mm atmospheric window. The camera has 1500 background-limited, horn-coupled lumped- element kinetic inductance detectors (LEKIDs) split across six arrays operating at 130-mK. The detector design for MUSCAT is based on a large-volume, double-meander geometry used as the inductive and two-polarization absorbing section of the LEKID resonator. In this paper we present the optical coupling of the meander to a choked waveguide output, the microwave design of the LEKID architecture, the device fabrication process and results demonstrating the detector sensitivity under a range of optical loads. Also presented are the performance of an aluminum absorbing layer used to minimize the optical cross-talk between detectors

Hair Cortisol in Twins : Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

A. Palotie on työryhmän jäsen.Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables.Peer reviewe

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe