Backward Scheduling to Minimize the Actual Mean Flow Time with Dependent and Independent Setup Times

The present paper deals with a new perfomance measure, the actual mean flow time, defined as a mean of the elapsed time of each job counted from the start time on a schedule to the corresponding due date. For the one machine backward scheduling model with a common due date and independent setup times, LPT schedule is shown as the optimal solution for the proposed measure. An optimal algorithm is presented for the case with dependent setup times on the basis of the algorithm by Arcelus and Chandra for a n / 1 / F forward scheduling problem. The proposed algorithm is coded in C-language and a computational experience is reported through a 16-bit computer

Le nô et l’escrime – autour du lien intime entre les familles Konparu et Yagyū

On a souvent mis en avant l’importance du bouddhisme zen dans la constitution des techniques guerrières comme les arts martiaux, et en particulier l’influence du moine Takuan Sōhō sur Yagyū Munenori. La vision de l’identité du sabre et du zen (ken zen ichinyo) a été affirmée par ce moine dans le Fudōchi shinmyōroku (La sagesse immuable), un traité philosophique sur l’art du sabre qui mettait notamment l’accent sur la nécessité de garder l’esprit libre de tout attachement et de toute fixation. Mais on peut signaler également l’influence du théâtre nô, qui s’est rapproché de l’escrime notamment aux débuts de l’époque d’Edo à travers le lien intime entre les familles Yagyū et Konparu, une école du nô. Quel pourrait être alors l’apport du nô dans la constitution des arts guerriers ? Cet article éclaire les deux aspects de cette contribution : l’aspect conceptuel et l’aspect pratique.The importance of Zen Buddhism has often been emphasized in the constitution of warlike techniques such as martial arts, and in particular the influence of the monk Takuan Sōhō on Yagyū Munenori. The vision of the identity of saber and zen (ken zen ichinyo) was stated by this monk in the Fudōchi shinmyōroku (Immutable Wisdom), a philosophical treatise on the art of the sword, which emphasized the need to keep the mind free from all attachment and fixation. But we can also point out the influence of Noh theater, which came close to fencing, especially at the beginning of the Edo period, through the intimate bond between the Yagyū and Konparu families, the latter a Noh school. What then could be the contribution of the Noh to the constitution of the warlike arts? This article sheds light on both aspects of this contribution: the conceptual and practical aspects

Experimental investigation of air–water two-phase flow through vertical 90° bend

The behaviour of two-phase air–water mixture flowing from the horizontal to the vertical through a 90° bend has been investigated experimentally. Cross sectional void fraction at nine positions, three upstream and six downstream of the bend have been measured using a conductance probe technique. The bend, manufactured from transparent acrylic resin has a diameter of 34 mm and a curvature (R/D) equal to 5. The superficial velocity of the air was varied between 0.3 and 4 m/s and that for the water between 0.21 and 0.91 m/s. The characteristics signatures of Probability Density Function (PDF), the Power Spectral Density (PSD) of the time series of cross sectionally average void fraction and visual observations have been used to characterise the flow behaviour. For the experimental conditions, plug, slug and stratified wavy flow pattern occurred in the horizontal pipe while slug and churn flow patterns were present in the vertical pipe. The void fraction increased with the gas superficial velocity. The correlation of Nicklin et al. predicted the structure velocity for the slug flow in both horizontal and vertical pipes reasonably accurately. With regards to the frequency of the periodic structures present, some conditions showed little change from upstream to downstream the bend whilst others showed an increasing in the structure frequency from horizontal to vertical pipe. The slug length increased by passing through the vertical bend

Photonic-plasmonic hybrid single-molecule nanosensor measures the effect of fluorescent labels on DNA-protein dynamics

Current methods to study molecular interactions require labeling the subject molecules with fluorescent reporters. However, the effect of the fluorescent reporters on molecular dynamics has not been quantified because of a lack of alternative methods. We develop a hybrid photonic-plasmonic antenna-in-a-nanocavity single-molecule biosensor to study DNA-protein dynamics without using fluorescent labels. Our results indicate that the fluorescein and fluorescent protein labels decrease the interaction between a single DNA and a protein due to weakened electrostatic interaction. Although the study is performed on the DNA-XPA system, the conclusion has a general implication that the traditional fluorescent labeling methods might be misestimating the molecular interactions

Design of a high-performance optical tweezer for nanoparticle trapping

Integrated optical nanotweezers offer a novel paradigm for optical trapping, as their ability to confine light at the nanoscale leads to extremely high gradient forces. To date, nanotweezers have been realized either as photonic crystal or as plasmonic nanocavities. Here, we propose a nanotweezer device based on a hybrid photonic/plasmonic cavity with the goal of achieving a very high quality factor-to-mode volume (Q/V) ratio. The structure includes a 1D photonic crystal dielectric cavity vertically coupled to a bowtie nanoantenna. A very high Q/V ~ 107 (λ/n)−3 with a resonance transmission T = 29 % at λR = 1381.1 nm has been calculated by 3D finite element method, affording strong light–matter interaction and making the hybrid cavity suitable for optical trapping. A maximum optical force F = −4.4 pN, high values of stability S = 30 and optical stiffness k = 90 pN/nm W have been obtained with an input power Pin = 1 mW, for a polystyrene nanoparticle with a diameter of 40 nm. This performance confirms the high efficiency of the optical nanotweezer and its potential for trapping living matter at the nanoscale, such as viruses, proteins and small bacteria

