Do variations in the theatre team have an impact on the incidence of complications?

BACKGROUND: To examine whether variations in non-medical personnel influence the incidence of complications in a cataract theatre. METHODS: A retrospective Case-Control study was undertaken in a single-site, designated cataract theatre. Staffing variations within theatre were examined and the incidence of cataract complications was assessed. RESULTS: 100 complicated lists and 200 uncomplicated control lists were chosen. At least 7 nurses were present for every list. Mean experience of the nurses was 6.4 years for case lists and 6.5 years for control lists. Average scrub nurse experience in years was 7.6 years for complicated lists and 8.0 years for controls. 26% of complicated case lists were affected by unplanned leave and 17% in control lists. Odds ratio 1.7 (1.0 to 3.1) 95% CI. CONCLUSION: Unplanned leave can have a detrimental effect on the operating list. The impact of this may be modifiable with careful planning

Shear stress induces osteogenic differentiation of human mesenchymal stem cells

Aim: To determine whether fluid flow-induced shear stress affects the differentiation of bone marrow-derived human mesenchymal stem cells (hMSCs) into osteogenic cells. Materials & methods: hMSCs cultured with or without osteogenic differentiation medium were exposed to fluid flow-induced shear stress and analyzed for alkaline phosphatase activity and expression of osteogenic genes. Results: Immediately following shear stress, alkaline phosphatase activity in osteogenic medium was significantly increased. At days 4 and 8 of culture the mRNA expression of bone morphogenetic protein-2 and osteopontin was significantly higher in hMSCs subjected to shear stress than those cultured in static conditions. However, hMSCs cultured in osteogenic differentiation medium were less responsive in gene expression of alkaline phosphatase and bone morphogenetic protein-2. Conclusion: These data demonstrate that shear stress stimulates hMSCs towards an osteoblastic phenotype in the absence of chemical induction, suggesting that certain mechanical stresses may serve as an alternative to chemical stimulation of stem cell differentiation

New targets for therapy in breast cancer: Small molecule tyrosine kinase inhibitors

Over the past several years many advances have been made in our understanding of critical pathways involved in carcinogenesis and tumor growth. These advances have led to the investigation of small molecule inhibitors of the ErbB family of receptor tyrosine kinases across a broad spectrum of malignancies. In this article we summarize the rationale for targeting members of the ErbB family in breast cancer, and review the preclinical and clinical data for the agents that are furthest in development. In addition, we highlight directions for future research, such as exploration of the potential crosstalk between the ErbB and hormone receptor signal transduction pathways, identification of predictive markers for tumor sensitivity, and development of rational combination regimens that include the tyrosine kinase inhibitors

Tumor mutational burden and PTEN alterations as molecular correlates of response to PD-1/L1 blockade in metastatic triple-negative breast cancer

Purpose: Few patients with metastatic triple-negative breast cancer (mTNBC) benefit from immune checkpoint inhibitors (ICI). On the basis of immunotherapy response correlates in other cancers, we evaluated whether high tumor mutational burden (TMB) ≥10 nonsynonymous mutations/megabase and PTEN alterations, defined as nonsynonymous mutations or 1 or 2 copy deletions, were associated with clinical benefit to anti-PD-1/L1 therapy in mTNBC. Experimental design: We identified patients with mTNBC, who consented to targeted DNA sequencing and were treated with ICIs on clinical trials between April 2014 and January 2019 at Dana-Farber Cancer Institute (Boston, MA). Objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were correlated with tumor genomic features. Results: Sixty-two women received anti-PD-1/L1 inhibitors alone (23%) or combined with targeted therapy (19%) or chemotherapy (58%). High TMB (18%) was associated with significantly longer PFS (12.5 vs. 3.7 months; P = 0.04), while PTEN alterations (29%) were associated with significantly lower ORR (6% vs. 48%; P = 0.01), shorter PFS (2.3 vs. 6.1 months; P = 0.01), and shorter OS (9.7 vs. 20.5 months; P = 0.02). Multivariate analyses confirmed that these associations were independent of performance status, prior lines of therapy, therapy regimen, and visceral metastases. The survival associations were additionally independent of PD-L1 in patients with known PD-L1 and were not found in mTNBC cohorts treated with chemotherapy (n = 90) and non-ICI regimens (n = 169). Conclusions: Among patients with mTNBC treated with anti-PD-1/L1 therapies, high TMB and PTEN alterations were associated with longer and shorter survival, respectively. These observations warrant validation in larger datasets

