264 research outputs found
Interpregnancy interval and the risk of preterm birth: a case-control study of infants born at Al-sadaqa general teaching hospital, Aden, Yemen
- Publication venue
- 'Medip Academy'
- Publication date
- 27/12/2016
- Field of study
Background: Interpregnancy interval (IPI) is a known risk factor for preterm birth. The aim of this study was to assess the relationship between IPI and spontaneous preterm birth, and to identify the influence of confounding variables such as socioeconomic status, maternal age, and reproductive history.Methods: This is a hospital-based, case-control study conducted in the department of neonatology, Al-Sadaqa General Teaching Hospital, Aden, during June to September 2011. A case was defined as infant born spontaneously before 37 weeks of gestation and control was a next eligible infant born between 37-42 complete weeks of gestation. Comparison between groups was assessed by statistical analysis and odds ratio were calculated for confounding factors.Results: A total of 100 preterm (cases) and 100 full-term (controls) infants were evaluated for the effects of IPI. Intervals of both <12 months and 12-˂24 months were significantly associated with preterm births compared to control (37% vs 12% and 73% vs 46% respectively, all p<0.05). The risk of preterm birth was higher in association with low number of antenatal care visits (OR=10, 95% CI=1.62-61.46, p=0.018), younger women’s age (OR=8, 95% CI= 1.35-8.4, p=0.001), non-educated mother (OR=7.92, 95% CI=2.49-25.22, p=0.002) and gravid 2-3 (OR=6.5, 95% CI= 5.06-53.8, p=0.001). Significant risk was also observed among mother with low socio-economic status and residents of rural areas (all p<0.05).Conclusions: Short IPI is significant risk factors for preterm birth. This highlights the importance of counseling women in childbearing age to wait at least 24 months between delivery and subsequent conception
Effects of Dietary Restriction on Cancer Development and Progression
- Author
- A Cangemi
- A Russo
- AG Renehan
- AJ Dirks-Naylor
- B Dirat
- BM Reid
- C Lee
- C Lee
- C Lee
- C Lu
- CE Champ
- D Fanale
- D Fanale
- D Hanahan
- D Massihnia
- E Cadoni
- E Giovannucci
- E Laconi
- EE Calle
- F Madia
- F Passiglia
- F Premoselli
- FM Safdie
- G Flemstrom
- GL Lluch
- H Remmen Van
- H Yamaza
- HH Hermsdorff
- HY Cohen
- J Jin
- J Standard
- JF Trepanowski
- K Esposito
- KL Tinkum
- L Fontana
- L Hlavata
- L Paglia La
- L Raffaghello
- L Siggens
- L Xie
- LK Heilbronn
- LM Berstein
- LT Robertson
- M Lefevre
- M Lv
- M Prisco
- MM Ramsey
- MP Cleary
- NY Kalaany
- P Toren
- R Ribeiro
- RJ Klement
- S Anton
- S Brandhorst
- S Pirkmajer
- T Chiba
- T Duan
- TN Seyfried
- VD Longo
- VD Longo
- VD Longo
- Y Katsuya
- Y Shi
- YY Wang
- Z Al-Wahab
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
The effects of caloric restriction on tumor growth and progression are known for
over a century. Indeed, fasting has been practiced for millennia, but just recently
has emerged the protective role that it may exert toward cells. Fasting cycles are
able to reprogram the cellular metabolism, by inducing protection against oxidative
stress and prolonging cellular longevity. The reduction of calorie intake as
well as short- or long-term fasting has been shown to protect against chronic and
degenerative diseases, such as diabetes, cardiovascular pathologies, and cancer.
In vitro and in vivo preclinical models showed that different restriction dietary
regimens may be effective against cancer onset and progression, by enhancing
therapy response and reducing its toxic side effects. Fasting-mediated beneficial
effects seem to be due to the reduction of inflammatory response and downregulation
of nutrient-related signaling pathways able to modulate cell proliferation
and apoptosis. In this chapter, we will discuss the most significant studies
present in literature regarding the molecular mechanisms by which dietary
restriction may contribute to prevent cancer onset, reduce its progression, and
positively affect the response to the treatments
Ammonia-Nitrogen Recovery from Synthetic Solution using Agricultural Waste Fibers
- Author
- Ali N Aziz CAC, Hassan O.
- Badri KH Juan CA, Hassan O, Mustapha WAW.
- Chen Y Ding L, Fan J.
- Demirak A Keskin F, Sahin Y, Kalemci V.
- Jellali S Wahab MA, Anane M, Riahi K, Jedidi N.
- Jeon H Kang K–E, Jeong J–S, Gong G, Choi J–W, Abimanyu H, Ahn BS, Suh D–J, Choi G–W.
- Kumar GS Bharadwaj J, Sruthi PL, Sekhar MC.
- Landner L.
- Liu H Dong Y, Liu Y, Wang H.
- Ma Z Li Q, Yue Q, Gao B, Li W, Xu X, Zhong Q.
- Sharifnia S Khadivi MA, Shojaeimehr T, Shavisi Y.
- Thornton A Pearce P, Parsons SA.
