Dichotomy for generic supercuspidal representations of G2G_2

The local Langlands conjectures imply that to every generic supercuspidal irreducible representation of $G_2$ over a $p$-adic field, one can associate a generic supercuspidal irreducible representation of either $PGSp_6$ or$PGL_3$. We prove this conjectural dichotomy, demonstrating a precise correspondence between certain representations of $G_2$ and other representations of $PGSp_6$ and $PGL_3$. This correspondence arises from theta correspondences in $E_6$ and $E_7$, analysis of Shalika functionals, and spin L-functions. Our main result reduces the conjectural Langlands parameterization of generic supercuspidal irreducible representations of $G_2$ to a single conjecture about the parameterization for $PGSp_6$.Comment: Version 2: Mistakes in Prop 3.2 and 3.5 corrected. Results strengthened in case p=2. Changes made throughout for consistency with stronger results and reformulatio

Monolingual and crosslingual comparison of tandem features derived from articulatory and phone MLPs

In recent years, the features derived from posteriors of a multilayer perceptron (MLP), known as tandem features, have proven to be very effective for automatic speech recognition. Most tandem features to date have relied on MLPs trained for phone classification. We recently showed on a relatively small data set that MLPs trained for articulatory feature classification can be equally effective. In this paper, we provide a similar comparison using MLPs trained on a much larger data set - 2000 hours of English conversational telephone speech. We also explore how portable phone- and articulatory feature- based tandem features are in an entirely different language - Mandarin - without any retraining. We find that while phone-based features perform slightly better in the matched-language condition, they perform significantly better in the cross-language condition. Yet, in the cross-language condition, neither approach is as effective as the tandem features extracted from an MLP trained on a relatively small amount of in-domain data. Beyond feature concatenation, we also explore novel observation modelling schemes that allow for greater flexibility in combining the tandem and standard features at hidden Markov model (HMM) outputs

Reading Companion: The Technical and Social Design of an Automated Reading Tutor

This paper describes IBM’s automatic reading tutor system, the Reading Companion. The reading tutor aims to improve the literacy skills of beginning readers, both children and adults, and help adults who are non-native speakers of English to learn the language. We describe Reading Companion’s architecture, which allows a large, globally distributed reading companion community to create and share new reading material. We also report substantial accuracy improvements in recognizing children’s speech gained by training the recognizer on the IBM Kidspeak corpus, a newly developed corpus of children’s speech

Articulatory feature-based methods for acoustic and audio-visual speech recognition: Summary from the 2006 JHU Summer Workshop.

We report on investigations, conducted at the 2006 Johns HopkinsWorkshop, into the use of articulatory features (AFs) for observation and pronunciation models in speech recognition. In the area of observation modeling, we use the outputs of AF classiers both directly, in an extension of hybrid HMM/neural network models, and as part of the observation vector, an extension of the tandem approach. In the area of pronunciation modeling, we investigate a model having multiple streams of AF states with soft synchrony constraints, for both audio-only and audio-visual recognition. The models are implemented as dynamic Bayesian networks, and tested on tasks from the Small-Vocabulary Switchboard (SVitchboard) corpus and the CUAVE audio-visual digits corpus. Finally, we analyze AF classication and forced alignment using a newly collected set of feature-level manual transcriptions

Combination leflunomide and methotrexate (MTX) therapy for patients with active rheumatoid arthritis failing MTX monotherapy: open-label extension of a randomized, double-blind, placebo controlled trial

P e r s o n a l n o n -c o m m e r c i a l u s e o n l y . T h e J o u r n a l o f R h e u m a t o l o g y . C o p y r i g h t © 2 0 0 4 . A l l r i g h t s r e s e r v e d Conclusion. Response to therapy was maintained to 48 weeks of treatment in patients who continued to receive LEF and MTX during the extension. Importantly, ACR20 response rates after 24 weeks of LEF therapy were similar between patients switched from PLA to LEF without loading dose, and those who received a loading does of LEF (100 mg/day × 2 days) at randomization. Fewer adverse events were reported in patients switched to LEF without a loading dose. (J Rheumatol 2004;31:1521-31

EFSA BIOHAZ Panel (EFSA Panel on Biological Hazards), 2013. Scientific Opinion on the public health hazards to be covered by inspection of meat (bovine animals).

A risk ranking process identified Salmonella spp. and pathogenic verocytotoxin-producing Escherichia coli (VTEC) as current high-priority biological hazards for meat inspection of bovine animals. As these hazards are not detected by traditional meat inspection, a meat safety assurance system for the farm-to-chilled carcass continuum using a risk-based approach was proposed. Key elements of the system are risk-categorisation of slaughter animals for high-priority biological hazards based on improved food chain information, as well as risk-categorisation of slaughterhouses according to their capability to control those hazards. Omission of palpation and incision during post-mortem inspection for animals subjected to routine slaughter may decrease spreading and cross-contamination with the high-priority biological hazards. For chemical hazards, dioxins and dioxin-like polychlorinated biphenyls were ranked as being of high potential concern; all other substances were ranked as of medium or lower concern. Monitoring programmes for chemical hazards should be more flexible and based on the risk of occurrence, taking into account the completeness and quality of the food chain information supplied and the ranking of chemical substances, which should be regularly updated to include new hazards. Control programmes across the food chain, national residue control programmes, feed control and monitoring of environmental contaminants should be better integrated. Meat inspection is a valuable tool for surveillance and monitoring of animal health and welfare conditions. Omission of palpation and incision would reduce detection effectiveness for bovine tuberculosis and would have a negative impact on the overall surveillance system especially in officially tuberculosis free countries. The detection effectiveness for bovine cysticercosis, already low with the current meat inspection system, would result in a further decrease, if palpation and incision are removed. Extended use of food chain information could compensate for some, but not all, the information on animal health and welfare lost if only visual post-mortem inspection is applied

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries