A revision of African Psammoecus (Coleoptera, Silvanidae) and descriptions of two new species from the collection of the Musée royal de l’Afrique centrale

A revision of the known African species of Psammoecus is given, including redescriptions and illustrations of diagnostic characters. Extensive material from the Musée royal de l’Afrique centrale (Tervuren) is studied. Two new species are described: Psammoecus leleupi sp. nov., and Ps. luchti sp. nov. Four specific names are synonymized: Psammoecus excellens Grouvelle, 1908 = Ps. trimaculatus Motschulsky, 1858; Ps. alluaudi Grouvelle, 1912 = Ps. trimaculatus Motschulsky, 1858; Ps. longulus Grouvelle, 1878 = Ps. longicornis Schaufuss, 1872; Ps. nitescens Grouvelle, 1914 = Ps. laetulus Grouvelle, 1914. A key to the African species is provided

Family networks and household outcomes in an economic crisis

Thesis (Ph.D.)--Boston UniversityThis thesis theoretically and empirically analyzes the nature and consequences of interactions between family members. The first chapter tests whether children's human capital accumulation was significantly affected by earnings shocks to their nonresident kin in the context of the 1997-8 financial crisis in Indonesia. The crisis produced sudden, heterogeneous shocks that facilitate the construction of an exogenous measure of earnings changes. Results indicate that earnings shocks to nonresident kin - including extended family and relatives living in other districts- significantly affected children's human capital accumulation between 1997 and 2000, and ultimate educational attainment measured nearly a decade after the crisis hit. Supplementary results point to intra-family transfers, underpinned by ex post altruism, as an important channel of causation. The second chapter develops a theoretical model of private transfers underpinned by ex post altruism among members of a network. I use this model to analyze equilibrium transfer patterns and inequality under alternative income distributions and network structures. I demonstrate the general intuition that transfers obtain in equilibrium when the amount of altruism is sufficiently strong relative to income inequality. Within the networks that I analyze, every equilibrium involving transfers takes the same form: unique income thresholds separate senders from receivers. Effective risk sharing takes place among senders and receivers, while those at intermediate incomes remain in autarky. Every equilibrium gives rise to the same set of allocations. I contrast these predictions with insurance-based theories of transfers in which risk sharing is operative for small in come differences and may fall apart at large income differences. The third chapter uses longitudinal data spanning nearly fifteen years to test whether transfers among family members within Indonesia are consistent with ex post altruism, against the alternative of insurance. I use the predicted effects of permanent versus transitory income on transfers, as well as theoretical predictions from the second chapter regarding the shape of transfer functions , to carry out this test. The results provide some evidence that transfer motives are inconsistent with insurance but consistent with ex post altruism

Irrational Numbers of Constant Type --- A New Characterization

We obtain a new characterization for irrational numbers of constant type -- defined as irrationals with bounded partial quotients in their continued fraction expansion. The result is essential in the formulation of stability criteria for orbits of quantum twist maps in a class of dynamical systems.Comment: 7 pages, AMS-LaTeX, with changes in reference

The effect of adding inhaled corticosteroids to tiotropium and long-acting beta(2)-agonists for chronic obstructive pulmonary disease (Review)

BackgroundLong-acting bronchodilators comprising long-acting beta(2)-agonists and the anticholinergic agent tiotropiumare commonly used, either on their own or in combination, for managing persistent symptoms of chronic obstructive pulmonary disease. Patients with severe chronic obstructive pulmonary disease who are symptomatic and who suffer repeated exacerbations are recommended to add inhaled corticosteroids to their bronchodilator treatment. However, the benefits and risks of adding inhaled corticosteroid to tiotropium and long-acting beta2-agonists for the treatment of chronic obstructive pulmonary disease are unclear.ObjectivesTo assess the relative effects of adding inhaled corticosteroids to tiotropium and long-acting beta2-agonists treatment in patients with chronic obstructive pulmonary disease.Search strategyWe searched the Cochrane Airways Group Specialised Register of trials (February 2011) and reference lists of articles.Selection criteriaWe included parallel group, randomised controlled trials of three months or longer comparing inhaled corticosteroid and long-acting beta(2)-agonist combination therapy in addition to inhaled tiotropium against tiotropium and long-acting beta2-agonist treatment for patients with chronic obstructive pulmonary disease (COPD).Data collection and analysisTwo review authors independently assessed trials for inclusion and then extracted data on trial quality and the outcome results. We contacted study authors for additional information. We collected information on adverse effects from the trials.Main resultsOne trial (293 patients) was identified comparing tiotropium in addition to inhaled corticosteroid and long-acting beta(2)-agonist combination therapy to tiotropium plus long-acting beta2-agonist. The study was of good methodological quality, however it suffered from high and uneven withdrawal rates between the treatment arms. There is currently insufficient evidence to know how much difference the addition of inhaled corticosteroids makes to people who are taking tiotropium and a long-acting beta(2)-agonist for COPD.Authors' conclusionsThe relative efficacy and safety of adding inhaled corticosteroid to tiotropium and a long-acting beta(2)-agonist for chronic obstructive pulmonary disease patients remains uncertain and additional trials are required to answer this question

