175 research outputs found
Post-modernism's use and abuse of Nietzsche
I focus on Nietzsche's architectural metaphor of self-construction in arguing for the claim that postmodern readings of Nietzsche misunderstand his various attacks on dogmatic philosophy as paving the way for acceptance of a self characterized by fundamental disunity. Nietzsche's attack on essentialist dogmatic metaphysics is a call to engage in a purposive self-creation under a unifying will, a will that possesses the strength to reinterpret history as a pathway to "the problem that we are". Nietzsche agrees with the postmodernists that unity is not a pre-given, however he would disavow their rejection of unity as a goal. Where the postmodernists celebrate "the death of the subject" Nietzsche rejects this valorization of disunity as a form of Nihilism and prescribes the creation of a genuine unified subjectivity to those few capable of such a goal. Postmodernists are nearer Nietzsche's idea of the Last Man than his idea of the Overman.Articl
Comparison of Operative Mortality and Complications between Bronchoplastic Lobectomy and Pneumonectomy in Lung Cancer Patients
Bronchoplastic lobectomy is a lung-saving procedure indicated for central tumors, for which the alternative is pneumonectomy. We compared operative mortality and complications between bronchoplastic lobectomy and pneumonectomy in lung cancer patients. From March 1993 through December 2005, 1,461 patients were surgically resected for non-small cell lung cancer, including 73 who underwent bronchoplastic lobectomy and 258 who underwent pneumonectomy. Bronchoplastic lobectomy was performed on any lesion that could be completely resected by this technique, whereas pneumonectomy was only performed on lesions that could not be removed by bronchoplastic lobectomy. Operative deaths occurred in 1 of 73 (1.4%) bronchoplastic lobectomy and 26 of 258 (10.1%) pneumonectomy patients (p=0.014). Major complications occurred in 16 of 73 (21.9%) bronchoplastic lobectomy and 58 of 258 (22.5%) pneumonectomy patients (p=1.0). Bronchoplastic lobectomy has a lower risk of operative mortality than pneumonectomy. Although the complication rates were similar, bronchoplastic lobectomy was associated with improved postoperative cardiopulmonary status and a low prevalence of fatal complications after bronchial anastomosis. These findings indicate that bronchoplastic lobectomy is a valuable alternative to pneumonectomy for anatomically appropriate patients, regardless of underlying cardiopulmonary function
Specific Subpopulations of Hypothalamic Leptin Receptor-Expressing Neurons Mediate the Effects of Early Developmental Leptin Receptor Deletion on Energy Balance
ACKNOWLEDGEMENTS We thank MedImmune, Inc. and James Trevaskis, PhD and Christopher Rhodes, PhD for the gift of leptin. We thank members of the Myers and Olson labs for helpful discussions. Research support was provided by the Michigan Diabetes Research Center (NIH P3 0 DK020572, including the Molecular Genetics, Animal Phenotyping, and Clinical Cores), the American Diabetes Association (MGM), the Marilyn H. Vincent Foundation (MGM), the NIH (MGM: D K05673 1; ACR:DK071212; MBA: DK097861), the BBSRC (LKH: BB/NO17838/1) and WellcomeTrust (LKH: 098012).Peer reviewedPublisher PD
Measurement of the Atmospheric Muon Spectrum from 20 to 3000 GeV
The absolute muon flux between 20 GeV and 3000 GeV is measured with the L3
magnetic muon spectrometer for zenith angles ranging from 0 degree to 58
degree. Due to the large exposure of about 150 m2 sr d, and the excellent
momentum resolution of the L3 muon chambers, a precision of 2.3 % at 150 GeV in
the vertical direction is achieved.
The ratio of positive to negative muons is studied between 20 GeV and 500
GeV, and the average vertical muon charge ratio is found to be 1.285 +- 0.003
(stat.) +- 0.019 (syst.).Comment: Total 32 pages, 9Figure
Forskningsintegritet og åpen vitenskap i ph.d.undervisningen: Praktiske spørsmål og etisk refleksjon.
