A randomised controlled trial of PEGASUS, a psychoeducational programme for young people with high-functioning autism spectrum disorder.

Psychoeducation is an essential component of postdiagnostic care for people with ASD (autism spectrum disorder), but there is currently no evidence base for clinical practice. We designed, manualised and evaluated PEGASUS (psychoeducation group for autism spectrum understanding and support), a group psychoeducational programme aiming to enhance the self-awareness of young people with ASD by teaching them about their diagnosis

О порядке роста числа инъективных и сверхрастущих рюкзачных векторов

In 1978 R. Mercle and M. Hellman offered to use the subset sum problem for constructing cryptographic systems. The proposed cryptosystems were based on a class of the knapsacks with super-increasing vectors. This class is a subset of the set of knapsacks with injective (cryptographic) vectors that allow the single-valued decoding (decryption) result. In this paper we consider the problems related to the order in the growth of the injective vectors knapsacks quantity and to the order in the growth of knapsacks quantity with the super-increasing vectors through the knapsack maximal element increasing.В 1978 году Р. Меркль и М. Хеллман предложили использовать для построения криптосистем одномерную аддитивную задачу об укладке рюкзака. В основе предложенной криптосистемы лежал класс рюкзаков, обладающих сверхрастущими векторами. Указанный класс является подмножеством множества рюкзаков с инъективными (криптографическими) векторами, допускающих однозначное декодирование (дешифрование). В настоящей работе рассмотрены вопросы о порядке роста числа рюкзаков с инъективными векторами и о порядке роста числа рюкзаков со сверхрастущими векторами при росте максимального элемента рюкзака

CO\u3ci\u3e2\u3c/i\u3e Fixation Kinetics of \u3ci\u3eHalothiobacillus neapolitanus\u3c/i\u3e Mutant Carboxysomes Lacking Carbonic Anhydrase Suggest the Shell Acts as a Diffusional Barrier for CO\u3csub\u3e2\u3c/sub\u3e

The widely accepted models for the role of carboxysomes in the carbon-concentrating mechanism of autotrophic bacteria predict the carboxysomal carbonic anhydrase to be a crucial component. The enzyme is thought to dehydrate abundant cytosolic bicarbonate and provide ribulose 1.5-bisphosphate carboxylase/oxygenase (RubisCO) sequestered within the carboxysome with sufficiently high concentrations of its substrate, CO2, to permit its efficient fixation onto ribulose 1,5-bisphosphate. In this study, structure and function of carboxysomes purified from wild type Halothiobacillus neapolitanus and from a high CO2-requiring mutant that is devoid of carboxysomal carbonic anhydrase were compared. The kinetic constants for the carbon fixation reaction confirmed the importance of a functional carboxysomal carbonic anhydrase for efficient catalysis by RubisCO. Furthermore, comparisons of the reaction in intact and broken microcompartments and by purified carboxysomal RubisCO implicated the protein shell of the microcompartment as impeding diffusion of CO2 into and out of the carboxysome interior

First mock-up of the CBM STS module based on a new assembly concept

A molecular dynamics model has been developed to investigate the effect of the crystallographic orientation on the material deformation behaviors in nano- indentation/scratching of BCC iron. Two cases with different substrate orientations have been simulated. The orientations along x, y and z direction are [001], [100] and [010] for Case I and [111], [-1-12] and [1-10] for Case II, respectively. Case I and Case II exhibit different deformation patterns in the substrate. During indentation, the pile-up can be observed in Case I, but not in Case II. During scratching the pile-up ahead of the movement of the indenter has been enlarged in Case I, while a chip with the disordered atoms is generated in Case II. It has been found that Case I has both higher hardness and larger coefficient of friction. The ratios of the hardness and the coefficient of friction between cases I and II are nearly 2. The reason is attributed to the different crystallographic orientations used in both cases

К вопросу использования «полезных» задач для обеспечения работой блокчейн систем

This paper is a logical continuation of the paper about possible approaches to solving the “Useful Proof-of-work for blockchains” problem. We suggest some alternative ways for searching useful tasks for Proof-of-work systems. These ways are based on the process of the multiple and independent repetition of a simple experiment. The experiment is to chose an element independently and uniformly from a quite large set and then to check if the chosen element has a specific rare property. In the classic blockchain of Bitcoin this experiment is a so-called hash-puzzle. In these terms the process of solving a hash-puzzle may be replaced by searching rare astronomical objects or Go positions with specific conditions. Moreover, we describe a possible attack on the blockchain systems in which the task instance generation algorithm is replaced by the algorithm of selecting the task instance from the existing database with public access for publication of task instances and discuss the way of protection.Статья является продолжением работы о возможных подходах к решению задачи «UsefulProof-of-workforblockchains». Мы предлагаем некоторые альтернативные направления поиска полезных задач для обеспечения работой, основанные на том, что процесс решения хеш-головоломки близок к многократному независимому повторению следующего эксперимента: пусть задано достаточно большое по мощности множество (например, состоящее из 2" элементов, для достаточно большого п), только незначительная часть элементов которого обладает определенным свойством. Эксперимент состоит в равномерном выборе элемента из этого множества с последующей проверкой наличия у него указанного свойства. Таким образом, процесс решения хеш-головоломки может быть заменен, например, поиском редких астрономических объектов или поиском позиций игры Го, удовлетворяющих определенным условиям. Кроме того, мы описываем возможную атаку на блокчейн-систему, в которой алгоритм генерации индивидуальных представителей задач для обеспечения работой заменен алгоритмом выбора индивидуальных представителей из имеющейся базы данных, со стороны недобросовестных поставщиков индивидуальных представителей задач, в случае их публичного сбора, и обсуждаем некоторые способы защиты от этой атаки

Multi-Jet Event Rates in Deep Inelastic Scattering and Determination of the Strong Coupling Constant

Jet event rates in deep inelastic ep scattering at HERA are investigated applying the modified JADE jet algorithm. The analysis uses data taken with the H1 detector in 1994 and 1995. The data are corrected for detector and hadronization effects and then compared with perturbative QCD predictions using next-to-leading order calculations. The strong coupling constant alpha_S(M_Z^2) is determined evaluating the jet event rates. Values of alpha_S(Q^2) are extracted in four different bins of the negative squared momentum transfer~\qq in the range from 40 GeV2 to 4000 GeV2. A combined fit of the renormalization group equation to these several alpha_S(Q^2) values results in alpha_S(M_Z^2) = 0.117+-0.003(stat)+0.009-0.013(syst)+0.006(jet algorithm).Comment: 17 pages, 4 figures, 3 tables, this version to appear in Eur. Phys. J.; it replaces first posted hep-ex/9807019 which had incorrect figure 4

Concomitant homozygosity for the prothrombin gene variant with mild deficiency of antithrombin III in a patient with multiple hepatic infarctions: a case report

<p>Abstract</p> <p>Introduction</p> <p>Hereditary causes of visceral thrombosis or thrombosis should be sought among young patients. We present a case of a young man presenting with multiple hepatic infarctions resulting in portal hypertension due to homozygosity of the prothrombin gene mutation not previously described in literature.</p> <p>Case presentation</p> <p>A 42-year-old Caucasian man with a previous history of idiopathic deep vein thrombosis 11 years earlier presented with vague abdominal pains and mildly abnormal liver function tests. An ultrasound and computed tomography scan showed evidence of hepatic infarction and portal hypertension (splenic varices). A thrombophilia screen confirmed a homozygous mutation for the prothrombin gene mutation, with mildly reduced levels of anti-thrombin III (AT III). Subsequent testing of his father and brother revealed heterozygosity for the same gene mutation.</p> <p>Conclusion</p> <p>Hepatic infarction is unusual due to the rich dual arterial and venous blood supply to the liver. In the absence of an arterial or haemodynamic insult causing hepatic infarction, a thrombophilia should be considered. To our knowledge, this is the first reported case of a hepatic infarction due to homozygosity of the prothrombin gene mutation. It is unclear whether homozygotes have a higher risk of thrombosis than heterozygotes. In someone presenting with a first thrombosis with this mutation, the case for life-long anticoagulation is unclear, but it may be necessary to prevent a second and more severe second thrombotic event, as occurred in this case.</p

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13