A Hybrid Metaheuristics based technique for Mutation Based Disease Classification

Due to recent advancements in computational biology, DNA microarray technology has evolved as a useful tool in the detection of mutation among various complex diseases like cancer. The availability of thousands of microarray datasets makes this field an active area of research. Early cancer detection can reduce the mortality rate and the treatment cost. Cancer classification is a process to provide a detailed overview of the disease microenvironment for better diagnosis. However, the gene microarray datasets suffer from a curse of dimensionality problems also the classification models are prone to be overfitted due to small sample size and large feature space. To address these issues, the authors have proposed an Improved Binary Competitive Swarm Optimization Whale Optimization Algorithm (IBCSOWOA) for cancer classification, in which IBCSO has been employed to reduce the informative gene subset originated from using minimum redundancy maximum relevance (mRMR) as filter method. The IBCSOWOA technique has been tested on an artificial neural network (ANN) model and the whale optimization algorithm (WOA) is used for parameter tuning of the model. The performance of the proposed IBCSOWOA is tested on six different mutation-based microarray datasets and compared with existing disease prediction methods. The experimental results indicate the superiority of the proposed technique over the existing nature-inspired methods in terms of optimal feature subset, classification accuracy, and convergence rate. The proposed technique has illustrated above 98% accuracy in all six datasets with the highest accuracy of 99.45% in the Lung cancer dataset

Feature Selection Approach based on Firefly Algorithm and Chi-square

Dimensionality problem is a well-known challenging issue for most classifiers in which datasets have unbalanced number of samples and features. Features may contain unreliable data which may lead the classification process to produce undesirable results. Feature selection approach is considered a solution for this kind of problems. In this paperan enhanced firefly algorithm is proposed to serve as a feature selection solution for reducing dimensionality and picking the most informative features to be used in classification. The main purpose of the proposedmodel is to improve the classification accuracy through using the selected features produced from the model, thus classification errors will decrease. Modeling firefly in this research appears through simulating firefly position by cell chi-square value which is changed after every move, and simulating firefly intensity by calculating a set of different fitness functionsas a weight for each feature. K-nearest neighbor and Discriminant analysis are used as classifiers to test the proposed firefly algorithm in selecting features. Experimental results showed that the proposed enhanced algorithmbased on firefly algorithm with chi-square and different fitness functions can provide better results than others. Results showed that reduction of dataset is useful for gaining higher accuracy in classification

Machine learning methods for omics data integration

High-throughput technologies produce genome-scale transcriptomic and metabolomic (omics) datasets that allow for the system-level studies of complex biological processes. The limitation lies in the small number of samples versus the larger number of features represented in these datasets. Machine learning methods can help integrate these large-scale omics datasets and identify key features from each dataset. A novel class dependent feature selection method integrates the F statistic, maximum relevance binary particle swarm optimization (MRBPSO), and class dependent multi-category classification (CDMC) system. A set of highly differentially expressed genes are pre-selected using the F statistic as a filter for each dataset. MRBPSO and CDMC function as a wrapper to select desirable feature subsets for each class and classify the samples using those chosen class-dependent feature subsets. The results indicate that the class-dependent approaches can effectively identify unique biomarkers for each cancer type and improve classification accuracy compared to class independent feature selection methods. The integration of transcriptomics and metabolomics data is based on a classification framework. Compared to principal component analysis and non-negative matrix factorization based integration approaches, our proposed method achieves 20-30% higher prediction accuracies on Arabidopsis tissue development data. Metabolite-predictive genes and gene-predictive metabolites are selected from transcriptomic and metabolomic data respectively. The constructed gene-metabolite correlation network can infer the functions of unknown genes and metabolites. Tissue-specific genes and metabolites are identified by the class-dependent feature selection method. Evidence from subcellular locations, gene ontology, and biochemical pathways support the involvement of these entities in different developmental stages and tissues in Arabidopsis