Deposition and solubility of airborne metals to four plant species grown at varying distances from two heavily trafficked roads in London

In urban areas, a highly variable mixture of pollutants is deposited as particulate matter. The concentration and bioavailability of individual pollutants within particles need to be characterised to ascertain the risks to ecological receptors. This study, carried out at two urban parks, measured the deposition and water-solubility of metals to four species common to UK urban areas. Foliar Cd, Cr, Cu, Fe, Ni, Pb and Zn concentrations were elevated in at least one species compared with those from a rural control site. Concentrations were, however, only affected by distance to road in nettle and, to a lesser extent, birch leaves. Greater concentrations of metal were observed in these species compared to cypress and maple possibly due to differences in plant morphology and leaf surfaces. Solubility appeared to be linked to the size fraction and, therefore, origin of the metal with those present predominantly in the coarse fraction exhibiting low solubility. © 2009

“Fracture” phenomena in shearing flow of viscous liquids

In start-up of steady shearing flow of two viscous unentangled liquids, namely low-molecular-weight polystyrene and α-D-glucose, the shear stress catastrophically collapses if the shear rate is raised above a value corresponding to a critical initial shear stress of around 0.1–0.3 MPa. The time dependence of the shear stress during this process is similar for the two liquids, but visualization of samples in situ and after quenching reveals significant differences. For α-D-glucose, the stress collapse evidently results from debonding of the sample from the rheometer tool, while in polystyrene, bubbles open up within the sample, as occurs in cavitation. Some similarities are pointed out between these phenomena and that of “lubrication failure” reported in the tribology literature.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47212/1/397_2004_Article_BF00368135.pd

Haemolymph constituents and osmolality as functions of moult stage, body weight, and feeding status in marron, Cherax cainii (Austin and Ryan, 2002) and yabbies, Cherax destructor (Clark, 1936)

The study investigates the change in osmolality and haemolymph constituents in marron Cherax cainii and yabbies Cherax destructor associated with moult stages, body weights and their feeding status. A total of 582 haemolymph samples from 5 moult stages (postmoult-AB, intermoult-C, and premoult stages – D0, D1, D2), two body weight classes (2–15 g and 61–75 g) and nutritional status were used for analysis of osmolality, protein, glucose, and ionic concentrations of potassium and chloride following the standard biochemical procedures. The haemolymph protein, glucose, potassium and chloride levels were highest at intermoult and early premoult stages, and lowest at postmoult in both crayfish species. Except protein, no significant differences were seen in analyzed parameters between various weight classes and two species. Haemolymph osmolality, protein and glucose were significantly higher in fed crayfish, whereas no variations in haemolymph potassium and chloride concentrations were observed between the fed and unfed crayfish. Maximum osmolality was recorded at 7–8 h after feeding in both crayfish species. The results showed that the biochemical changes in the haemolymph of marron and yabbies are related to moult stages, body weight and feeding and thus can be used as tools for determining suitable diets

Developmental role of the tomato Mediator complex subunit MED18 in pollen ontogeny

