338 research outputs found
Comparison Between Wolfe, Boyd, BI-RADS and TabĂĄr Based Mammographic Risk Assessment
Abstract. Mammographic risk assessment provides an indication of the likelihood of women developing breast cancer. Anumber ofmammographic image based classification methods have been developed, such as Wolfe, Boyd, BI-RADS and TabaÌr based assessment. We provide a comparative study of these four approaches. Results on the full MIAS database are presented, which indicate strong correlation (Spearmanâs> 0.9) between Wolfe, Boyd andBI-RADSbased classification, whilst the correlation with TabaÌr based classification is less straight forward (Spearmanâs < 0.5, but low correlations mainly caused by one of the classes).
Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy
Acknowledgments Blood biochemistry analysis and serum analysis were performed by the Easter Bush Pathology Department, University of Edinburgh. Animal husbandry was performed by Centre for Integrative Physiology bio-research restructure technical staff, University of Edinburgh. Assistance with intravenous injections was provided by Ian Coldicott (University of Sheffield) and Hannah Shorrock (University of Edinburgh). Human blood cDNA was a gift to GH from Kathy Evans, University of Edinburgh. Imaging was performed at the IMPACT imaging facility, University of Edinburgh, with technical assistance from Anisha Kubasik-Thayil. The authors would also like to thank Lyndsay Murray for technical discussions relating to qRT-PCR analysis. This work was supported by funding from the SMA Trust and the Anatomical Society (via grants to THG); the Euan MacDonald Centre for Motor Neurone Disease Research (via grants to THG and SHP); the Wellcome Trust (via grants to EJNG and THG); Muscular Dystrophy UK (via grants to THG and CGB); a Elphinstone Scholarship from the University of Aberdeen (to SHP); and The French Muscular Dystrophy Association (via grants to CM and JC).Peer reviewedPublisher PD
Semileptonic form factors - a model-independent approach
We demonstrate that the B->D(*) l nu form factors can be accurately predicted
given the slope parameter rho^2 of the Isgur-Wise function. Only weak
assumptions, consistent with lattice results, on the wavefunction for the light
degrees of freedom are required to establish this result. We observe that the
QCD and 1/m_Q corrections can be systematically represented by an effective
Isgur-Wise function of shifted slope. This greatly simplifies the analysis of
semileptonic B decay. We also investigate what the available semileptonic data
can tell us about lattice QCD and Heavy Quark Effective Theory. A rigorous
identity relating the form factor slope difference rho_D^2-rho_A1^2 to a
combination of form factor intercepts is found. The identity provides a means
of checking theoretically evaluated intercepts with experiment.Comment: 18 pages, Revtex, 4 postscript figures, uses epsfig.st
Fibrin glue obliteration is safe, effective and minimally invasive as first line treatment for pilonidal sinus disease in children
Background / Purpose: Sacrococcygeal pilonidal sinus disease (PSD) has an incidence of 1.2â2.5/1000 in children. Onset is around puberty. Symptoms of recurrent abscess and chronic suppuration may interfere with education and social integration. Treatments should cause minimal disruption while having good cure and recurrence rates. Curettage and Fibrin glue obliteration (FGO) show promising results in adults. We present our experience of its use in children.Methods: Review of all pediatric patients receiving FGO of pilonidal sinus performed by a single surgeon from September 2014 to February 2018.Results: Eighteen patients were identified. Median age was 16 (range 15â17), 55.6% were male. All procedures were completed as day cases. Median operative duration was 14 .1 (6â29) min. Twelve patients required only 1 procedure, 4 required 2 procedures, 1 required 5 procedures and 1 elected for formal excision after 2 FGO treatments. Median return to normal activities was 3âŻdays, with 1âŻday school absence. Two patients developed minor surgical site infections. Median follow-up was 52âŻweeks (17â102), during which time there was 1 recurrence (5.6%).Conclusion: This study demonstrates FGO is a safe, effective procedure for pediatric PNS, with results comparable to off-midline flap techniques and without the need for extensive tissue excision and the associated morbidity
Measuring Atmospheric Neutrino Oscillations with Neutrino Telescopes
Neutrino telescopes with large detection volumes can demonstrate that the
current indications of neutrino oscillation are correct or if a better
description can be achieved with non-standard alternatives. Observations of
contained muons produced by atmospheric neutrinos can better constrain the
allowed region for oscillations or determine the relevant parameters of
non-standard models. We analyze the possibility of neutrino telescopes
measuring atmospheric neutrino oscillations. We suggest adjustments to improve
this potential. An addition of four densely-instrumented strings to the AMANDA
II detector makes observations feasible. Such a configuration is competitive
with current and proposed experiments.Comment: 36 pages, 21 figures, revte
Patterns in reporting and participant inclusion related to race and ethnicity in autism intervention literature: Data from a large-scale systematic review of evidence-based practices
