APEX-CHAMP+ high-J CO observations of low-mass young stellar objects: IV. Mechanical and radiative feedback

During the embedded stage of star formation, bipolar molecular outflows and UV radiation from the protostar are important feedback processes. Our aim is to quantify the feedback, mechanical and radiative, for a large sample of low-mass sources. The outflow activity is compared to radiative feedback in the form of UV heating by the accreting protostar to search for correlations and evolutionary trends. Large-scale maps of 26 young stellar objects, which are part of the Herschel WISH key program are obtained using the CHAMP+ instrument on the APEX (12CO and 13CO 6-5), and the HARP-B instrument on the JCMT (12CO and 13CO 3-2). Maps are used to determine outflow parameters and envelope models are used to quantify the amount of UV-heated gas and its temperature from 13CO 6-5 observations. All sources in our sample show outflow activity and the outflow force, F_CO, is larger for Class 0 sources than for Class I sources, even if their luminosities are comparable. The outflowing gas typically extends to much greater distances than the power-law envelope and therefore influences the surrounding cloud material directly. Comparison of the CO 6-5 results with Herschel-HIFI H2O and PACS high-J CO lines, both tracing currently shocked gas, shows that the two components are linked, even though the transitions do not probe the same gas. The link does not extend down to CO 3-2. The conclusion is that CO 6-5 depends on the shock characteristics (density and velocity), whereas CO 3-2 is more sensitive to conditions in the surrounding environment (density). The radiative feedback is responsible for increasing the gas temperature by a factor of two, up to 30-50 K, on scales of a few thousand AU, particularly along the direction of the outflow. The mass of the UV heated gas exceeds the mass contained in the entrained outflow in the inner ~3000 AU and is therefore at least as important on small scales.Comment: 30 pages with Appendix, Accepted by Astronomy & Astrophysic

Heterodyne Array Receivers for Space and Ground Based Applications

The first heterodyne array receivers have been successfully built for ground-based telescopes and airborne observatories. In the talk we give a very quick overview of some prior heterodyne arrays. In particular, we will look at the innovations they introduced and how these could be applied to future large (100 to 1000 pixel) arrays or space missions. Then we will present the first detailed design for a space application, the Heterodyne Receiver for the Origins Space Telescope (HERO). HERO follows the traditional design, but limited cooling power and the limited electrical power of the satellite pose major challenges. Minor challenges are limited availability of space and weight. For the eight 3x3 pixel arrays of which 4 can operate simultaneously we attributed 20mW at 4.5K, 35mW at 35K and 205 W at the satellite temperature. Therefore we propose to use SiGe cryogenic low noise amplifiers, with a dissipation of about 0.5mW for 6 GHz bandwidth. The power of the backends also needs to be reduced drastically to about 1 W for 6 GHz bandwidth. CMOS ASIC backends are one option, ADC, followed by FFTs and ACCs another. To reduce the volume and mass, we propose the cover the RF bandwidth of 486 GHz to 2700 GHz in only 4 bands, each with about 50% relative width.The design might not only be a helpful starting point for any heterodyne array on a satellite, but the low heat and power consumption might be also an essential first step for large (100 to 1000 pixels) heterodyne arrays for ground based telescopes or simply a more energy efficient alternative for any ALMA single pixel or array receiver

A Swedish heterodyne facility instrument for the APEX telescope

In March 2008, the APEX facility instrument was installed on the telescope at the site of Lliano Chajnantor in northern Chile. The main objective of the paper is to introduce the new instrument to the radio astronomical community. It describes the hardware configuration and presents some initial results from the on-sky commissioning. The heterodyne instrument covers frequencies between 211 GHz and 1390 GHz divided into four bands. The first three bands are sideband-separating mixers operating in a single sideband mode and based on superconductor-insulator-superconductor (SIS) tunnel junctions. The fourth band is a hot-electron bolometer, waveguide balanced mixer. All bands are integrated in a closedcycle temperature-stabilized cryostat and are cooled to 4 K. We present results from noise temperature, sideband separation ratios, beam, and stability measurements performed on the telescope as a part of the receiver technical commissioning. Examples of broad extragalactic lines are also included

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness

Genetic architecture of subcortical brain structures in 38,851 individuals

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease

Novel genetic loci underlying human intracranial volume identified through genome-wide association

Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five novel loci for intracranial volume and confirmed two known signals. Four of the loci are also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic=0.748), which indicated a similar genetic background and allowed for the identification of four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, Parkinson’s disease, and enriched near genes involved in growth pathways including PI3K–AKT signaling. These findings identify biological underpinnings of intracranial volume and provide genetic support for theories on brain reserve and brain overgrowth

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Low Noise SIS Mixers and Cryogenic Amplifiers for Sub-Millimeter Astronomy

This PhD thesis presents the work that was done developing radioastronomy instrumentation. The first part of this work deals with 2-stage low-noise cryogenic amplifiers using commercial GaAs HEMT transistors for frequency bnads: 3.4-4.6 GHz, 4-8 GHz and 8-9 GHz. Considerations on the design. construction and testing of these devices are described. The achieve performance is state-of-the-art, with about 9.7 K/GHz noise temperature and about 13 dB of gain per stage at a cryogenic temperature of 12 K. The applications for these amplifiers are various, even though they are designed for the intermediate frequency (IF) part of superconducting-insulating-superconducting (SIS) heterodyne receivers; they are also currently being used as radio frequency (RF) front-ends for C-band and X-band receivers at Onsala Space Observatory 20 m and 25 m telescopes