1,225 research outputs found
Optimisation of downy mildew (Plasmopara viticola) control in organic viticulture with low copper doses, new copper formulations and plant strengtheners, results of four years of on farm research
In three different wine growing regions in Germany, due to weather and infection conditions several fungicide (copper formulations) and plant strengtheners (Myco-Sin VIN®, Kendal®, Frutogard ®) applications against downy mildew are required in order to obtain satisfactory disease control. Results of the four years of on farm trials confirmed good efficacy of the copper based substances like copper hydroxide, partly in combination with two or three applications of potassium phosphonate, new copper-hydroxide formulation or copper oxychloride used in a low doses of copper and alternative products like Myco-Sin-VIN® (clay with high aluminium content) in combination with Kendal® ( plant extract)
Untersuchungen des BÖL-Verbundprojektes zur Kupferminimierung im ökologischen Weinbau
The development of sustainable and economically feasible strategies to get an effec-tual control of downy mildew on grapes (Plasmopara viticola) with less than 3 kg/(ha*a) of copper to avoid further environmental risks is the intention of this project. Due to harmful effects on the natural environment, copper applications are under considera-tion. Therefore, in this four-year-project first of all test products are screened under greenhouse conditions on potted vines. Thereafter the best test agents are studied in organically managed test vineyards. Finally the selected strategies are tested under practical conditions on organically managed vineyards. Beyond these examinations a close link between wineries and research is given by SME and consultant partners. The results indicate that plant extracts, finely ground stones and new copper formula-tions could probably serve as plant resistance improvers and plant protection prod-ucts, respectively, to prevent attacks of P. viticola. Moreover, it was possible to select prosperous agents and strategies for the growing period 2007. These were agents of the substance categories “new copper formulations”, “plant extracts” and “finely ground stones”. Regarding the results of three growing periods, the project will provide effective and economically feasible alternatives for copper applications in order to deliver sustainable approaches for P. viticola control in practise
Measuring the equation of state of a hard-disc fluid
We use video microscopy to study a two-dimensional (2D) model fluid of
charged colloidal particles suspended in water and compute the pressure from
the measured particle configurations. Direct experimental control over the
particle density by means of optical tweezers allows the precise measurement of
pressure as a function of density. We compare our data with theoretical
predictions for the equation of state, the pair-correlation function and the
compressibility of a hard-disc fluid and find good agreement, both for the
fluid and the solid phase. In particular the location of the transition point
agrees well with results from Monte Carlo simulations.Comment: 7 pages, to appear in EPL, slightly corrected versio
Renormalized kinetic theory of classical fluids in and out of equilibrium
We present a theory for the construction of renormalized kinetic equations to
describe the dynamics of classical systems of particles in or out of
equilibrium. A closed, self-consistent set of evolution equations is derived
for the single-particle phase-space distribution function , the correlation
function , the retarded and advanced density response
functions to an external potential , and
the associated memory functions . The basis of the theory is an
effective action functional of external potentials that
contains all information about the dynamical properties of the system. In
particular, its functional derivatives generate successively the
single-particle phase-space density and all the correlation and density
response functions, which are coupled through an infinite hierarchy of
evolution equations. Traditional renormalization techniques are then used to
perform the closure of the hierarchy through memory functions. The latter
satisfy functional equations that can be used to devise systematic
approximations. The present formulation can be equally regarded as (i) a
generalization to dynamical problems of the density functional theory of fluids
in equilibrium and (ii) as the classical mechanical counterpart of the theory
of non-equilibrium Green's functions in quantum field theory. It unifies and
encompasses previous results for classical Hamiltonian systems with any initial
conditions. For equilibrium states, the theory reduces to the equilibrium
memory function approach. For non-equilibrium fluids, popular closures (e.g.
