Interventional Techniques for Head and Neck Cancer Pain

One of the most feared consequences of cancer is the possibility of severe and uncontrolled pain in patients with advanced cancer. Patients with head and neck cancer (HNC) have the highest prevalence of pain among patients with cancer,and it is often one of the major reasons for seeking care. A subspecialty approach that incorporates anatomical and technical knowledge to alleviate pain through minimally invasive procedures is relatively recent. The purpose of this chapter is to present different interventional techniques which are used for the treatment of pain in HNC patients when drug treatment is unsuccessful

Estudio farmacognóstico de la semilla de Phalaris canariensis L. “alpiste”y su cuantificación de esteroles

Se realizó el estudio farmacognóstico de la semilla de Phalaris canariensis L., procedente del distrito de Simbal, determinándose las características macromorfológicas, parámetros físico-químicos del control de calidad de la droga según la Norma Ramal para drogas crudas del MINSAP, tales como: porcentaje de humedad  residual,  cenizas  totales,  cenizas  insolubles  en  ácido,  cenizas  solubles  en  agua, materia extraña; cuyos valores promedios obtenidos, se encontraron dentro del rango permisible. Además, se realizó la huella dactilar del extracto hidroalcohólico al 70%v/v; y el tamizaje fitoquímico – según la prueba de la gota, evidenciándose la presencia de esteroles. Se identificó y cuantificó los esteroles mediante espectrofotometría UV/Visible a 236nm; donde, según las reglas de Woodward-Fieser, el esqueleto base de los esteroles es la 3 – hidroxiandrosta – 5,7 – dieno, y se encuentran en una cantidad de 3,2471 ±0,0119%.Palabras Clave: Phalaris canariensis L., estudio farmacognóstico, esteroles, cuantificación, espectrofotometría UV/Visible

Enhanced Seismic Structural Reliability on Reinforced Concrete Buildings by Using Buckling Restrained Braces

The control of vibrations and damage in traditional reinforced concrete (RC) buildings under earthquakes is a difficult task. It requires the use of innovative devices to enhance the seismic behavior of concrete buildings. In this paper, we design RC buildings with buckling restrained braces (BRBs) to achieve this objective. For this aim, three traditional RC framed structures with 3, 6, and 9 story levels are designed by using the well-known technique nondominated sorting genetic algorithm (NSGA-II) in order to reduce the cost and maximize the seismic performance. Then, equivalent RC buildings are designed but including buckling restrained braces. Both structural systems are subjected to several narrow-band ground motions recorded at soft soil sites of Mexico City scaled at different levels of intensities in terms of the spectral acceleration at first mode of vibration of the structure Sa(T1). Then, incremental dynamic analysis, seismic fragility, and structural reliability in terms of the maximum interstory drift are computed for all the buildings. For the three selected structures and the equivalent models with BRBs, it is concluded that the annual rate of exceedance is considerably reduced when BRBs are incorporated. For this reason, the structural reliability of the RC buildings with BRBs has a better behavior in comparison with the traditional reinforced concrete buildings. The use of BRBs is a good option to improve strength and seismic behavior and hence the structural reliability of RC buildings subjected to strong earthquake ground motions

Descriptive analysis of histological types in women undergoing post mastectomy breast reconstruction

Background: Breast cancer is a pathological entity that widely compromises the life and quality of life of affected women; in addition to the great affectation to the current health services. Therefore, maintaining an accurate and complete cancer registry program is one of the most important factors in implementing national cancer control programs and evaluating the results of screening, diagnosis, and treatment. Among the current limitations in the studies, there is a gap in the study of the population undergoing breast reconstruction. Methods: A retrospective study was carried out at hospital general de México “Dr. Eduardo Licéaga” with the information from the clinical records of the period 2019-2020. Patients undergoing breast reconstruction after mastectomy with histological report were included. Through non-probabilistic sampling, a population of 138 women was formed. For data analysis, frequencies and percentages were calculated for the qualitative variables; while for the quantitative variables, mean and standard deviation were calculated. Results: 138 women who underwent breast reconstruction were included, the mean age was 49.9±10.85 years, the mean BMI was 26.80±4.62 kg/m2, the secondary educational level predominated (34.8%), radiotherapy was applied to 34.1%, reconstruction was late in 75.4%, the most frequent reconstruction technique was TRAM flap (44.2%), the histological type of invasive ductal carcinoma predominated (68.1%). Conclusions: In women undergoing post-mastectomy breast reconstruction, the histological type of invasive ductal carcinoma predominates.

