Performance Analysis of Selection Combining Over Correlated Nakagami-m Fading Channels with Constant Correlation Model for Desired Signal and Cochannel Interference

A very efficient technique that reduces fading and channel interference influence is selection diversity based on the signal to interference ratio (SIR). In this pa¬per, system performances of selection combiner (SC) over correlated Nakagami-m channels with constant correlation model are analyzed. Closed-form expressions are obtained for the output SIR probability density function (PDF) and cumulative distribution function (CDF) which is main contribution of this paper. Outage probability and the average error probability for coherent, noncoherent modulation are derived. Numerical results presented in this paper point out the effects of fading severity and cor¬relation on the system performances. The main contribu¬tion of this analysis for multibranch signal combiner is that it has been done for general case of correlated co-channel interference (CCI)

Performance analysis of wireless communication system in general fading environment subjected to shadowing and interference

In this paper, performance analysis of wireless communication over α−η−μ fading channels has been investigated. First, analysis has been carried out for the case when communication is subjected to the influence of co-channel interference. Closed-form expressions have been derived for the probability density function and cumulative distribution function of the received signal-to-interference ratio. Outage probability has been obtained for this case, in the function of various values of system parameters, and also for the case when selection diversity has been presented at the reception. Further, simultaneous multipath fading and shadowing occurrence has been analyzed, through deriving novel composite Gamma long-time faded α−η−μ fading distribution. First-order statistical parameters have been obtained in closed form, for this novel composite distribution, and capitalizing on them, standard performance measures have been efficiently evaluated, graphically presented and discussed in the function of system parameters

On Higher-Order Statistics of the Channel Model for UAV-to-Ground Communications

Proceedings of: 2021 IEEE 93rd Vehicular Technology (VTC2021-Spring), 25-28 april, 2021, Helsinki, Finland.Unmanned-aerial-vehicles (UAVs) based communications are envisioned to play an important role in 5G and beyond 5G (B5G) systems. UAV-to-ground communications in urban cities are often characterized by highly dynamic propagation environments that can be described by composite fading channels. Most of the UAV-to-ground systems are based on first order (FO) performance evaluation, however the models based on FO statistics are insufficient for characterization of time variant fading channels. We provide comprehensive mathematical framework for the second order (SO) statistics over double-scattered, double-shadowed (DS-DS) fading channels, modeled as the product of double Nakagami-m (DN) and double inverse Gamma (DIG) random processes (RPs). In particular, we obtained exact mathematical expressions for average fade duration (AFD) and level crossing rate (LCR) of the proposed UAV-to-ground channel model. Moreover, the exact, integral form SO statistical expressions are approximated by Laplace Integration (LI) and exponential LI in order to provide closed form, easily computing mathematical expressions. Numerical results show that approximate and exact results are fitting well, especially for higher output threshold values. The impact of DS-DS fading severities on the SO statistics are well investigated. Furthermore, the proposed method is extended to analyze SO performances for the selection scenario of UAV with the highest signal level from among N-UAVs links.C. Stefanovic would like to acknowledge CONEX-Plus. The CONEX-Plus is funded by UC3M, the European Commission through the Marie Sklodowska Curie COFUND Action (H2020-MSCA-COFUND-2017- GA 801538)

Recent Advances in RF Propagation Modeling for 5G Systems

Stefanovic, M.; Panic, SR.; De Souza, RAA.; Reig, J. (2017). Recent Advances in RF Propagation Modeling for 5G Systems. International Journal of Antennas and Propagation (Online). 2017(4701208):1-5. doi:10.1155/2017/4701208S152017470120

On the ASER performance of UAV-based communication systems for QAM schemes

In this letter, we derive an average symbol error rate (ASER) expression of rectangular quadrature amplitude modulation (RQAM) scheme for unmanned aerial vehicle-enabled communication systems operating over double-shadowing and double-scattering composite fading channel. A moment generating function for the receiver output signal-to-noise ratio is obtained to analyze the ASER expression of non-coherent modulation schemes. An asymptotic expression of ASER for RQAM scheme is also derived to examine diversity order of the considered system. Further, the impact of composite fading parameters and path loss on ASER performance is highlighted. Finally, we validate all the theoretical results through Monte Carlo simulations

PERFORMANCE OF MACRO DIVERSITY WIRELESS COMMUNICATION SYSTEM OPERATING IN WEIBUL MULTIPATH FADING ENVIRONMENT

In this paper, we consider wireless mobile radio communication system with macro diversity reception. Signal is subject to Weibull small scale fading and Gamma large scale fading resulting in system performance degradation. Receiver uses macro diversity selection combining (SC) technique in order to reduce the impact of long term fading effects, and two micro diversity SC branches are used to mitigate Weibull short term fading effects on system performance. Probability density function (PDF), and cumulative distribution function (CDF), as well as level crossing rate (LCR) and average fade duration (AFD) of the SC receiver output signal envelope are evaluated. The obtained expressions converge rapidly for all considered values of Weibull fading parameter and Gamma shadowing severity parameter. Mathematical results are studied in order to analyze the influence of Weibull fading parameter and Gamma shadowing severity parameter on statistical properties of the SC receiver output signal

Cellular Immune Responses and Immune Escape Mechanisms in Breast Cancer: Determinants of Immunotherapy

More recently, immunotherapy has emerged as a novel potentially effective therapeutic option also for solid malignancies such as breast cancer (BC). Relevant approaches, however, are determined by the 2 main elements of cancer immunoediting - the elimination of nascent transformed cells by immunosurveillance on the one hand and tumor immune escape on the other hand. Correspondingly, we here review the role of the various cellular immune players within the host-protective system and dissect the mechanisms of immune evasion leading to tumor progression. If the immune balance of disseminated BC cell dormancy (equilibrium phase) is lost, distant metastatic relapse may occur. The relevant cellular antitumor responses and translational immunotherapeutic options will also be discussed in terms of clinical benefit and future directions in BC management

Physiologic and pathologic functions of the NPP nucleotide pyrophosphatase/phosphodiesterase family focusing on NPP1 in calcification

The catabolism of ATP and other nucleotides participates partly in the important function of nucleotide salvage by activated cells and also in removal or de novo generation of compounds including ATP, ADP, and adenosine that stimulate purinergic signaling. Seven nucleotide pyrophosphatase/phosphodiesterase NPP family members have been identified to date. These isoenzymes, related by up conservation of catalytic domains and certain other modular domains, exert generally non-redundant functions via distinctions in substrates and/or cellular localization. But they share the capacity to hydrolyze phosphodiester or pyrophosphate bonds, though generally acting on distinct substrates that include nucleoside triphosphates, lysophospholipids and choline phosphate esters. PPi generation from nucleoside triphosphates, catalyzed by NPP1 in tissues including cartilage, bone, and artery media smooth muscle cells, supports normal tissue extracellular PPi levels. Balance in PPi generation relative to PPi degradation by pyrophosphatases holds extracellular PPi levels in check. Moreover, physiologic levels of extracellular PPi suppress hydroxyapatite crystal growth, but concurrently providing a reservoir for generation of pro-mineralizing Pi. Extracellular PPi levels must be supported by cells in mineralization-competent tissues to prevent pathologic calcification. This support mechanism becomes dysregulated in aging cartilage, where extracellular PPi excess, mediated in part by upregulated NPP1 expression stimulates calcification. PPi generated by NPP1modulates not only hydroxyapatite crystal growth but also chondrogenesis and expression of the mineralization regulator osteopontin. This review pays particular attention to the role of NPP1-catalyzed PPi generation in the pathogenesis of certain disorders associated with pathologic calcification

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder