Экологическая культура политического восприятия глобальных природоохранных проблем

The article discusses the theoretical and methodological problems of actively developing in modern conditions ecological culture, determining its place in the system of humanities. The growing importance of new conception of scientific research and sociocultural practices in the context of the global problems of our time is determined.It is necessary to know the experts’ opinion which environmental problems are being identified as most significant. Only afterwards we can find the ways to solve them. Thereby based on the analysis of materials of the Russian scientific-practical conference with international participation “Environmental protection as a factor of the socio-economic development of municipalities: experience and problems” (2017, Rostov-on-Don, Kurgan), and the results of the Russian expert opinion research conducted by scientists of Rostov scientific elitological school it was concluded that there is an objective necessity to create a unified structure of natural resource management and environmental protection in territorial entities (Vorontsov, Mamychev, Ponedelkov, Yanguzin and Vildanov, 2017; Ponedelkov, Starostin, Mamychev, Grigoryan and Verenich, 2018). At the same time, the prerequisites and trends, the problematic aspects of the development of environmentally-oriented processes in modern Russian conditions determine that the organization of an effective environmental protection policy as a factor of socio-economic development and mechanisms of the implementation its strategic goals in the field of environmental development existing public administration system is possible only if appropriate conditions are created for the dynamic development of the system of environmental education and upbringing, as well as the necessity of developing the implementation of a new civilizational paradigm as a new eco-human behavioral paradigmEl artículo discute los problemas teóricos y metodológicos de desarrollar activamente en las condiciones modernas la cultura ecológica, determinando su lugar en el sistema de humanidades. Se determina la importancia creciente de la nueva concepción de la investigación científica y las prácticas socioculturales en el contexto de los problemas globales de nuestro tiempo.Es necesario conocer la opinión de los expertos sobre qué problemas ambientales se están identificando como los más significativos. Solo después podremos encontrar las formas de resolverlos. De este modo, se basa en el análisis de los materiales de la conferencia científico-práctica rusa con participación internacional "La protección del medio ambiente como factor del desarrollo socioeconómico de los municipios: experiencia y problemas" (2017, Rostov-on-Don, Kurgan), y el Los resultados de la investigación de expertos rusos realizada por científicos de la escuela científica elitológica de Rostov concluyeron que existe una necesidad objetiva de crear una estructura unificada de gestión de recursos naturales y protección ambiental en entidades territoriales (Vorontsov, Mamychev, Ponedelkov, Yanguzin y Vildanov, 2017; Ponedelkov, Starostin, Mamychev, Grigoryan y Verenich, 2018). Al mismo tiempo, los prerrequisitos y las tendencias, los aspectos problemáticos del desarrollo de procesos orientados al medio ambiente en las condiciones modernas de Rusia determinan que la organización de una política de protección ambiental efectiva como un factor del desarrollo socioeconómico y los mecanismos de implementación sean estratégicos. objetivos en el campo del desarrollo ambiental El sistema de administración pública existente solo es posible si se crean las condiciones adecuadas para el desarrollo dinámico del sistema de educación y educación ambiental, así como la necesidad de desarrollar la implementación de un nuevo paradigma de civilización como un nuevo eco. -el paradigma del comportamiento humano.Экологические интересы, выступая одной из материализованных предпосылок человеческой деятельности являются также и показателем качества жизни, уровня развитости общественной морали, правовой культуры общества. В современных политических условиях первостепенное значение имеет институциализация экологических интересов в трех основных секторах общества – государство, сфера производства, общественность (в любой последовательности, но обязательно при наличии этих трех компонентов). В этом контексте интерес представляет как свойство определенной социальной общности, отдельного индивида или группы и выступает в качестве одного из самых существенных факторов, воздействующих на поведение этих социальных единиц в экологической среде, так, и определяющих их наиболее существенные поведенческие акции. и социокультурных практик в контексте глобальных проблем современности.Для установления болевых точек и определения путей решения экологических проблем необходимо знать мнение экспертов о том, какие из этих проблем волнуют людей в наибольшей степени. В связи с этим, на основе анализа материалов Всероссийской научно-практической конференции с международным участием «Защита окружающей среды как фактор социально-экономического развития территорий муниципальных образований: опыт и проблемы» (2017 год, Ростов-на-Дону, Курган), а также результатов общероссийского экспертного опроса, проведенного учеными Ростовской научной элитологической школы, были сделаны о том, что объективно назрела необходимость в создании единой структуры природоресурсного и природоохранного регулирования в территориальных образованиях. В то же время предпосылки и тенденции, проблемные аспекты развития эколого-ориентированных процессов в современных российских условиях таковы, что формирование эффективной политики защиты окружающей среды, рассматриваемой как фактор социально-экономического развития и механизмов реализации ее стратегических целей в области экологического развития в рамках функционирования действующей системы государственного управления, возможно только при создании соответствующих условий для динамичного развития системы экологического образования и воспитания, как и необходимость разработки осуществления новой цивилизационной парадигмы в качестве новой поведенческой парадигмы эко-человека в целом.В статье рассматриваются теоретико-методологические проблемы активно развивающейся в современных условиях экологической культуры, определения ее места в системе гуманитарного знания. Определено все возрастающее значение этого нового представления научных исследовани

