Sight, sound, the chicken and the egg: Audio-visual co-dependency in music

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Amongst the modern day abundance of audio-visual media, where sounds represent everything from the swooping of virtual cameras through 3D spaces to the pressing of buttons and receiving of emails, and conversely where VJs routinely accompany live musical performance with an increasingly sophisticated language of abstract computer animation, the notion of music as a necessarily exclusively aural medium seems somewhat out of place. Psychological theories relating to the cognition of sound, in particular physical schema, accounting for the ubiquity of vertical plane pitch metaphors in most musical cultures, provide evidence of a deep-rooted spatially informed understanding of sound thus providing a common ground for both sound and vision in music. Furthermore, Western Classical composition is rife with examples of visually conceived forms from Bach’s Crab Canon (1747) to Xenakis’ architecturally inspired Metastasis (1954). However, in practice the gap between the listener’s auditory experience and the composer’s visual concept is often insurmountable. Rising to Schaeffer’s call for “Primacy to the ear!” (Schaeffer, 1967, pp. 28-30), acousmatic composers have sought to derive music exclusively from experientially verifiable criteria. However, in its pervasiveness of other musical genres, no doubt aided by technologically and commercially driven domination of the pre-recorded over the live listening experience in the latter half of the twentieth century, such an approach has lead to the neglect of visual aspects in the live performance of much art-music. This research aims to begin to redress this balance through the composition of, largely computer realised, audio-visual works whose conception arises not from a superimposition of one medium upon another, but through the very relations between the media themselves. Utilising modern computers’ ability to synchronise physical and virtual visual events with synthesised sound in real time not only affords composers an invaluable tool for enhancing listener’s perception of formal structures but also implies causal relationships between the sonic and the visual which can provide a base of intuitive understanding on which more complex formal ideas can be built.Sponsored by the Brunel University Isambard Scholarship

User-Defined Gestural Interactions Through Multi-Modal Feedback

Rapid advancements are being made in the field of HCI. However, most commercial designs using these technologies employ limited control schema and privilege interactions borrowed from pre-existing technologies. This paper suggests considering the whole body to create rich environments using coadaptive technologies

Digitally supported assessment

This chapter focuses on digital assessment and feedback practices in distance education. Providing evidence of learning through assessment is at the heart of students’ experience of higher education (HE), whatever their mode of study. Open and distance education-focused institutions have justifiably been proud of their technical innovation, tending to move rapidly to harness available technologies (from post to broadcast media and, most recently, online media) in their mission to enable education for remote, distributed groups of learners. In recent years, distance education courses have, in the main, moved from paper and digital media delivered physically to wholly online delivery, except where the circumstances of target learners preclude reliance on a reliable and fast internet connection. In terms of content, discussion and collaboration, where distance education has forged ahead, campus-based, blended programmes have generally followed. However, in terms of assessment and feedback, distance education has remained somewhat conservative. While most assessment in distance education has taken place online along with content and communication, there has been a tendency to replicate fairly traditional assessment formats using digital tools

Using Interactive Machine Learning to Support Interface Development Through Workshops with Disabled People

We have applied interactive machine learning (IML) to the creation and customisation of gesturally controlled musical interfaces in six workshops with people with learning and physical disabilities. Our observations and discussions with participants demonstrate the utility of IML as a tool for participatory design of accessible interfaces. This work has also led to a better understanding of challenges in end-user training of learning models, of how people develop personalised interaction strategies with different types of pre-trained interfaces, and of how properties of control spaces and input devices influence people’s customisation strategies and engagement with instruments. This work has also uncovered similarities between the musical goals and practices of disabled people and those of expert musicians

Digitally supported assessment

This chapter focuses on digital assessment and feedback practices in distance education. Providing evidence of learning through assessment is at the heart of students’ experience of higher education (HE), whatever their mode of study. Open and distance education-focused institutions have justifiably been proud of their technical innovation, tending to move rapidly to harness available technologies (from post to broadcast media and, most recently, online media) in their mission to enable education for remote, distributed groups of learners. In recent years, distance education courses have, in the main, moved from paper and digital media delivered physically to wholly online delivery, except where the circumstances of target learners preclude reliance on a reliable and fast internet connection. In terms of content, discussion and collaboration, where distance education has forged ahead, campus-based, blended programmes have generally followed. However, in terms of assessment and feedback, distance education has remained somewhat conservative. While most assessment in distance education has taken place online along with content and communication, there has been a tendency to replicate fairly traditional assessment formats using digital tools

Directional excitation of a high-density magnon gas using coherently driven spin waves