Multi-Agent based Intelligent Decision Support Systems for Cancer Classification

There is evidence that early detection of cancer diseases can improve the treatment and increase the survival rate of patients. This paper presents an efficient CAD system for cancer diseases diagnosis by gene expression profiles of DNA microarray datasets. The proposed CAD system combines Intelligent Decision Support System (IDSS) and Multi-Agent (MA) system. The IDSS represents the backbone of the entire CAD system. It consists of two main phases; feature selection/reduction phase and a classification phase. In the feature selection/reduction phase, eight diverse methods are developed. While, in the classification phase, three evolutionary machine learning algorithms are employed. On the other hand, the MA system manages the entire operation of the CAD system. It first initializes several IDSSs (exactly 24 IDSSs) with the aid of mobile agents and then directs the generated IDSSs to run concurrently on the input dataset. Finally, a master agent selects the best classification, as the final report, based on the best classification accuracy returned from the 24 IDSSs The proposed CAD system is implemented in JAVA, and evaluated by using three microarray datasets including; Leukemia, Colon tumor, and Lung cancer. The system is able to classify different types of cancer diseases accurately in a very short time. This is because the MA system invokes 24 different IDSS to classify the diseases concurrently in parallel processing manner before taking the decision of the best classification result

Hybrid feature selection of breast cancer gene expression microarray data based on metaheuristic methods: a comprehensive review

Breast cancer (BC) remains the most dominant cancer among women worldwide. Numerous BC gene expression microarray-based studies have been employed in cancer classification and prognosis. The availability of gene expression microarray data together with advanced classification methods has enabled accurate and precise classification. Nevertheless, the microarray datasets suffer from a large number of gene expression levels, limited sample size, and irrelevant features. Additionally, datasets are often asymmetrical, where the number of samples from different classes is not balanced. These limitations make it difficult to determine the actual features that contribute to the existence of cancer classification in the gene expression profiles. Various accurate feature selection methods exist, and they are being widely applied. The objective of feature selection is to search for a relevant, discriminant feature subset from the basic feature space. In this review, we aim to compile and review the latest hybrid feature selection methods based on bio-inspired metaheuristic methods and wrapper methods for the classification of BC and other types of cancer

A survey on computational intelligence approaches for predictive modeling in prostate cancer

Predictive modeling in medicine involves the development of computational models which are capable of analysing large amounts of data in order to predict healthcare outcomes for individual patients. Computational intelligence approaches are suitable when the data to be modelled are too complex forconventional statistical techniques to process quickly and eciently. These advanced approaches are based on mathematical models that have been especially developed for dealing with the uncertainty and imprecision which is typically found in clinical and biological datasets. This paper provides a survey of recent work on computational intelligence approaches that have been applied to prostate cancer predictive modeling, and considers the challenges which need to be addressed. In particular, the paper considers a broad definition of computational intelligence which includes evolutionary algorithms (also known asmetaheuristic optimisation, nature inspired optimisation algorithms), Artificial Neural Networks, Deep Learning, Fuzzy based approaches, and hybrids of these,as well as Bayesian based approaches, and Markov models. Metaheuristic optimisation approaches, such as the Ant Colony Optimisation, Particle Swarm Optimisation, and Artificial Immune Network have been utilised for optimising the performance of prostate cancer predictive models, and the suitability of these approaches are discussed

HYEI: A New Hybrid Evolutionary Imperialist Competitive Algorithm for Fuzzy Knowledge Discovery

In recent years, imperialist competitive algorithm (ICA), genetic algorithm (GA), and hybrid fuzzy classification systems have been successfully and effectively employed for classification tasks of data mining. Due to overcoming the gaps related to ineffectiveness of current algorithms for analysing high-dimension independent datasets, a new hybrid approach, named HYEI, is presented to discover generic rule-based systems in this paper. This proposed approach consists of three stages and combines an evolutionary-based fuzzy system with two ICA procedures to generate high-quality fuzzy-classification rules. Initially, the best feature subset is selected by using the embedded ICA feature selection, and then these features are used to generate basic fuzzy-classification rules. Finally, all rules are optimized by using an ICA algorithm to reduce their length or to eliminate some of them. The performance of HYEI has been evaluated by using several benchmark datasets from the UCI machine learning repository. The classification accuracy attained by the proposed algorithm has the highest classification accuracy in 6 out of the 7 dataset problems and is comparative to the classification accuracy of the 5 other test problems, as compared to the best results previously published

Supervised Methods for Biomarker Detection from Microarray Experiments

Biomarkers are valuable indicators of the state of a biological system. Microarray technology has been extensively used to identify biomarkers and build computational predictive models for disease prognosis, drug sensitivity and toxicity evaluations. Activation biomarkers can be used to understand the underlying signaling cascades, mechanisms of action and biological cross talk. Biomarker detection from microarray data requires several considerations both from the biological and computational points of view. In this chapter, we describe the main methodology used in biomarkers discovery and predictive modeling and we address some of the related challenges. Moreover, we discuss biomarker validation and give some insights into multiomics strategies for biomarker detection.Non peer reviewe