Tuberculosis y SIDA pediátrico: a propósito de un caso en Mozambique / Tuberculosis and pediatric AIDS: a case report in Mozambique

La Tuberculosis (TB), es una enfermedad producida por el Mycobacterium tuberculosis hominis, bacilo débilmente Gram positivo, aerobio, ácido-alcohol resistente, de aspecto curvo, inmóvil, no esporulado, constituye una de las enfermedades  re - emergentes en la infancia a nivel mundial, el Síndrome de inmunodeficiencia adquirida (sida) es el factor de riesgo mayor para la progresión de la TB. a pesar de que la incidencia de ambas enfermedades es baja con relación a las estadísticas mundiales según la OMS; los estados y autoridades sanitarias ponen el mayor empeño para un control eficaz y manejo adecuado de los casos registrados. Motivados con la presencia del Internacionalismo médico cubano en diversos países fue considerado de interés transmitir una experiencia, presentando el caso de un niño de 4 años de edad, raza negra, procedente de un área rural en  Nampula, Mozambique (África), donde el cuadro clínico y los complementarios confirmaron una TB pulmonar, constatando además la presencia de sida  (VIH positivo y linfocitos  CD4+ en  < 15 %). Se aplicó la terapéutica adecuada siguiendo los protocolos establecidos en Mozambique para ambas enfermedades, que permitió una mejoría del estado clínico e hizo posible un cambio en la calidad y esperanza de vida de este.Palabras clave: TUBERCULOSIS/diagnóstico, VIH, SÍNDROME DE INMUNODEFICIENCIA ADQUIRIDA/terapia. ABSTRACT Tuberculosis (abbreviated TB for tubercle bacillus or Tuberculosis), is a disease caused by Mycobacterium Tuberculosis Hominis, weakly Gram-positive bacillus, aerobic, acid-alcohol resistance, of curved aspect, motionless and sporeless. TB constitutes one of the re-emergent diseases in the childhood all over the world. Acquired Immunodeficiency Syndrome (AIDS) is the most important risk factor to the TB development. Despite the incidence of both diseases is low in relation to the worldwide statistics; and according to the World Health Organization (WHO), the states and sanitary authorities are making a great effort to carry out an effective control and an adequate management of the cases recorded. Encouraged by the presence of the Cuban Medical Internationalist Missions in several countries the case is presented in order to transmit experience. A 4-year-old, black boy,  coming from a rural region in Mampula City, Mozambique, sub-Saharan Africa; the clinical and laboratory findings confirmed a pulmonary TB, also the presence of AIDS was verified (positive HIV and lymphocytes CD4+ in 15%). An adequate therapeutic taking into account the protocols established in Mozambique for both diseases was followed with the purpose of  improving the clinical conditions of the patient, which  made possible changes  in the quality of life and life expectancy. Key words: Tuberculosis/diagnosis, HIV, ACQUIRED IMMUNODEFICIENCY SYNDROME/therapy

Tuberculosis y SIDA pediátrico: a propósito de un caso en Mozambique / Tuberculosis and pediatric AIDS: a case report in Mozambique

