Photometric Variability of the T2.5 Brown Dwarf SIMP J013656.5+093347; Evidence for Evolving Weather Patterns

We report the discovery of a photometric variability in the bright T2.5 brown dwarf SIMP J013656.5+093347. Continuous J-band photometry has been obtained for several hours on four different nights. The light curves show a periodic modulation with a period of ~2.4 hours, a peak-to-peak amplitude of ~50 mmag and significant night-to-night evolution. We suggest that the light curve modulation is due to the brown dwarf's rotation and that the longer term variations come from surface features evolution and/or differential rotation. We obtained complementary observations over a single night in the J and Ks bands; the object displays correlated photometric variability in both bands, albeit with smaller Ks-band amplitude. The ratio of the Ks and J variability amplitudes puts strong constraints on the physical mechanisms at play. Based on theoretical models of brown dwarf atmospheres, our results suggest that the atmosphere of SIMP0136 is comprised of both grain-free and colder (by ~100 K) grain-bearing cloudy regions. This discovery, and its interpretation, provide a natural explanation of the so-called J-band brightening.Comment: Accepted for publication in ApJ. Modification in the replacement : One author missing in the astro-ph metadat

IRAS04325+2402C: A very low mass object with an edge-on disk

IRAS04325+2402C is a low luminosity object located near a protostar in Taurus. We present new spatially-resolved mm observations, near-infrared spectroscopy, and Spitzer photometry that improve the constraints on the nature of this source. The object is clearly detected in our 1.3 mm interferometry map, allowing us to estimate the mass in a localized disk+envelope around it to be in the range of 0.001 to 0.01Ms. Thus IRAS04325C is unlikely to accrete significantly more mass. The near-infrared spectrum cannot be explained with an extincted photosphere alone, but is consistent with a 0.03-0.1Ms central source plus moderate veiling, seen in scattered light, confirming the edge-on nature of the disk. Based on K-band flux and spectral slope we conclude that a central object mass >~0.1Ms is unlikely. Our comparison of the full spectral energy distribution, including new Spitzer photometry, with radiative transfer models confirms the high inclination of the disk (>~80deg), the very low mass of the central source, and the small amount of circumstellar material. IRAS04325C is one of the lowest mass objects with a resolved edge-on disk known to date, possibly a young brown dwarf, and a likely wide companion to a more massive star. With these combined properties, it represents a unique case to study the formation and early evolution of very low mass objects.Comment: 5 pages, 3 figures, Astrophysical Journal Letters, in pres

Hotspots of Large Rare Deletions in the Human Genome

Background: We have examined the genomic distribution of large rare autosomal deletions in a sample of 440 parentparent-child trios from the Quebec founder population (QFP) which was recruited for a study of Attention Deficit Hyperactivity Disorder. Methodology/Principal Findings: DNA isolated from blood was genotyped on Illumina Hap300 arrays. PennCNV combined with visual evaluation of images generated by the Beadstudio program was used to determine deletion boundary definition of sufficient precision to discern independent events, with near-perfect concordance between parent and child in about 98 % of the 399 events detected in the offspring; the remaining 7 deletions were considered de novo. We defined several genomic regions of very high deletion frequency (‘hotspots’), usually of 0.4–0.6 Mb in length where independent rare deletions were found at frequencies of up to 100 fold higher than the average for the genome as a whole. Five of the 7 de novo deletions were in these hotspots. The same hotspots were also observed in three other studies on members of the QFP, those with schizophrenia, with endometriosis and those from a longevity cohort. Conclusions/Significance: Nine of the 13 hotspots carry one gene (7 of which are very long), while the rest contain no known genes. All nine genes have been implicated in disease. The patterns of exon deletions support the proposed roles for some of these genes in human disease, such as NRXN1 and PARKIN, and suggest limited roles or no role at all, for others

A WFI survey in the Chamaeleon II dark cloud

We present the results of an optical multi-band survey for low-mass Pre-Main Sequence (PMS) stars and young Brown Dwarfs (BDs) in the Chamaeleon II (Cha II) dark cloud. This survey constitutes the complementary optical data to the c2d Spitzer Legacy survey in Cha II. Using the Wide-Field Imager (WFI) at the ESO 2.2m telescope, we surveyed a sky area of about 1.75 square degrees in Cha II. The region was observed in the Rc, Ic and z broad-bands, in H-alpha and in two medium-band filters centered at 856 and 914 nm. We select PMS star and young BD candidates using colour-magnitude diagrams (CMDs) and theoretical isochrones reproduced ad-hoc for the WFI at the ESO2.2m telescope system. The selection criteria are also reinforced by using the previously known PMS stars in Cha II to define the PMS locus on the CMDs and by investigating the infrared (IR) colours of the candidates. By exploiting the WFI intermediate-band photometry we also estimate the effective temperature and the level of H-alpha emission of the candidates. Our survey, which is one of the largest and deepest optical surveys conducted so far in Cha II, recovered the majority of the PMS stars and 10 member candidates of the cloud from previous IR surveys. In addition, the survey revealed 10 new potential members. From our photometric characterisation, we estimate that some 50% of the 20 candidates will result in true Cha II members. Based on our temperature estimates, we conclude that several of these objects are expected to be sub-stellar and give a first estimate of the fraction of sub-stellar objects.Comment: 26 pages, 18 figure

