480 research outputs found
Iclaprim reduces the incidence and severity of Staphylococcus aureus-induced septic arthritis in a murine model
Staphylococcus aureus is the most common non-gonococcal aetiology of septic arthritis. The efficacy of iclaprim against S. aureus LS-1, a clinical strain identified from a patient with septic arthritis, was studied in MF1 mice to evaluate the activity of iclaprim, which is in clinical development, in preventing joint infections. Iclaprim (2.5–80 mg kg− 1) administered as a single dose via the tail vein reduced the incidence of S. aureus septic arthritis and mortality in an experimental murine model of septic arthritis
Sedative effects of intramuscular alfaxalone in pet guinea pigs (Cavia porcellus)
Objective: To evaluate the efficacy and side effects of alfaxalone administered intramuscularly (IM) as a sedative agent in guinea pigs undergoing survey radiographs
Multimode horn antennas for far-infrared astronomy
Multi-mode horns combined with bolometric or incoherent detectors are finding application in astronomical receivers for which partially coherent operation can provide increased throughput and thus sensitivity. This is advantageous when observing faint sources, especially if diffraction limited resolution is not required, or if the horn beam is truncated by a cold stop in the optical train. We discuss how such horns can be simulated and present examples from receiver instrumentation on the Planck and SPICA space telescopes
In-Vivo Expansion of T Regulatory Cells by Rapamycin in a Calcineurin-Inhibitor Free GVHD Prophylaxis in Unmanipulated Haploidentical Stem Cell Transplantation (SCT)
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Planck 2015 results. XXIII. The thermal Sunyaev-Zeldovich effect--cosmic infrared background correlation
We use Planck data to detect the cross-correlation between the thermal
Sunyaev-Zeldovich (tSZ) effect and the infrared emission from the galaxies that
make up the the cosmic infrared background (CIB). We first perform a stacking
analysis towards Planck-confirmed galaxy clusters. We detect infrared emission
produced by dusty galaxies inside these clusters and demonstrate that the
infrared emission is about 50% more extended than the tSZ effect. Modelling the
emission with a Navarro--Frenk--White profile, we find that the radial profile
concentration parameter is . This indicates
that infrared galaxies in the outskirts of clusters have higher infrared flux
than cluster-core galaxies. We also study the cross-correlation between tSZ and
CIB anisotropies, following three alternative approaches based on power
spectrum analyses: (i) using a catalogue of confirmed clusters detected in
Planck data; (ii) using an all-sky tSZ map built from Planck frequency maps;
and (iii) using cross-spectra between Planck frequency maps. With the three
different methods, we detect the tSZ-CIB cross-power spectrum at significance
levels of (i) 6 , (ii) 3 , and (iii) 4 . We model the
tSZ-CIB cross-correlation signature and compare predictions with the
measurements. The amplitude of the cross-correlation relative to the fiducial
model is . This result is consistent with
predictions for the tSZ-CIB cross-correlation assuming the best-fit
cosmological model from Planck 2015 results along with the tSZ and CIB scaling
relations.Comment: 18 pages, 16 figure
Planck Intermediate Results. IV. The XMM-Newton validation programme for new Planck galaxy clusters
We present the final results from the XMM-Newton validation follow-up of new
Planck galaxy cluster candidates. We observed 15 new candidates, detected with
signal-to-noise ratios between 4.0 and 6.1 in the 15.5-month nominal Planck
survey. The candidates were selected using ancillary data flags derived from
the ROSAT All Sky Survey (RASS) and Digitized Sky Survey all-sky maps, with the
aim of pushing into the low SZ flux, high-z regime and testing RASS flags as
indicators of candidate reliability. 14 new clusters were detected by XMM,
including 2 double systems. Redshifts lie in the range 0.2 to 0.9, with 6
clusters at z>0.5. Estimated M500 range from 2.5 10^14 to 8 10^14 Msun. We
discuss our results in the context of the full XMM validation programme, in
which 51 new clusters have been detected. This includes 4 double and 2 triple
systems, some of which are chance projections on the sky of clusters at
different z. We find that association with a RASS-BSC source is a robust
indicator of the reliability of a candidate, whereas association with a FSC
source does not guarantee that the SZ candidate is a bona fide cluster.
Nevertheless, most Planck clusters appear in RASS maps, with a significance
greater than 2 sigma being a good indication that the candidate is a real
cluster. The full sample gives a Planck sensitivity threshold of Y500 ~ 4 10^-4
arcmin^2, with indication for Malmquist bias in the YX-Y500 relation below this
level. The corresponding mass threshold depends on z. Systems with M500 > 5
10^14 Msun at z > 0.5 are easily detectable with Planck. The newly-detected
clusters follow the YX-Y500 relation derived from X-ray selected samples.
Compared to X-ray selected clusters, the new SZ clusters have a lower X-ray
luminosity on average for their mass. There is no indication of departure from
standard self-similar evolution in the X-ray versus SZ scaling properties.
(abridged)Comment: accepted by A&
Planck 2015 results. XXVII. The Second Planck Catalogue of Sunyaev-Zeldovich Sources
We present the all-sky Planck catalogue of Sunyaev-Zeldovich (SZ) sources detected from the 29 month full-mission data. The catalogue (PSZ2) is the largest SZ-selected sample of galaxy clusters yet produced and the deepest all-sky catalogue of galaxy clusters. It contains 1653 detections, of which 1203 are confirmed clusters with identified counterparts in external data-sets, and is the first SZ-selected cluster survey containing > confirmed clusters. We present a detailed analysis of the survey selection function in terms of its completeness and statistical reliability, placing a lower limit of 83% on the purity. Using simulations, we find that the Y5R500 estimates are robust to pressure-profile variation and beam systematics, but accurate conversion to Y500 requires. the use of prior information on the cluster extent. We describe the multi-wavelength search for counterparts in ancillary data, which makes use of radio, microwave, infra-red, optical and X-ray data-sets, and which places emphasis on the robustness of the counterpart match. We discuss the physical properties of the new sample and identify a population of low-redshift X-ray under- luminous clusters revealed by SZ selection. These objects appear in optical and SZ surveys with consistent properties for their mass, but are almost absent from ROSAT X-ray selected samples
Planck Intermediate Results. IX. Detection of the Galactic haze with Planck
Using precise full-sky observations from Planck, and applying several methods
of component separation, we identify and characterize the emission from the
Galactic "haze" at microwave wavelengths. The haze is a distinct component of
diffuse Galactic emission, roughly centered on the Galactic centre, and extends
to |b| ~35 deg in Galactic latitude and |l| ~15 deg in longitude. By combining
the Planck data with observations from the WMAP we are able to determine the
spectrum of this emission to high accuracy, unhindered by the large systematic
biases present in previous analyses. The derived spectrum is consistent with
power-law emission with a spectral index of -2.55 +/- 0.05, thus excluding
free-free emission as the source and instead favouring hard-spectrum
synchrotron radiation from an electron population with a spectrum (number
density per energy) dN/dE ~ E^-2.1. At Galactic latitudes |b|<30 deg, the
microwave haze morphology is consistent with that of the Fermi gamma-ray "haze"
or "bubbles," indicating that we have a multi-wavelength view of a distinct
component of our Galaxy. Given both the very hard spectrum and the extended
nature of the emission, it is highly unlikely that the haze electrons result
from supernova shocks in the Galactic disk. Instead, a new mechanism for
cosmic-ray acceleration in the centre of our Galaxy is implied.Comment: 15 pages, 9 figures, submitted to Astronomy and Astrophysic
Planck Intermediate Results II: Comparison of Sunyaev-Zeldovich measurements from Planck and from the Arcminute Microkelvin Imager for 11 galaxy clusters
A comparison is presented of Sunyaev-Zeldovich measurements for 11 galaxy
clusters as obtained by Planck and by the ground-based interferometer, the
Arcminute Microkelvin Imager. Assuming a universal spherically-symmetric
Generalised Navarro, Frenk & White (GNFW) model for the cluster gas pressure
profile, we jointly constrain the integrated Compton-Y parameter (Y_500) and
the scale radius (theta_500) of each cluster. Our resulting constraints in the
Y_500-theta_500 2D parameter space derived from the two instruments overlap
significantly for eight of the clusters, although, overall, there is a tendency
for AMI to find the Sunyaev-Zeldovich signal to be smaller in angular size and
fainter than Planck. Significant discrepancies exist for the three remaining
clusters in the sample, namely A1413, A1914, and the newly-discovered Planck
cluster PLCKESZ G139.59+24.18. The robustness of the analysis of both the
Planck and AMI data is demonstrated through the use of detailed simulations,
which also discount confusion from residual point (radio) sources and from
diffuse astrophysical foregrounds as possible explanations for the
discrepancies found. For a subset of our cluster sample, we have investigated
the dependence of our results on the assumed pressure profile by repeating the
analysis adopting the best-fitting GNFW profile shape which best matches X-ray
observations. Adopting the best-fitting profile shape from the X-ray data does
not, in general, resolve the discrepancies found in this subset of five
clusters. Though based on a small sample, our results suggest that the adopted
GNFW model may not be sufficiently flexible to describe clusters universally.Comment: update to metadata author list onl
Planck intermediate results. III. The relation between galaxy cluster mass and Sunyaev-Zeldovich signal
We examine the relation between the galaxy cluster mass M and
Sunyaev-Zeldovich (SZ) effect signal D_A^2 Y for a sample of 19 objects for
which weak lensing (WL) mass measurements obtained from Subaru Telescope data
are available in the literature. Hydrostatic X-ray masses are derived from
XMM-Newton archive data and the SZ effect signal is measured from Planck
all-sky survey data. We find an M_WL-D_A^2 Y relation that is consistent in
slope and normalisation with previous determinations using weak lensing masses;
however, there is a normalisation offset with respect to previous measures
based on hydrostatic X-ray mass-proxy relations. We verify that our SZ effect
measurements are in excellent agreement with previous determinations from
Planck data. For the present sample, the hydrostatic X-ray masses at R_500 are
on average ~ 20 per cent larger than the corresponding weak lensing masses, at
odds with expectations. We show that the mass discrepancy is driven by a
difference in mass concentration as measured by the two methods, and, for the
present sample, the mass discrepancy and difference in mass concentration is
especially large for disturbed systems. The mass discrepancy is also linked to
the offset in centres used by the X-ray and weak lensing analyses, which again
is most important in disturbed systems. We outline several approaches that are
needed to help achieve convergence in cluster mass measurement with X-ray and
weak lensing observations.Comment: 19 pages, 9 figures, matches accepted versio
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