Desarrollo de prototipo funcional de aplicación móvil para el Viceministerio de Transporte, que ayude a los usuarios a localizar recorridos del transporte público urbano de la ciudad de San Miguel

RESUMEN: Este documento, contiene información detallada de cómo se realizó el proyecto de investigación denominado “DESARROLLO DE PROTOTIPO FUNCIONAL DE APLICACIÓN MÓVIL PARA EL VICEMINISTERIO DE TRANSPORTE, QUE AYUDE A LOS USUARIOS A LOCALIZAR RECORRIDOS DEL TRANSPORTE PÚBLICO URBANO DE LA CIUDAD DE SAN MIGUEL” como trabajo de grado para optar al título de Ingeniero de Sistemas Informáticos. Dicha investigación surge a raíz de la necesidad que se tiene en la ciudad de san miguel, de no tener información detallada de las rutas de transporte público urbano de dicha ciudad, al igual que los recorridos que estas hacen, y las paradas autorizadas de dicha ciudad. Esta investigación se realizó con la gestión y colaboración del Viceministerio de Transporte. Es por ello que se desarrolló un sistema administrador en el cual se realizan todas las gestiones de rutas de transporte, recorridos de las rutas de transporte y las paradas autorizadas por el Viceministerio de Transporte. Y principalmente se desarrolló la aplicación móvil la cual pretende dar la solución a dicha problemática. ABSTRACT: This document contains detailed information on how the research project called “DEVELOPMENT OF A FUNCTIONAL PROTOTYPE OF MOBILE APPLICATION FOR THE VICEMINISTRY OF TRANSPORTATION, THAT HELP USERS TO LOCATE PUBLIC URBAN TRANSPORT ROUTES IN THE CITY OF SAN MIGUEL” as a degree project to qualify for the title of Computer Systems Engineer. This investigation arises as a result of the need in the city of San Miguel, not to have detailed information on the urban public transport routes of said city, as well as the routes they make, and the authorized stops of said city. This research was carried out with the management and collaboration of the Vice Ministry of Transport. For this reason, an administrative system was developed in which all the management of transport routes, routes of transport routes and stops authorized by the Vice Ministry of Transport are carried out. And mainly the mobile application was developed which aims to provide the solution to this proble

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Revista Temas Agrarios Volumen 26; Suplemento 1 de 2021

1st International and 2nd National Symposium of Agronomic Sciences: The rebirth of the scientific discussion space for the Colombian Agro.1 Simposio Intenacional y 2 Nacional de Ciencias Agronómicas: El renacer del espacio de discusión científica para el Agro colombiano