Microresonator solitons for massively parallel coherent optical communications

Optical solitons are waveforms that preserve their shape while propagating, relying on a balance of dispersion and nonlinearity. Soliton-based data transmission schemes were investigated in the 1980s, promising to overcome the limitations imposed by dispersion of optical fibers. These approaches, however, were eventually abandoned in favor of wavelength-division multiplexing (WDM) schemes that are easier to implement and offer improved scalability to higher data rates. Here, we show that solitons may experience a comeback in optical communications, this time not as a competitor, but as a key element of massively parallel WDM. Instead of encoding data on the soliton itself, we exploit continuously circulating dissipative Kerr solitons (DKS) in a microresonator. DKS are generated in an integrated silicon nitride microresonator by four-photon interactions mediated by Kerr nonlinearity, leading to low-noise, spectrally smooth and broadband optical frequency combs. In our experiments, we use two interleaved soliton Kerr combs to transmit a data stream of more than 50Tbit/s on a total of 179 individual optical carriers that span the entire telecommunication C and L bands. Equally important, we demonstrate coherent detection of a WDM data stream by using a pair of microresonator Kerr soliton combs - one as a multi-wavelength light source at the transmitter, and another one as a corresponding local oscillator (LO) at the receiver. This approach exploits the scalability advantages of microresonator soliton comb sources for massively parallel optical communications both at the transmitter and receiver side. Taken together, the results prove the significant potential of these sources to replace arrays of continuous-wave lasers in high-speed communications.Comment: 10 pages, 3 figure

XMM-Newton and optical follow-up observations of SDSS J093249.57+472523.0 and SDSS J102347.67+003841.2

We report follow-up XMM-Newton and ground-based optical observations of the unusual X-ray binary SDSS J102347.67+003841.2 (=FIRST J102347.6+003841), and a new candidate intermediate polar found in the Sloan Digital Sky Survey: SDSS J093249.57+472523.0. SDSS J1023 was observed in its low-state, with similar magnitude/color (V=17.4 and B=17.9), and smooth orbital modulation as seen in most previous observations. We further refine the ephemeris (for photometric minimum) to: HJD(TT)_min= 2453081.8546(3) + E* 0.198094(1) d. It is easily detected in X-rays at an unabsorbed flux (0.01-10.0 keV) of 5x10e-13 erg/cm^2/s. Fitting a variety of models we find that: (i) either a hot (kT>~15 keV) optically thin plasma emission model (bremsstrahlung or MEKAL) or a simple power law can provide adequate fits to the data; (ii) these models prefer a low column density ~10e19 cm^-2; (iii) a neutron star atmosphere plus power law model (as found for quiescent low-mass X-ray binaries) can also produce a good fit (for plausible distances), though only for a much higher column of about 4x10e20 cm^-2 and a very cool atmosphere kT<~50eV. These results support the case that SDSS J1023 is a transient LMXB, and indeed places it in the subclass of such systems whose quiescent X-ray emission is dominated by a hard power law component. Our optical photometry of SDSS J0932 reveals that it is an high inclination eclipsing system. Combined with its optical characteristics -- high excitation emission lines, and brightness, yielding a large F_X/F_opt ratio -- its highly absorbed X-ray spectrum argues that SDSS J0932 is a strong IP candidate. However, only more extensive optical photometry and a detection of its spin or spin-orbit beat frequency can confirm this classification. (abridged)Comment: 9 pages, 7 figures, accepted for publication in the Astronomical Journal (page formatting corrected

Dynamics of conversion of supercurrents into normal currents, and vice versa

The generation and destruction of the supercurrent in a superconductor (S) between two resistive normal (N) current leads connected to a current source is computed from the source equation for the supercurrent density. This equation relates the gradient of the pair potential's phase to electron and hole wavepackets that create and destroy Cooper pairs in the N/S interfaces. Total Andreev reflection and supercurrent transmission of electrons and holes are coupled together by the phase rigidity of the non-bosonic Cooper-pair condensate. The calculations are illustrated by snapshots from a computer film.Comment: 8 pages, 1 figure, accepted by Phys. Rev.

Hermitian K-theory and 2-regularity for totally real number fields

We completely determine the 2-primary torsion subgroups of the hermitian K-groups of rings of 2-integers in totally real 2-regular number fields. The result is almost periodic with period 8. We also identify the homotopy fibers of the forgetful and hyperbolic maps relating hermitian and algebraic K-theory. The result is then exactly periodic of period 8. In both the orthogonal and symplectic cases, we prove the 2-primary hermitian Quillen-Lichtenbaum conjecture.Comment: To appear in Mathematische Annale

LSST Science Book, Version 2.0

A survey that can cover the sky in optical bands over wide fields to faint magnitudes with a fast cadence will enable many of the exciting science opportunities of the next decade. The Large Synoptic Survey Telescope (LSST) will have an effective aperture of 6.7 meters and an imaging camera with field of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over 20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a total point-source depth of r~27.5. The LSST Science Book describes the basic parameters of the LSST hardware, software, and observing plans. The book discusses educational and outreach opportunities, then goes on to describe a broad range of science that LSST will revolutionize: mapping the inner and outer Solar System, stellar populations in the Milky Way and nearby galaxies, the structure of the Milky Way disk and halo and other objects in the Local Volume, transient and variable objects both at low and high redshift, and the properties of normal and active galaxies at low and high redshift. It then turns to far-field cosmological topics, exploring properties of supernovae to z~1, strong and weak lensing, the large-scale distribution of galaxies and baryon oscillations, and how these different probes may be combined to constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at http://www.lsst.org/lsst/sciboo

