Age as a Correlate of Quality of Academic Programmes: the Case of Public Universities in South West Nigeria

This study examined the influence of age on quality of academicprogrammes in South West Nigerian universities. A descriptive survey design was used in the study. Data were collected from 600 academic staff using stratified, purposive and simple random techniques. The data were analysed using frequency counts, percentages, means, standard deviation and t-test statistic. The study revealed that there was significant difference between first generation and third generation universities in their extent of compliance with quality assurance measures on academic programmes. Also, a significant difference was found between first generation and third generation universities on constraints to quality assurance measures with third generation universities facing greater constraints. It was recommended that both categories of universities be given adequate  attention in the provision of quality-enhancing inputs. However, third generation universities should be accorded greater priority in allocation of resources. In addition, greater collaboration is recommended between first and third generation universities while newly established universities must be affiliated with older universities for mentoring.Keywords: Age of University; Quality assurance; Programme accreditatio

Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury.

OBJECTIVE: This study tests the hypothesis that injury to the somatosensory cortex is associated with periorbital allodynia and increases in nociceptive neuropeptides in the brainstem in a mouse model of controlled cortical impact (CCI) injury. METHODS: Male C57BL/6 mice received either CCI or craniotomy-only followed by weekly periorbital von Frey (mechanical) sensory testing for up to 28 days post-injury. Mice receiving an incision only and naïve mice were included as control groups. Changes in calcitonin gene-related peptide (CGRP) and substance P (SP) within the brainstem were determined using enzyme-linked immunosorbent assay and immunohistochemistry, respectively. Activation of ionized calcium-binding adaptor molecule-1-labeled macrophages/microglia and glial fibrillary acidic protein (GFAP)-positive astrocytes were evaluated using immunohistochemistry because of their potential involvement in nociceptor sensitization. RESULTS: Incision-only control mice showed no changes from baseline periorbital von Frey mechanical thresholds. CCI significantly reduced mean periorbital von Frey thresholds (periorbital allodynia) compared with baseline and craniotomy-only at each endpoint, analysis of variance P \u3c .0001. Craniotomy significantly reduced periorbital threshold at 14 days but not 7, 21, or 28 days compared with baseline threshold, P \u3c .01. CCI significantly increased SP immunoreactivity in the brainstem at 7 and 14 days but not 28 days compared with craniotomy-only and controls, P \u3c .001. CGRP levels in brainstem tissues were significantly increased in CCI groups compared with controls (incision-only and naïve mice) or craniotomy-only mice at each endpoint examined, P \u3c .0001. There was a significant correlation between CGRP and periorbital allodynia (P \u3c .0001, r = -0.65) but not for SP (r = 0.20). CCI significantly increased the number of macrophage/microglia in the injured cortex at each endpoint up to 28 days, although cell numbers declined over weeks post-injury, P \u3c .001. GFAP(+) immunoreactivity was significantly increased at 7 but not 14 or 28 days after CCI, P \u3c .001. Craniotomy resulted in transient periorbital allodynia accompanied by transient increases in SP, CGRP, and GFAP immunoreactivity compared with control mice. There was no increase in the number of macrophage/microglia cells compared with controls after craniotomy. CONCLUSION: Injury to the somatosensory cortex results in persistent periorbital allodynia and increases in brainstem nociceptive neuropeptides. Findings suggest that persistent allodynia and increased neuropeptides are maintained by mechanisms other than activation of macrophage/microglia or astrocyte in the injured somatosensory cortex

Vibration under variable magnitude moving distributed masses of non-uniform Bernoulli-Euler beam resting on Pasternak elastic foundation