Multiplicación, histodiferenciación y regeneración de suspensiones celulares embriogénicas en plátanos vianda “Navolean” (AAB)

The results obtained show that the best cell density for the multiplication of the cell suspensions in the cultivar ‘Navolean’ is 3.0% settled cell volume. In the histo-differentiation phase the greatest formation of somatic embryos in the globular stage was obtained using a density of 12.0% final cell volume in liquid culture medium. The maturation of the embryos and an increase in germination was possible on using 0.5 gFW of somatic embryos during 30 days in the maturation culture medium. Using temporary immersion systems with 0.5 gFW of mature somatic embryos, the germination value was increased to 77.40%Key words: Musa, settled cell volume (SCV), somatic embryogenesis, temporary immersionEl mejor resultado para la multiplicación de las suspensiones celulares embriogénicas en el cv. ‘Navolean’ se obtuvo al utilizar una densidad celular del 3.0% del Volumen de Células Sedimentadas. En la etapa de histodiferenciación se logró la mayor formación de embriones somáticos en etapa globular utilizando como densidad 12.0% de volumen final de células en medio de cultivo líquido. Al emplear 0.5 gMF de embriones somáticos durante 30 días de cultivo en el medio de cultivo de maduración, fue posible lograr la maduración de los embriones e incrementar la germinación. Empleando sistemas de inmersión temporal con 0.5 gMF de embriones somáticos maduros se incrementó el valor de germinación a 77.40%.Palabras clave: embriogénesis somática, inmersión temporal, Musa, volumen de células sedimentadas (VCS

Respiratory viruses detected in Mexican children younger than 5 years old with community-acquired pneumonia: a national multicenter study

Background: Acute respiratory infections are the leading cause of mortality in children worldwide, especially in developing countries. Pneumonia accounts for 16% of all deaths of children under 5 years of age and was the cause of death of 935 000 children in 2015. Despite its frequency and severity, information regarding its etiology is limited. The aim of this study was to identify respiratory viruses associated with community-acquired pneumonia (CAP) in children younger than 5 years old. Methods: One thousand four hundred and four children younger than 5 years of age with a clinical and/or radiological diagnosis of CAP in 11 hospitals in Mexico were included. Nasal washes were collected, placed in viral medium, and frozen at �70 C until processing. The first 832 samples were processed using the multiplex Bio-Plex/Luminex system and the remaining 572 samples using the Anyplex multiplex RT-PCR. Clinical data regarding diagnosis, clinical signs and symptoms, radiographic pattern, and risk factors were obtained and recorded. Results: Of the samples tested, 81.6% were positive for viruses. Respiratory syncytial virus (types A and B) was found in 23.7%, human enterovirus/rhinovirus in 16.6%, metapneumovirus in 5.7%, parainfluenza virus (types 1–4) in 5.5%, influenza virus (types A and B) in 3.6%, adenovirus in 2.2%, coronavirus (NL63, OC43, 229E, and HKU1) in 2.2%, and bocavirus in 0.4%. Co-infection with two or more viruses was present in 22.1%; 18.4% of the samples were negative. Using biomass for cooking, daycare attendance, absence of breastfeeding, and co-infections were found to be statistically significant risk factors for the presence of severe pneumonia. Conclusions: Respiratory syncytial virus (types A and B), human enterovirus/rhinovirus, and metapneumovirus were the respiratory viruses identified most frequently in children younger than 5 years old with CAP. Co-infection was present in an important proportion of the children

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London