35 research outputs found
Changes in the gut microbiota of mice orally exposed to methylimidazolium ionic liquids
Ionic liquids are salts used in a variety of industrial processes, and being relatively non-volatile, are proposed as environmentally-friendly replacements for existing volatile liquids. Methylimidazolium ionic liquids resist complete degradation in the environment, likely because the imidazolium moiety does not exist naturally in biological systems. However, there is limited data available regarding their mammalian effects in vivo. This study aimed to examine the effects of exposing mice separately to 2 different methylimidazolium ionic liquids (BMI and M8OI) through their addition to drinking water. Potential effects on key target organs-the liver and kidney-were examined, as well as the gut microbiome. Adult male mice were exposed to drinking water containing ionic liquids at a concentration of 440 mg/L for 18 weeks prior to examination of tissues, serum, urine and the gut microbiome. Histopathology was performed on tissues and clinical chemistry on serum for biomarkers of hepatic and renal injury. Bacterial DNA was isolated from the gut contents and subjected to targeted 16S rRNA sequencing. Mild hepatic and renal effects were limited to glycogen depletion and mild degenerative changes respectively. No hepatic or renal adverse effects were observed. In contrast, ionic liquid exposure altered gut microbial composition but not overall alpha diversity. Proportional abundance of Lachnospiraceae, Clostridia and Coriobacteriaceae spp. were significantly greater in ionic liquid-exposed mice, as were predicted KEGG functional pathways associated with xenobiotic and amino acid metabolism. Exposure to ionic liquids via drinking water therefore resulted in marked changes in the gut microbiome in mice prior to any overt pathological effects in target organs. Ionic liquids may be an emerging risk to health through their potential effects on the gut microbiome, which is implicated in the causes and/or severity of an array of chronic disease in humans
Improving the simulation of landfast ice by combining tensile strength and a parameterization for grounded ridges
ABSTRACT: In some coastal regions of the Arctic Ocean, grounded ice ridges contribute to stabilizing andmaintaining a landfast ice cover. Recently, a grounding scheme representing this effect on sea ice dynamicswas introduced and tested in a viscous-plastic sea ice model. This grounding scheme, based on a basalstress parameterization, improves the simulation of landfast ice in many regions such as in the East SiberianSea, the Laptev Sea, and along the coast of Alaska. Nevertheless, in some regions like the Kara Sea, the areaof landfast ice is systematically underestimated. This indicates that another mechanism such as ice archingis at play for maintaining the ice cover fast. To address this problem, the combination of the basal stressparameterization and tensile strength is investigated using a 0.258Pan-Arctic CICE-NEMO configuration.Both uniaxial and isotropic tensile strengths notably improve the simulation of landfast ice in the Kara Seabut also in the Laptev Sea. However, the simulated landfast ice season for the Kara Sea is too short com-pared to observations. This is especially obvious for the onset of the landfast ice season which systematical-ly occurs later in the model and with a slower build up. This suggests that improvements to the sea icethermodynamics could reduce these discrepancies with the data. Key Points - A grounding scheme is not enough to simulate landfast ice in Pan-Arctic simulations; - Both uniaxial and isotropic tensile strengths notably improve the simulation of landfast ice in deep coastal regions; - Simulated landfast ice season in the Kara Sea is still too short suggesting that thermodynamics should be improved
The Infrared Continuum of Active Galaxies
We discuss the different physical processes contributing to the infrared
continuum of AGN, assuming that both photoionization from the active center and
shocks ionize and heat the gas and dust contained in an ensemble of clouds
surrounding the nucleus. Radiation transfer of primary and secondary radiation
throughout a cloud is calculated consistently with collisional processes due to
the shock. We consider that the observed continuum corresponds to reprocessed
radiation from both dust and gas in the clouds. The model is applied to the
continuum of Seyfert galaxies from which best estimate of the nuclear, stellar
subtracted, emission is available. The results show that radiation-dominated
high velocity clouds are more numerous in Seyfert 1-1.5 whereas shock-dominated
low velocity clouds are dominant in Seyfert type 2 in full agreement with the
