Exploring factors affecting math achievement using large scale assessment results in Saskatchewan

Current research suggests that a high level of confidence and a low level of anxiety are predictive of higher math achievement. Compared to students from other provinces, previous research has found that Saskatchewan students have a higher level of confidence and a lower level of anxiety for learning math, but still tend to achieve lower math scores compared to students in other provinces. The data suggest that there may be unique factors effecting math learning for students in Saskatchewan. The purpose of the study is to determine the factors that may affect Saskatchewan students’ math achievement. Exploratory factor analyses and regression methods were employed to investigate possible traits that aid students in achieving higher math scores. Results from a 2007 math assessment administered to grade 5 students in Saskatchewan were used for the current study. The goal of the study was to provide a better understanding of the factors and trends unique to students for mathematic achievements in Saskatchewan. Using results from a province-wide math assessment and an accompanying questionnaire administered to students in grade five across public school in Saskatchewan (n=11,279), the present study found statistical significance in three factors that have been supported by previous studies to influence math achievement differences, specifically in (1) confidence in math, (2) parental involvement in math and (3) extracurricular participation in math. The three aforementioned factors were found to be related to math achievement as predicted by the Assessment for Learning (AFL) program in Saskatchewan, although there were reservations to the findings due to a weak amount of variances accounted for in the regression model (r2 =.084). Furthermore, a multivariate analysis of variance indicated gender and locations of schools to have effects on students’ math achievement scores. Although a high amount of measurement errors in the questionnaire (and subsequently a low variance accounted for by the regression model) limited the scope and implications of the model, future implications and improvements are discusse

Teacher Induction: Exploring Beginning Teacher Mentorship

Induction programs, including mentorship, serve to bridge the transition from pre‐ service to in‐service teaching. This study explored the mentorship experiences of Saskatchewan beginning teachers. Analysis of interviews identified three themes: assigned/unassigned mentors, engaged/disengaged mentors, and single/multiple mentors. One moderating theme also emerged: the compatibility of the mentor and beginning teacher. The combination of themes provides preliminary support for an alternative model of mentoring based on learning communities and founded on the concepts of strong and weak ties and the constructivist model of knowledge. Key Words: theoretical model, mentor relationship, multiple mentors, learning com‐ munities Les programmes d’insertion professionnelle, dont les programmes de mentorat, ser‐ vent à faciliter la transition entre la formation initiale à l’enseignement et la prati‐ qued’enseignement. Cette recherche porte sur les expériences de nouveaux ensei‐ gnants en Saskatchewan. L’analyse des entrevues effectuées a permis d’identifier trois thèmes : mentors attitrés/non attitrés, mentors actifs/peu impliqués et mentor unique/mentors multiples. Un autre thème entre également en ligne de compte : la compatibilité entre le mentor et le nouvel enseignant. La combinaison de ces thèmes fournit un cadre préliminaire pour un nouveau modèle de mentorat axé sur des communautés d’apprentissage et fondé sur les concepts de liens étroits et faibles et le modèle constructiviste du savoir. Mots clés : modèle théorique, relation au mentor, mentors multiples, communautés d’apprentissage

Reactivating Fetal Hemoglobin Expression in Human Adult Erythroblasts Through BCL11A Knockdown Using Targeted Endonucleases.

We examined the efficiency, specificity, and mutational signatures of zinc finger nucleases (ZFNs), transcriptional activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 systems designed to target the gene encoding the transcriptional repressor BCL11A, in human K562 cells and human CD34+ progenitor cells. ZFNs and TALENs were delivered as in vitro transcribed mRNA through electroporation; CRISPR/Cas9 was codelivered by Cas9 mRNA with plasmid-encoded guideRNA (gRNA) (pU6.g1) or in vitro transcribed gRNA (gR.1). Analyses of efficacy revealed that for these specific reagents and the delivery methods used, the ZFNs gave rise to more allelic disruption in the targeted locus compared to the TALENs and CRISPR/Cas9, which was associated with increased levels of fetal hemoglobin in erythroid cells produced in vitro from nuclease-treated CD34+ cells. Genome-wide analysis to evaluate the specificity of the nucleases revealed high specificity of this specific ZFN to the target site, while specific TALENs and CRISPRs evaluated showed off-target cleavage activity. ZFN gene-edited CD34+ cells had the capacity to engraft in NOD-PrkdcSCID-IL2Rγnull mice, while retaining multi-lineage potential, in contrast to TALEN gene-edited CD34+ cells. CRISPR engraftment levels mirrored the increased relative plasmid-mediated toxicity of pU6.g1/Cas9 in hematopoietic stem/progenitor cells (HSPCs), highlighting the value for the further improvements of CRISPR/Cas9 delivery in primary human HSPCs

