Appraisal of geothermal potentials of some parts of the Abakaliki Anticlinorium and adjoining areas (Southeast Nigeria) using magnetic data

The Abakaliki Anticlinorium and its adjoining areas were appraised with the object of delineating high geothermal potential zones. Spectral depth analysis involving an improved centroid technique was used to analyze high-quality magnetic data. The obtained geothermal parameters were gridded to map various geothermal features within the investigated area. The obtained results varied from 4.99–9.35 km, 2.31–6.15 km, 6.11–16.28 km, 35.63°C–94.93°C/km, and 89.07–237.32 mW/m2 for centroid depth, top depth, Curie point depth, geothermal gradient, and heat flow values, respectively. The delineated semioval structure in the central zone of the investigated region characterized by a shallow Curie point depth (< 8.5 km) correlates with the location of the high-heat flow (>191.0 mW/m2) and geothermal gradient (>74.0°C/km) region. The high geothermal potential of the region is triggered by the massive post-rift tectonic event of the Santonian period related to the Abakaliki Anticlinorium. Further geophysical exploration programs should be carried out before exploitation activities at anomalous geothermal regions

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Development of ECC for infrastructure projects

By covering several potential risks as feasible, a well-drafted infrastructure construction contract decreases the probability of disputes occurring to a significant degree. The Executive Regulations of the Egyptian Tender Law No.182 of 2018 is the governing document for drafting Egyptian Construction Contracts (ECC). However, to handle the requirements of various infrastructure projects, the ECC still requires some amendment additions. This paper sets out a guide that includes a number of amendments to the clauses that contract experts must consider when drafting new contracts in order to prevent potential disputes. This study aims to explore and investigate the major sources of conflicts facing infrastructure construction contracts, as reflected in the literature review and interview results with contract professionals. The methodology mainly incorporates undertaking a literature review, implementing a comparison and analysis of general conditions of the Egyptian, International Federation of Consulting Engineers (FIDIC), and American Institute of Architects (AIA) construction contracts, and presenting international directions for dealing with the causes of conflicts in these contracts. These steps have been followed to propose amendments for the clauses that cause disputes in the ECC while the final step is conducted to verify the amendments’ findings through experts’ interviews. The findings show that these amendments are of significant importance to be considered while drafting new construction contracts, considering FIDIC 99 (Red Book), AIA A201-1997, and the general conditions of the Egyptian Ministry of Housing, Utilities and Urban Communities are the forms of general conditions that are used for comparison

Integration of ERT and shallow seismic refraction for geotechnical investigation on El-Alamein Hotel Building Area, El-Alamein new city, Egypt

Abstract El-Alamein new city is regarded as one of the iconic cities of the Egyptian North Western Coast to be not only residential units but also summer resorts for tourist attractions. This study examines the efficiency of integrating geophysical methods for determining if clay lenses exist or seawater has intruded into shallow strata and for calculating the geotechnical parameters of near-surface layers for construction purposes. Nine electrical resistivity tomography (ERT) and shallow seismic refraction (SSR) profiles are conducted in this study. From ERT data, we observed the intrusion of seawater in layers at different depths. From SSR data, two layers are observed along profiles, while three layers are observed along the other profiles according to their velocities. Near-surface geotechnical parameters, that were calculated from SSR data, are integrated to evaluate our study area. Accordingly, it was considered a low-competent area and suitable for buildings with low heights, and the only difference is the intrusion of seawater, therefore, it is subdivided into 2 zones. In zone (A), the second layer is used as a foundation layer. Zone (B) is pretentious by the intrusion of seawater, and it is not suggested to construct any buildings or to improve the strength of concrete exposed to seawater in this zone to be suitable also for buildings with a low height

Comparing trastuzumab-related cardiotoxicity between elderly and younger patients with breast cancer : a prospective cohort study