unified model for AGN. In type 2 objects, radiation is partly suppressed by a
central dusty medium with a high dust-to-gas ratio. A grid of models is used to
provide a phenomenological analysis of the observed infrared spectral energy
distribution.Comment: 14 pages, 10 figures. in press in MNRA
The 1-1000 micron SEDs of far-infrared galaxies
Galaxies selected at 170um by the ISO FIRBACK survey represent the brightest
\~10% of the Cosmic Infrared Background. Examining their nature in detail is
therefore crucial for constraining models of galaxy evolution. Here we combine
Spitzer archival data with previous near-IR, far-IR, and sub-mm observations of
a representative sample of 22 FIRBACK galaxies spanning three orders of
magnitude in infrared luminosity. We fit a flexible, multi-component, empirical
SED model of star-forming galaxies designed to model the entire ~1-1000um
wavelength range. The fits are performed with a Markov Chain Monte Carlo (MCMC)
approach, allowing for meaningful uncertainties to be derived. This approach
also highlights degeneracies such as between Td and beta, which we discuss in
detail. From these fits and standard relations we derive: L_IR, L_PAH, SFR,
tau_V, M_star, M_dust, Td, and beta. We look at a variety of correlations
between these and combinations thereof in order to examine the physical nature
of these galaxies. Our conclusions are supplemented by morphological
examination of the sources, and comparison with local samples. We find the bulk
of our sample to be consistent with fairly standard size and mass disk galaxies
with somewhat enhanced star-formation relative to local spirals, but likely not
bona fide starbursts. A few higher-z LIGs and ULIGs are also present, but
contrary to expectation, they are weak mid-IR emitters and overall are
consistent with star-formation over an extended cold region rather than
concentrated in the nuclear regions. We discuss the implications of this study
for understanding populations detected at other wavelengths, such as the bright
850um SCUBA sources or the faint Spitzer 24um sources.Comment: 19 pages, 20 figures, accepted for publication in MNRA
Acute high-intensity exercise and skeletal muscle mitochondrial respiratory function: role of metabolic perturbation
Recently it was documented that fatiguing, high-intensity exercise resulted in a significant attenuation in maximal skeletal muscle mitochondrial respiratory capacity, potentially due to the intramuscular metabolic perturbation elicited by such intense exercise. With the utilization of intrathecal fentanyl to attenuate afferent feedback from group III/IV muscle afferents, permitting increased muscle activation and greater intramuscular metabolic disturbance, this study aimed to better elucidate the role of metabolic perturbation on mitochondrial respiratory function. Eight young, healthy males performed high-intensity cycle exercise in control (CTRL) and fentanyl-treated (FENT) conditions. Liquid chromatography-mass spectrometry and high-resolution respirometry were used to assess metabolites and mitochondrial respiratory function, respectively, pre- and postexercise in muscle biopsies from the vastus lateralis. Compared with CTRL, FENT yielded a significantly greater exercise-induced metabolic perturbation (PCr: −67% vs. −82%, Pi: 353% vs. 534%, pH: −0.22 vs. −0.31, lactate: 820% vs. 1,160%). Somewhat surprisingly, despite this greater metabolic perturbation in FENT compared with CTRL, with the only exception of respiratory control ratio (RCR) (−3% and −36%) for which the impact of FENT was significantly greater, the degree of attenuated mitochondrial respiratory capacity postexercise was not different between CTRL and FENT, respectively, as assessed by maximal respiratory flux through complex I (−15% and −33%), complex II (−36% and −23%), complex I + II (−31% and −20%), and state 3CI+CII control ratio (−24% and −39%). Although a basement effect cannot be ruled out, this failure of an augmented metabolic perturbation to extensively further attenuate mitochondrial function questions the direct role of high-intensity exercise-induced metabolite accumulation in this postexercise response
Spitzer Photometry of WISE-Selected Brown Dwarf and Hyper-Luminous Infrared Galaxy Candidates
We present Spitzer 3.6 and 4.5 m photometry and positions for a sample
of 1510 brown dwarf candidates identified by the WISE all-sky survey. Of these,
166 have been spectroscopically classified as objects with spectral types M(1),
L(7), T(146), and Y(12); Sixteen other objects are non-(sub)stellar in nature.
The remainder are most likely distant L and T dwarfs lacking spectroscopic
verification, other Y dwarf candidates still awaiting follow-up, and assorted
other objects whose Spitzer photometry reveals them to be background sources.