The structure of molecular clumps around high-mass young stellar objects

We have used the IRAM 30-m and FCRAO 14-m telescopes to observe the molecular clumps associated with 12 ultracompact (UC) HII regions in the J=6-5, 8-7 and 13-12 rotational transitions of methyl-acetylene (CH3C2H). Under the assumption of LTE and optically thin emission, we have derived temperature estimates ranging from 30 to 56 K. We estimate that the clumps have diameters of 0.2-1.6 pc, H_2 densities of 10^5-10^6 {cm^{-3}}, and masses of 10^2-2 10^4 M_\odot. We compare these values with those obtained by other authors from different molecular tracers and find that the H_2 density and the temperature inside the clumps vary respectively like n_{H_2} ~ R^{-2.6} and T ~ R^{-0.5}, with R distance from the centre. We also find that the virial masses of the clumps are ~3 times less than those derived from the CH3C2H column densities: we show that a plausible explanation is that magnetic fields play an important role to stabilise the clumps, which are on the verge of gravitational collapse. Finally, we show that the CH3C2H line width increases for decreasing distance from the clump centre: this effect is consistent with infall in the inner regions of the clumps. We conclude that the clumps around UC HII regions are likely to be transient (~10^(5) yr) entities, remnants of isothermal spheres currently undergoing gravitational collapse: the high mass accretion rates (~10^{-2} M_\odot yr^{-1}) lead to massive star formation at the centre of such clumps.Comment: 15 pages, 11 figures, A & A in pres

On the formation of glycolaldehyde in dense molecular cores

Glycolaldehyde is a simple monosaccharide sugar linked to prebiotic chemistry. Recently, it was detected in a molecular core in the star-forming region G31.41+0.31 at a reasonably high abundance. We investigate the formation of glycolaldehyde at 10 K to determine whether it can form efficiently under typical dense core conditions. Using an astrochemical model, we test five different reaction mechanisms that have been proposed in the astrophysical literature, finding that a gas-phase formation route is unlikely. Of the grain-surface formation routes, only two are efficient enough at very low temperatures to produce sufficient glycolaldehyde to match the observational estimates, with the mechanism culminating in CH3OH + HCO being favored. However, when we consider the feasibility of these mechanisms from a reaction chemistry perspective, the second grain-surface route looks more promising, H3CO + HCO

Analytical bias in the measurement of serum 25-hydroxyvitamin D concentrations impairs assessment of vitamin D status in clinical and research settings