[EN] Pollen development is a crucial step in higher plants, which not only makes possible plant fertilization and seed formation, but also determines fruit quality and yield in crop species. Here, we reported a tomato T-DNA mutant, pollen deficient1 (pod1), characterized by an abnormal anther development and the lack of viable pollen formation, which led to the production of parthenocarpic fruits. Genomic analyses and the characterization of silencing lines proved that pod1 mutant phenotype relies on the tomato SlMED18 gene encoding the subunit 18 of Mediator multi-protein complex involved in RNA polymerase II transcription machinery. The loss of SlMED18 function delayed tapetum degeneration, which resulted in deficient microspore development and scarce production of viable pollen. A detailed histological characterization of anther development proved that changes during microgametogenesis and a significant delay in tapetum degeneration are associated with a high proportion of degenerated cells and, hence, should be responsible for the low production of functional pollen grains. Expression of pollen marker genes indicated that SlMED18 is essential for the proper transcription of a subset of genes specifically required to pollen formation and fruit development, revealing a key role of SlMED18 in male gametogenesis of tomato. Additionally, SlMED18 is able to rescue developmental abnormalities of the Arabidopsis med18 mutant, indicating that most biological functions have been conserved in both species. Significance Statement Pollination is a key development process in the life cycle of flowering plants. Genetic and molecular characterization of a tomato mutant have led to the identification of POD1 gene encoding the Mediator complex subunit MED18 whose function is required for tapetum tissue degeneration, a crucial step for pollen development. Furthermore, we show that MED18 fulfils an essential role in tomato, ensuring proper gene regulation during pollen ontogeny.This research was supported by the Spanish Ministry of Economy and Competitiveness (grants AGL2015-64991-C3-1-R, AGL2015-64991-C3-2-R, AGL2015-64991-C3-3-R, BIO2013-43098-R, BFU2016-77243-P and BIO2016-77559-R) and Junta de Andalucia (grant P12-AGR-1482).Pérez Martín, F.; Juan Yuste-Lisbona, F.; Pineda, B.; García Sogo, B.; Del Olmo, I.; Alché, JDD.; Egea, I.... (2018). Developmental role of the tomato Mediator complex subunit MED18 in pollen ontogeny. The Plant Journal. 96(2):300-315. https://doi.org/10.1111/tpj.14031S300315962Allen, B. L., & Taatjes, D. J. (2015). The Mediator complex: a central integrator of transcription. Nature Reviews Molecular Cell Biology, 16(3), 155-166. doi:10.1038/nrm3951Atarés, A., Moyano, E., Morales, B., Schleicher, P., García-Abellán, J. O., Antón, T., … Pineda, B. (2011). An insertional mutagenesis programme with an enhancer trap for the identification and tagging of genes involved in abiotic stress tolerance in the tomato wild-related species Solanum pennellii. Plant Cell Reports, 30(10), 1865-1879. doi:10.1007/s00299-011-1094-yBaulcombe, D. C. (1996). Mechanisms of Pathogen-Derived Resistance to Viruses in Transgenic Plants. The Plant Cell, 1833-1844. doi:10.1105/tpc.8.10.1833Bourbon, H.-M. (2008). Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex. Nucleic Acids Research, 36(12), 3993-4008. doi:10.1093/nar/gkn349Buendía-Monreal, M., & Gillmor, C. S. (2016). Mediator: A key regulator of plant development. Developmental Biology, 419(1), 7-18. doi:10.1016/j.ydbio.2016.06.009Canales, C., Bhatt, A. M., Scott, R., & Dickinson, H. (2002). EXS, a Putative LRR Receptor Kinase, Regulates Male Germline Cell Number and Tapetal Identity and Promotes Seed Development in Arabidopsis. Current Biology, 12(20), 1718-1727. doi:10.1016/s0960-9822(02)01151-xCarbonell-Bejerano, P., Urbez, C., Carbonell, J., Granell, A., & Perez-Amador, M. A. (2010). A Fertilization-Independent Developmental Program Triggers Partial Fruit Development and Senescence Processes in Pistils of Arabidopsis. Plant Physiology, 154(1), 163-172. doi:10.1104/pp.110.160044Chadick, J. Z., & Asturias, F. J. (2005). Structure of eukaryotic Mediator complexes. Trends in Biochemical Sciences, 30(5), 264-271. doi:10.1016/j.tibs.2005.03.001Chuang, C.-F., & Meyerowitz, E. M. (2000). Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana. Proceedings of the National Academy of Sciences, 97(9), 4985-4990. doi:10.1073/pnas.060034297Clough, S. J., & Bent, A. F. (1998). Floral dip: a simplified method forAgrobacterium-mediated transformation ofArabidopsis thaliana. The Plant Journal, 16(6), 735-743. doi:10.1046/j.1365-313x.1998.00343.xColeman, A. W., & Goff, L. J. (1985). Applications of Fluorochromes to Pollen Biology. I. Mithramycin and 4′,6-Diamidino-2-Phenylindole (Dapi) as Vital Stains and for Quantitation of Nuclear Dna. Stain Technology, 60(3), 145-154. doi:10.3109/10520298509113905Conaway, R. C., Sato, S., Tomomori-Sato, C., Yao, T., & Conaway, J. W. (2005). The mammalian Mediator complex and its role in transcriptional regulation. Trends in Biochemical Sciences, 30(5), 250-255. doi:10.1016/j.tibs.2005.03.002Cottrell, H. J. (1948). Tetrazolium Salt as a Seed Germination Indicator. Annals of Applied Biology, 35(1), 123-131. doi:10.1111/j.1744-7348.1948.tb07355.xCrane, M. B. (1915). Heredity of types of inflorescence and fruits in tomato. Journal of Genetics, 5(1), 1-11. doi:10.1007/bf02982149Davoine, C., Abreu, I. N., Khajeh, K., Blomberg, J., Kidd, B. N., Kazan, K., … Björklund, S. (2017). Functional metabolomics as a tool to analyze Mediator function and structure in plants. PLOS ONE, 12(6), e0179640. doi:10.1371/journal.pone.0179640Ellul, P., Garcia-Sogo, B., Pineda, B., Ríos, G., Roig, L., & Moreno, V. (2003). The ploidy level of transgenic plants in Agrobacterium-mediated transformation of tomato cotyledons (Lycopersicon esculentum L.Mill.) is genotype and procedure dependent. Theoretical and Applied Genetics, 106(2), 231-238. doi:10.1007/s00122-002-0928-yFallath, T., Kidd, B. N., Stiller, J., Davoine, C., Björklund, S., Manners, J. M., … Schenk, P. M. (2017). MEDIATOR18 and MEDIATOR20 confer susceptibility to Fusarium oxysporum in Arabidopsis thaliana. PLOS ONE, 12(4), e0176022. doi:10.1371/journal.pone.0176022Feng, B., Lu, D., Ma, X., Peng, Y., Sun, Y., Ning, G., & Ma, H. (2012). Regulation of the Arabidopsis anther transcriptome by DYT1 for pollen development. The Plant Journal, 72(4), 612-624. doi:10.1111/j.1365-313x.2012.05104.xGillaspy, G., Ben-David, H., & Gruissem, W. (1993). Fruits: A Developmental Perspective. The Plant Cell, 1439-1451. doi:10.1105/tpc.5.10.1439Gleave, A. P. (1992). A versatile binary vector system with a T-DNA organisational structure conducive to efficient integration of cloned DNA into the plant genome. Plant Molecular Biology, 20(6), 1203-1207. doi:10.1007/bf00028910Gómez, J. F., Talle, B., & Wilson, Z. A. (2015). Anther and pollen development: A conserved developmental pathway. Journal of Integrative Plant Biology, 57(11), 876-891. doi:10.1111/jipb.12425Gorman, S. W., McCormick, S., & Rick, C. (1997). Male Sterility in Tomato. Critical Reviews in Plant Sciences, 16(1), 31-53. doi:10.1080/07352689709701945Helliwell, C. (2003). Constructs and methods for high-throughput gene silencing in plants. Methods, 30(4), 289-295. doi:10.1016/s1046-2023(03)00036-7Honys, D., & Twell, D. (2004). Transcriptome analysis of haploid male gametophyte development in Arabidopsis. Genome Biology, 5(11). doi:10.1186/gb-2004-5-11-r85Jeong, H.