Causal evidence that intrinsic beta frequency is relevant for enhanced signal propagation in the motor system as shown through rhythmic TMS

Correlative evidence provides support for the idea that brain oscillations underpin neural computations. Recent work using rhythmic stimulation techniques in humans provide causal evidence but the interactions of these external signals with intrinsic rhythmicity remain unclear. Here, we show that sensorimotor cortex precisely follows externally applied rhythmic TMS (rTMS) stimulation in the beta-band but that the elicited responses are strongest at the intrinsic individual beta-peak-frequency. While these entrainment effects are of short duration, even subthreshold rTMS pulses propagate through the network and elicit significant cortico-spinal coupling, particularly when stimulated at the individual beta-frequency. Our results show that externally enforced rhythmicity interacts with intrinsic brain rhythms such that the individual peak frequency determines the effect of rTMS. The observed downstream spinal effect at the resonance frequency provides evidence for the causal role of brain rhythms for signal propagation

An Adaptive Algorithm for Synchronization in Diffusively Coupled Systems

We present an adaptive algorithm that guarantees synchronization in diffusively coupled systems. We first consider compartmental systems of ODEs, where each compartment represents a spatial domain of components interconnected through diffusion terms with like components in different compartments. Each set of like components may have its own weighted undirected graph describing the topology of the interconnection between compartments. The link weights are updated adaptively according to the magnitude of the difference between neighboring agents connected by the link. We next consider reaction-diffusion PDEs with Neumann boundary conditions, and derive an analogous algorithm guaranteeing spatial homogenization of solutions. We provide a numerical example demonstrating the results

Global entrainment of transcriptional systems to periodic inputs

This paper addresses the problem of giving conditions for transcriptional systems to be globally entrained to external periodic inputs. By using contraction theory, a powerful tool from dynamical systems theory, it is shown that certain systems driven by external periodic signals have the property that all solutions converge to a fixed limit cycle. General results are proved, and the properties are verified in the specific case of some models of transcriptional systems. The basic mathematical results needed from contraction theory are proved in the paper, making it self-contained

Synchronization in complex networks

Synchronization processes in populations of locally interacting elements are in the focus of intense research in physical, biological, chemical, technological and social systems. The many efforts devoted to understand synchronization phenomena in natural systems take now advantage of the recent theory of complex networks. In this review, we report the advances in the comprehension of synchronization phenomena when oscillating elements are constrained to interact in a complex network topology. We also overview the new emergent features coming out from the interplay between the structure and the function of the underlying pattern of connections. Extensive numerical work as well as analytical approaches to the problem are presented. Finally, we review several applications of synchronization in complex networks to different disciplines: biological systems and neuroscience, engineering and computer science, and economy and social sciences.Comment: Final version published in Physics Reports. More information available at http://synchronets.googlepages.com

Synchronization and Transient Stability in Power Networks and Non-Uniform Kuramoto Oscillators

Motivated by recent interest for multi-agent systems and smart power grid architectures, we discuss the synchronization problem for the network-reduced model of a power system with non-trivial transfer conductances. Our key insight is to exploit the relationship between the power network model and a first-order model of coupled oscillators. Assuming overdamped generators (possibly due to local excitation controllers), a singular perturbation analysis shows the equivalence between the classic swing equations and a non-uniform Kuramoto model. Here, non-uniform Kuramoto oscillators are characterized by multiple time constants, non-homogeneous coupling, and non-uniform phase shifts. Extending methods from transient stability, synchronization theory, and consensus protocols, we establish sufficient conditions for synchronization of non-uniform Kuramoto oscillators. These conditions reduce to and improve upon previously-available tests for the standard Kuramoto model. Combining our singular perturbation and Kuramoto analyses, we derive concise and purely algebraic conditions that relate synchronization and transient stability of a power network to the underlying system parameters and initial conditions