Test-Retest Reliability And Minimal Detectable Change Of The Modified Fresno Test Of Evidence Based Practice In DPT Students

Poster presenting a research study whose purpose was to determine the test-retest reliability and MDC of the MFT in first, second, and third year DPT students, and to compare the mean total score of the MFT among the three student groups. Using a simple random sample, 21 students were recruited from each of the three UNE DPT classes. The participants completed the MFT twice, separated by 14 days, in a UNE classroom. Students in the third year class completed the validated 13-item MFT and, due to a photocopying error, students in the first and second year class completed an 11-item MFT. The first year students had the lowest 11-item MFT mean score (68.5 points) which was significantly lower than the second and third year student groups (85.7 and 88.2 points, respectively). First year students had the lowest ICC and highest MDC (0.23 and 40.4 points). Third year students had the highest ICC and lowest MDC (0.73 and 23.0 points). The 13 and 11-item MFT has good test-retest reliability for UNE\u27s third year DPT student group. The 11-item MFT has poor to moderate test-retest reliability for first and second year DPT students.https://dune.une.edu/pt_studrrposter/1000/thumbnail.jp

The Test-Retest Reliability And Minimal Detectable Change In The Modified Fresno Test In Doctor Of Physical Therapy Students

Background: The American Physical Therapy Association identified the need for training in evidence based practice (EBP) and set forth guidelines for doctor of physical therapy (DPT) curricula to educate practitioners who are efficient and critical users of best evidence. Since DPT programs are teaching EBP, educators need an assessment tool to evaluate the competence of students. The Modified Fresno Test (MFT) of EBP was validated for physical therapists and the test-retest reliability and minimal detectable change (MDC) has been found for first year DPT students. Objective: The purpose is to determine the test-retest reliability and MDC of the MFT in first, second, and third year DPT students. A secondary purpose is to compare the mean total score of the MFT among the three student groups. Design: Test-retest design Methods: Using a simple random sample, we recruited 21 University of New England (UNE) DPT students from each of the three classes. The participants completed the MFT twice, separated by 14 days, in a classroom on UNE\u27s campus. Results: Students in the third year class completed the validated 13-item MFT and due to a photocopying error, students in the first and second year class completed an 11-item MFT. The first year students had the lowest 11-item MFT mean score (68.5 points) which was significantly lower than the second and third year student groups (85.7 and 88.2 points, respectively). First year students had the lowest ICC and highest MDC (0.23 and 40.4 points). Third year students had the highest ICC and lowest MDC (0.73 and 23.0 points). Limitations: We were unable to analyze scores from the 13-item MFT for all three student groups. The rater did not receive training in the MFT scoring rubric. Participation in the study was not a requirement. Conclusions: The 13 and 11-item MFT has good test-retest reliability for UNE\u27s third year DPT student group. The 11-item MFT has poor to moderate test-retest reliability for first and second year DPT students

Cancer Survivorship Care: An Emphasis On Rehabilitation Needs In Maine

The first section of this report addresses the evidence of causation concerning impairments developed as a result of a cancer diagnosis and cancer treatment. The second section investigates the evidence regarding rehabilitation and physical activity as an effective intervention in the prevention and treatment of impairments from cancer diagnosis and cancer treatment. The third section discusses the underlying behavioral change theory for incorporation of our Cancer Survivorship Rehabilitation Algorithm (Appendix 1), which details our proposed use of rehabilitation and wellness services in the continuum of cancer care and includes an outline for a survivorship care plan. This section also discusses the efficacy of delivery of our product to healthcare professionals. The fourth section outlines our proposed methods of evaluation for the utilization of our algorithm

LSST: from Science Drivers to Reference Design and Anticipated Data Products

(Abridged) We describe here the most ambitious survey currently planned in the optical, the Large Synoptic Survey Telescope (LSST). A vast array of science will be enabled by a single wide-deep-fast sky survey, and LSST will have unique survey capability in the faint time domain. The LSST design is driven by four main science themes: probing dark energy and dark matter, taking an inventory of the Solar System, exploring the transient optical sky, and mapping the Milky Way. LSST will be a wide-field ground-based system sited at Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m effective) primary mirror, a 9.6 deg$^2$ field of view, and a 3.2 Gigapixel camera. The standard observing sequence will consist of pairs of 15-second exposures in a given field, with two such visits in each pointing in a given night. With these repeats, the LSST system is capable of imaging about 10,000 square degrees of sky in a single filter in three nights. The typical 5$\sigma$ point-source depth in a single visit in $r$ will be $\sim 24.5$ (AB). The project is in the construction phase and will begin regular survey operations by 2022. The survey area will be contained within 30,000 deg$^2$ with $\delta<+34.5^\circ$, and will be imaged multiple times in six bands, $ugrizy$, covering the wavelength range 320--1050 nm. About 90\% of the observing time will be devoted to a deep-wide-fast survey mode which will uniformly observe a 18,000 deg$^2$ region about 800 times (summed over all six bands) during the anticipated 10 years of operations, and yield a coadded map to $r\sim27.5$. The remaining 10\% of the observing time will be allocated to projects such as a Very Deep and Fast time domain survey. The goal is to make LSST data products, including a relational database of about 32 trillion observations of 40 billion objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures available from https://www.lsst.org/overvie

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Field Performance of South-Facing and East-West Facing Bifacial Modules in the Arctic

This paper presents the first systematic comparison between south-facing monofacial and bifacial photovoltaic (PV) modules, as well as between south-facing bifacial and vertical east-west facing bifacial PV modules in Alaska. The state’s solar industry, driven by the high price of energy and dropping equipment costs, is quickly growing. The challenges posed by extreme sun angles in Alaska’s northern regions also present opportunities for unique system designs. Annual bifacial gains of 21% were observed between side by side south-facing monofacial and bifacial modules. Vertical east-west bifacial modules had virtually the same annual production as south-facing latitude tilt bifacial modules, but with different energy production profiles

Field Performance of South-Facing and East-West Facing Bifacial Modules in the Arctic

This paper presents the first systematic comparison between south-facing monofacial and bifacial photovoltaic (PV) modules, as well as between south-facing bifacial and vertical east-west facing bifacial PV modules in Alaska. The state’s solar industry, driven by the high price of energy and dropping equipment costs, is quickly growing. The challenges posed by extreme sun angles in Alaska’s northern regions also present opportunities for unique system designs. Annual bifacial gains of 21% were observed between side by side south-facing monofacial and bifacial modules. Vertical east-west bifacial modules had virtually the same annual production as south-facing latitude tilt bifacial modules, but with different energy production profiles