We present a catalog of Spitzer photometry for all astrophysical sources
identified in these fields and use this catalog to identify 7 fainter (4.5
m 17.0 mag) brown dwarf candidates, which are possibly wide-field
companions to the original WISE sources. To test this hypothesis, we use a
sample of 919 Spitzer observations around WISE-selected high-redshift
hyper-luminous infrared galaxy (HyLIRG) candidates. For this control sample we
find another 6 brown dwarf candidates, suggesting that the 7 companion
candidates are not physically associated. In fact, only one of these 7 Spitzer
brown dwarf candidates has a photometric distance estimate consistent with
being a companion to the WISE brown dwarf candidate. Other than this there is
no evidence for any widely separated ( 20 AU) ultra-cool binaries. As an
adjunct to this paper, we make available a source catalog of 7.33
objects detected in all of these Spitzer follow-up fields for use
by the astronomical community. The complete catalog includes the Spitzer 3.6
and 4.5 m photometry, along with positionally matched and
photometry from USNO-B; , , and photometry from 2MASS; and ,
, , and photometry from the WISE all-sky catalog
Spitzer Photometry of WISE-Selected Brown Dwarf and Hyper-Lumninous Infrared Galaxy Candidates
We present Spitzer 3.6 and 4.5 micrometer photometry and positions for a sample of 1510 brown dwarf candidates identified by the Wide-field Infrared Survey Explorer (WISE) all-sky survey. Of these, 166 have been spectroscopically classified as objects with spectral types M(1), L(7), T(146), and Y(12). Sixteen other objects are non-(sub)stellar in nature. The remainder are most likely distant L and T dwarfs lacking spectroscopic verification, other Y dwarf candidates still awaiting follow-up, and assorted other objects whose Spitzer photometry reveals them to be background sources. We present a catalog of Spitzer photometry for all astrophysical sources identified in these fields and use this catalog to identify seven fainter (4.5 m to approximately 17.0 mag) brown dwarf candidates, which are possibly wide-field companions to the original WISE sources. To test this hypothesis, we use a sample of 919 Spitzer observations around WISE-selected high-redshift hyper-luminous infrared galaxy candidates. For this control sample, we find another six brown dwarf candidates, suggesting that the seven companion candidates are not physically associated. In fact, only one of these seven Spitzer brown dwarf candidates has a photometric distance estimate consistent with being a companion to the WISE brown dwarf candidate. Other than this, there is no evidence for any widely separated (greater than 20 AU) ultra-cool binaries. As an adjunct to this paper, we make available a source catalog of 7.33 x 10(exp 5) objects detected in all of these Spitzer follow-up fields for use by the astronomical community. The complete catalog includes the Spitzer 3.6 and 4.5 m photometry, along with positionally matched B and R photometry from USNO-B; J, H, and Ks photometry from Two Micron All-Sky Survey; and W1, W2, W3, and W4 photometry from the WISE all-sky catalog
Empirical modelling of the BLASTPol achromatic half-wave plate for precision submillimetre polarimetry
A cryogenic achromatic half-wave plate (HWP) for submillimetre astronomical polarimetry
has been designed, manufactured, tested and deployed in the Balloon-borne Large-Aperture
Submillimeter Telescope for Polarimetry (BLASTPol). The design is based on the five-slab
Pancharatnam recipe and itworks in thewavelength range 200–600 μm, making it the broadestband
HWP built to date at (sub)millimetre wavelengths. The frequency behaviour of the HWP
has been fully characterized at room and cryogenic temperatures with incoherent radiation
from a polarizing Fourier transform spectrometer. We develop a novel empirical model, complementary
to the physical and analytical ones available in the literature, that allows us to
recover the HWP Mueller matrix and phase shift as a function of frequency and extrapolated
to 4 K. We show that most of the HWP non-idealities can be modelled by quantifying one
wavelength-dependent parameter, the position of the HWP equivalent axes, which is then readily
implemented in a map-making algorithm. We derive this parameter for a range of spectral
signatures of input astronomical sources relevant to BLASTPol, and provide a benchmark
example of how our method can yield improved accuracy on measurements of the polarization
angle on the sky at submillimetre wavelengths
The First Post-Kepler Brightness Dips of KIC 8462852
We present a photometric detection of the first brightness dips of the unique variable star KIC 8462852 since the end of the Kepler space mission in 2013 May. Our regular photometric surveillance started in October 2015, and a sequence of dipping began in 2017 May continuing on through the end of 2017, when the star was no longer visible from Earth. We distinguish four main 1-2.5% dips, named "Elsie," "Celeste," "Skara Brae," and "Angkor", which persist on timescales from several days to weeks. Our main results so far are: (i) there are no apparent changes of the stellar spectrum or polarization during the dips; (ii) the multiband photometry of the dips shows differential reddening favoring non-grey extinction. Therefore, our data are inconsistent with dip models that invoke optically thick material, but rather they are in-line with predictions for an occulter consisting primarily of ordinary dust, where much of the material must be optically thin with a size scale <<1um, and may also be consistent with models invoking variations intrinsic to the stellar photosphere. Notably, our data do not place constraints on the color of the longer-term "secular" dimming, which may be caused by independent processes, or probe different regimes of a single process