Ultracompact AM CVn Binaries from the Sloan Digital Sky Survey: Three Candidates Plus the First Confirmed Eclipsing System

AM CVn systems are a rare (about a dozen previously known) class of cataclysmic variables, arguably encompassing the shortest orbital periods (down to about 10 minutes) of any known binaries. Both binary components are thought to be degenerate (or partially so), likely with mass-transfer from a helium-rich donor onto a white dwarf, driven by gravitational radiation. Although rare, AM CVn systems are of high interest as possible SN Ia progenitors, and because they are predicted to be common sources of gravity waves in upcoming experiments such as LISA. We have identified four new AM CVn candidates from the Sloan Digital Sky Survey (SDSS) spectral database. All four show hallmark spectroscopic characteristics of the AM CVn class: each is devoid of hydrogen features, and instead shows a spectrum dominated by helium. All four show double-peaked emission, indicative of helium-dominated accretion disks. Limited time-series CCD photometric follow-on data have been obtained for three of the new candidates from the ARC 3.5m; most notably, a 28.3 minute binary period with sharp, deep eclipses is discovered in one case, SDSS J0926+3624. This is the first confirmed eclipsing AM CVn, and our data allow initial estimates of binary parameters for this ultracompact system. The four new SDSS objects also provide a substantial expansion of the currently critically-small sample of AM CVn systems.Comment: 7 pages, 3 figures, submitted to the Astronomical Journa

Impaired Nuclear Nrf2 Translocation Undermines the Oxidative Stress Response in Friedreich Ataxia

BACKGROUND: Friedreich ataxia originates from a decrease in mitochondrial frataxin, which causes the death of a subset of neurons. The biochemical hallmarks of the disease include low activity of the iron sulfur cluster-containing proteins (ISP) and impairment of antioxidant defense mechanisms that may play a major role in disease progression. METHODOLOGY/PRINCIPAL FINDINGS: We thus investigated signaling pathways involved in antioxidant defense mechanisms. We showed that cultured fibroblasts from patients with Friedreich ataxia exhibited hypersensitivity to oxidative insults because of an impairment in the Nrf2 signaling pathway, which led to faulty induction of antioxidant enzymes. This impairment originated from previously reported actin remodeling by hydrogen peroxide. CONCLUSIONS/SIGNIFICANCE: Thus, the defective machinery for ISP synthesis by causing mitochondrial iron dysmetabolism increases hydrogen peroxide production that accounts for the increased susceptibility to oxidative stress

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls

Objective: To determine whether common variants in familial cerebral small vessel disease (SVD) genes confer risk of sporadic cerebral SVD. Methods: We meta-analyzed genotype data from individuals of European ancestry to determine associations of common single nucleotide polymorphisms (SNPs) in 6 familial cerebral SVD genes (COL4A1, COL4A2, NOTCH3, HTRA1, TREX1, and CECR1) with intracerebral hemorrhage (ICH) (deep, lobar, all; 1,878 cases, 2,830 controls) and ischemic stroke (IS) (lacunar, cardioembolic, large vessel disease, all; 19,569 cases, 37,853 controls). We applied data quality filters and set statistical significance thresholds accounting for linkage disequilibrium and multiple testing. Results: A locus in COL4A2 was associated (significance threshold p , 3.5 3 1024) with both lacunar IS (lead SNP rs9515201: odds ratio [OR] 1.17, 95%confidence interval [CI] 1.11-1.24, p 56.62 31028) and deep ICH (lead SNP rs4771674: OR 1.28, 95%CI 1.13-1.44, p 55.76 3 1025). A SNP in HTRA1 was associated (significance threshold p , 5.5 3 1024) with lacunar IS (rs79043147: OR 1.23, 95%CI 1.10-1.37, p 5 1.90 3 1024) and less robustly with deep ICH. There was no clear evidence for association of common variants in either COL4A2 or HTRA1 with non-SVD strokes or in any of the other genes with any stroke phenotype

Keratinocytes Determine Th1 Immunity during Early Experimental Leishmaniasis

Experimental leishmaniasis is an excellent model system for analyzing Th1/Th2 differentiation. Resistance to Leishmania (L.) major depends on the development of a L. major specific Th1 response, while Th2 differentiation results in susceptibility. There is growing evidence that the microenvironment of the early affected tissue delivers the initial triggers for Th-cell differentiation. To analyze this we studied differential gene expression in infected skin of resistant and susceptible mice 16h after parasite inoculation. Employing microarray technology, bioinformatics, laser-microdissection and in-situ-hybridization we found that the epidermis was the major source of immunomodulatory mediators. This epidermal gene induction was significantly stronger in resistant mice especially for several genes known to promote Th1 differentiation (IL-12, IL-1β, osteopontin, IL-4) and for IL-6. Expression of these cytokines was temporally restricted to the crucial time of Th1/2 differentiation. Moreover, we revealed a stronger epidermal up-regulation of IL-6 in the epidermis of resistant mice. Accordingly, early local neutralization of IL-4 in resistant mice resulted in a Th2 switch and mice with a selective IL-6 deficiency in non-hematopoietic cells showed a Th2 switch and dramatic deterioration of disease. Thus, our data indicate for the first time that epidermal cytokine expression is a decisive factor in the generation of protective Th1 immunity and contributes to the outcome of infection with this important human pathogen