Structures in gas–liquid churn flow in a large diameter vertical pipe

Gas–Liquid two phase co-current flow in a vertical riser with an internal diameter of 127 mm was investigated in the churn flow pattern. This paper presents detailed experimental data obtained using a Wire Mesh Sensor. It shows that the most obvious features of the flow are huge waves travelling on the liquid film. Wisps, large tendrils of liquid and the product of incomplete atomisation, which had previously detected in smaller diameter pipes, have also been found in the larger diameter pipe employed here. The output of the Wire Mesh Sensor has been used to determine the overall void fraction. When examined within a drift flux framework, it shows a distribution coefficient of ∼1, in contrast to data for lower gas flow rates. Film thickness time series extracted from the Wire Mesh Sensor output have been examined and the trends of mean film thickness, that of the base film and the wave peaks are presented and discussed. The occurrence of wisps and their frequencies have been quantified

Telomere Attrition Due to Infection

BACKGROUND: Telomeres--the terminal caps of chromosomes--become shorter as individuals age, and there is much interest in determining what causes telomere attrition since this process may play a role in biological aging. The leading hypothesis is that telomere attrition is due to inflammation, exposure to infectious agents, and other types of oxidative stress, which damage telomeres and impair their repair mechanisms. Several lines of evidence support this hypothesis, including observational findings that people exposed to infectious diseases have shorter telomeres. Experimental tests are still needed, however, to distinguish whether infectious diseases actually cause telomere attrition or whether telomere attrition increases susceptibility to infection. Experiments are also needed to determine whether telomere erosion reduces longevity. METHODOLOGY/PRINCIPAL FINDINGS: We experimentally tested whether repeated exposure to an infectious agent, Salmonella enterica, causes telomere attrition in wild-derived house mice (Mus musculus musculus). We repeatedly infected mice with a genetically diverse cocktail of five different S. enterica strains over seven months, and compared changes in telomere length with sham-infected sibling controls. We measured changes in telomere length of white blood cells (WBC) after five infections using a real-time PCR method. Our results show that repeated Salmonella infections cause telomere attrition in WBCs, and particularly for males, which appeared less disease resistant than females. Interestingly, we also found that individuals having long WBC telomeres at early age were relatively disease resistant during later life. Finally, we found evidence that more rapid telomere attrition increases mortality risk, although this trend was not significant. CONCLUSIONS/SIGNIFICANCE: Our results indicate that infectious diseases can cause telomere attrition, and support the idea that telomere length could provide a molecular biomarker for assessing exposure and ability to cope with infectious diseases

Subwavelength vacuum lattices and atom–atom interactions in two-dimensional photonic crystals

Quantum simulation with cold atoms in optical lattices is an attractive avenue for explorations of quantum many-body physics. A principal challenge in the field is to increase the energy and length scales in current set-ups, thereby reducing temperature and coherence-time requirements. Here, we present a new paradigm for high-density, two-dimensional optical lattices in photonic crystal waveguides. Specially engineered two-dimensional photonic crystals provide a practical platform to trap atoms and engineer their interactions in ways that surpass the limitations of current technologies and enable investigations of novel quantum many-body matter. Our schemes remove the constraint on the lattice constant set by the free-space optical wavelength in favour of deeply sub-wavelength atomic arrays. We further describe possibilities for atom–atom interactions mediated by photons in two-dimensional photonic crystal waveguides with energy scales several orders of magnitude larger than for exchange interactions in free-space lattices and with the capability to engineer strongly long-range interactions

Label-Free Optical Single-Molecule Micro- and Nanosensors

This is the author accepted manuscript. The final version is available from Wiley via the DOI in this recordLabel-free optical sensor systems have emerged that exhibit extraordinary sensitivity for detecting physical, chemical, and biological entities at the micro/nanoscale. Particularly exciting is the detection and analysis of molecules, on miniature optical devices that have many possible applications in health, environment, and security. These micro- and nanosensors have now reached a sensitivity level that allows for the detection and analysis of even single molecules. Their small size enables an exceedingly high sensitivity, and the application of quantum optical measurement techniques can allow the classical limits of detection to be approached or surpassed. The new class of label-free micro- and nanosensors allows dynamic processes at the single-molecule level to be observed directly with light. By virtue of their small interaction length, these micro- and nanosensors probe light–matter interactions over a dynamic range often inaccessible by other optical techniques. For researchers entering this rapidly advancing field of single-molecule micro- and nanosensors, there is an urgent need for a timely review that covers the most recent developments and that identifies the most exciting opportunities. The focus here is to provide a summary of the recent techniques that have either demonstrated label-free single-molecule detection or claim single-molecule sensitivity.Living Systems Institute, University of Exete