La Tuberculosis (TB), es una enfermedad producida por el Mycobacterium tuberculosis hominis, bacilo débilmente Gram positivo, aerobio, ácido-alcohol resistente, de aspecto curvo, inmóvil, no esporulado, constituye una de las enfermedades  re - emergentes en la infancia a nivel mundial, el Síndrome de inmunodeficiencia adquirida (sida) es el factor de riesgo mayor para la progresión de la TB. a pesar de que la incidencia de ambas enfermedades es baja con relación a las estadísticas mundiales según la OMS; los estados y autoridades sanitarias ponen el mayor empeño para un control eficaz y manejo adecuado de los casos registrados. Motivados con la presencia del Internacionalismo médico cubano en diversos países fue considerado de interés transmitir una experiencia, presentando el caso de un niño de 4 años de edad, raza negra, procedente de un área rural en  Nampula, Mozambique (África), donde el cuadro clínico y los complementarios confirmaron una TB pulmonar, constatando además la presencia de sida  (VIH positivo y linfocitos  CD4+ en  < 15 %). Se aplicó la terapéutica adecuada siguiendo los protocolos establecidos en Mozambique para ambas enfermedades, que permitió una mejoría del estado clínico e hizo posible un cambio en la calidad y esperanza de vida de este.Palabras clave: TUBERCULOSIS/diagnóstico, VIH, SÍNDROME DE INMUNODEFICIENCIA ADQUIRIDA/terapia. ABSTRACT Tuberculosis (abbreviated TB for tubercle bacillus or Tuberculosis), is a disease caused by Mycobacterium Tuberculosis Hominis, weakly Gram-positive bacillus, aerobic, acid-alcohol resistance, of curved aspect, motionless and sporeless. TB constitutes one of the re-emergent diseases in the childhood all over the world. Acquired Immunodeficiency Syndrome (AIDS) is the most important risk factor to the TB development. Despite the incidence of both diseases is low in relation to the worldwide statistics; and according to the World Health Organization (WHO), the states and sanitary authorities are making a great effort to carry out an effective control and an adequate management of the cases recorded. Encouraged by the presence of the Cuban Medical Internationalist Missions in several countries the case is presented in order to transmit experience. A 4-year-old, black boy,  coming from a rural region in Mampula City, Mozambique, sub-Saharan Africa; the clinical and laboratory findings confirmed a pulmonary TB, also the presence of AIDS was verified (positive HIV and lymphocytes CD4+ in 15%). An adequate therapeutic taking into account the protocols established in Mozambique for both diseases was followed with the purpose of  improving the clinical conditions of the patient, which  made possible changes  in the quality of life and life expectancy. Key words: Tuberculosis/diagnosis, HIV, ACQUIRED IMMUNODEFICIENCY SYNDROME/therapy

Schistosomiasis en la infancia. Una experiencia para el internacionalismo médico cubano / Schistosomiasis in childhood: an experience to the Cuban Medical Internationalist Missions

El Schistosoma es un parásito no endémico de Cuba, pero con una elevada frecuencia en los países de África, Asia y América Latina; de ellos, cinco especies infectan al hombre. No existen evidencias de dicho parasitismo en nuestro país. Con la presencia del internacionalismo médico cubano en las diversas tierras del mundo es que fue considerado útil transmitir la experiencia profesional en un país africano. Se presenta un caso clínico de un paciente de 7 años de edad, sexo masculino y estado nutricional adecuado, procedente de un área suburbana de la Cuidad de Nampula, Mozambique, África Subsahariana que al examen físico se constató que tenía lesiones de dermatitis en las manos y los pies, de varias semanas en evolución; acude por la aparición de edemas en miembros inferiores, dificultad para orinar y orinas oscuras. Se sospecha una posible Glomerulonefritis Difusa Aguda según la frecuencia de la entidad en nuestro medio. Después de una respuesta terapéutica escasa, un cambio en la visión epidemiológica y los resultados complementarios, se confirma una forma de presentación infantil de esquistosomiasis masiva, entidad frecuente en las regiones geográficas donde hoy en día está presente el internacionalismo médico cubano. Después de una revisión bibliográfica se consideró útil trasmitir la experiencia al médico internacionalista y se hacen algunas consideraciones al respecto. Palabras Clave: Esquistosomiasis, glomerulonefritis, diagnóstico. ABSTRACT Schistosome is a non-endemic parasite in Cuba, but with an elevated frequency in Africa, Asia and Latin-America; of them, five species infest man. No evidences of this parasite are found in Cuba. Considering the presence of Cuban Medical Internationalist Missions in other parts of the world, it is useful to transmit the professional experience in an African country. A 7-year-old-male patient, presenting an adequate nutritional status, coming from a sub-urban district of Mampula City. Mozambique, sub-Saharan Africa, at physical examination showed dermatitis in hands and feet for several weeks in evolution. The patient attended to the clinic presenting edema in the lower limbs, difficulties to urinate and dark urines. Suspecting, a possible Acute Diffuse Glomerulonephritis according to the frequency of the disease in that environment. After a limited therapeutic response, and a change in the epidemiologic view and the laboratory results; a childhood presentation of a form of massive schistosomiasis was confirmed, a frequent entity in the geographic regions where Cuban medical missions work. Some suggestions to transmit the experience to the medical missions were made taking into consideration several aspects after a medical literature review. Key words: Schistosomiasis, glomerulonephritis, diagnosis