- Wang L–S Hu H–Y, Wang C.
- Zahrim AY Asis T, Hashim MA, Al-Mizi TMTMA, Ravindra P.
- Zahrim AY Gilbert ML, Janaun J.
- Zahrim AY Lija Y, Ricky LNS, Azreen I.
- Zahrim AY Ricky LNS, Shahril Y, Rosalam S, Nurmin B, Harun AM, Azreen I.
- Publication venue
- 'Indian Society for Education and Environment'
- Publication date
- 01/01/2016
- Field of study
In this study, modification of Empty Fruit Bunch (EFB) fibers as a means to recover ammonianitrogen from a synthetic solution was investigated. Methods: The EFB fiber was modified using sodium hydroxide.Adsorption-desorption studies of ammonia nitrogen into the modified EFB fiber were investigated Findings: Theincrease in adsorption capacity was found to be proportional with the increase of pH up to 7, temperature and ammoniaconcentration. The maximum adsorption capacity is 0.53-10.89 mg/g. The attachment of ammonia nitrogen involves ionexchange-chemisorption. The maximum desorption capacity of 0.0999 mg/g. Applications: This study can be used as abaseline for designing a low cost adsorbent system for ammonia nitrogen recovery drainage and industrial wastewater aswell as EFBs-palm oil mill effluent composting
Folic acid tagged nanoceria as a novel therapeutic agent in ovarian cancer
- Author
- A Cimini
- A Satelli
- A Tebbi
- A Wicki
- Adnan Munkarah
- AJ Ambrosio
- AL Niles
- Ankur Gupta
- AY Estevez
- C Marchetti
- C Xia
- Calvin Tebbe
- DK Armstrong
- DR Petersen
- H Elnakat
- HJ Kim
- I Noguera-Troise
- Ismail Mert
- J Barar
- J Chen
- J Ridgway
- Jasdeep Chhina
- JI Coward
- KA Conklin
- L Alili
- L Elit
- LZ Liu
- M Berndtsson
- M Das
- Miriana Hijaz
- MS Wason
- R Rattan
- R Rattan
- R Saini
- R Viswambari Devi
- Ramandeep Rattan
- RH Prabhu
- RL Siegel
- RW Naumann
- RW Tarnuzzer
- S Das
- S Das
- S Das
- S Deshpande
- S Giri
- S Markert
- S Schweyer
- S Tanida
- Sajad Dar
- Shailendra Giri
- SJ Lunt
- SK Jana
- SM Hirst
- Soumen Das
- Sudipta Seal
- SW Choi
- V Calugaru
- V Turkowski
- VM Gonzalez
- YL Chen
- Z Al-Wahab
- Z Wang
- Zaid Al-Wahab
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Influence of socioeconomic factors on pregnancy outcome in women with structural heart disease
- Author
- Abd-El Aziz M. Gamal
- Aboleineen W.
- Al Hatou E.
- Al Mulla A.
- Ali L. Ait
- Almahmeed W.
- Alonso Angeles
- Anastasiou-Nana M.
- Andarala Maryna
- Aquieri A.
- Ashour Z.
- Azzarelli A.
- Baart Sara
- Baldi D.
- Balint H.
- Baumgartner H.
- Bazargani N.
- Beaubien E.
- Beckx M.
- Bellersen L.
- Berger F.
- Bhatt A. B.
- Blanco M. Vázquez
- Blatt A.
- Botti J.
- Bouchardy J.
- Bovenzi F.
- Bowater S.
- Bowen M.
- Bowers N.
- Budts Werner
- Carmina M. G.
- Caruana M.
- Cassar A.
- Chilingirova N.
- Chintala K.
- Cichocka-Radwan A.
- Clifford P.
- Cohen S.
- Coman I. Mircea
- Cornette J. M.J.
- Crepaz R.
- Cullen M.
- Curry R.
- Dardier A.
- Davidson W. R.
- De Backer J.
- De Faria-Yeh D.
- De Groot C.
- de Hosson M.
- de Sousa L.
- Delgado-Jiménez J.
- Dellborg M.
- Demulier L.
- Donhauser E.
- Donvito V.
- Duijnhouwer T.
- Ebaid H. H.
- El Nagar A.
- El Sayed Makled W. A.
- Elbaz-Greener G.
- Elkayam Uri
- Elliott C.
- Elrakshy Y.
- Eltamawey K.
- Enar S. Catirli
- Escribano-Subías P.
- Esen O. Batukan
- Estensen M.
- Faflik U.
- Fagermo N.
- Farook F.
- Ferrari Roberto
- Ferreira Thierry
- Fesslova V.
- Festa P.
- Fiorucci Emanuela
- Fong Soe Khioe Rebekah
- Fordham Richard
- Freeman L.
- Freire C. Vilas
- Frogoudaki A.
- Fuhrmann A. Vazan
- Furenas E.
- Gabriel H.
- Gaisin I. Ravilevich
- Galian-Gay L.
- Gasimov Z.
- Gembruch U.
- Gil M.
- Ginghina C.
- Glémot Myriam
- Goland S.
- Gordon E.
- Gracia Gérard
- Guerra N.
- Gumbiene L.
- Gupta P.
- Gurvitz M.
- Hall Roger
- Hammerstingl C.
- Hammond S.
- Hasanova I.
- Hoffman P.
- Hudsmith L.
- Husarova V.
- Irtyuga O.
- Iserin L.
- Iung B.
- Ivanov D.
- Jahangirov T.
- Johnson Mark R.
- Jonkaitiene R.
- Jovanova S.
- Jovovic L.
- Jurcut R.
- Kaemmerer Harald
- Karamermer Y.
- Kerr J.
- Khatri N.
- Kohalmi D.
- Komajda Michel
- Konte Marème
- Kovacevic-Preradovic T.
- Kozelj M.
- Kozic M.
- Kratunkov P.
- Ladouceur M.
- Lafay Myriam
- Laroche Cécile
- Lefrancq Elin Folkesson
- Lelonek Malgorzata
- Lesniak-Sobelga A.
- Lindsay C.
- Liptai C.
- Lovric M.
- Lust K.
- Maggioni Aldo Pietro
- Mahdy M. A.Meguid
- Maisuradze D.
- Maniadakis Nikolaos
- Marelli Ariane
- McNeill Patti Ann
- Mebus S.
- Mekebekova D.
- Merkely B.
- Merz W. M.
- Missiamenou Viviane
- Moissens M.
- Montesclaros A. R.
- Moravsky G.
- Mottolese B. D.Agata
- Motz R.
- Murga N.
- Murphy D.
- Mussagaliyeva A.
- Nagdyman N.
- Nihoyannopoulos P.
- Niwa K.
- Oliver J. M.
- Olsson A.
- Orwat S.
- Otto C.
- Pare E.
- Parsonage William Anthony
- Perlroth M. G.
- Petrauskaite J.
- Petrescu V.
- Pieper E. P.G.
- Pijuan-Domenech A.
- Pinto Fausto
- Plaskota K.
- Podolec P.
- Polak P.
- Pommier Caroline
- Popelova Jana
- Prokselj K.
- Przepiesc J.
- Puggia I.
- Romeo C.
- Roos-Hesselink Jolien W.
- Ruiz-Cano M. J.
- Rutz T.
- Ruys Titia
- Saad A.
- Salih B.
- Sarac L.
- Schmidt R.
- Schroeder F.
- Schwerzmann M.
- Scott N.
- Shabaan M.
- Sharashkina N.
- Sharipova S.
- Shilina L. Valeryevna
- Shotan A.
- Sinagra G.
- Sliwa Karen
- Sliwa-Hahnle Karen
- Sobczak S.
- Sorour K.
- Stein Joerg
- Subirana-Domenech M. T.
- Taha Nasser
- Talluto C.
- Tavazzi Luigi
- Taylor Charles
- Tellett L.
- Temesvari A.
- Thilen Ulf
- Thilén U.
- Thompson P.
- Thorne S.
- Thornton P.
- Ting J.
- Tkacheva O.
- Tobler D.
- Todros T.
- Tomaszuk-Kazberuk A.
- Tornos P.
- Trojnarska O.
- Trybuch A.
- Tsiaras S.
- van Dijk A.
- Van Hagen Iris M.
- van Oppen C.
- Vardas Panos
- Vasario E.
- Vavera Z.
- Vega H. Ruda
- Veldtman G.
- Vered Z.
- Wagenaar L.
- Wahab N.
- Wajon E.
- Wald C.
- Walter L.
- Webb Gary
- Wendler R.
- Wisniowska-Smialek S.
- Wood David
- Zaliunas R.
- Publication venue
- 'BMJ'
- Publication date
- 15/10/2017
- Field of study
OBJECTIVE: Cardiac disease is the leading cause of indirect maternal mortality. The aim of this study was to analyse to what extent socioeconomic factors influence the outcome of pregnancy in women with heart disease. METHODS: The Registry of Pregnancy and Cardiac disease is a global prospective registry. For this analysis, countries that enrolled ≥10 patients were included. A combined cardiac endpoint included maternal cardiac death, arrhythmia requiring treatment, heart failure, thromboembolic event, aortic dissection, endocarditis, acute coronary syndrome, hospitalisation for cardiac reason or intervention. Associations between patient characteristics, country characteristics (income inequality expressed as Gini coefficient, health expenditure, schooling, gross domestic product, birth rate and hospital beds) and cardiac endpoints were checked in a three-level model (patient-centre-country). RESULTS: A total of 30 countries enrolled 2924 patients from 89 centres. At least one endpoint occurred in 645 women (22.1%). Maternal age, New York Heart Association classification and modified WHO risk classification were associated with the combined endpoint and explained 37% of variance in outcome. Gini coefficient and country-specific birth rate explained an additional 4%. There were large differences between the individual countries, but the need for multilevel modelling to account for these differences disappeared after adjustment for patient characteristics, Gini and country-specific birth rate. CONCLUSION: While there are definite interregional differences in pregnancy outcome in women with cardiac disease, these differences seem to be mainly driven by individual patient characteristics. Adjustment for country characteristics refined the results to a limited extent, but maternal condition seems to be the main determinant of outcome
PDXK mutations cause polyneuropathy responsive to pyridoxal 5'-phosphate supplementation.