There are marked racial and ethnic disparities in diagnosis and services for individuals on the autism spectrum, yet race and ethnicity are underreported and underexamined in autism research. The current study examines the reporting of race and ethnicity and the inclusion of participants across racial and ethnic groups in studies included in a large-scale systematic review of autism intervention research (1990â2017). Trained research assistants reviewed 1013 articles and extracted data on the reporting of race and ethnicity data and the inclusion of participants from different racial and ethnic categories from each article. Only 25% of the articles reported any data on race and ethnicity and reporting over time has slowly increased across the 28 years of the review. Descriptive statistics suggest that race and ethnicity reporting varied by study design, intervention, and outcomes. In studies with reported data, White participants had the highest rate of participation (64.8%), with a large gap between the next highest rates of participation, which were among Hispanic/Latino (9.4%), Black (7.7%), and Asian (6.4%) participants. The lack of reporting and the limited inclusion of participants across minoritized racial and ethnic groups are concerning and suggest a need to examine practices in autism research from planning to dissemination. Lay Abstract: Researchers who study autism-related interventions do a poor job reporting data related to the race and ethnicity of autistic individuals who participate in their studies, and of those who do report these data, the participants are overwhelmingly White. This is problematic for many reasons, as we know little about how interventions are meeting the needs of culturally and linguistically diverse populations, and we assume that interventions are effective for all when they have been developed and validated primarily with and for White children. This study examined the reporting patterns of autism intervention researchers whose work was included in a large-scale systematic review of the intervention literature published between 1990 and 2017. We found that only 25% of studies (out of 1,013 included in the review) included data related to the race and ethnicity of their participants, with minimal change in reporting patterns across the years. In studies with reported data, White participants had the highest rate of participation, with a large gap between the next highest rates of participation among Hispanic/Latino, Black, and Asian participants. Other race and ethnicity groups had very low representation. This study includes additional analyses which examine how the reporting patterns and the inclusion of racially and ethnically diverse participants varies across study types, interventions, and outcome areas. Reporting this data is merely a starting point to begin to address the many disparities in autism-related healthcare, education, and research practices, and this article includes broader implications and next steps to ensure the field becomes more equitable and inclusive
Massive stars as thermonuclear reactors and their explosions following core collapse
Nuclear reactions transform atomic nuclei inside stars. This is the process
of stellar nucleosynthesis. The basic concepts of determining nuclear reaction
rates inside stars are reviewed. How stars manage to burn their fuel so slowly
most of the time are also considered. Stellar thermonuclear reactions involving
protons in hydrostatic burning are discussed first. Then I discuss triple alpha
reactions in the helium burning stage. Carbon and oxygen survive in red giant
stars because of the nuclear structure of oxygen and neon. Further nuclear
burning of carbon, neon, oxygen and silicon in quiescent conditions are
discussed next. In the subsequent core-collapse phase, neutronization due to
electron capture from the top of the Fermi sea in a degenerate core takes
place. The expected signal of neutrinos from a nearby supernova is calculated.
The supernova often explodes inside a dense circumstellar medium, which is
established due to the progenitor star losing its outermost envelope in a
stellar wind or mass transfer in a binary system. The nature of the
circumstellar medium and the ejecta of the supernova and their dynamics are
revealed by observations in the optical, IR, radio, and X-ray bands, and I
discuss some of these observations and their interpretations.Comment: To be published in " Principles and Perspectives in Cosmochemistry"
Lecture Notes on Kodai School on Synthesis of Elements in Stars; ed. by Aruna
Goswami & Eswar Reddy, Springer Verlag, 2009. Contains 21 figure
Cost-based domain filtering for stochastic constraint programming
Cost-based filtering is a novel approach that combines techniques from Operations Research and Constraint Programming to filter from decision variable domains values that do not lead to better solutions [7]. Stochastic Constraint Programming is a framework for modeling combinatorial optimization problems that involve uncertainty [9]. In this work, we show how to perform cost-based filtering for certain classes of stochastic constraint programs. Our approach is based on a set of known inequalities borrowed from Stochastic Programming Âż a branch of OR concerned with modeling and solving problems involving uncertainty. We discuss bound generation and cost-based domain filtering procedures for a well-known problem in the Stochastic Programming literature, the static stochastic knapsack problem. We also apply our technique to a stochastic sequencing problem. Our results clearly show the value of the proposed approach over a pure scenario-based Stochastic Constraint Programming formulation both in terms of explored nodes and run time
A search for periodic modulations of the solar neutrino flux in Super-Kamiokande-I
A search for periodic modulations of the solar neutrino flux was performed
using the Super-Kamiokande-I data taken from May 31st, 1996 to July 15th, 2001.
The detector's capability of measuring the exact time of events, combined with
a relatively high yield of solar neutrino events, allows a search for
short-time variations in the observed flux. We employed the Lomb test to look
for periodic modulations of the observed solar neutrino flux. The obtained
periodogram is consistent with statistical fluctuation and no significant
periodicity was found
Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment
This paper describes an analysis of the angular distribution of W->enu and
W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with
the ATLAS detector at the LHC in 2010, corresponding to an integrated
luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and
the missing transverse energy, the W decay angular distribution projected onto
the transverse plane is obtained and analysed in terms of helicity fractions
f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV
and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw
> 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour,
are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017
+/- 0.030, where the first uncertainties are statistical, and the second
include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables,
revised author list, matches European Journal of Physics C versio
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