Hormonal Assessment for Patients with Systemic Lupus Erythematosus Disease in Babylon Province

الذئبة الحمامية مرض المناعة الذاتية النظامية المزمن مع اعراض سريريه متغيره ويمكن ان يؤثر على جميع اعضاء الجسم ويهدد الحياة. هدفت الدراسة الى تحديد العلاقة بين عامل نمو البشرة وهرمون الكورتزول عند مرضى الذئبة الحمامية وقد اجريت الدراسة على 70 عينه شملت 36 مريضا و34 شخصا يمثلون مجموعه السيطرة واثبت الدراسة وجود فروقات ذات دلاله احصائية لعامل نمو البشة والكورتزول بين مجموعات الدراسةSystemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with variable clinical presentation. SLE can affect all organs and the involvement of major organs can be life threatening. This study aimed to determine the relationship of Epidermal Growth Factor (EGF) and Cortisol hormone on SLE Disease. This study was carried out on (70) study sample, (36) were patients and (34) control. SLE disease had significant association between study groups and sex of patients with SEE disease were 16 times more likely to be female. There were significant mean differences of Epidermal growth factor and Cortisol Hormones by study group

Prevalence and Predictors of Pulmonary Arterial Hypertension in a Sample of Iraqi Patients with Systemic Sclerosis: A Cross-Sectional Study

Background: Pulmonary arterial hypertension (PAH) is now the most frequent cause of death in systemic sclerosis (SSc). Aims: The aims of the present study were to evaluate the prevalence of pulmonary arterial hypertension (PAH) and predictors in SSc among Iraqi patients. Materials and Methods: A cross-sectional study conducted on 56 patients with SSc diagnosed according to the criteria developed by the American College of Rheumatology. Baseline characteristics [age, sex, body mass index (BMI), duration of SSc, type of SSc, duration of Raynaud’s phenomenon, and presence of telangiectasia] were documented.  Antiscleroderma 70 (anti-SCL70) and anticentromere antibodies were measured. Doppler echocardiography was done to diagnose PAH. A risk score was obtained from 7 criteria, namely: Anti-Centromere Ab, Limited disease type, short duration of Raynaud's phenomena (<2.5 years), older age group (40+ years), absence of Telangiectasia, female gender, and absence of anti SCL70 Ab.  Results: We found that PAH was present in 11 (19.6%) SSc patients with a 95% confidence interval of (9.2% to 30.0%). Risk score in addition to anti-centromere antibodies were enough to diagnose PAH with accuracy level of 89.3%. Conclusions: PAH in SSc occurs in significant proportion of patients. Risk score and anti-centromere antibodies had high accuracy level in predicting PAH. Screening of patients with SSc for PAH will help in early diagnosis and appropriate timely therapeutic intervention before significant endorgan damage occurs. Key words Systemic sclerosis. Connective  tissue. Pulmonary hypertension

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

A Study of the Relationship between Osteoporosis with Demographic Characteristics and Some Other Factors by Using Bone Densitometry 1023 ‫الرابع-‬ ‫العدد‬ ‫العاشر-‬ ‫المجلد‬ ‫الطبية-‬ ‫بابل‬ ‫مجلة‬ 938 ‫العظام‬ ‫هشاشة‬ ‫وجدت‬ ‫المزدحمة‬ ‫ية‬ ‫الحضر‬ ‫المن

Abstract Background: Osteoporosis presents to be a major public health problem because it is associated with increased morbidity and mortality, particularly hip and vertebral fractures, which are a huge burden on the health system due to the high economic costs of those care fractures and disability derivatives they produce. Objectives: This study aims to determine relationships between osteoporosis and some factors (demographic factors, menstrual and obstetrical factors in females and life style). Materials and Methods: The study was carried out on 235 person, 150 of them had been referred to the Rheumatology-Rehabilitation unit in Marjan teaching hospital and considered them as a patients group and 85 of them were completely healthy people without any history of diseases and considered as healthy group. The risk factors were assessed from the patients' interview and bone mineral density measurement had been done for each one of them. Results: The results of this study showed high significant association between osteoporosis and aging ,female gender, low body mass index probability value of (p<0.05), Also being menopause, long time since menopause specially more than 10 yeas and high parity number (more than 4 children) were significantly associated with osteoporosis(p<0.05). High incidence of osteoporosis was found among people with low educational level and those lived in crowded urban areas at (p<0.05 for each criterion respectively). Conclusion: Osteoporosis in our population appears to be associated with several risk factors include (older age, female gender, low body mass index, menopause, long time since menopause, high parity number, low education and living in urban areas. All that may contribute to the adverse prognosis associated with osteoporosis. ‫الخالصه

Deterministic Extensional Viscosity and Cracking Index of Polypropylene-Modified-Asphalt Binder

The extensional viscosity and cracking prospectus of polypropylene modified asphalt cement (PPMAC) was explored. Forty/fifty penetration class asphalt cement with five-contents of polypropylene polymer were chosen. Conventional traits such as: Standard penetration, standard softening point, ductility, utter viscosity, elasticity moduli, penetration prospectus, ageing, cracking prospectus, homogeneity, and extensional viscosity were performed on PPMAC. The PPMAC shows better viscosity, elasticity, enduringness and lower cracking properties at cold regions

Synthesis of lanthanide tag and experimental studies on paramagnetically induced residual dipolar couplings

Abstract Nuclear Magnetic Resonance (NMR) spectroscopy is an indispensable technique for the structure elucidation of molecules and determination of their characteristic interactions. Residual Dipolar Coupling (RDC) is an NMR parameter that provides global orientation information of molecules but necessitates the use of an anisotropic orientation medium for the partial alignment of the target molecule with respect to the magnetic field. Importantly, anisotropic paramagnetic tags have been successful as orienting media in biomolecular NMR applications but their use in small organic molecules remains imperfect due to challenges in designing functional lanthanide complexes with varying degrees of bonding in the Ln(III) inner coordination sphere. In this study, we propose a strategy for the synthesis of the lanthanide tag 4-mercaptomethylpyridine-2,6-dicarboxylic acid, 4-MMDPA and the measurement of RDCs in a target molecule using several paramagnetic lanthanide complexes. Graphical Abstrac