Collaborative Simulation for Hybrid Networks

An experiment for using more than one simulation of sub-networks collaborating as a single large simulation is suggested, based on work with a similar situation. The background and relevant details of the initial solution are described to provide an outline for the solution. Work on this method will help development of simulations for hybrid networks, where newer pieces may be added to the simulation without having to build a large, monolithic and a site-centric development effor

Advanced Orbiting Systems Data Generator/Simulator: A Functional Description of the Software (Version 3)

The Advanced Orbiting System (AOS) Data Generator/Simulator is a software implementation of the transmitter (data generation) section of the CCSDS Recommendation 701.0-B-2 for Advanced Orbiting Systems: Networks and Data Links. An object-oriented approach to the simulation of a complex, high-performance communication protocol, it makes full use of the concepts of data-encapsulation and inheritance to ease implementation. The backbone of the software is a general-purpose packet description and generation module that may be used as part of any packet- based simulation software. The user-interface to the program is in the form of a command-language, designed to ease the process of generation of large, multiple data-streams. The output of the program may be configured for interpretation by a graphical user interface (for visual inspection of the data), or as a bit-stream suitable for further processing. This paper consists of three sections. The first two sections provide a brief, yet comprehensive description of the above CCSDS Recommendation. The various kinds and qualities of user-services, data units involved, and data-paths defined by the protocol are discussed. The different qualities of service (in terms or data reliability) available to the user (and the error-control schemes used to provide them) are also discussed. The last section describes the structure and user-interfaces of the AOS Data Generator/Simulator

A Summary of Satellite Orbit Related Calculations

The configuration of satellite network systems is based on the quantities and properties related to the satellite orbit. It is extremely important to carefully define parameters and equations describing the orbit path correctly to make the whole configuration correct. Three different coordinate systems are in use to define satellite orbit: the Latitude-Longitude-Altitude coordinate system, the Right Ascension-Declination coordinate system and the Azimuth-Elevation coordinate system. These coordinate systems are equivalent with respect to the position of the satellite of interest and can easily be converted one to another. One of these coordinate systems would be used depending on the nature of the problem to be solved. Based upon these coordinate systems, the position of a satellite, the visibility of a satellite and antenna direction from a ground station, and a footprint radius of a satellite, etc. can be calculated.<P

Object Oriented Hybrid Network Simulation

As the complexity and diversity of networks have grown, simulation has proved an important tool in their design, analysis, testing and performance estimation of networks. Hybrid networks involve a variety of network elements - both mobile (e.g., satellites, mobile radio) and fixed nodes (e.g., switches, hubs, network gateways) linked via varied broadcast, multicast and point-to-point communication channels. Because of their complex nature, design and evaluation of hybrid networks is a particularly complicated task. Major requirements of a hybrid network simulation tool are (i) Flexibility and Adaptability - to accommodate all kinds of hybrid networks and protocols, (ii) Advanced Network Visualization Techniques - to clearly visualize complex communication network systems, (iii) Data Management - to organize and analyze the vast quantities of data generated in a typical simulation run, and (iv) Distributed Implementation - to fully utilize available computing resources to speed up simulation. This paper describes the design and functional description of an Object-Oriented Hybrid Network Simulation tool. Its object oriented design and implementation (in C++) allows flexibility through incorporation of new, user specified network elements, protocols and functional blocks. Advanced visualization techniques are combined with the graphical user interface to allow better visualization of complex network structures. A sophisticated geographical database is also incorporated to aid terrestrial mobile, and satellite network systems. To handle and effectively analyze the vast quantities of data generated, an object-oriented database is incorporated into the simulation. In addition to network simulation, the tool is also designed to serve other needs. An interface is provided to allow the user to run real network applications over the simulated network, allowing network application designers to judge the performance of their applications over various network configurations. Incorporation of a database allows computation of network performance dynamically. A network management tool receiving network performance data both from the actual and the simulated network may use the simulation data to make a long term prediction of the actual network behavior to perform long-term network management