The Milky Way bar and bulge revealed by APOGEE and Gaia EDR3

We investigate the inner regions of the Milky Way using data from APOGEE and Gaia EDR3. Our inner Galactic sample has more than 26 500 stars within |XGal|< 5 kpc, |YGal|< 3.5 kpc, |ZGal|< 1 kpc, and we also carry out the analysis for a foreground-cleaned subsample of 8000 stars that is more representative of the bulge-bar populations. These samples allow us to build chemo-dynamical maps of the stellar populations with vastly improved detail. The inner Galaxy shows an apparent chemical bimodality in key abundance ratios [α/Fe], [C/N], and [Mn/O], which probe different enrichment timescales, suggesting a star formation gap (quenching) between the high- and low-α populations. Using a joint analysis of the distributions of kinematics, metallicities, mean orbital radius, and chemical abundances, we can characterize the different populations coexisting in the innermost regions of the Galaxy for the first time. The chemo-kinematic data dissected on an eccentricity-|Z|max plane reveal the chemical and kinematic signatures of the bar, the thin inner disc, and an inner thick disc, and a broad metallicity population with large velocity dispersion indicative of a pressure-supported component. The interplay between these different populations is mapped onto the different metallicity distributions seen in the eccentricity-|Z|max diagram consistently with the mean orbital radius and Vφ distributions. A clear metallicity gradient as a function of |Z|max is also found, which is consistent with the spatial overlapping of different populations. Additionally, we find and chemically and kinematically characterize a group of counter-rotating stars that could be the result of a gas-rich merger event or just the result of clumpy star formation during the earliest phases of the early disc that migrated into the bulge. Finally, based on 6D information, we assign stars a probability value of being on a bar orbit and find that most of the stars with large bar orbit probabilities come from the innermost 3 kpc, with a broad dispersion of metallicity. Even stars with a high probability of belonging to the bar show chemical bimodality in the [α/Fe] versus [Fe/H] diagram. This suggests bar trapping to be an efficient mechanism, explaining why stars on bar orbits do not show a significant, distinct chemical abundance ratio signature

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

p38γ is essential for cell cycle progression and liver tumorigenesis

The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)–cyclin protein complex1. However, control of the G0-to-G1 transition is not completely understood. Here we demonstrate that p38 MAPK gamma (p38γ) acts as a CDK-like kinase and thus cooperates with CDKs, regulating entry into the cell cycle. p38γ shares high sequence homology, inhibition sensitivity and substrate specificity with CDK family members. In mouse hepatocytes, p38γ induces proliferation after partial hepatectomy by promoting the phosphorylation of retinoblastoma tumour suppressor protein at known CDK target residues. Lack of p38γ or treatment with the p38γ inhibitor pirfenidone protects against the chemically induced formation of liver tumours. Furthermore, biopsies of human hepatocellular carcinoma show high expression of p38γ, suggesting that p38γ could be a therapeutic target in the treatment of this disease

