成熟膵および膵腫瘍形成においてHes1は状況依存性の役割を果たす

京都大学新制・課程博士博士(医学)甲第24523号医博第4965号新制||医||1065(附属図書館)京都大学大学院医学研究科医学専攻(主査)教授 川口 義弥, 教授 藤田 恭之, 教授 波多野 悦朗学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA

Suggestive evidence on the genetic link between mitochondria dysfunction and autism

An editorial comment to Marui T, Funatogawa I, Koishi S et al. “The NADH-ubiquinone oxidoreductase 1 alpha subcomplex 5 (NDUFA5) gene variants are associated with autism” ( 1 )Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79051/1/j.1600-0447.2010.01654.x.pd

Chaotic vibrations in a regenerative cutting process

We have analyzed vibrations generated in an orthogonal cutting process. Using a simple one degree of freedom model of the regenerative cutting we have observed the complex behaviour of the system. In presence of a shaped cutting surface, the nonlinear interaction between the tool and a worpiece leads to chatter vibrations of periodic, quasi-periodic or chaotic type depending on system parameters. To describe the profile of the surface machined by the first pass we used a harmonic function. We analysed the impact phenomenon between the tool and a workpiece after their contact loss.Comment: 7 pages, 3 figure

Categories of Perception for Vibrato, Flange, and Stereo Chorus

Vibrato, Flange, and Stereo Chorus are perhaps the three most often used digital audio effects that are created by smoothly modulating the duration of a delay line at typically sub-audio rates. Common practice is to use a periodic or quasi-periodic modulation control signal with frequency roughly between 2 and 9 Hz, and both the rate and depth of delay modulation are typically adjusted according to the aesthetic criteria of a performer or by an audio production engineer. In order to establish norms for the musically useful range of modulation rate and depth for such delay-based effects, 25 listeners were asked to make categorical judgments regarding their perception of vibrato, flange, and stereo chorus effects. The results map out for these two modulation parameters three perceptual regions for these three related effects: the region in which modulation is too subtle for effective use, the parameter ranges that seem most musically useful, and the region in which it is too extreme for most musical applications. Of particular interest is the observed commonality between these perceptual regions for vibrato, flange, and stereo chorus effects.Architecture & Allied Art

Erosion of synchronization and its prevention among noisy oscillators with simplicial interactions

Previous studies of oscillator populations with two-simplex interaction report novel phenomena such as discontinuous desynchronization transitions and multistability of synchronized states. However, the noise effect has not been well understood. Here, we find that when oscillators with two-simplex interaction alone are subjected to external noise, synchrony is eroded and eventually completely disappears even when the noise is infinitesimally weak. Nonetheless, synchronized states may persist for extended periods, with the lifetime increasing approximately exponentially with the strength of the two-simplex interaction. Assuming weak noise and using Kramers' rate theory, we derive a closed dynamical equation for the Kuramoto order parameter, by which the exponential dependence is derived. Further, when sufficiently strong one-simplex coupling is additionally introduced, noise erosion is prevented and synchronized states become persistent. The bifurcation analysis of the desynchronized state reveals that as one-simplex coupling increases, the synchronized state appears supercritically or subscritically depending on the strength of two-simplex coupling. Our study uncovers the processes of synchronization and desynchronization of oscillator assemblies in higher-order networks and is expected to provide insight into the design and control principles in such systems