Black-hole scattering with general spin directions from minimal-coupling amplitudes

We study the link between classical scattering of spinning black holes and quantum amplitudes for massive spin-$s$ particles. Generic spin orientations of the black holes are considered, allowing their spins to be deflected on par with their momenta. We re-derive the spin-exponentiated structure of the relevant tree-level amplitude from minimal coupling to Einstein's gravity, which in the $s\to\infty$ limit generates the black holes' complete series of spin-induced multipoles. The resulting scattering function is seen to encode in a simple way the known net changes in the black-hole momenta and spins at first post-Minkowskian order. We connect our findings to a rigorous framework developed elsewhere for computing such observables from amplitudes

A worldsheet for Kerr

We show that the Newman-Janis shift property of the exact Kerr solution can be interpreted in terms of a worldsheet effective action. This holds both in gravity, and for the single-copy $\sqrt{\text{Kerr}}$ solution in electrodynamics. At the level of equations of motion, we show that the Newman-Janis shift holds also for the leading interactions of the Kerr black hole. These leading interactions are conveniently described using chiral classical equations of motion with the help of the spinor-helicity method familiar from scattering amplitudes

Perturbative spacetimes from Yang-Mills theory

SCOAP

Wound-healing effect of polyguanidine-based hydrogel

This article present the evaluation of polyhexamethyleneguanidine hydrochloride hydrogel influence on the course of wound healing processes. Synthesis of hydrogel is based on the interaction of amino-end groups of the polymer with carbonyl compounds. The presence of significant biocidal properties of the gel-forming polymer is allowed to consider the hydrogel as a wound healing agent. Since most wound healing agents for external use are made in the form of gels, ointments, polymer-based, it was decided to use the wound healing agent "Levomekol", a gel which consists of poly (ethylene oxide) as a comparison drug. So, in terms of linear skin-muscle wound we established the pronounced wound-healing effect of a polyhexamethyleneguanidine hydrochloride hydrogel. The results of pathomorphological studies revealed that in animals of the experimental "hydrogel" group on the eighth day of the experiment, the wound was undergoing a process of rejection of the scab, the presence of mature granulation tissue and no exudate was also observed. In the comparison group, the healing process was more slow, on the eighth day of the experiment in the animal group we observed the presence of fluid under the eschar, and lower amount of mature granulation tissue. Tensiometry of the scar has shown that the strength of scar rupture in the "hydrogel" group requires 65 % more force compared to the control group, while in the group of comparison this parameter made only 48 %

WOUND HEALING EFFECT OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE HYDROGELAT BURNS

This article considers the wound-healing effect of a hydrogel based on polyhexamethyleneguanidine hydrochloride under conditions of thermal shock modeling. The presence of gelling properties in combination with the high biocidal activity of polyguanidins opens the prospect of obtaining an effective single-component external agent, which is very important for antimicrobial chemotherapy of wounds and burns, as in their treatment there is a high probability of infecting the wound with microorganisms causing various infectious diseases. Previously, we developed a method for the preparation of a hydrogel based on polyhexamethyleneguanidine hydrochloride, which involves the cross-linking of the amino-end groups of the branched polymer with formaldehyde, resulting in a cross-linked polymer, which is a lump-like mass. The mechanical treatment of the hydrogel makes it possible to give the material an ointment form that is convenient for application to the skin. An experiment on the evaluation of the wound healing action of hydrogel was carried out under the conditions of modeling a thermal burn. The comparative preparation was multicomponent gel "Levomekol", in which polyethylene oxide was used as the basis. It was established that the hydrogel activates the growth of antioxidants and leukocytes in the blood of animals in dynamics on the 10th, 17th and 24th day of the experiment, amounting to 56.4 %, 33.8 % and 20.9 %, and of leukocytes - 27.7 %, 19.6 %; 6,2 % in relation to the norm. The method of contrast radiography of penetrating wounds showed that the daily reduction in the wound area is most pronounced in the hydrogel group, which indicates a pronounced reparative effect

Acute Toxicity of Hydrogel Polyhexamethylene Guanidine Hydrochloride

Background. Previously, we have shown that the polyhexamethylene guanidine hydrochloride hydrogel exhibits a pronounced wound healing. At the same time, no studies of the toxic effect of the hydrogel on animals have been conducted. Aim of the research. In the framework of this work, the acute toxicity of the hydrogel polyhexamethylene guanidine hydrochloride was studied in laboratory animals with intragastric administration. Materials and methods. The polyhexamethylene guanidine hydrochloride hydrogel was obtained by crosslinking the amino end groups with formaldehyde. An acute toxicity study was carried out (P 1.2.3156-13, GOST 32644-2014 and the Guidelines for conducting preclinical studies of drugs) in an experiment on outbred mice with a single addition of the test substance in different doses (1000, 3000, 5000, 8000 mg/kg) with fixing indicators (appearance, behavior, condition of the body hair coat, water and food consumption, excretion, body weight and its growth) during 14 days. After the animals were withdrawn from the experiment, autopsy, macroscopic evaluation and weighing of the internal organs were performed. The results showed that with the introduction of the test substance into the animal organism, death during the observation period (14 days) did not occur. It was not possible to determine the semi-lethal dose for the test compound. Conclusion. The conducted studies allow us to conclude that this substance is practically non-toxic and can be classified as hazard class V. Further research will be directed to the formation of hydrogel compositions with medicinal substances