- Author
- Abis G.
- Abubakar S.
- Aguennouz M.
- Al-Khawaja I.
- Al-Mutairi F.
- Alkuraya F. S.
- Arning L.
- Atawneh O.
- Avdjieva D.
- Banu S.
- Bello A. H.
- Bello O.
- Boesch S.
- Boles R.
- Borgione E.
- Borgione E.
- Botia J. A.
- Bourinaris T.
- Bourque P.
- Boycott K. M.
- Bremner F.
- Breza M.
- Chelban V.
- Chelban V.
- Christodoulou K.
- Clayton P. T.
- Conte M. R.
- Cordivari C.
- Cormand B.
- Dardiotis E.
- Dauvilliers Y. A.
- Di Rosa G.
- Eaton A.
- Efthymiou S.
- Efthymiou S.
- Ekenze O.
- Ferrari M. D.
- Fidani L.
- Foiani M.
- Garavaglia B.
- Garcia-Silva M.
- Giunti P.
- Goraya J. S.
- Groppa S.
- Guliyeva U.
- Haridy N.
- Haridy N. A.
- Heales S. J. R.
- Heimer G.
- Heslegrave A.
- Hostettler I.
- Houlden H.
- Houlden H.
- Ibrahim S.
- Isrofilov M.
- Ito Y.
- Iyagba A.
- Jepson J. E. C.
- Kaiyrzhanov R.
- Kathom H.
- Kernohan K. D.
- Khachatryan S.
- Khan A. M.
- Khorassani M. E.
- Kirmani S.
- Komolafe M.
- Koneyev K.
- Koutsis G.
- Kriouile Y.
- Kullmann D.
- Lim S. -Y.
- Liu Y. -T.
- Mangano S.
- Manizha G.
- Maqbool S.
- Marinova Karashova B.
- Marseglia G.
- Mills P. B.
- Minaidou A.
- Mine J.
- Morello G.
- Nachbauer W.
- Nicolaou P.
- Nwazor E.
- Obiabo Y.
- Oconnor E.
- Oguntunde O.
- Ojo O. O.
- Okubadejo N. U.
- Oshinaike O. O.
- Osmond M.
- Papacostas S.
- Papanicolaou E. Z.
- Pchelina S.
- Perez-Duenas B.
- Pineda-Marfa M.
- Pope S.
- Portaro S.
- Rana N. N.
- Reilly M. M.
- Rizig M.
- Rossi S.
- Rothman J.
- Rothman J. E.
- Ruiz A. M.
- Ryten M.
- Salayev K.
- Salpietro V.
- Sanchez B. M.
- Savasta S.
- Scuderi C.
- Senkevich K.
- Shaikh F.
- Shashkin C.
- Sherifa H.
- Silvestri G.
- Spanaki C.
- Stojkovic T.
- Striano P.
- Sullivan R.
- Sultan T.
- Taiwo L.
- Timmann D.
- Tincheva R.
- Torti E.
- Tribollet E.
- Tucci A.
- van den Maagdenberg A. M. J. M.
- Van Maldergem L.
- Vandrovcova J.
- Veggiotti P.
- Verrotti A.
- Vikelis M.
- Wahab K.
- Warman Chardon J.
- Williams U.
- Wilson M. P.
- Wood N. W.
- Xiromerisiou G.
- Yau W. Y.
- Zamba-Papanicolaou E.
- Zanetti M. N.
- Zetterberg H.
- Zharkynbekova N.
- Zollo M.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
OBJECTIVE: To identify disease-causing variants in autosomal recessive axonal polyneuropathy with optic atrophy and provide targeted replacement therapy. METHODS: We performed genome-wide sequencing, homozygosity mapping, and segregation analysis for novel disease-causing gene discovery. We used circular dichroism to show secondary structure changes and isothermal titration calorimetry to investigate the impact of variants on adenosine triphosphate (ATP) binding. Pathogenicity was further supported by enzymatic assays and mass spectroscopy on recombinant protein, patient-derived fibroblasts, plasma, and erythrocytes. Response to supplementation was measured with clinical validated rating scales, electrophysiology, and biochemical quantification. RESULTS: We identified biallelic mutations in PDXK in 5 individuals from 2 unrelated families with primary axonal polyneuropathy and optic atrophy. The natural history of this disorder suggests that untreated, affected individuals become wheelchair-bound and blind. We identified conformational rearrangement in the mutant enzyme around the ATP-binding pocket. Low PDXK ATP binding resulted in decreased erythrocyte PDXK activity and low pyridoxal 5'-phosphate (PLP) concentrations. We rescued the clinical and biochemical profile with PLP supplementation in 1 family, improvement in power, pain, and fatigue contributing to patients regaining their ability to walk independently during the first year of PLP normalization. INTERPRETATION: We show that mutations in PDXK cause autosomal recessive axonal peripheral polyneuropathy leading to disease via reduced PDXK enzymatic activity and low PLP. We show that the biochemical profile can be rescued with PLP supplementation associated with clinical improvement. As B6 is a cofactor in diverse essential biological pathways, our findings may have direct implications for neuropathies of unknown etiology characterized by reduced PLP levels. ANN NEUROL 2019;86:225-240
Global economic burden of unmet surgical need for appendicitis
- Author
- Aahlin E. K.