Academic presentation at the Virak conference 08. - 09.06.22, Trondheim, Norway
Galaxies Going Bananas: Inferring the 3D Geometry of High-Redshift Galaxies with JWST-CEERS
The 3D geometry of high-redshift galaxies remains poorly understood. We build
a differentiable Bayesian model and use Hamiltonian Monte Carlo to efficiently
and robustly infer the 3D shapes of star-forming galaxies in JWST-CEERS
observations with at . We reproduce
previous results from HST-CANDELS in a fraction of the computing time and
constrain the mean ellipticity, triaxiality, size and covariances with samples
as small as galaxies. We find high 3D ellipticities for all
mass-redshift bins suggesting oblate (disky) or prolate (elongated) geometries.
We break that degeneracy by constraining the mean triaxiality to be for
dwarfs at (favoring the prolate scenario),
with significantly lower triaxialities for higher masses and lower redshifts
indicating the emergence of disks. The prolate population traces out a
``banana'' in the projected diagram with an excess of low ,
large galaxies. The dwarf prolate fraction rises from at
to at . If these are disks, they cannot be
axisymmetric but instead must be unusually oval (triaxial) unlike local
circular disks. We simultaneously constrain the 3D size-mass relation and its
dependence on 3D geometry. High-probability prolate and oblate candidates show
remarkably similar S\'ersic indices (), non-parametric morphological
properties and specific star formation rates. Both tend to be visually
classified as disks or irregular but edge-on oblate candidates show more dust
attenuation. We discuss selection effects, follow-up prospects and theoretical
implications.Comment: Submitted to ApJ, main body is 35 pages of which ~half are full-page
figures, comments welcom
Titin-truncating variants affect heart function in disease cohorts and the general population
Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). TTNtv are also encountered in ~1% of the general population, where they may be silent, perhaps reflecting allelic factors. To better understand TTNtv, we integrated TTN allelic series, cardiac imaging and genomic data in humans and studied rat models with disparate TTNtv. In patients with DCM, TTNtv throughout titin were significantly associated with DCM. Ribosomal profiling in rat showed the translational footprint of premature stop codons in Ttn, TTNtv-position-independent nonsense-mediated degradation of the mutant allele and a signature of perturbed cardiac metabolism. Heart physiology in rats with TTNtv was unremarkable at baseline but became impaired during cardiac stress. In healthy humans, machine-learning-based analysis of high-resolution cardiac imaging showed TTNtv to be associated with eccentric cardiac remodeling. These data show that TTNtv have molecular and physiological effects on the heart across species, with a continuum of expressivity in health and disease
The nature of massive transition galaxies in CANDELS, GAMA and cosmological simulations
We explore observational and theoretical constraints on how galaxies might
transition between the "star-forming main sequence" (SFMS) and varying "degrees
of quiescence" out to . Our analysis is focused on galaxies with stellar
mass , and is enabled by GAMA and CANDELS observations, a
semi-analytic model (SAM) of galaxy formation, and a cosmological
hydrodynamical "zoom in" simulation with momentum-driven AGN feedback. In both
the observations and the SAM, transition galaxies tend to have intermediate
S\'ersic indices, half-light radii, and surface stellar mass densities compared
to star-forming and quiescent galaxies out to . We place an observational
upper limit on the average population transition timescale as a function of
redshift, finding that the average high-redshift galaxy is on a "fast track"
for quenching whereas the average low-redshift galaxy is on a "slow track" for
quenching. We qualitatively identify four physical origin scenarios for
transition galaxies in the SAM: oscillations on the SFMS, slow quenching, fast
quenching, and rejuvenation. Quenching timescales in both the SAM and the
hydrodynamical simulation are not fast enough to reproduce the quiescent
population that we observe at . In the SAM, we do not find a clear-cut
morphological dependence of quenching timescales, but we do predict that the
mean stellar ages, cold gas fractions, SMBH masses, and halo masses of
transition galaxies tend to be intermediate relative to those of star-forming
and quiescent galaxies at .Comment: Re-submitted to MNRAS after referee revisions, the main change is
that the paper has been significantly streamlined and is shorter (25 pages
and 8 figures, without appendices
- …