Landau, Boltzmann, Lenard-Balescu) are simply recovered and we discuss the
correspondence with the seminal approaches of Martin-Siggia-Rose and of
Rose.and we discuss the correspondence with the seminal approaches of
Martin-Siggia-Rose and of Rose.Comment: 63 pages, 10 figure
HSP90 is essential for Jak-STAT signaling in classical Hodgkin lymphoma cells
In classical Hodgkin lymphoma (cHL) chemotherapeutic regimens are associated with stagnant rates of secondary malignancies requiring the development of new therapeutic strategies. We and others have shown that permanently activated Signal Transducer and Activator of Transcription (STAT) molecules are essential for cHL cells. Recently an overexpression of heat-shock protein 90 (HSP90) in cHL cells has been shown and inhibition of HSP90 seems to affect cHL cell survival. Here we analysed the effects of HSP90 inhibition by geldanamycin derivative 17-AAG or RNA interference (RNAi) on aberrant Jak-STAT signaling in cHL cells. Treatment of cHL cell lines with 17-AAG led to reduced cell proliferation and a complete inhibition of STAT1, -3, -5 and -6 tyrosine phosphorylation probably as a result of reduced protein expression of Janus kinases (Jaks). RNAi-mediated inhibition of HSP90 showed similar effects on Jak-STAT signaling in L428 cHL cells. These results suggest a central role of HSP90 in permanently activated Jak-STAT signaling in cHL cells. Therapeutics targeting HSP90 may be a promising strategy in cHL and other cancer entities associated with deregulated Jak-STAT pathway activation
The JAK inhibitor AZD1480 regulates proliferation and immunity in Hodgkin lymphoma
Aberrant activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway has been reported to promote proliferation and survival of Hodgkin and Reed–Sternberg cells of Hodgkin lymphoma (HL). We investigated the activity of the JAK inhibitor AZD1480 in HL-derived cell lines and determined its mechanisms of action. AZD1480 at low doses (0.1–1 μ) potently inhibited STATs phosphorylation, but did not predictably result in antiproliferative effects, as it activated a negative-feedback loop causing phosphorylation of JAK2 and extracellular signal-regulated kinases 1 and 2 (ERK1/2), and increased IP-10, RANTES and interleukin (IL)-8 concentrations in the supernatants. Inhibition of the ERK activity by mitogen-activated extracellular signal regulated kinase (MEK) inhibitors (UO126 and PD98059) enhanced the cytotoxic activity of AZD1480. Interestingly, submicromolar concentrations of AZD1480 demonstrated significant immunoregulatory effects by downregulating T-helper 2 cytokines and chemokines, including IL-13 and thymus- and activation-regulated chemokine, and the surface expression of the immunosuppressive programmed death ligands 1 and 2. Higher concentrations of AZD1480 (5 μ) induced G2/M arrest and cell death by inhibiting Aurora kinases. Our study demonstrates that AZD1480 regulates proliferation and immunity in HL cell lines and provides mechanistic rationale for evaluating AZD1480 alone or in combination with MEK inhibitors in HL
Funktionalität und Bedienung von eGENA, der elektronischen Gedächtnis- und Entscheidungshilfe für Notfälle in der Anästhesiologie
A search for point sources of EeV photons
Measurements of air showers made using the hybrid technique developed with
the fluorescence and surface detectors of the Pierre Auger Observatory allow a
sensitive search for point sources of EeV photons anywhere in the exposed sky.
A multivariate analysis reduces the background of hadronic cosmic rays. The
search is sensitive to a declination band from -85{\deg} to +20{\deg}, in an
energy range from 10^17.3 eV to 10^18.5 eV. No photon point source has been
detected. An upper limit on the photon flux has been derived for every
direction. The mean value of the energy flux limit that results from this,
assuming a photon spectral index of -2, is 0.06 eV cm^-2 s^-1, and no celestial
direction exceeds 0.25 eV cm^-2 s^-1. These upper limits constrain scenarios in
which EeV cosmic ray protons are emitted by non-transient sources in the
Galaxy.Comment: 28 pages, 10 figures, accepted for publication in The Astrophysical
Journa
Reconstruction of inclined air showers detected with the Pierre Auger Observatory
We describe the method devised to reconstruct inclined cosmic-ray air showers
with zenith angles greater than detected with the surface array of
the Pierre Auger Observatory. The measured signals at the ground level are
fitted to muon density distributions predicted with atmospheric cascade models
to obtain the relative shower size as an overall normalization parameter. The
method is evaluated using simulated showers to test its performance. The energy
of the cosmic rays is calibrated using a sub-sample of events reconstructed
with both the fluorescence and surface array techniques. The reconstruction
method described here provides the basis of complementary analyses including an
independent measurement of the energy spectrum of ultra-high energy cosmic rays
using very inclined events collected by the Pierre Auger Observatory.Comment: 27 pages, 19 figures, accepted for publication in Journal of
Cosmology and Astroparticle Physics (JCAP
Compressed representation of a partially defined integer function over multiple arguments
In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
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