Controlling magnon densities in magnetic materials enables driving spin transport in magnonic devices. We demonstrate the creation of large, out-of-equilibrium magnon densities in a thin-film magnetic insulator via microwave excitation of coherent spin waves and subsequent multimagnon scattering. We image both the coherent spin waves and the resulting incoherent magnon gas using scanning-probe magnetometry based on electron spins in diamond. We find that the gas extends unidirectionally over hundreds of micrometers from the excitation stripline. Surprisingly, the gas density far exceeds that expected for a boson system following a Bose-Einstein distribution with a maximum value of the chemical potential. We characterize the momentum distribution of the gas by measuring the nanoscale spatial decay of the magnetic stray fields. Our results show that driving coherent spin waves leads to a strong out-of-equilibrium occupation of the spin-wave band, opening new possibilities for controlling spin transport and magnetic dynamics in target directions.Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Nanocharacterization of Soft Biological Samples in Shear Mode with Quartz Tuning Fork Probes

Quartz tuning forks are extremely good resonators and their use is growing in scanning probe microscopy. Nevertheless, only a few studies on soft biological samples have been reported using these probes. In this work, we present the methodology to develop and use these nanosensors to properly work with biological samples. The working principles, fabrication and experimental setup are presented. The results in the nanocharacterization of different samples in different ambients are presented by using different working modes: amplitude modulation with and without the use of a Phase-Locked Loop (PLL) and frequency modulation. Pseudomonas aeruginosa bacteria are imaged in nitrogen using amplitude modulation. Microcontact printed antibodies are imaged in buffer using amplitude modulation with a PLL. Finally, metastatic cells are imaged in air using frequency modulation

Prior Anticoagulation in Patients with Ischemic Stroke and Atrial Fibrillation.

The aim was to evaluate, in patients with atrial fibrillation (AF) and acute ischemic stroke, the association of prior anticoagulation with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) with stroke severity, utilization of intravenous thrombolysis (IVT), safety of IVT, and 3-month outcomes. This was a cohort study of consecutive patients (2014-2019) on anticoagulation versus those without (controls) with regard to stroke severity, rates of IVT/mechanical thrombectomy, symptomatic intracranial hemorrhage (sICH), and favorable outcome (modified Rankin Scale score 0-2) at 3 months. Of 8,179 patients (mean [SD] age, 79.8 [9.6] years; 49% women), 1,486 (18%) were on VKA treatment, 1,634 (20%) on DOAC treatment at stroke onset, and 5,059 controls. Stroke severity was lower in patients on DOACs (median National Institutes of Health Stroke Scale 4, [interquartile range 2-11]) compared with VKA (6, [2-14]) and controls (7, [3-15], p < 0.001; quantile regression: β -2.1, 95% confidence interval [CI] -2.6 to -1.7). The IVT rate in potentially eligible patients was significantly lower in patients on VKA (156 of 247 [63%]; adjusted odds ratio [aOR] 0.67; 95% CI 0.50-0.90) and particularly in patients on DOACs (69 of 464 [15%]; aOR 0.06; 95% CI 0.05-0.08) compared with controls (1,544 of 2,504 [74%]). sICH after IVT occurred in 3.6% (2.6-4.7%) of controls, 9 of 195 (4.6%; 1.9-9.2%; aOR 0.93; 95% CI 0.46-1.90) patients on VKA and 2 of 65 (3.1%; 0.4-10.8%, aOR 0.56; 95% CI 0.28-1.12) of those on DOACs. After adjustments for prognostic confounders, DOAC pretreatment was associated with a favorable 3-month outcome (aOR 1.24; 1.01-1.51). Prior DOAC therapy in patients with AF was associated with decreased admission stroke severity at onset and a remarkably low rate of IVT. Overall, patients on DOAC might have better functional outcome at 3 months. Further research is needed to overcome potential restrictions for IVT in patients taking DOACs. ANN NEUROL 2021;89:42-53

Effect of Synthetic Dietary Triglycerides: A Novel Research Paradigm for Nutrigenomics

The effect of dietary fats on human health and disease are likely mediated by changes in gene expression. Several transcription factors have been shown to respond to fatty acids, including SREBP-1c, NF-kappaB, RXRs, LXRs, FXR, HNF4alpha, and PPARs. However, it is unclear to what extent these transcription factors play a role in gene regulation by dietary fatty acids in vivo

Performance of the CMS Cathode Strip Chambers with Cosmic Rays

The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device in the CMS endcaps. Their performance has been evaluated using data taken during a cosmic ray run in fall 2008. Measured noise levels are low, with the number of noisy channels well below 1%. Coordinate resolution was measured for all types of chambers, and fall in the range 47 microns to 243 microns. The efficiencies for local charged track triggers, for hit and for segments reconstruction were measured, and are above 99%. The timing resolution per layer is approximately 5 ns