Measured serum 25-hydroxyvitamin D concentrations vary depending on the type of assay used and the specific laboratory undertaking the analysis, impairing the accurate assessment of vitamin D status. We investigated differences in serum 25-hydroxyvitamin D concentrations measured at three laboratories (laboratories A and B using an assay based on liquid chromatography-tandem mass spectrometry and laboratory C using a DiaSorin Liaison assay), against a laboratory using an assay based on liquid chromatography-tandem mass spectrometry that is certified to the standard reference method developed by the National Institute of Standards and Technology and Ghent University (referred to as the ‘ certified laboratory ’ ). Separate aliquots from the same original serum sample for a subset of 50 participants from the Ausimmune Study were analysed at the four laboratories. Bland-Altman plots were used to visually check agreement between each laboratory against the certified laboratory. Compared with the certified laboratory, serum 25-hydroxyvitamin D concentrations were on average 12.4 nmol/L higher at laboratory A (95% limits of agreement: -17 .8,42.6); 12.8 nmol/L higher at laboratory B (95% limits of agreement: 0.8,24.8); and 10.6 nmol/L lower at laboratory C (95% limits of agreement: -48.4,27.1). The prevalence of vitamin D deficiency (defined here as 25-hydroxyvitamin D < 50 nmol/L) was 24%, 16%, 12% and 41% at the certified laboratory, and laboratories A, B, and C, respectively. Our results demonstrate considerable differences in the measurement of 25-hydroxyvitamin D concentrations compared with a certified laboratory, even between laboratories using assays based on liquid chromatography-tandem mass spectrometry, which is often considered the gold-standard assay. To ensure accurate and reliable measurement of serum 25-hydroxyvitamin D concentrations, all laboratories should use an accuracy-based quality assurance system and, ideally, comply with international standardisation effort

Interventions for treating depression after stroke

Background: Depression is an important consequence of stroke that impacts on recovery yet is often not detected or inadequately treated. This is an update of a Cochrane review first published in 2004. Objectives: To determine whether pharmaceutical, psychological, or electroconvulsive treatment (ECT) of depression in patients with stroke can improve outcome. Search strategy: We searched the trials registers of the Cochrane Stroke Group (last searched October 2007) and the Cochrane Depression Anxiety and Neurosis Group (last searched February 2008). In addition, we searched the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 1, 2008), MEDLINE (1966 to May 2006), EMBASE (1980 to May 2006), CINAHL (1982 to May 2006), PsycINFO (1967 to May 2006) and other databases. We also searched reference lists, clinical trials registers, conference proceedings and dissertation abstracts, and contacted authors, researchers and pharmaceutical companies. Selection criteria: Randomised controlled trials comparing pharmaceutical agents with placebo, or various forms of psychotherapy or ECT with standard care (or attention control), in patients with stroke, with the intention of treating depression. Data collection and analysis: Two review authors selected trials for inclusion and assessed methodological quality; three review authors extracted, cross-checked and entered data. Primary analyses were the prevalence of diagnosable depressive disorder at the end of treatment. Secondary outcomes included depression scores on standard scales, physical function, death, recurrent stroke and adverse effects. Main results: Sixteen trials (17 interventions), with 1655 participants, were included in the review. Data were available for 13 pharmaceutical agents, and four trials of psychotherapy. There were no trials of ECT. The analyses were complicated by the lack of standardised diagnostic and outcome criteria, and differing analytic methods. There was some evidence of benefit of pharmacotherapy in terms of a complete remission of depression and a reduction (improvement) in scores on depression rating scales, but there was also evidence of an associated increase in adverse events. There was no evidence of benefit of psychotherapy. Authors' conclusions: A small but significant effect of pharmacotherapy (not psychotherapy) on treating depression and reducing depressive symptoms was found, as was a significant increase in adverse events. More research is required before recommendations can be made about the routine use of such treatments

Once-weekly oral medication with alendronate does not prevent migration of knee prostheses: A double-blind randomized RSA study

Background and purpose Early migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement

J/psi suppression at forward rapidity in Au+Au collisions at sqrt(s_NN)=39 and 62.4 GeV

We present measurements of the J/psi invariant yields in sqrt(s_NN)=39 and 62.4 GeV Au+Au collisions at forward rapidity (1.2<|y|<2.2). Invariant yields are presented as a function of both collision centrality and transverse momentum. Nuclear modifications are obtained for central relative to peripheral Au+Au collisions (R_CP) and for various centrality selections in Au+Au relative to scaled p+p cross sections obtained from other measurements (R_AA). The observed suppression patterns at 39 and 62.4 GeV are quite similar to those previously measured at 200 GeV. This similar suppression presents a challenge to theoretical models that contain various competing mechanisms with different energy dependencies, some of which cause suppression and others enhancement.Comment: 365 authors, 10 pages, 11 figures, 4 tables. Submitted to Phys. Rev. C. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm