1,403 research outputs found
A novel approach to assessing validity in sports performance research: integrating expert practitioner opinion into the statistical analysis
Purpose: Using elite youth soccer playersâ maximal sprinting speeds collected from a criterion and non-criterion measure, we demonstrate how expert practitioner opinion can be used to determine measurement validity. Methods: Expert soccer practitioners (n = 50) from around the world were surveyed on issues relating to the measurement of maximal sprinting speed and 12 elite youth soccer players performed two maximal 40 m sprints, measured by 10-Hz GPS units (non-criterion) and a 100-Hz Laser (criterion). Setting statistical equivalence bounds as practitioner opinion of the practically acceptable amount of measurement error for maximal sprinting speed, we assessed agreement between GPS and Laser. Results: Survey respondents reported a combination of methods for deriving maximal sprinting speed (tests, training, match) but most did not assess system validity. Median value of the practically acceptable amount of measurement error for maximal sprinting speed was 0.20 m/s. Maximal sprinting speed was 8.79 ± 0.33 m/s (Laser) and 8.75 ± 0.32 m/s (GPS), and the mean difference was 0.04 (90% confidence interval â0.03 to 0.11) m/s. Using the median acceptable amount of measurement error, we set our lower and upper equivalence bounds to â0.10 m/s and +0.10 m/s, respectively. Equivalence testing showed Laser and GPS as likely equivalent measures (probability 93.7%). Conclusion: Using expert-informed equivalence thresholds represents a novel way to assess validity in sports performance research. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group
Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial
Background:
Intraventricular haemorrhage is a subtype of intracerebral haemorrhage, with 50% mortality and serious disability for survivors. We aimed to test whether attempting to remove intraventricular haemorrhage with alteplase versus saline irrigation improved functional outcome.
Methods:
In this randomised, double-blinded, placebo-controlled, multiregional trial (CLEAR III), participants with a routinely placed extraventricular drain, in the intensive care unit with stable, non-traumatic intracerebral haemorrhage volume less than 30 mL, intraventricular haemorrhage obstructing the 3rd or 4th ventricles, and no underlying pathology were adaptively randomly assigned (1:1), via a web-based system to receive up to 12 doses, 8 h apart of 1 mg of alteplase or 0·9% saline via the extraventricular drain. The treating physician, clinical research staff, and participants were masked to treatment assignment. CT scans were obtained every 24 h throughout dosing. The primary efficacy outcome was good functional outcome, defined as a modified Rankin Scale score (mRS) of 3 or less at 180 days per central adjudication by blinded evaluators. This study is registered with ClinicalTrials.gov, NCT00784134.
Findings:
Between Sept 18, 2009, and Jan 13, 2015, 500 patients were randomised: 249 to the alteplase group and 251 to the saline group. 180-day follow-up data were available for analysis from 246 of 249 participants in the alteplase group and 245 of 251 participants in the placebo group. The primary efficacy outcome was similar in each group (good outcome in alteplase group 48% vs saline 45%; risk ratio [RR] 1·06 [95% CI 0·88â1·28; p=0·554]). A difference of 3·5% (RR 1·08 [95% CI 0·90â1·29], p=0·420) was found after adjustment for intraventricular haemorrhage size and thalamic intracerebral haemorrhage. At 180 days, the treatment group had lower case fatality (46 [18%] vs saline 73 [29%], hazard ratio 0·60 [95% CI 0·41â0·86], p=0·006), but a greater proportion with mRS 5 (42 [17%] vs 21 [9%]; RR 1·99 [95% CI 1·22â3·26], p=0·007). Ventriculitis (17 [7%] alteplase vs 31 [12%] saline; RR 0·55 [95% CI 0·31â0·97], p=0·048) and serious adverse events (114 [46%] alteplase vs 151 [60%] saline; RR 0·76 [95% CI 0·64â0·90], p=0·002) were less frequent with alteplase treatment. Symptomatic bleeding (six [2%] in the alteplase group vs five [2%] in the saline group; RR 1·21 [95% CI 0·37â3·91], p=0·771) was similar.
Interpretation:
In patients with intraventricular haemorrhage and a routine extraventricular drain, irrigation with alteplase did not substantially improve functional outcomes at the mRS 3 cutoff compared with irrigation with saline. Protocol-based use of alteplase with extraventricular drain seems safe. Future investigation is needed to determine whether a greater frequency of complete intraventricular haemorrhage removal via alteplase produces gains in functional status
The JCMT Gould Belt Survey: Evidence for radiative heating in Serpens MWC 297 and its influence on local star formation
We present SCUBA-2 450micron and 850micron observations of the Serpens MWC
297 region, part of the JCMT Gould Belt Survey of nearby star-forming regions.
Simulations suggest that radiative feedback influences the star-formation
process and we investigate observational evidence for this by constructing
temperature maps. Maps are derived from the ratio of SCUBA-2 fluxes and a two
component model of the JCMT beam for a fixed dust opacity spectral index of
beta = 1.8. Within 40 of the B1.5Ve Herbig star MWC 297, the submillimetre
fluxes are contaminated by free-free emission with a spectral index of
1.03+-0.02, consistent with an ultra-compact HII region and polar winds/jets.