Methods for Classifying Nonprofit Organizations According to their Field of Activity: A Report on Semi-automated Methods Based on Text

There are various methods for classifying nonprofit organizations (NPOs) according to their field of activity. We report our experiences using two semi-automated methods based on textual data: rule-based classification and machine learning with curated keywords. We use those methods to classify Austrian nonprofit organizations based on the International Classification of Nonprofit Organizations. Those methods can provide a solution to the widespread research problem that quantitative data on the activities of NPOs are needed but not readily available from administrative data, long high-quality texts describing NPOs' activities are mostly unavailable, and human labor resources are limited. We find that in such a setting, rule-based classification performs about as well as manual human coding in terms of precision and sensitivity, while being much more labor-saving. Hence, we share our insights on how to efficiently implement such a rule-based approach. To address scholars with a background in data analytics as well as those without, we provide non-technical explanations and open-source sample code that is free to use and adapt

Bmp induces osteoblast differentiation through both Smad4 and mTORC1 signaling

The bone morphogenetic protein (Bmp) family of secreted molecules has been extensively studied in the context of osteoblast differentiation. However, the intracellular signaling cascades that mediate the osteoblastogenic function of Bmp have not been fully elucidated. By profiling mRNA expression in the bone marrow mesenchymal progenitor cell line ST2, we discover that BMP2 induces not only genes commonly associated with ossification and mineralization but also genes important for general protein synthesis. We define the two groups of genes as mineralization related versus protein anabolism signatures of osteoblasts. Although it induces the expression of several Wnt genes, BMP2 activates the osteogenic program largely independently of de novo Wnt secretion. Remarkably, although Smad4 is necessary for the activation of the mineralization-related genes, it is dispensable for BMP2 to induce the protein anabolism signature, which instead critically depends on the transcription factor Atf4. Upstream of Atf4, BMP2 activates mTORC1 to stimulate protein synthesis, resulting in an endoplasmic reticulum stress response mediated by Perk. Thus, Bmp signaling induces osteoblast differentiation through both Smad4- and mTORC1-dependent mechanisms

Combination formoterol and budesonide as maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in adults and children.

