Alien Registration- Murchison, Clayton (Presque Isle, Aroostook County)

https://digitalmaine.com/alien_docs/33677/thumbnail.jp

Noradrenergic Control of Gene Expression and Long-Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds

Norepinephrine (NE) is thought to play important roles in the consolidation and retrieval of long-term memories, but its role in the processing and memorization of complex acoustic signals used for vocal communication has yet to be determined. We have used a combination of gene expression analysis, electrophysiological recordings and pharmacological manipulations in zebra finches to examine the role of noradrenergic transmission in the brain’s response to birdsong, a learned vocal behavior that shares important features with human speech. We show that noradrenergic transmission is required for both the expression of activity-dependent genes and the long-term maintenance of stimulus-specific electrophysiological adaptation that are induced in central auditory neurons by stimulation with birdsong. Specifically, we show that the caudomedial nidopallium (NCM), an area directly involved in the auditory processing and memorization of birdsong, receives strong noradrenergic innervation. Song-responsive neurons in this area express α-adrenergic receptors and are in close proximity to noradrenergic terminals. We further show that local α-adrenergic antagonism interferes with song-induced gene expression, without affecting spontaneous or evoked electrophysiological activity, thus dissociating the molecular and electrophysiological responses to song. Moreover, α-adrenergic antagonism disrupts the maintenance but not the acquisition of the adapted physiological state. We suggest that the noradrenergic system regulates long-term changes in song-responsive neurons by modulating the gene expression response that is associated with the electrophysiological activation triggered by song. We also suggest that this mechanism may be an important contributor to long-term auditory memories of learned vocalizations

Pliocene sand injectites from a submarine lobe fringe during hydrocarbon migration and salt diapirism: a seismic example from the Lower Congo Basin

International audienceLarge-scale conical and saucer-shaped sand injectites have been identified in the Upper Miocene sediments of the Lower Congo Basin. These structures are evidenced on the 3D high-resolution seismic data at about 600 ms TWT (two-way traveltime) beneath the seabed. The conical and saucer-shaped anomalies range from 20 to 80 m in height, 50 to 300 m in diameter, and 10 to 20 ms TWT in thickness. They are located within a sedimentary interval of about 100 m in thickness and are aligned over 20 km in dip direction (NE-SW), above the NW margin of an underlying Upper Miocene submarine fan. We have interpreted the conical and saucer-shaped anomalies as upward-emplaced sand injectites sourced from the Upper Miocene fan because of their discordant character, the postsedimentary uplifting of the sediments overlying the cones and saucer-shaped bodies, the alignment with the lateral fringe of the Upper Miocene submarine fan, and the geological context. Sand injection dates from the Miocene-Pliocene transition (approximately 5.3 Ma). The prerequisite overpressure to the sand injection process may be due to the buoyancy effect of hydrocarbons accumulated in the margins of the fan. Additionally, overpressure could have been enhanced by the lateral transfer of fluids operating in the inclined margins of the lobe. The short duration of sand injection and the presence of many sandstone intrusions suggested that the process of injection was triggered by an event, likely due to a nearby fault displacement related to diapiric movements. This is the first time that sand injectites of seismic scale have been described from the Lower Congo Basin. The localized nature of these injectites has led to a change in the migration path of fluids through the sedimentary cover. Consequently, the sand intrusions are both evidence and vectors of fluid migration within the basin fill