Discovery of a Wide Planetary-mass Companion to the Young M3 Star GU Psc

We present the discovery of a comoving planetary-mass companion ~42" (~2000 AU) from a young M3 star, GU Psc, a likely member of the young AB Doradus Moving Group (ABDMG). The companion was first identified via its distinctively red i − z color (>3.5) through a survey made with Gemini-S/GMOS. Follow-up Canada–France–Hawaii Telescope/WIRCam near-infrared (NIR) imaging, Gemini-N/GNIRS NIR spectroscopy and Wide-field Infrared Survey Explorer photometry indicate a spectral type of T3.5 ± 1 and reveal signs of low gravity which we attribute to youth. Keck/Adaptive Optics NIR observations did not resolve the companion as a binary. A comparison with atmosphere models indicates T_eff = 1000–1100 K and log g = 4.5–5.0. Based on evolution models, this temperature corresponds to a mass of 9–13  M_Jup for the age of ABDMG (70–130 Myr). The relatively well-constrained age of this companion and its very large angular separation to its host star will allow its thorough characterization and will make it a valuable comparison for planetary-mass companions that will be uncovered by forthcoming planet-finder instruments such as Gemini Planet Imager and SPHERE

Host Protein Biomarkers Identify Active Tuberculosis in HIV Uninfected and Co-infected Individuals

AbstractBiomarkers for active tuberculosis (TB) are urgently needed to improve rapid TB diagnosis. The objective of this study was to identify serum protein expression changes associated with TB but not latent Mycobacterium tuberculosis infection (LTBI), uninfected states, or respiratory diseases other than TB (ORD). Serum samples from 209 HIV uninfected (HIV−) and co-infected (HIV+) individuals were studied. In the discovery phase samples were analyzed via liquid chromatography and mass spectrometry, and in the verification phase biologically independent samples were analyzed via a multiplex multiple reaction monitoring mass spectrometry (MRM-MS) assay. Compared to LTBI and ORD, host proteins were significantly differentially expressed in TB, and involved in the immune response, tissue repair, and lipid metabolism. Biomarker panels whose composition differed according to HIV status, and consisted of 8 host proteins in HIV− individuals (CD14, SEPP1, SELL, TNXB, LUM, PEPD, QSOX1, COMP, APOC1), or 10 host proteins in HIV+ individuals (CD14, SEPP1, PGLYRP2, PFN1, VASN, CPN2, TAGLN2, IGFBP6), respectively, distinguished TB from ORD with excellent accuracy (AUC=0.96 for HIV− TB, 0.95 for HIV+ TB). These results warrant validation in larger studies but provide promise that host protein biomarkers could be the basis for a rapid, blood-based test for TB

Histopathological Features of Aspirated Thrombi after Primary Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction

BACKGROUND: Plaque disruption with superimposed thrombus is the predominant mechanism responsible for the onset of acute coronary syndromes. Studies have shown that plaque disruption and thrombotic occlusion are frequently separated in time. We established the histopathological characteristics of material aspirated during primary percutaneous coronary intervention (PCI) in a large consecutive ST-elevation myocardial infarction (STEMI) population. METHODOLOGY/PRINCIPAL FINDINGS: Thrombus aspiration during primary PCI was performed in 1,362 STEMI patients. Thrombus age was classified as fresh (<1 day), lytic (1-5 days), or organized (>5 day). Further, the presence of plaque was documented. The histopathological findings were related to the clinical, angiographic, and procedural characteristics. Material could be aspirated in 1,009 patients (74%). Components of plaque were found in 395 of these patients (39%). Fresh thrombus was found in 577 of 959 patients (60%) compared to 382 patients (40%) with lytic or organized thrombi. Distal embolization was present in 21% of patients with lytic thrombus compared to 12% and 15% of patients with fresh or organized thrombus. CONCLUSIONS/SIGNIFICANCE: Material could be obtained in 74% of STEMI patients treated with thrombus aspiration during primary PCI. In 40% of patients thrombus age is older than 24 h, indicating that plaque disruption and thrombus formation occur significantly earlier than the onset of symptoms in many patients