Редкий случай сочетания рака шейки матки с односторонней полной аплазией придатков

We  present  a  rare  case  of  the  combination   of  cervical  cancer  and  unilateral complete   aplasia  of  the uterine  adnexa.    Female  genital  tract anomalies  account  for  about  4% of all congenital  malformations.Congenital  malformations  of the  adnexa  are  very  rare,  accounting  for  less than  0.5%. In  the  presented case, this abnormality was found incidentally during surgery for cervical cancer. Medical genetic counseling confirmed  the presence  of the isolated congenital  pathology.В статье  представлен  случай редкого  сочетания  рака  шейки матки  с врожденной патологией  придатков – полной односторонней аплазией  маточных придатков.  Пороки  развития  женских  половых органов  составляют   около  4% всех  врожденных   аномалий  развития,   при  этом  пороки  развития придатков  очень редки (менее 0,5%). В данном случае это была случайная  находка  при оперативном вмешательстве по поводу рака шейки матки. При проведении медико-генетического консультирования сделано  заключение  о наличие изолированной врожденной патологии

Подходы к разработке индивидуализированных схем лечения экссудативного среднего отита у пациентов с низкой эффективностью традиционной консервативной терапии

Management of otitis media with effusion is a challenging problem in view of its high prevalence and frequent complications in the form of stable hearing loss. High frequency of secondary immunodeficiencies in ENT diseases dictates the necessity of immunocorrection in combined treatment. Dinamic pure tone audiometry, tympanometry and subjective response demonstrated higher treatment efficiency in the «Gepon» groups.Актуальность проблемы экссудативного среднего отита объясняется его распространенностью и частотой развития стойкой тугоухости. Высокая частота вторичных иммунодефицитов при ЛОР-патологии диктует необходимость иммунокоррекции в их комплексном лечении. Динамическая тональная аудиометрия, тимпанометрия, а также субъективные данные выявили более высокие результаты лечения у больных, получавших транстимпанальное введение иммуномодулирующего препарата «Гепон»

Charge separation relative to the reaction plane in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}}= 2.76 TeV

Measurements of charge dependent azimuthal correlations with the ALICE detector at the LHC are reported for Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV. Two- and three-particle charge-dependent azimuthal correlations in the pseudo-rapidity range $|\eta| < 0.8$ are presented as a function of the collision centrality, particle separation in pseudo-rapidity, and transverse momentum. A clear signal compatible with a charge-dependent separation relative to the reaction plane is observed, which shows little or no collision energy dependence when compared to measurements at RHIC energies. This provides a new insight for understanding the nature of the charge dependent azimuthal correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286

Transverse sphericity of primary charged particles in minimum bias proton-proton collisions at s=0.9\sqrt{s}=0.9, 2.76 and 7 TeV

Measurements of the sphericity of primary charged particles in minimum bias proton--proton collisions at $\sqrt{s}=0.9$, 2.76 and 7 TeV with the ALICE detector at the LHC are presented. The observable is linearized to be collinear safe and is measured in the plane perpendicular to the beam direction using primary charged tracks with $p_{\rm T}\geq0.5$ GeV/c in $|\eta|\leq0.8$. The mean sphericity as a function of the charged particle multiplicity at mid-rapidity ($N_{\rm ch}$) is reported for events with different $p_{\rm T}$ scales ("soft" and "hard") defined by the transverse momentum of the leading particle. In addition, the mean charged particle transverse momentum versus multiplicity is presented for the different event classes, and the sphericity distributions in bins of multiplicity are presented. The data are compared with calculations of standard Monte Carlo event generators. The transverse sphericity is found to grow with multiplicity at all collision energies, with a steeper rise at low $N_{\rm ch}$, whereas the event generators show the opposite tendency. The combined study of the sphericity and the mean $p_{\rm T}$ with multiplicity indicates that most of the tested event generators produce events with higher multiplicity by generating more back-to-back jets resulting in decreased sphericity (and isotropy). The PYTHIA6 generator with tune PERUGIA-2011 exhibits a noticeable improvement in describing the data, compared to the other tested generators.Comment: 21 pages, 9 captioned figures, 3 tables, authors from page 16, published version, figures from http://aliceinfo.cern.ch/ArtSubmission/node/308