- Aamer A.
- Aaniana K.
- Ababneh A.
- Abaliksta T.
- Abantanga F.
- Abbas M.
- Abbasy J.
- Abbo O.
- Abbouch M.
- Abd-Elmawla M.
- Abd-Elrasoul Y.
- Abdallah E.
- Abdel-Aty A.
- Abdel-Hameed N.
- Abdel-Kader S. M.
- Abdel-Wahab N. Y. E.
- Abdelaal A.
- Abdelaty M.
- Abdelazeam A. R.
- Abdelazim G.
- Abdelaziz M. A.
- Abdelbadeai K.
- Abdelfatah A.
- AbdelFattah I.
- Abdelgelil A.
- Abdelghany S.
- Abdelhady S.
- Abdelhamed R.
- Abdelhamid A.
- Abdelhaq A.
- Abdelkader M.
- Abdelkader O.
- Abdelkareem A.
- Abdelkhalek M.
- Abdelmageed E.
- Abdelmotaleb I.
- Abdelraheim M.
- Abdelraouf A. M.
- Abdelrouf D. M.
- Abdelshafy M.
- Abdelshakour M.
- Abdrabou A. K.
- Abdul-Latif S.
- Abdulaziz H.
- Abdulbagi O.
- Abdulgawad M.
- Abdulhakeem E. M.
- Abdullah M. A.
- Abdullah N.
- Abdullah N. A. N.
- Abdullahi L.
- Abdurrazzaaq A.
- Abebe N. S.
- Abebe N. S.
- Abem O. E.
- Abiola O.
- Aboarab A.
- Aboelella M.
- Aboelmagd O.
- Aboelsoud M. R.
- Aboraya M.
- Aboraya M.
- Abouelnasr A.
- Aboul-Naga M. S.
- Abouzahra A.
- Abouzaid A.
- Abozaid M.
- Abozeid K.
- Abozyed M. A. F.
- Abu-Toyour M.
- Abubakr M.
- Abudeeb H.
- Abuowda Y.
- Abuqwaider E.
- Abusalem L.
- Abuseif M.
- Abushamleh S.
- Ackom E.
- Acquah E.
- Adam N.
- Adams R.
- Adamu A.
- Adawi I.
- Adawi M.
- Adebanjo A.
- Adebola O.
- Adedeji A.
- Adekoya A.
- Adel A.
- Adel A.
- Adel B. E.
- Adel I.
- Adella F. J.
- Adelshone A.
- Ademuyiwa A. O.
- Adenekan B.
- Adeniran J.
- Adeniyi A.
- Adesanya O.
- Adesina A.
- Adesuyi A.
- Adeyeye A.
- Adham W.
- Adhitama N.
- Adil M.
- Adisa A. O.
- Adu-Aryee N.
- Afana S.
- Afandy A.
- Afifi A. M.
- Africa S.
- Agalianos C.
- Agarwal A.
- Agbedinu K.
- Agius M.
- Aglan A.
- Aguilar W. L. M.
- Aguilar-Jimenez J.
- Aguilera M. L.
- Aguilera O.
- Aguilera-Arevalo M. -L.
- Ahlonsou G.
- Ahlqvist S.
- Ahmed A.
- Ahmed A.
- Ahmed A.
- Ahmed E. A.
- Ahmed H.
- Ahmed H.
- Ahmed H.
- Ahmed L. A. M.
- Ahmed S.
- Ahmed S.
- Ahmed S. M.
- Ahounou E. Y. S.
- Aigrain Y.
- Ajah J.
- Ajai O.
- Ajao A. E.
- Ajiboye A.
- Akatibo E.
- Akeel N.
- Akoto E.
- Al Amin S.
- Al Attar S. M.
- Al Awwad S.
- Al Barrawi F. E.
- Al Bastawis F.
- Al Meligy A.
- Al Rafati A. A. R.
- Al Raouf E. A.
- Al Saied G.
- Al Subaie N.
- Al-Aarag A. A. -R.
- Al-Azraqi I. A. A.
- Al-Buhaisi A.
- Al-Dakka E.
- Al-Faifi J. J.
- Al-Faqawi M.
- Al-Farram H.
- Al-Hameedi H. I. I.
- Al-Hasani R. K. M. J.
- Al-Khatib A.
- Al-Mallah A.
- Al-Marakby D.
- Al-Mousa M.
- Al-Nahrawi S.
- Al-Obaedi O.
- Al-Saqqa S.
- Al-Saqqa S. W.
- Al-Shammari A.
- Al-Slaibi I.
- Al-Taher T.
- Alada M.
- Alahmady O.
- Alakaloko F.
- Alaloul E.
- Alamin S.
- Alamoudi M.
- Alamoudi U.
- Albeladi B.
- Albiety A.
- Aldalaq A.
- Aldhafeeri S.
- Aledrisy M.
- Alexander P.
- Alexandre C.
- Alfarsi M. A.
- Alghamdi A.
- Alghamdi B.
- Alghamdi M.
- Alghamdi M. S. A.
- Algohary O.
- Alhabli I.
- Alhady K.
- Alhassan B.
- Alhazmi W.
- Alhendy M.
- Alherz M.
- Ali A.
- Ali A.
- Ali A.
- Ali C. D. M.
- Ali E.
- Ali F. M.
- Ali H.
- Ali S.
- Ali S. A. W. E. W.
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- Publication venue
- Oxford University Press
- Publication date
- 01/01/2022
- Field of study
Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
- Author
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry
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- A. L. R. Ng
- Abardia Oliva F. J.
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- Abdel Wahab H.
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- Vieyra G.
- Vijayaraghavan G.
- Villar Mariscal C.
- Villasenor F. M.
- Vinereanu D.
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- Weinrich L.
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- Wellenkamp E.
- Wernham C.
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- Wettstein T.
- Weytjens C.
- Whetstone S.
- Widimsky P.
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- Wilkinson I.
- Williams H.
- Williams S.
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- Windstetter U.
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- Xue M.
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- Yanez Wonenburger J. C.
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- Yao X.
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- Yeo C. K.
- Yeung M. M. M.
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- Yordanova V.
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- Yu B.
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- Yuan C.
- Yusuf A.
- Yusufali A.
- Yvorra S.
- Zaca F.
- Zachos V.
- Zagozen P.
- Zagreanu M.
- Zakirova V.
- Zakopoulos C.
- Zalewska D.
- Zamorano Gomez J. L.
- Zamorano J. L.
- Zaoral L.
- Zarauza Navarro J.
- Zarechnova S.
- Zaronskiene D.
- Zatsarina E.
- Zdrojewska J.
- Zeitouni R.
- Zhabina L.
- Zhang A.
- Zhang C.
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- Zhang Y.
- Zhao G.
- Zhao H.
- Zhao R.
- Zhao S.
- Zhao Y.
- Zharikova L.
- Zheng S.
- Zheng X.
- Zheng Y.
- Zherebtsova A.
- Zherlitsyna E.
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- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf AM
- Abdelrouf DM
- Abdelshafy M
- Abdelshakour M
- Abdrabou AK
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem EM
- Abdullah AAN
- Abdullah MA
- Abdullah N
- Abdullah NAN
- Abdullah NAN
- Abdullahi L
- Abdurrazzaaq A
- Abebe NS
- Abebe NS
- Abem OE
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud MR
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga MS
- Abouzahra A
- Abouzaid A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abu Qumbos A
- Abu-toyour M
- Abubakr M
- Abudeeb H
- Abuowda Y
- Abuqwaider E
- Abusalem L
- Abuseif M
- Abushamleh S
- Acharya P
- Ackom E
- Acquah E
- Adam A
- Adam N
- Adams R
- Adamu A
- Adawi I
- Adawi M
- Adebanjo A
- Adebanjo A
- Adebola O
- Adedeji A
- Adekoya A
- Adel A
- Adel A
- Adel BE
- Adel I
- Adella FJ
- Adelshone A
- Ademuyiwa A
- Ademuyiwa A
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Adenekan B
- Adeniran J
- Adeniran J
- Adeniyi A
- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
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- Adeyeye A
- Adham W
- Adhitama N
- Adil M
- Adisa AO
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- Adu-Aryee N
- Afana S
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agalianos C
- Agarwal A
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- Agarwal A
- Agbedinu K
- Agius M
- Aglan A
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- Aguilera ML
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- Ahmed A
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- Ahounou EYS
- Aigrain Y
- Aiyaman C
- Ajah J
- Ajai O
- Ajao A
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- Ajiboye A
- Akatibo E
- Akeel N
- Akhtar M
- Akoto E
- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi JJ
- Al-faqawi M
- Al-farram H
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-saqqa S
- Al-Saqqa SW
- Al-Saqqa SW
- Al-shammari A
- Al-Slaibi I
- Al-taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Alcca Ticona W
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alejos Bermudez YE
- Alexander P
- Alexander P
- Alexander P
- Alexandre C
- Alfarsi MA
- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi MSA
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali CDM
- Ali E
- Ali FM
- Ali H
- Ali S
- Ali SAWEW
- Ali SS
- Ali THA
- Ali W
- Alihonou T
- Alimi Q
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- Aliyu H
- Aliyu M
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- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
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- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby MH
- Alnawam E
- Alnuqaydan SA
- Alnusairat A
- Alomar IN
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Alsaggaf MU
- Alser OH
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry AM
- Altwijri A
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alvi AR
- Alwafai MG
- Aly AK
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani A
- Alzahrani M
- Alzahrani M
- Alzayat T
- Aman NF
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin HAA
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar MS
- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika FFA
- Andreotti D
- Andres Garcia-Marin J
- Andress C
- Andriola V
- Ang YL
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar AW
- Anwar N
- Anwer W
- Anyanwu L-J
- Anyanwu L-J
- Aonzo P
- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
- Arachchige LAJJ
- Arafa O
- Arafa S
- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arman S
- Armando ChunguiBravo J
- Armellini A
- Arnaud A
- Arnaud AP
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arshad MM
- Arslan E
- Arsyad HM
- Arthur T
- Arulampalam T
- Aruldas N
- Asal M
- Asar YH
- Asare-Bediako K
- Asele FA
- Ashour A
- Ashour A
- Ashour K
- Ashraf SF
- Ashtari M
- Ashton A
- Asi F
- Asilah SMD
- Assal A
- Assouto PA
- Asturia S
- Asumah H
- Ata A
- Ata AAA
- Ata AY
- Atiyeh A
- Atkins ET
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia A
- Attia AM
- Augestad KM
- Aung KP
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad SA
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
- Aziz NA
- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Azzie G
- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki MA
- Badicel M
- Badr A
- Badr MFM
- Badwi NM
- Badwi NM
- Badwy A
- Bahar S
- Baheeg M
- Bailey K
- Baillie K
- Baillie K
- Baird A
- Bakhaidar M
