SHREC’20 Track:Retrieval of digital surfaces with similar geometric reliefs

International audienceThis paper presents the methods that have participated in the SHREC'20 contest on retrieval of surface patches with similar geometric reliefs and 1 the analysis of their performance over the benchmark created for this challenge. The goal of the context is to verify the possibility of retrieving 3D models only based on the reliefs that are present on their surface and to compare methods that are suitable for this task. This problem is related to many real world applications, such as the classification of cultural heritage goods or the analysis of different materials. To address this challenge, it is necessary to characterize the local "geometric pattern" information, possibly forgetting model size and bending. Seven groups participated in this contest and twenty runs were submitted for evaluation. The performances of the methods reveal that good results are achieved with a number of techniques that use different approaches

Insights into Land Plant Evolution Garnered from the Marchantia polymorpha Genome.

The evolution of land flora transformed the terrestrial environment. Land plants evolved from an ancestral charophycean alga from which they inherited developmental, biochemical, and cell biological attributes. Additional biochemical and physiological adaptations to land, and a life cycle with an alternation between multicellular haploid and diploid generations that facilitated efficient dispersal of desiccation tolerant spores, evolved in the ancestral land plant. We analyzed the genome of the liverwort Marchantia polymorpha, a member of a basal land plant lineage. Relative to charophycean algae, land plant genomes are characterized by genes encoding novel biochemical pathways, new phytohormone signaling pathways (notably auxin), expanded repertoires of signaling pathways, and increased diversity in some transcription factor families. Compared with other sequenced land plants, M. polymorpha exhibits low genetic redundancy in most regulatory pathways, with this portion of its genome resembling that predicted for the ancestral land plant. PAPERCLIP

Semiautomatic Toolmark Classification in Chased Metals Using Surface Microtopography

Chasing is one of the main decorative techniques found in metal work. The imprints left by different chasing tools are unique not only to the tool, but also to the chaser. The analysis and characterisation of toolmarks provide vast information that is valuable for the understanding of an object. Microtopography is a non-contact imaging technique that allows a metrical analysis of a surface on a microscopic scale. In this paper, metal mock-ups made using different chasing tools were scanned using microtopography, and their morphological features were used to classify the tools used for their fabrication. The mock-ups were artificially aged to replicate conditions of real archaeological metal objects. The overall classification accuracy obtained for the non-aged mock-ups was 91% for brass and 84% for copper mock-ups. After ageing, the classification accuracy was 65% for brass and 68% for copper. The change in classification accuracy before and after ageing was caused by the corrosion on the aged mock-ups. These results show that this is a promising methodology that could be applied on real chased metal objects

Image-based goniometric appearance characterisation of bronze patinas

Patinas are a form of metal polychromy used to decorate metallic artworks. Due to the nature of the metallic surface, their colour and gloss is perceived differently when the illumination and viewing directions vary. Sparkle effect on surfaces is a physical phenomenom caused by micro-facets on the surface coating which are also perceived with changing viewing and illumination geometry. In this paper, a method designed for the measurement of sparkle is applied for the goniometric characterisation of bronze patinas. Using a set of six different patinas, in three colours and two surface finishes, it is found that these surfaces exhibit different appearance when illuminated and viewed at different angles. Moreover, the roughness of the patinas is measured and as expected, as the roughness increases the specular reflection peak decreases. The experiment is repeated at two different institutions with different sets of equipment to test its repeatability and robustness. The sparkle is presented as a function of the angle of tilting, and it is characterised by its maximum value and full-width halfmaximum. It is found that the maximum and the roughness have a negative exponential relationship whereas the full-width halfmaximum and the roughness have a linear relationship

Loss of CG methylation in Marchantia polymorpha causes disorganization of cell division and reveals unique DNA methylation regulatory mechanisms of non-CG methylation

International audienc

Adenomatous Polyposis Coli and Asef Function Downstream of Hepatocyte Growth Factor and Phosphatidylinositol 3-Kinase*

Mutations of the tumor suppressor adenomatous polyposis coli (APC) are responsible for sporadic and familial colorectal tumors. APC negatively regulates Wnt signaling by inducing β-catenin degradation. It has also been shown that APC plays a role in the organization of cytoskeletal networks. APC interacts with Asef and Asef2, Rac1- and Cdc42-specific guanine nucleotide exchange factors (GEFs), and stimulates their GEF activity; thereby regulating cell morphology, adhesion, and migration. Truncated mutant APCs present in colorectal tumor cells activate Asef and Asef2 constitutively and contribute to their aberrant migratory properties. We show here that hepatocyte growth factor (HGF), as well as basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF), induce the accumulation and colocalization of APC and Asef in membrane ruffles and lamellipodia of epithelial cells. Both APC and Asef were found to be required for HGF-induced cell migration. Furthermore, we show that the effects of HGF, bFGF, and EGF on APC and Asef are mediated by the activation of phosphatidylinositol 3-kinase (PI3-kinase) and require the PH domain of Asef. These results suggest that Asef and APC function downstream of HGF and PI3-kinase, and play critical roles in growth factor-mediated regulation of cell morphology and migration

Empagliflozin in Patients with Chronic Kidney Disease

Background The effects of empagliflozin in patients with chronic kidney disease who are at risk for disease progression are not well understood. The EMPA-KIDNEY trial was designed to assess the effects of treatment with empagliflozin in a broad range of such patients. Methods We enrolled patients with chronic kidney disease who had an estimated glomerular filtration rate (eGFR) of at least 20 but less than 45 ml per minute per 1.73 m(2) of body-surface area, or who had an eGFR of at least 45 but less than 90 ml per minute per 1.73 m(2) with a urinary albumin-to-creatinine ratio (with albumin measured in milligrams and creatinine measured in grams) of at least 200. Patients were randomly assigned to receive empagliflozin (10 mg once daily) or matching placebo. The primary outcome was a composite of progression of kidney disease (defined as end-stage kidney disease, a sustained decrease in eGFR to < 10 ml per minute per 1.73 m(2), a sustained decrease in eGFR of & GE;40% from baseline, or death from renal causes) or death from cardiovascular causes. Results A total of 6609 patients underwent randomization. During a median of 2.0 years of follow-up, progression of kidney disease or death from cardiovascular causes occurred in 432 of 3304 patients (13.1%) in the empagliflozin group and in 558 of 3305 patients (16.9%) in the placebo group (hazard ratio, 0.72; 95% confidence interval [CI], 0.64 to 0.82; P < 0.001). Results were consistent among patients with or without diabetes and across subgroups defined according to eGFR ranges. The rate of hospitalization from any cause was lower in the empagliflozin group than in the placebo group (hazard ratio, 0.86; 95% CI, 0.78 to 0.95; P=0.003), but there were no significant between-group differences with respect to the composite outcome of hospitalization for heart failure or death from cardiovascular causes (which occurred in 4.0% in the empagliflozin group and 4.6% in the placebo group) or death from any cause (in 4.5% and 5.1%, respectively). The rates of serious adverse events were similar in the two groups. Conclusions Among a wide range of patients with chronic kidney disease who were at risk for disease progression, empagliflozin therapy led to a lower risk of progression of kidney disease or death from cardiovascular causes than placebo