Advanced Orbiting Systems Data Generator/Simulator: A Functional Description of the Software (Version 3)

The Advanced Orbiting System (AOS) Data Generator/Simulator is a software implementation of the transmitter (data generation) section of the CCSDS Recommendation 701.0-B-2 for Advanced Orbiting Systems: Networks and Data Links. An object-oriented approach to the simulation of a complex, high-performance communication protocol, it makes full use of the concepts of data-encapsulation and inheritance to ease implementation. The backbone of the software is a general-purpose packet description and generation module that may be used as part of any packet- based simulation software. The user-interface to the program is in the form of a command-language, designed to ease the process of generation of large, multiple data-streams. The output of the program may be configured for interpretation by a graphical user interface (for visual inspection of the data), or as a bit-stream suitable for further processing. This paper consists of three sections. The first two sections provide a brief, yet comprehensive description of the above CCSDS Recommendation. The various kinds and qualities of user-services, data units involved, and data-paths defined by the protocol are discussed. The different qualities of service (in terms or data reliability) available to the user (and the error-control schemes used to provide them) are also discussed. The last section describes the structure and user-interfaces of the AOS Data Generator/Simulator

Next Generation Network Management Technology

Today's telecommunications networks are becoming increasingly large, complex, mission critical and heterogeneous in several dimensions. For example, the underlying physical transmission facilities of a given network may be ﲭixed media (copper, fiber- optic, radio, and satellite); the sub networks may be acquired from different vendors due to economic, performance, or general availability reasons; the information being transmitted over the network may be ﲭultimedia (video, data, voice, and images) and, finally, varying performance criteria may be imposed e.g. data transfer may require high throughput while the others, whose concern is voice communications, may require low call blocking probability. For these reasons, future telecommunications networks are expected to be highly complex in their services and operations. Due to this growing complexity and the disparity among management systems for individual sub networks, efficient network management systems have become critical to the current and future success of telecommunications companies. This paper addresses a research and development effort which focuses on prototyping configuration management, since that is the central process of network management and all other network management functions must be built upon it. Our prototype incorporates ergonomically designed graphical user interfaces tailored to the network configuration management subsystem and to the proposed advanced object-oriented database structure. The resulting design concept follows open standards such as Open Systems Interconnection (OSI) and incorporates object oriented programming methodology to associate data with functions, permit customization, and provide an open architecture environment. A revised version of this technical report has been published in The 12th Symposium on Space Nuclear Power and Propulsion/Commercialization, pp. 75-82, Albuquerque, NM, January 8-12, 1995.</ul

First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data

Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto- noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far

Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantation.

BACKGROUND: Allogeneic bone marrow transplantation (allo-BMT) is a potentially curative therapy for a variety of hematologic diseases, but benefits, including graft-versus-tumor (GVT) activity are limited by graft-versus-host-disease (GVHD). Carcinoembryonic antigen related cell adhesion molecule 1 (Ceacam1) is a transmembrane glycoprotein found on epithelium, T cells, and many tumors. It regulates a variety of physiologic and pathological processes such as tumor biology, leukocyte activation, and energy homeostasis. Previous studies suggest that Ceacam1 negatively regulates inflammation in inflammatory bowel disease models. METHODS: We studied Ceacam1 as a regulator of GVHD and GVT after allogeneic bone marrow transplantation (allo-BMT) in mouse models. In vivo, Ceacam1(-/-) T cells caused increased GVHD mortality and GVHD of the colon, and greater numbers of donor T cells were positive for activation markers (CD25(hi), CD62L(lo)). Additionally, Ceacam1(-/-) CD8 T cells had greater expression of the gut-trafficking integrin α(4)β(7), though both CD4 and CD8 T cells were found increased numbers in the gut post-transplant. Ceacam1(-/-) recipients also experienced increased GVHD mortality and GVHD of the colon, and alloreactive T cells displayed increased activation. Additionally, Ceacam1(-/-) mice had increased mortality and decreased numbers of regenerating small intestinal crypts upon radiation exposure. Conversely, Ceacam1-overexpressing T cells caused attenuated target-organ and systemic GVHD, which correlated with decreased donor T cell numbers in target tissues, and mortality. Finally, graft-versus-tumor survival in a Ceacam1(+) lymphoma model was improved in animals receiving Ceacam1(-/-) vs. control T cells. CONCLUSIONS: We conclude that Ceacam1 regulates T cell activation, GVHD target organ damage, and numbers of donor T cells in lymphoid organs and GVHD target tissues. In recipients of allo-BMT, Ceacam1 may also regulate tissue radiosensitivity. Because of its expression on both the donor graft and host tissues, this suggests that targeting Ceacam1 may represent a potent strategy for the regulation of GVHD and GVT after allogeneic transplantation

Anti-proliferative effect of Rosmarinus officinalis L. extract on human melanoma A375 cells

Rosemary (Rosmarinus officinalis L.) has been used since ancient times in traditional medicine, while nowadays various rosemary formulations are increasingly exploited by alternative medicine to cure or prevent a wide range of health disorders. Rosemary's bioproperties have prompted scientific investigation, which allowed us to ascertain antioxidant, anti-inflammatory, cytostatic, and cytotoxic activities of crude extracts or of pure components. Although there is a growing body of experimental work, information about rosemary's anticancer properties, such as chemoprotective or anti-proliferative effects on cancer cells, is very poor, especially concerning the mechanism of action. Melanoma is a skin tumor whose diffusion is rapidly increasing in the world and whose malignancy is reinforced by its high resistance to cytotoxic agents; hence the availability of new cytotoxic drugs would be very helpful to improve melanoma prognosis. Here we report on the effect of a rosemary hydroalcoholic extract on the viability of the human melanoma A375 cell line. Main components of rosemary extract were identified by liquid chromatography coupled to tandem mass spectrometry (LC/ESI-MS/MS) and the effect of the crude extract or of pure components on the proliferation of cancer cells was tested by MTT and Trypan blue assays. The effect on cell cycle was investigated by using flow cytometry, and the alteration of the cellular redox state was evaluated by intracellular ROS levels and protein carbonylation analysis. Furthermore, in order to get information about the molecular mechanisms of cytotoxicity, a comparative proteomic investigation was performed

Properties of the Binary Neutron Star Merger GW170817

On August 17, 2017, the Advanced LIGO and Advanced Virgo gravitational-wave detectors observed a low-mass compact binary inspiral. The initial sky localization of the source of the gravitational-wave signal, GW170817, allowed electromagnetic observatories to identify NGC 4993 as the host galaxy. In this work, we improve initial estimates of the binary's properties, including component masses, spins, and tidal parameters, using the known source location, improved modeling, and recalibrated Virgo data. We extend the range of gravitational-wave frequencies considered down to 23 Hz, compared to 30 Hz in the initial analysis. We also compare results inferred using several signal models, which are more accurate and incorporate additional physical effects as compared to the initial analysis. We improve the localization of the gravitational-wave source to a 90% credible region of 16  deg2. We find tighter constraints on the masses, spins, and tidal parameters, and continue to find no evidence for nonzero component spins. The component masses are inferred to lie between 1.00 and 1.89  M⊙ when allowing for large component spins, and to lie between 1.16 and 1.60  M⊙ (with a total mass 2.73−0.01+0.04  M⊙) when the spins are restricted to be within the range observed in Galactic binary neutron stars. Using a precessing model and allowing for large component spins, we constrain the dimensionless spins of the components to be less than 0.50 for the primary and 0.61 for the secondary. Under minimal assumptions about the nature of the compact objects, our constraints for the tidal deformability parameter Λ are (0,630) when we allow for large component spins, and 300−230+420 (using a 90% highest posterior density interval) when restricting the magnitude of the component spins, ruling out several equation-of-state models at the 90% credible level. Finally, with LIGO and GEO600 data, we use a Bayesian analysis to place upper limits on the amplitude and spectral energy density of a possible postmerger signal