A chemical survey of exoplanets with ARIEL

Thousands of exoplanets have now been discovered with a huge range of masses, sizes and orbits: from rocky Earth-like planets to large gas giants grazing the surface of their host star. However, the essential nature of these exoplanets remains largely mysterious: there is no known, discernible pattern linking the presence, size, or orbital parameters of a planet to the nature of its parent star. We have little idea whether the chemistry of a planet is linked to its formation environment, or whether the type of host star drives the physics and chemistry of the planet’s birth, and evolution. ARIEL was conceived to observe a large number (~1000) of transiting planets for statistical understanding, including gas giants, Neptunes, super-Earths and Earth-size planets around a range of host star types using transit spectroscopy in the 1.25–7.8 μm spectral range and multiple narrow-band photometry in the optical. ARIEL will focus on warm and hot planets to take advantage of their well-mixed atmospheres which should show minimal condensation and sequestration of high-Z materials compared to their colder Solar System siblings. Said warm and hot atmospheres are expected to be more representative of the planetary bulk composition. Observations of these warm/hot exoplanets, and in particular of their elemental composition (especially C, O, N, S, Si), will allow the understanding of the early stages of planetary and atmospheric formation during the nebular phase and the following few million years. ARIEL will thus provide a representative picture of the chemical nature of the exoplanets and relate this directly to the type and chemical environment of the host star. ARIEL is designed as a dedicated survey mission for combined-light spectroscopy, capable of observing a large and well-defined planet sample within its 4-year mission lifetime. Transit, eclipse and phase-curve spectroscopy methods, whereby the signal from the star and planet are differentiated using knowledge of the planetary ephemerides, allow us to measure atmospheric signals from the planet at levels of 10–100 part per million (ppm) relative to the star and, given the bright nature of targets, also allows more sophisticated techniques, such as eclipse mapping, to give a deeper insight into the nature of the atmosphere. These types of observations require a stable payload and satellite platform with broad, instantaneous wavelength coverage to detect many molecular species, probe the thermal structure, identify clouds and monitor the stellar activity. The wavelength range proposed covers all the expected major atmospheric gases from e.g. H2O, CO2, CH4 NH3, HCN, H2S through to the more exotic metallic compounds, such as TiO, VO, and condensed species. Simulations of ARIEL performance in conducting exoplanet surveys have been performed – using conservative estimates of mission performance and a full model of all significant noise sources in the measurement – using a list of potential ARIEL targets that incorporates the latest available exoplanet statistics. The conclusion at the end of the Phase A study, is that ARIEL – in line with the stated mission objectives – will be able to observe about 1000 exoplanets depending on the details of the adopted survey strategy, thus confirming the feasibility of the main science objectives.Peer reviewedFinal Published versio

Technology roadmap for cold-atoms based quantum inertial sensor in space

Recent developments in quantum technology have resulted in a new generation of sensors for measuring inertial quantities, such as acceleration and rotation. These sensors can exhibit unprecedented sensitivity and accuracy when operated in space, where the free-fall interrogation time can be extended at will and where the environment noise is minimal. European laboratories have played a leading role in this field by developing concepts and tools to operate these quantum sensors in relevant environment, such as parabolic flights, free-fall towers, or sounding rockets. With the recent achievement of Bose-Einstein condensation on the International Space Station, the challenge is now to reach a technology readiness level sufficiently high at both component and system levels to provide "off the shelf"payload for future generations of space missions in geodesy or fundamental physics. In this roadmap, we provide an extensive review on the status of all common parts, needs, and subsystems for the application of atom-based interferometers in space, in order to push for the development of generic technology components

Potentially inappropriate prescriptions for older patients in long-term care

BACKGROUND: Inappropriate medication use is a major healthcare issue for the elderly population. This study explored the prevalence of potentially inappropriate prescriptions (PIPs) in long-term care in metropolitan Quebec. METHODS: A cross sectional chart review of 2,633 long-term care older patients of the Quebec City area was performed. An explicit criteria list for PIPs was developed based on the literature and validated by a modified Delphi method. Medication orders were reviewed to describe prescribing patterns and to determine the prevalence of PIPs. A multivariate analysis was performed to identify predictors of PIPs. RESULTS: Almost all residents (94.0%) were receiving one or more prescribed medication; on average patients had 4.8 prescribed medications. A majority (54.7%) of treated patients had a potentially inappropriate prescription (PIP). Most common PIPs were drug interactions (33.9% of treated patients), followed by potentially inappropriate duration (23.6%), potentially inappropriate medication (14.7%) and potentially inappropriate dosage (9.6%). PIPs were most frequent for medications of the central nervous system (10.8% of prescribed medication). The likelihood of PIP increased significantly as the number of drugs prescribed increased (odds ratio [OR]: 1.38, 95% confidence interval [CI]: 1.33 – 1.43) and with the length of stay (OR: 1.78, CI: 1.43 – 2.20). On the other hand, the risk of receiving a PIP decreased with age. CONCLUSION: Potentially inappropriate prescribing is a serious problem in the highly medicated long-term care population in metropolitan Quebec. Use of explicit criteria lists may help identify the most critical issues and prioritize interventions to improve quality of care and patient safety