5 research outputs found

    Treatment of osteoporosis in children with glucocorticoid-treated diseases.

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    Glucocorticoid induced osteoporosis (GIO) is the most frequent form of drug induced osteoporosis. Glucocorticoids (GCs) affect osteoblastogenesis, osteoclastogenesis, and promote the apoptosis of osteoblasts and osteocytes. A decrease of bone mineral density (BMD) has been described in several pediatric diseases that require GCs, both as long term replacement therapy, such as Congenital Adrenal Hyperplasia, and as treatment of acute phase or relapses, such as asthma, juvenile rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, organ transplantation, and Steroid Sensitive Nephrotic Syndrome. The increasing number of children with GIO and at risk of fractures reflects the complex nature of this condition, and the need of development of anti-osteoporotic drugs. In this review, we focus on the mechanisms of GIO in some pediatric diseases and on treatment of osteoporosis. We also report data on new signaling pathways as potential targets for future anti-osteoporotic drugs

    Search for a heavy pseudoscalar boson decaying to a Z and a Higgs boson at <tex>\sqrt{s}$</tex>=13TeV

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    Search for WH production with a light Higgs boson decaying to prompt electron-jets in proton-proton collisions at s\sqrt{s}=7 TeV with the ATLAS detector

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    A search is performed for WH production with a light Higgs boson decaying to hidden-sector particles resulting in clusters of collimated electrons, known as electron-jets. The search is performed with 2.04 fb-1 of data collected in 2011 with the ATLAS detector at the LHC in proton-proton collisions at s\sqrt{s}=7 TeV. One event satisfying the signal selection criteria is observed, which is consistent with the expected background rate. Limits on the product of the WH production cross section and the branching ratio of a Higgs boson decaying to prompt electron-jets are calculated as a function of a Higgs boson mass in the range from 100 GeV to 140 GeV.Peer Reviewe

    Measurement of W(+/-)Z production in proton-proton collisions at root s=7 TeV with the ATLAS detector

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