Paramagnetic properties of carbon-doped titanium dioxide

This paper reports the experimental results on paramagnetic properties of carbon-doped titanium dioxide. The electron paramagnetic resonance study of the samples has been carried out both in dark and under illumination. The nature of defects and their dynamics under illumination of carbon-doped TiO(2) samples is discussed

Functional annotation of human long noncoding RNAs via molecular phenotyping

Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression of 285 lncRNAs in human dermal fibroblasts and quantified cellular growth, morphological changes, and transcriptomic responses using Capped Analysis of Gene Expression (CAGE). Antisense oligonucleotides targeting the same lncRNAs exhibited global concordance, and the molecular phenotype, measured by CAGE, recapitulated the observed cellular phenotypes while providing additional insights on the affected genes and pathways. Here, we disseminate the largest-todate lncRNA knockdown data set with molecular phenotyping (over 1000 CAGE deep-sequencing libraries) for further exploration and highlight functional roles for ZNF213-AS1 and lnc-KHDC3L-2.Peer reviewe

The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome.

X chromosomes are unusual in many regards, not least of which is their nonrandom gene content. The causes of this bias are commonly discussed in the context of sexual antagonism and the avoidance of activity in the male germline. Here, we examine the notion that, at least in some taxa, functionally biased gene content may more profoundly be shaped by limits imposed on gene expression owing to haploid expression of the X chromosome. Notably, if the X, as in primates, is transcribed at rates comparable to the ancestral rate (per promoter) prior to the X chromosome formation, then the X is not a tolerable environment for genes with very high maximal net levels of expression, owing to transcriptional traffic jams. We test this hypothesis using The Encyclopedia of DNA Elements (ENCODE) and data from the Functional Annotation of the Mammalian Genome (FANTOM5) project. As predicted, the maximal expression of human X-linked genes is much lower than that of genes on autosomes: on average, maximal expression is three times lower on the X chromosome than on autosomes. Similarly, autosome-to-X retroposition events are associated with lower maximal expression of retrogenes on the X than seen for X-to-autosome retrogenes on autosomes. Also as expected, X-linked genes have a lesser degree of increase in gene expression than autosomal ones (compared to the human/Chimpanzee common ancestor) if highly expressed, but not if lowly expressed. The traffic jam model also explains the known lower breadth of expression for genes on the X (and the Z of birds), as genes with broad expression are, on average, those with high maximal expression. As then further predicted, highly expressed tissue-specific genes are also rare on the X and broadly expressed genes on the X tend to be lowly expressed, both indicating that the trend is shaped by the maximal expression level not the breadth of expression per se. Importantly, a limit to the maximal expression level explains biased tissue of expression profiles of X-linked genes. Tissues whose tissue-specific genes are very highly expressed (e.g., secretory tissues, tissues abundant in structural proteins) are also tissues in which gene expression is relatively rare on the X chromosome. These trends cannot be fully accounted for in terms of alternative models of biased expression. In conclusion, the notion that it is hard for genes on the Therian X to be highly expressed, owing to transcriptional traffic jams, provides a simple yet robustly supported rationale of many peculiar features of X's gene content, gene expression, and evolution