The dynamic response to variable magnitude moving distributed masses of simply supported non-uniform Bernoulli-Euler beam resting on Pasternak elastic foundation is investigated in this paper. The problem is governed by fourth-order partial differential equation with variable and singular coefficients. The main objective of this work is to obtain closed form solution to this class of dynamical problem. In order to obtain the solution, a technique based on the method of Galerkin with the series representation of Heaviside function is first used to reduce the equation to second order ordinary differential equations with variable coefficients. Thereafter the transformed equations are simplified using (i) The Laplace transformation technique in conjunction with convolution theory to obtain the solution for moving force problem and (ii) finite element analysis in conjunction with Newmark method to solve the analytically unsolvable moving mass problem because of the harmonic nature of the moving load. The finite element method is first used to solve the moving force problem and the solution is compared with the analytical solution of the moving force problem in order to validate the accuracy of the finite element method in solving the analytically unsolvable moving mass problem. The numerical solution using the finite element method is shown to compare favorably with the analytical solution of the moving force problem. The displacement response for moving distributed force and moving distributed mass models for the dynamical problem are calculated for various time t and presented in plotted curves

Phytochemical Screening of the Bark of Vernonia Amygdalina

The bark of vernoniaamygdalina has been selected for this work in order to ascertain the natural and  medicinal endowment based on the ethnobotanical evidences of the plant. Phytochemical screening was carried out on the bark of vernoniaamygdalina (bitter leave), using both methanolic and chloroform extracts, this screening analysis confirmed the presence of saponins, alkaloids, cardiac glycosides, anthraquinones and phobatannins. Keywords: Phytochemical Screening, Vernoniaamygdalina

Nutritionally Improved Cookies from Composite Flour: African Walnut (Tetracarpidium conophorum) with Wheat

African walnut seed (Tetracarpidium conophorum) is rich in protein and phytochemical with great potentials for food application, but has limited uses in food industry. The African walnut seed was procured from Oje market and commercial wheat flour in Aleshiloye market, Ibadan. The commercial wheat and African walnut flours were composites of varying ratios; 100:0, 90:10, 80:20, 70:30 and 60:40 to prepare cookies and labeled samples X, A, B, C and D respectively. The proximate composition, anti-nutrients (oxalates, phytate and protease inhibitor), phyto-chemical (tannins, flavonoids, alkaloids, terpenoids, saponins, and Oxygen Radical Absorbance Capacity (ORAC) and sensory evaluation of the cookies were determined using standard methods. The result of proximate composition of cookies showed that carbohydrate (47.0-52.36%), protein (16.3-19.6%) and fat (18.5-19.2%) were the major components in the cookie samples. Other components including; moisture (7.7-8.4%), ash (4.1-4.2%) and fibre (0.9-1.8%) were generally low. Anti-nutrient factors of cookie samples ranged from 11.3-17.7mg/100g for Phytate and no traces of oxalates and protease inhibitors in all cookie samples. Control cookie sample had no traces of tannin, flavonoids and saponins, but enriched cookie ranged from 10.3-14.7mg/100g; 3.4-5.7mg/100g and 10.7-15.3mg/100g, respectively. Phytochemical constituents of cookie samples in ORAC ranged from 3.4-12.0mg/100g and alkaloids (3.7-7.7mg/100g). Organoleptic panelists preferred sample X to all other samples, followed by sample A. Inclusion of 10% African walnut flour compared favorably with wheat cookie in terms of sensory quality

Afforestation/Reforestation Based on Gmelina Arborea (Verbenaceae) in Tropical Africa: Floristic and Structural Analysis, Carbon Storage and Economic Value (Cameroon)

The study was carried out in three selected plantations. Sampling was made infive 100x20 m2 plots per site. Overall, 32 species, 36 genera and 17 families were surveyed. Hymenocardia acida, Combretum adenogonium, Daniellia oliveri, Entada africana, Terminalia macroptera, T. laxiflora, Lannea schimperi, Lophira lanceolata, Maytenus senegalensis, Ochna schweinfurthiana, Protea madiensis, Psorospermum senegalense, Piliostigma thonningii, Sarcocephalus latifolius and Securidaca longepedunculata were the most important species. The richness index ranged from 2.53±0.05-7.74±0.03. Shannon index was 3 in all sites. Density ranged from 98±2.01-253±10.23 stems/ha. Basal area was statistically significant among the sites (p70 %). The vertical structure showed three types of figures; L shape, symmetrical bell shape and unsymmetrical bell shape. These structures confirmed a good regeneration of timbers in the sites. There was a positive correlation of the species dispersal in the sites (p<0.001). The amount of AGB was 23.50±0.38 t C/ha. The amount of C sequestration was 86.28±16.57 t CO2eq/ha. The ecosystem service payments ranged between 258.87±24.88-8629.25±248.16 €/ha with the lowest values for CDM price and the highest for REDD+price. A financing of such projects is required in the frame of creating adaptation and attenuation measures to global warming effects