- Baki BE
- Bakr A
- Bakry HM
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila RMH
- Balkan AZA
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baraka H
- Barakat SAE
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas GN
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basilico S
- Basir ERM
- Bassem M
- Bassit KA
- Basso SMM
- Basson S
- Batt J
- Bayram S
- Beamon M
- Beasley W
- Beaton C
- Bedada AG
- Bediako-Bowan A
- Behar N
- Beisa V
- Beisa V
- Bekhet AH
- Bekhet NM
- Beleno AEM
- Belkouchi A
- Belli A
- Bello B
- Benammi S
- Benevento A
- Benevento A
- Benger M
- Bennai RM
- Benons N
- Bentounsi Z
- Benyaiche C
- Berti S
- Bertuello I
- Beuran M
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhang A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal KF
- Bhopal KF
- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Bin Ismail MJ
- Bin Mahamood A
- Birindelli A
- Birring A
- Bisset C
- Bjorklund I
- Bjorklund I
- Blacker S
- Blackwell J
- Blanco R
- Blanco-Colino R
- Blencowe N
- Blencowe N
- Bliksoen M
- Blower E
- Bluelle R
- Blundell R
- Boakye-Yiadom K
- Boal M
- Bocchetti T
- Boddy A
- Bode C
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- Bodur S
- Boereboom C
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- Bonavia K
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- Bond-Smith G
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- Bonnard A
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- Boshnaq M
- Botes S
- Bottini C
- Botto N
- Bouali O
- Bougard H
- Boukhal K
- Bowabsak A
- Bowe R
- Bowley D
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- Bradulskis S
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- Braungart S
- Bray LD
- Breaud J
- Breistrand M
- Breitenstein S
- Breslin R
- Brincat SD
- Broch A
- Brogden T
- Brown D
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- Brown J
- Browning DRL
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- Bsisu I
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- Cheung YHE
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- Chiesa D
- Chilton G
- Chin PX
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- Chiu S
- Chiu S
- Chiu SMY
- Choi J
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- Chong BFHK
- Chong CL
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- Chong HY
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- Chow CYN
- Chowdhury A
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- Chun A
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- Dragatas D
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- Drake TM
- Drake TM
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy MM
- Ebrahim OS
- Eduard P
- Edwards J
- Edye M
- Eid MM
- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahmy MAB
- Fahy C
- Fairfield C
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- Fairfield C
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- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat MM
- Faraz A
- Fares M
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- Farhan-Alanie MMH
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fermani C
- Fermani CG
- Fernandes C
- Fernandez C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald JE
- Fitzgerald JE
- Florez Farfan ES
- Foco M
- Fok CYJ
- Fontana T
- Foo CC
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler AJ
- Fozard T
- Fozard T
- Frade F
- Fraga GP
- Francisco Roxas M
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas AV
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan MM
- Gaafar S
- Gaarder T
- Gad A
- Gad MO
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaignard E
- Gaignard E
- Gaizauskas V
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez CP
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan YY
- Gani MA
- Garaycochea O
- Garcia Bernardo C
- Garcia Florez LJ
- Garcia Septiem J
- Garcia Torres CP
- Garcia-Florez L
- Garland A
- Gash K
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- Gastaldi P
- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi DG
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
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- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
- Ghanem E
- Ghanem S
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- Ghannam M
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- Ghazy AA
- Gheith A
- Ghetia M
- Ghetia M
- Ghonaim MA
- Ghoneem M
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- Giavarini L
- Giglio MC
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- Gkiokas G
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- Glover-Addy H
- Glynn M
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- Goh W
- Gohar ME-SAM
- Gokani S
- Goldin E
- Golding D
- Gomaa A
- Gomah M
- Gonzales Montejo MS
- Gonzales Stuva JP
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- Gosling S
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- Gran M
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- Grant A
- Grasset E
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- Grassi V
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- Griffiths E
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- Grizhja B
- Grobler DC
- Grosos C
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- Guevara Torres S
- Guevara R
- Guglielmo V
- Gui D
- Gul E
- Gulbinas A
- Gulcicek OB
- Gulielmi A
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- Gunawan R
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- Gyanchandani N
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- Hache-Marliere M
- Haddad N
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- Hafiz S
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- Hajeh H
- Hakim H
- Halhouli O
- Halhouli O
- Halicioglu I
- Hall E
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- Hamarshi A
- Hamasaki Hamaguchi JL
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- Hamdan A
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- Hanley I
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- Hasanah A
- Hasanain D
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- Hashad E
- Hasheminia A
- Hashim A
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- Ibrahem AA
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- Ibrahim I
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- Imoro O
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- Iordache F-M
- Iqbal FM
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- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
- Mironescu A
- Mironescu AS
- Mironescu AS
- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
- Mitroudis N
- Mittal A
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- Miyarde Leon A
- Mizzi C
- Mizzi S
- Mlotshwa M
- Moaty M
- Mochet S
- Modolo MM