OBJECTIVE: Trastuzumab is an HER-2 targeted humanized monoclonal antibody that significantly improves metastatic and non-metastatic breast cancer therapeutic outcomes. This study compares trastuzumab outcomes between two age cohorts in the Kuwait Cancer Control Centre (KCCC). PATIENTS AND METHODS: In a prospective comparative observational study, 93 HER-2 positive breast cancer patients undergoing different chemotherapy protocols + trastuzumab between April 2016 and April 2019 were included and divided into two cohorts based on their age (<60 and ≥60 years old). The individual decline in the LVEF from the baseline was calculated and compared between the two age cohorts. Logistic regression analysis was applied to investigate the association between age, comorbidities, BMI, anthracycline treatment, and baseline LVEF value, and trastuzumab-induced cardiotoxicity after adjustments made for the disease stage. RESULTS: The median baseline LVEF was 65% in both age cohorts (IQR 8% and 9% for older and younger patients, respectively). Whereas the median LVEF post-trastuzumab treatment was 51% and 55% in older and younger patients, respectively (IQR 8%; p-value = 0.22), even though older patients had significantly lower exposure to anthracyclines compared to younger patients (60% and 84.1%, respectively; p-value <0.001). 86.7% and 55.6% of older and younger patients, respectively, developed ≥10% decline in their LVEF from the baseline. Statistically, age was the only factor that significantly correlated with developing ≥10% decline in the LVEF (OR 4; p-value <0.012). CONCLUSIONS: Breast cancer patients aged 60 years and above in Kuwait were at a 4-fold higher risk of developing ≥10% decline in their LVEF from the baseline value compared to younger patients during trastuzumab treatment. Previous exposure to anthracyclines and comorbidities were not associated with a significantly increased cardiotoxicity risk in this study

Exploratory assessment of geothermal resources in some parts of the Middle Benue Trough of Nigeria using airborne potential field data

Some parts of the Middle Benue Trough (MBT) of Nigeria were evaluated with the aim of detecting prospective geothermal potential regions. Spectral depth analysis using a modified centroid procedure was applied to analyze high-resolution airborne magnetic data. The Curie point depth (CPD) within the study area is in the range of 6.0 and 16 km. It was observed that the Gboko Anticlines (GA) that are interrelated with the Santonian intrusions of Abakaliki Anticlinorium (AA) are characterized by thin CPD (6.0–8.0 km). The mapped geothermal anomalies within the GA with shallow CPD (74 °C/km) and heat flow (HF) (>155 mW/m2) values. The adjoining areas within the study area are defined by medium-deep CPD (8.0–16.0 km), medium–low GG (<74 °C/km), and HF (<155 mW/m2) values. The further integrated geophysical investigation and subsequent exploitation programs should be sited in the delineated GA and adjoining A

Mapping Main Structures and Related Mineralization of the Arabian Shield (Saudi Arabia) Using Sharp Edge Detector of Transformed Gravity Data

Saudi Arabia covers most of the Arabian Peninsula and is characterized by tectonic regimes ranging from Precambrian to Recent. Using gravity data to produce the lateral boundaries of subsurface density bodies, and edge detection of potential field data, a new subsurface structural map was created to decipher the structural framework controls on the distribution of gold deposits in Saudi Arabia. Moreover, we detected the relationships between major structures and mineral accumulations, thereby simultaneously solving the problem of edge detectors over complex tectonic patterns for both deeper and shallower origins. Analytic signal (ASg), theta map (TM), TDX, and softsign function (SF) filters were applied to gravity data of Saudi Arabia. The results unveil low connectivity along the Najd fault system (NFS) with depth, except perhaps for the central zones along each segment. The central zones are the location of significant gold mineralization, i.e., Fawarah, Gariat Avala, Hamdah, and Ghadarah. Moreover, major fault zones parallel to the Red Sea extend northward from the south, and their connectivity increases with depth and controls numerous gold mines, i.e., Jadmah, Wadi Bidah, Mamilah, and Wadi Leif. These fault zones intersect the NFS in the Midyan Terrane at the northern part of the AS, and their conjugation is suggested to be favorable for gold mineralization. The SF maps revealed the boundary between the Arabian Shield and Arabian Shelf, which comprises major shear zones, implying that most known mineralization sites are linked to post-accretionary structures and are not limited to the Najd fault system (NFS)