Nutrición enteral domiciliaria en España: registro Nadya del año 2011-2012

Objective: To describe the results of the home enteral nutrition (HEN) registry of the NADYA-SENPE group in 2011 and 2012. Material and methods: We retrieved the data of the patients recorded from January 1st 2011 to December 31st 2012. Results: There were 3021 patients in the registry during the period from 29 hospitals, which gives 65.39 per million inhabitants. 97.95% were adults, 51.4% male. Mean age was 67.64 ± 19.1, median age was 72 years for adults and 7 months for children. Median duration with HEN was 351 days and for 97.5% was their first event with HEN. Most patients had HEN because of neurological disease (57.8%). Access route was nasogastric tube for 43.5% and gastrostomy for 33.5%. Most patients had limited activity level and, concerning autonomy, 54.8% needed total help. Nutritional formula was supplied from chemist’s office to 73.8% of patients and disposables, when necessary, was supplied from hospitals to 53.8% of patients. HEN was finished for 1,031 patients (34.1%) during the period of study, 56.6% due to decease and 22.2% due to recovery of oral intake. Conclusions: Data from NADYA-SENPE registry must be explained cautiously because it is a non-compulsory registry. In spite of the change in the methodology of the registry in 2010, tendencies regarding HEN have been maintained, other than oral routeObjetivos: Describir los resultados del registro de nutrición enteral domiciliaria (NED) del grupo NADYASENPE de los años 2011 y 12. Material y métodos: Se recopilaron los datos introducidos en el registro desde el 1 de enero de 2011 al 31 de diciembre de 2012. Resultados: Hubo 3021 pacientes en el registro durante el periodo, procedentes de 29 hospitales, lo que da una prevalencia de 65,39 casos por millón de habitantes. 97.95% fueron adultos, 51,4% varones. La edad media fue 67,64 ± 19,1 años y la mediana 72 años para los adultos y 7 meses para los niños. La duración media de la NED fue 351 días y para el 97,5% fue el primer episodio con NED. La mayoría de pacientes tenían NED por una enfermedad neurológica (57,8%). La vía de acceso fue sonda nasogástrica para el 43,5% y gastrostomía para el 33,5%. La mayoría de pacientes tuvieron un nivel de actividad física limitado y, respecto a la autonomía, 54,8% necesitaba ayuda total. La fórmula de nutrición se suministró desde las oficinas de farmacia para el 73,8% y los fungibles, cuando fueron necesarios, desde los hospitales para el 53,8%. La NED se suspendió en 1.031 pacientes (34,1%) durante el periodo de estudio, 56,6% debido a fallecimiento y 22,2% debido a recuperación de la vía oral. Conclusiones: Los datos del registro NADYA-SENPE deben ser interpretados con precaución ya que se trata de un registro voluntario. A pesar del cambio de metodología del registro en 2010, las tendencias en NED se han mantenido, salvo la importancia cuantitativa de la vía ora

Database of spatial distribution of non indigenous species in Spanish marine waters

Research in marine Spanish waters are focused on several actions to achieve an effectively management on protected areas, with the active participation of the stakeholders and research as basic tools for decision-making. Among these actions, there is one about the knowledge and control on NIS. One of its objectives is the creation of NIS factsheets, which are going to be added to the National Marine Biodiversity Geographical System (GIS) providing complementary information about taxonomic classification, common names, taxonomic synonyms, species illustrations, identification morphological characters, habitat in the native and introduced regions, biological and ecological traits, GenBank DNA sequences, world distribution, first record and evolution in the introduced areas, likely pathways of introduction, effects in the habitats and interaction with native species, and potential management measures to apply. The database will also provide data for (1) the European online platforms, (2) the environmental assessment for the Descriptor 2 (D2-NIS) of the EU Marine Strategy Framework Directive (MSFD), as well as (3) supporting decisions made by stakeholders. It is the result of extensive collaboration among scientist, manager’s and citizen science in the Spanish North-Atlantic, South-Atlantic, Gibraltar Strait-Alboran, Levantine-Balearic and Canary Islands marine divisions, providing an updated overview of the spatial distribution of relevant extended and invasive NIS of recent and established NIS introduced by maritime transport and aquaculture pathways, as well as on cryptogenic or native species in expansion due to the climatic water warming trend