- Modolo MM
- Modolo MM
- Moe TT
- Mogan YP
- Moghazy ME
- Mohamed A
- Mohamed A
- Mohamed AM
- Mohamed AR
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed AR
- Mohammed H
- Mohammed MM
- Mohammed MMH
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok YT
- Mokhtar A
- Molina G
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- Monrad-Hansen PW
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montoya Botero JA
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
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- Mora JJV
- Morales C
- Morandi E
- Moreira G
- Moreno SC
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- Morshedy EM
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- Morton R
- Mosad A
- Mosalum O
- Mostafa HA
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe AM
- Mshelbwala P
- Msiska N
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- Muktar U
- Mukuzunga C
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- Munipalle PC
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- Musyoka CK
- Mutabazi A
- Mutabazi AZ
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- Mutlu V
- Muzio E
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- Mykoniatis I
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- Nada F
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- Nadkarni S
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- Nagy GS
- Nahar SN
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- Nanthakumaran S
- Napolitano L
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- Naqvi SA
- Naqvi T
- Naranjo Aristizaibal FA
- Narayanan R
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- Narvestad JK
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- Nashat M
- Nasher O
- Nashidengo P
- Nasir A
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- Nasir WNWM
- Nasr A
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- Nassif D
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- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
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- Nayel AR
- Nazir M
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- Ndegwa W
- Ndlovu SR
- Ndwambi P
- Negida A
- Negoi I
- Nel D
- Nemeth K
- Neo YN
- Neo YT
- Neophytou C
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
- Ng JCK
- Ng S
- Ng YK
- Ng ZH
- Ngayu N
- Ngwa TE
- Niazi AK
- Nicholson L
- Nighat B
- Nigo S
- Nikberg M
- Nikoloudis N
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- Niranjan N
- Nirumal MK
- Niska K
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- Niyirera E
- Njokanma I
- Nnajiuba H
- Nocito A
- Nocito A
- Nofal E
- Noor F
- Normile C
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- Notarnicola M
- Notarnicola M
- Nouh T
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- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana VJP
- Nsengiyumva C
- Ntirenganya F
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- Nurqistan HD
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
- Nymo L
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- Ortega-Vazquez I
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- Oshati O
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- Palomino Castillo VD
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- Paludi MA
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- Panteli C
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- Papaskarlatos I-A
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- Parseliunas A
- Parthiban S
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- Pasquali S
- Pastora J
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- Pata F
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- Paulouski D
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- Pellino G
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- Pena L
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- Perez Velasquez CI
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- Pertersen Servin GR
- Pesenti G
- Petrikenas S
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- Picciariello A
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- Pinkney T
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- Punja V
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- Qaissieh A
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- Qureshi AU
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- Ramarez Cabrera CC
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- Samalavicius NE
- Samaraweera DI
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- Sokratous A
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- Tan CY
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- Tan YK
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- Tang L
- Tani SI
- Tansoker I
- Tarek A
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- Tarek D
- Targa S
- Tariq S
- Tata MD
- Tatagiba LS
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- Tawfik G
- Taylor F
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- Teasdale E
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- Tedeschi U
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- Telfah MM
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- Temoche E
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- Teo SY
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- Toto OF
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- Turkustani S
- Turner M
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- Tutino R
- Tverskis Z
- Tyler R
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- Ubhi HK
- Ubiali P
- Ugalde P
- Ukwenya Y
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbina Rojas NM
- Urbonas T
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- Urniezius Z
- Urniezius Z
- Usaityte A
- Uscinas L
- Utter M
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- Valcarcel-Saldana M
- Valente Laufer LA
- Valioulis I
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- Vartic M
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- Velasquez R
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- Venskutonis D
- Venskutonis D
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- Venugopal C
- Verbeek A
- Vergara Celis JM
- Vergara Mejia AG
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- Vermaas M
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- Vicario E
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- Yifieyeh A
- Yildirim R
- Yip C
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif JH
- Yuksek MA
- Yusufali T
- Zaa'treh R
- Zachariades D-C
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia MF
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zilinskiene R
- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
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