Fight Corruption at the State and Municipal Levels in Russia: Following Sociological (Field) Researches

The need to improve the efficiency of combating corruption presupposes an increase in the influence of ethical and moral norms on the observance of prohibitions, restrictions, and requirements established in order to counter corruption, as well as the development of additional mechanisms and tools for preventing corruption manifestations. Moreover, it is clearly not enough to legalize the norms of anti-corruption behaviour, through which law enforcement activities in this area could provide real results. Anti-corruption norms require not only legalization, but also legitimation, that is, recognition and support by citizens and society of this work as a whole. Only a combination of these two components can ensure an increase in the effectiveness of the prevention of corruption offenses in the Russian Federation. Legislative and law enforcement activities in the field of combating corruption systematically demonstrate not resistance, but a compromise, which negatively affects the authority of state bodies responsible for solving problems in the field of combating corruption, provokes legal nihilism among some citizens, disbelief in the goals and objectives declared by the anti-corruption policy

Nucleophilic addition to an achiral dehydroalanine Schiff base Ni(II) complex as a route to amino acids. A case of stereodetermining asymmetric protonation in the presence of TADDOL

We describe herein the elaboration of a new type of a substrate based on the Ni(II) complex of a Schiff base of dehydroalanine, 1, and Michael addition of nucleophiles to it, leading to the synthesis of racemic α-amino acids. We have also developed a catalytic method for the asymmetric 1,4 conjugate addition of achiral CH-acids to 1 promoted by TADDOLs with enantioselective catalytic protonation of the intermediate enolate in the stereodetermining stage of the reaction. A sizable 80% ee of the product was observed.

Federal clinical guidelines on diagnosis and treatment of diabetes insipidus in adults

We do not recommend population screening for diabetes insipidus (DI) (B3). We recommend to perform diagnostic testing for central diabetes insipidus (CDI) in patients who underwent neurosurgery, after skull and brain trauma, subarchnoid hemorrhage (B3). We recommend excluding thirst impairment during all stages of diagnostic assessment (С3). We recommend excluding DI in cases of persistent hypotonic polyuria: excretion of more than 3 L. or more than 40 mL/kg of urine daily; urine osmolality less than 300 mOsm/kg or urinary specific gravity less than 1004 g/L in all urine samples or during Zimnitsky test (В3). After hypotonic polyuria is confirmed, we recommend excluding of the main causes of nephrogenic diabetes insipidus (NDI) (B3). We recommend simultaneous measurement of urine osmolality and blood osmolality/sodium level in order to confirm DI. Blood hyperosmolality (more than 300 mOsm/kg) and/or hypernatremia with low urine osmolality (less than 300 mOsm/kg) confirms DI (B2). If testing does not reveal these findings, we recommend performing a fluid deprivation test to exclude primary polydipsia (PP) (B2). Desmopressin test is recommended to distinguish CDI and NDI (B2). In cases of CDI we recommend to perform head MRI with contrast (B3). In cases of NDI we recommend assessing renal structure and function and possible electrolyte disturbances (C3). In cases of PP we recommend to refer a patient to psychiatrist (B3). We recommend treating CDI with synthetic vasopressin analogue – desmopressin (B1). We recommend an individual approach in choosing desmopressin dosage form (B2). As the initial dose is difficult to predict when starting desmopressin treatment, we recommend titrating the dosage using two approaches: “the average dose” and “as required” (C4). We recommend educating the patients to ensure knowledge of the features of various desmopressin dosage forms (C4). To decrease the risk of water intoxication, we recommend educating the patients to the water intake regimen adherence (С4). When CDI is accompanied by thirst impairment, we recommend titrating the dose in a clinical setting, with assessment of blood sodium, bodyweight and/or urine volume (C4)