-J., Kang, J.-H., Zhao, M., Kwon, J.-K., Choi, H.-S., Bae, J. H., … Kang, B.-C. (2014). Tomato Male sterile 1035 is essential for pollen development and meiosis in anthers. Journal of Experimental Botany, 65(22), 6693-6709. doi:10.1093/jxb/eru389Jimenez-Lopez, J. C., Zienkiewicz, A., Zienkiewicz, K., Alché, J. D., & Rodríguez-García, M. I. (2015). Biogenesis of protein bodies during legumin accumulation in developing olive (Olea europaea L.) seed. Protoplasma, 253(2), 517-530. doi:10.1007/s00709-015-0830-5Kornberg, R. D. (2005). Mediator and the mechanism of transcriptional activation. Trends in Biochemical Sciences, 30(5), 235-239. doi:10.1016/j.tibs.2005.03.011Lai, Z., Schluttenhofer, C. M., Bhide, K., Shreve, J., Thimmapuram, J., Lee, S. Y., … Mengiste, T. (2014). MED18 interaction with distinct transcription factors regulates multiple plant functions. Nature Communications, 5(1). doi:10.1038/ncomms4064Larivière, L., Geiger, S., Hoeppner, S., Röther, S., Sträßer, K., & Cramer, P. (2006). Structure and TBP binding of the Mediator head subcomplex Med8–Med18–Med20. Nature Structural & Molecular Biology, 13(10), 895-901. doi:10.1038/nsmb1143Lee, S. K., Chen, X., Huang, L., & Stargell, L. A. (2013). The head module of Mediator directs activation of preloaded RNAPII in vivo. Nucleic Acids Research, 41(22), 10124-10134. doi:10.1093/nar/gkt796Li, D.-D., Xue, J.-S., Zhu, J., & Yang, Z.-N. (2017). Gene Regulatory Network for Tapetum Development in Arabidopsis thaliana. Frontiers in Plant Science, 8. doi:10.3389/fpls.2017.01559Liu, X., Huang, J., Parameswaran, S., Ito, T., Seubert, B., Auer, M., … Zhao, D. (2009). The SPOROCYTELESS/NOZZLE Gene Is Involved in Controlling Stamen Identity in Arabidopsis. Plant Physiology, 151(3), 1401-1411. doi:10.1104/pp.109.145896Lora, J., Hormaza, J. I., Herrero, M., & Gasser, C. S. (2011). Seedless fruits and the disruption of a conserved genetic pathway in angiosperm ovule development. Proceedings of the National Academy of Sciences, 108(13), 5461-5465. doi:10.1073/pnas.1014514108Lozano, R., Angosto, T., Gómez, P., Payán, C., Capel, J., Huijser, P., … Martı́nez-Zapater, J. M. (1998). Tomato Flower Abnormalities Induced by Low Temperatures Are Associated with Changes of Expression of MADS-Box Genes. Plant Physiology, 117(1), 91-100. doi:10.1104/pp.117.1.91Ma, H. (2005). MOLECULAR GENETIC ANALYSES OF MICROSPOROGENESIS AND MICROGAMETOGENESIS IN FLOWERING PLANTS. Annual Review of Plant Biology, 56(1), 393-434. doi:10.1146/annurev.arplant.55.031903.141717McNeil, K. J., & Smith, A. G. (2009). A glycine-rich protein that facilitates exine formation during tomato pollen development. Planta, 231(4), 793-808. doi:10.1007/s00425-009-1089-xMercier, R. (2003). The meiotic protein SWI1 is required for axial element formation and recombination initiation in Arabidopsis. Development, 130(>14), 3309-3318. doi:10.1242/dev.00550Mukundan, B., & Ansari, A. (2011). Novel Role for Mediator Complex Subunit Srb5/Med18 in Termination of Transcription. Journal of Biological Chemistry, 286(43), 37053-37057. doi:10.1074/jbc.c111.295915Muschietti, J., Dircks, L., Vancanneyt, G., & McCormick, S. (1994). LAT52 protein is essential for tomato pollen development: pollen expressing antisense LAT52 RNA hydrates and germinates abnormally and cannot achieve fertilization. The Plant Journal, 6(3), 321-338. doi:10.1046/j.1365-313x.1994.06030321.xOzga, J. A., & Reinecke, D. M. (2003). Hormonal Interactions in Fruit Development. Journal of Plant Growth Regulation, 22(1), 73-81. doi:10.1007/s00344-003-0024-9Pacini, E. (2010). Relationships between Tapetum, Loculus, and Pollen during Development. International Journal of Plant Sciences, 171(1), 1-11. doi:10.1086/647923Pérez-Martín, F., Yuste-Lisbona, F. J., Pineda, B., Angarita-Díaz, M. P., García-Sogo, B., Antón, T., … Lozano, R. (2017). A collection of enhancer trap insertional mutants for functional genomics in tomato. Plant Biotechnology Journal, 15(11), 1439-1452. doi:10.1111/pbi.12728Pina, C., Pinto, F., Feijó, J. A., & Becker, J. D. (2005). Gene Family Analysis of the Arabidopsis Pollen Transcriptome Reveals Biological Implications for Cell Growth, Division Control, and Gene Expression Regulation. Plant Physiology, 138(2), 744-756. doi:10.1104/pp.104.057935Polowick, P. L., & Sawhney, V. K. (1993). An ultrastructural study of pollen development in tomato (Lycopersicon esculentum). I. Tetrad to early binucleate microspore stage. Canadian Journal of Botany, 71(8), 1039-1047. doi:10.1139/b93-120Polowick, P. L., & Sawhney, V. K. (1993). An ultrastructural study of pollen development in tomato (Lycopersicon esculentum). II. Pollen maturation. Canadian Journal of Botany, 71(8), 1048-1055. doi:10.1139/b93-121Rutley, N., & Twell, D. (2015). A decade of pollen transcriptomics. Plant Reproduction, 28(2), 73-89. doi:10.1007/s00497-015-0261-7Samanta, S., & Thakur, J. K. (2015). Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plants. Frontiers in Plant Science, 6. doi:10.3389/fpls.2015.00757Schiefthaler, U., Balasubramanian, S., Sieber, P., Chevalier, D., Wisman, E., & Schneitz, K. (1999). Molecular analysis of NOZZLE, a gene involved in pattern formation and early sporogenesis during sex organ development in Arabidopsis thaliana. Proceedings of the National Academy of Sciences, 96(20), 11664-11669. doi:10.1073/pnas.96.20.11664Scott, R. J. (2004). Stamen Structure and Function. THE PLANT CELL ONLINE, 16(suppl_1), S46-S60. doi:10.1105/tpc.017012Smirnova, A., Leide, J., & Riederer, M. (2012). Deficiency in a Very-Long-Chain Fatty Acid β-Ketoacyl-Coenzyme A Synthase of Tomato Impairs Microgametogenesis and Causes Floral Organ Fusion. Plant Physiology, 161(1), 196-209. doi:10.1104/pp.112.206656Sorensen, A.-M., Kröber, S., Unte, U. S., Huijser, P., Dekker, K., & Saedler, H. (2003). TheArabidopsis ABORTED MICROSPORES(AMS) gene encodes a MYC class transcription factor. The Plant Journal, 33(2), 413-423. doi:10.1046/j.1365-313x.2003.01644.xWang, Y., Hu, Z., Zhang, J., Yu, X., Guo, J.-E., Liang, H., … Chen, G. (2018). Silencing SlMED18, tomato Mediator subunit 18 gene, restricts internode elongation and leaf expansion. Scientific Reports, 8(1). doi:10.1038/s41598-018-21679-1Wesley, S. V., Helliwell, C. A., Smith, N. A., Wang, M., Rouse, D. T., Liu, Q., … Waterhouse, P. M. (2001). Construct design for efficient, effective and high-throughput gene silencing in plants. The Plant Journal, 27(6), 581-590. doi:10.1046/j.1365-313x.2001.01105.xWilson, Z. A., & Zhang, D.-B. (2009). From Arabidopsis to rice: pathways in pollen development. Journal of Experimental Botany, 60(5), 1479-1492. doi:10.1093/jxb/erp095Wilson, Z. A., Morroll, S. M., Dawson, J., Swarup, R., & Tighe, P. J. (2001). The Arabidopsis MALE STERILITY1 (MS1) gene is a transcriptional regulator of male gametogenesis, with homology to the PHD-finger family of transcription factors. The Plant Journal, 28(1), 27-39. doi:10.1046/j.1365-313x.2001.01125.xWiner, J., Jung, C. K. S., Shackel, I., & Williams, P. M. (1999). Development and Validation of Real-Time Quantitative Reverse Transcriptase–Polymerase Chain Reaction for Monitoring Gene Expression in Cardiac Myocytesin Vitro. Analytical Biochemistry, 270(1), 41-49. doi:10.1006/abio.1999.4085Yang, W.-C., Ye, D., Xu, J., & Sundaresan, V. (1999). The SPOROCYTELESS gene of Arabidopsis is required for initiation of sporogenesis and encodes a novel nuclear protein. Genes & Development, 13(16), 2108-2117. doi:10.1101/gad.13.16.2108Yang, C.-Y., Spielman, M., Coles, J. P., Li, Y., Ghelani, S., Bourdon, V., … Dickinson, H. G. (2003). TETRASPORE encodes a kinesin required for male meiotic cytokinesis in Arabidopsis. The Plant Journal, 34(2), 229-240. doi:10.1046/j.1365-313x.2003.01713.xYang, C., Vizcay-Barrena, G., Conner, K., & Wilson, Z. A. (2007). MALE STERILITY1 Is Required for Tapetal Development and Pollen Wall Biosynthesis. The Plant Cell, 19(11), 3530-3548. doi:10.1105/tpc.107.054981Yuan, W., Li, X., Chang, Y., Wen, R., Chen, G., Zhang, Q., & Wu, C. (2009). Mutation of the rice genePAIR3results in lack of bivalent formation in meiosis. The Plant Journal, 59(2), 303-315. doi:10.1111/j.1365-313x.2009.03870.xYuste-Lisbona, F. J., Quinet, M., Fernández-Lozano, A., Pineda, B., Moreno, V., Angosto, T., & Lozano, R. (2016). Characterization of vegetative inflorescence (mc-vin) mutant provides new insight into the role of MACROCALYX in regulating inflorescence development of tomato. Scientific Reports, 6(1). doi:10.1038/srep18796Zhao, D.-Z. (2002). The EXCESS MICROSPOROCYTES1 gene encodes a putative leucine-rich repeat receptor protein kinase that controls somatic and reproductive cell fates in the Arabidopsis anther. Genes & Development, 16(15), 2021-2031. doi:10.1101/gad.997902Zheng, Z., Guan, H., Leal, F., Grey, P. H., & Oppenheimer, D. G. (2013). Mediator Subunit18 Controls Flowering Time and Floral Organ Identity in Arabidopsis. PLoS ONE, 8(1), e53924. doi:10.1371/journal.pone.0053924Zhou, S., Wang, Y., Li, W., Zhao, Z., Ren, Y., Wang, Y., … Wan, J. (2011). Pollen Semi-Sterility1 Encodes a Kinesin-1–Like Protein Important for Male Meiosis, Anther Dehiscence, and Fertility in Rice. The Plant Cell, 23(1), 111-129. doi:10.1105/tpc.109.07369

Evidence for the h_b(1P) meson in the decay Upsilon(3S) --> pi0 h_b(1P)

Using a sample of 122 million Upsilon(3S) events recorded with the BaBar detector at the PEP-II asymmetric-energy e+e- collider at SLAC, we search for the $h_b(1P)$ spin-singlet partner of the P-wave chi_{bJ}(1P) states in the sequential decay Upsilon(3S) --> pi0 h_b(1P), h_b(1P) --> gamma eta_b(1S). We observe an excess of events above background in the distribution of the recoil mass against the pi0 at mass 9902 +/- 4(stat.) +/- 2(syst.) MeV/c^2. The width of the observed signal is consistent with experimental resolution, and its significance is 3.1sigma, including systematic uncertainties. We obtain the value (4.3 +/- 1.1(stat.) +/- 0.9(syst.)) x 10^{-4} for the product branching fraction BF(Upsilon(3S)-->pi0 h_b) x BF(h_b-->gamma eta_b).Comment: 8 pages, 4 postscript figures, submitted to Phys. Rev. D (Rapid Communications