BACKGROUND: Asthma is characterised by chronic inflammation of the airways and recurrent exacerbations with wheezing, chest tightness and cough. Treatment with inhaled steroids and bronchodilators often results in good control of symptoms, prevention of further morbidity and mortality and improved quality of life. Several steroids and beta2-agonists (long- and short-acting) as well as combinations of these treatments are available in a single inhaler to be used once or twice a day, with a separate inhaler for relief of symptoms when needed (for patients in Step three or higher, according to Global Initiative for Asthma (GINA) guidelines). Budesonide/formoterol is also licenced for use as maintenance and reliever therapy from a single inhaler (SiT; sometimes referred to as SMART therapy). SiT can be prescribed at a lower dose than other combination therapy because of the additional steroid doses being received as reliever therapy. It has been suggested that using SiT improves compliance and hence reduces symptoms and exacerbations, but it is unclear whether it increases side effects associated with the use of inhaled steroids. OBJECTIVES: To assess the efficacy and safety of budesonide/formoterol in a single inhaler (SiT) to be used for both maintenance and reliever therapy in asthma in comparison with maintenance treatment provided through combination inhalers with a higher maintenance steroid dose (either fluticasone/salmeterol or budesonide/formoterol), along with additional fast-acting beta2-agonists for relief of symptoms. SEARCH METHODS: We searched the Cochrane Airways Group Specialised Register of trials, online trial registries and drug company websites. The most recent search was conducted in November 2013. SELECTION CRITERIA: We included parallel-group, randomised controlled trials of at least 12 weeks' duration. Studies were included if they compared single-inhaler therapy with budesonide/formoterol (SiT) versus combination inhalers at a higher maintenance dose of steroids than was given in the SiT arm (either salmeterol/fluticasone or budesonide/formoterol). DATA COLLECTION AND ANALYSIS: We used standard methods expected by The Cochrane Collaboration. Primary outcomes were exacerbations requiring hospitalisation, exacerbations requiring oral corticosteroids and serious adverse events (including mortality). MAIN RESULTS: Four studies randomly assigning 9130 people with asthma were included; two were six-month double-blind studies, and two were 12-month open-label studies. No trials included children younger than age 12. Trials included more women than men, with mean age ranging from 38 to 45, and mean baseline steroid dose (inhaled beclomethasone (BDP) equivalent) from 636 to 888 μg. Mean baseline forced expiratory volume in one second (FEV1) percentage predicted was between 70% and 73% in three of the trials, and 96% in another. All studies were funded by AstraZeneca and were generally free from methodological biases, although the two open-label studies were rated as having high risk for blinding, and some evidence of selective outcome reporting was found. These possible sources of bias did not lead us to downgrade the quality of the evidence. The quantity of inhaled steroids, including puffs taken for relief from symptoms, was consistently lower for SiT than for the comparison groups.Separate data for exacerbations leading to hospitalisations, to emergency room (ER) visits or to a course of oral steroids could not be obtained. Compared with higher fixed-dose combination inhalers, fewer people using SiT had exacerbations requiring hospitalisation or a visit to the ER (odds ratio (OR) 0.72, 95% confidence interval (CI) 0.57 to 0.90; I(2) = 0%, P = 0.66), and fewer had exacerbations requiring a course of oral corticosteroids (OR 0.75, 95% CI 0.65 to 0.87; I(2) = 0%, P = 0.82). This translates to one less person admitted to hospital or visiting the ER (95% CI 0 to 2 fewer) and two fewer people needing oral steroids (95% CI 1 to 3 fewer) compared with fixed-dose combination treatment with a short-acting beta-agonist (SABA) reliever (per 100 treated over eight months). No statistical heterogeneity was observed in either outcome, and the evidence was rated of high quality. Although issues with blinding were evident in two of the studies, and one study recruited a less severe population, sensitivity analyses did not change the main results, so quality was not downgraded.We could not rule out the possibility that SiT increased rates of serious adverse events (OR 0.92, 95% CI 0.74 to 1.13; I(2) = 0%, P = 0.98; moderate-quality evidence, downgraded owing to imprecision).We were unable to say whether SiT improved results for several secondary outcomes (morning and evening peak expiratory flow (PEF), rescue medication use, symptoms scales), and in cases where results were significant, the effect sizes were not considered clinically meaningful (predose FEV1, nocturnal awakenings and quality of life). AUTHORS' CONCLUSIONS: SiT reduces the number of people having asthma exacerbations requiring oral steroids and the number requiring hospitalisation or an ER visit compared with fixed-dose combination inhalers. Evidence for serious adverse events was unclear. The mean daily dose of inhaled corticosteroids (ICS) in SiT, including the total dose administered with reliever use, was always lower than that of the other combination groups. This suggests that the flexibility in steroid administration that is possible with SiT might be more effective than a standard fixed-dose combination by increasing the dose only when needed and keeping it low during stable stages of the disease. Data for hospitalisations alone could not be obtained, and no studies have yet addressed this question in children younger than age 12

Signs of the nation: resisting globalization?

A cross large parts of Europe, and beyond, we are currently witnessing a curious phenomenon of what may be most succinctly described as a semio-tic merging of hitherto arguably separate social domains: those of consumer capitalism, on one hand, and of various symbolisms of national identity, history and (self-)ascription on the other. Prominent manifestations of this include what has come to be called " nation branding " (Dinnie 2007). This is the phenomenon of nation-states now concerning themselves particularly with their economic image and employing brand consultants, to measure and rank the associations their " people, products, governments, culture, education, tourist attractions, and lifestyle " trigger internationally (http://www.simonanholt.com), to ascertain possible business benefi ts. In its unapologetically instrumentalist register with singularly economic undertones this is a marked departure from nation-states' well-known but much older preoccupation with their " world position " (Spillman 1997), or wider standing in the international order, that was formerly tied to geo-political importance, historical image and derived symbolic status. Yet more poignantly, we are now surrounded by national fl ags not just in their " traditional " spaces (e.g. fl ag posts, international borders, offi cial documents and buildings) but we see them being " worn " and " carried " as markers – of exactly what I will attempt to illuminate in this paper – on t-shirts, bags and consumer items of many other kinds. These, and this is my starting assumption, are evocations of the nation qualitatively different from, for example, an oath of allegiance being sworn or a national anthem being sung, as the latter are largely non-commodifi ed cultural-political practices. What, then, is this apparent blurring of the world of commodities and the domain of national symbolism all about, how might we read it, and which theoretical and methodological tools might help us in the process? In what follows, I discuss these questions by drawing on a series of discursive-visual " snapshots " from various European contexts, while focusing on the theoretical work demanded by this curious blurring of " the national " and " the bought and sold "