Water Level Uncertainties Due to Uncertain Bedform Dynamics in the Dutch Rhine System

Quantitative estimations of water level uncertainties are essential for the design and assessment of flood protection systems. This work aims to quantify the water level uncertainties in the bifurcating Dutch river Rhine system as a result of main channel roughness uncertainty. An one-dimensional hydraulic model of the Rhine branches is used to estimate the water levels in the system for several roughness scenarios. Model results show that the roughness effect has a large influence on the modelled water levels. However, for the larger Waal branch, the changing discharge distribution counteracts the roughness effect, thereby decreasing the range of possible water levels. For the smaller Nederrijn and IJssel branch it is possible that the discharge in the respective branch increases even though the branch has a high roughness. Thereby, for these branches the discharge distribution effect increases the range in modelled water levels. The large and varying effects on water levels by roughness uncertainty and changing discharge distributions in a bifurcating river system indicate the importance to consider the system as a whole instead of as separate branches in the design and assessment of river engineering works

A study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians

BACKGROUND: In studies on the genetics of human aging, we observed an age-related variation of the 3'APOB-VNTR genotypic pool (alleles: Short, S, <35 repeats; Medium, M, 35–39 repeats; Long, L, >39 repeats) with the homozygous SS genotype showing a convex frequency trajectory in a healthy aging population. This genotype was rare in centenarians, thus indicating that the S alleles are unfavorable to longevity, while common in adults, thus indicating a protective role at middle age. This apparent paradox could be due to possible effects exerted by the above polymorphism on lipidemic parameters. Aim of the work was to get insights into these puzzling findings METHODS: We followed a double strategy. Firstly, we analyzed the average effects of S (α(S)), M (α(M)), and L (α(L)) alleles on lipidemic parameters in a sample of healthy people (409 subjects aged 20–102 years) recruited in Calabria (southern Italy). The (α(S)), (α(M)), and (α(L)) values were estimated by relating 3'APOB-VNTR genotypes to lipidemic parameters, after adjustment for age, sex and body mass index (multiple regression). Then, we analyzed the S alleles as susceptibility factors of Cardiovascular Atherosclerotic Disease (CD) in CD patients characterized either by low serum HDL-Cholesterol or by high serum LDL-Cholesterol (CD-H and CD-L patients, 40 and 40 subjects respectively). The Odds Ratios (OR) were computed for carriers of S alleles in CD-H and CD-L patients matched for origin, sex and age with controls extracted from the sample of healthy subjects. RESULTS: By the analysis of the healthy sample group we found that the S alleles lower the average values of serum Total Cholesterol (α(S )= -5.98 mg/dL with [-11.62 ÷ -0.74] 95% confidence interval) and LDL-Cholesterol (α(S )= -4.41 mg/dL with [-8.93 ÷ -0.20] 95% confidence interval) while the alleles M and L have no significant effect on the lipidemic phenotype. In line with these findings, the analysis of CD patients showed that the S alleles are protective as for CD-L (O.R. = 0.55 with [0.21 ÷ 0.98] 95% confidence interval) while neutral as for CD-H (O.R. = 0.75 with [0.32 ÷ 1.60] 95% confidence interval). CONCLUSION: On the whole, the S alleles would be advantageous in adults (by protecting from CD-L) while dangerous in the elderly, probably by lowering serum cholesterol below a critical threshold. This could explain the convex frequency trajectory of SS genotypes previously observed in a healthy aging population