Contamination accounts for 73+-5 per cent and 82+-4 per cent of peak flux at
450micron and 850micron respectively. The residual thermal disk of the star is
almost undetectable at these wavelengths. Young Stellar Objects are confirmed
where SCUBA-2 850micron clumps identified by the fellwalker algorithm coincide
with Spitzer Gould Belt Survey detections. We identify 23 objects and use Tbol
to classify nine YSOs with masses 0.09 to 5.1 Msun. We find two Class 0, one
Class 0/I, three Class I and three Class II sources. The mean temperature is
15+-2K for the nine YSOs and 32+-4K for the 14 starless clumps. We observe a
starless clump with an abnormally high mean temperature of 46+-2K and conclude
that it is radiatively heated by the star MWC 297. Jeans stability provides
evidence that radiative heating by the star MWC 297 may be suppressing clump
collapse.Comment: 24 pages, 13 figures, 7 table
Social marketing and healthy eating : Findings from young people in Greece
This document is the Accepted Manuscript version. The final publication is available at Springer via http://dx.doi.org/10.1007/s12208-013-0112-xGreece has high rates of obesity and non-communicable diseases owing to poor dietary choices. This research provides lessons for social marketing to tackle the severe nutrition-related problems in this country by obtaining insight into the eating behaviour of young adults aged 18â23. Also, the main behavioural theories used to inform the research are critically discussed. The research was conducted in Athens. Nine focus groups with young adults from eight educational institutions were conducted and fifty-nine participantsâ views towards eating habits, healthy eating and the factors that affect their food choices were explored. The study found that the participants adopted unhealthier nutritional habits after enrolment. Motivations for healthy eating were good health, appearance and psychological consequences, while barriers included lack of time, fast-food availability and taste, peer pressure, lack of knowledge and lack of family support. Participants reported lack of supportive environments when deciding on food choices. Based on the findings, recommendations about the development of the basic 4Ps of the marketing mix, as well as of a fifth P, for Policy are proposedPeer reviewe
The transformation of the business angel market: empirical evidence and research implications
Business angel investing â a key source of finance for entrepreneurial businesses â is rapidly evolving from a fragmented and largely anonymous activity dominated by individuals investing on their own to one that is increasingly characterised by groups of investors investing together through managed angel groups. The implications of this change have been largely ignored by scholars. The paper examines the investment activity and operation of angel groups in Scotland to highlight the implications of this change for the nature of angel investing. It goes on to argue that this transformation challenges both the ongoing relevance of prior research on business angels and current methodological practices, and raises a set of new research questions
Observation of two new baryon resonances
Two structures are observed close to the kinematic threshold in the mass spectrum in a sample of proton-proton collision data, corresponding
to an integrated luminosity of 3.0 fb recorded by the LHCb experiment.
In the quark model, two baryonic resonances with quark content are
expected in this mass region: the spin-parity and
states, denoted and .
Interpreting the structures as these resonances, we measure the mass
differences and the width of the heavier state to be
MeV,
MeV,
MeV, where the first and second
uncertainties are statistical and systematic, respectively. The width of the
lighter state is consistent with zero, and we place an upper limit of
MeV at 95% confidence level. Relative
production rates of these states are also reported.Comment: 17 pages, 2 figure
Observation of associated production of a boson with a meson in the~forward region
A search for associated production of a boson with an open charm meson is
presented using a data sample, corresponding to an integrated luminosity of
of proton--proton collisions at a centre-of-mass energy
of 7\,TeV, collected by the LHCb experiment. %% Seven candidate events for
associated production of a boson with a meson and four candidate
events for a boson with a meson are observed with a combined
significance of 5.1standard deviations. The production cross-sections in the
forward region are measured to be where the first uncertainty is statistical and the
second systematic.Comment: 18 pages, 2 figure
Observation of the decay
The decay is observed for the first
time, using proton-proton collisions collected with the LHCb detector
corresponding to an integrated luminosity of 3fb. A signal yield of
decays is reported with a significance of 6.2 standard deviations.
The ratio of the branching fraction of \B_c \rightarrow J/\psi K^+ K^- \pi^+
decays to that of decays is measured to be
, where the first uncertainty is statistical and the
second is systematic.Comment: 18 pages, 2 figure
Measurements of the , , meson and baryon lifetimes
Measurements of -hadron lifetimes are reported using collision data,
corresponding to an integrated luminosity of 1.0fb, collected by the
LHCb detector at a centre-of-mass energy of Tev. Using the exclusive decays
, , ,
and the average decay
times in these modes are measured to be = 0.004 0.003 ps, =
0.006 0.004 ps, = 0.013
0.005 ps, = 0.027
0.006 ps and = 0.011
0.005 ps, where the first uncertainty is statistical and the second is
systematic. These represent the most precise lifetime measurements in these
decay modes. In addition, ratios of these lifetimes, and the ratio of the
decay-width difference, , to the average width, , in
the system, , are
reported. All quantities are found to be consistent with Standard Model
expectations.Comment: 28 pages, 4 figures. Updated reference
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