942 research outputs found
Analysis of the NGXO Telescope X-Ray Hartmann Data
Next Generation X-Ray Optics (NGXO) team at the Goddard Space Flight Center (GSFC) has been developing a new silicon-based grazing incidence mirror technology for future high resolution x-ray astronomical missions. Recently, the GSFC team completed the construction of first few mirror modules that contain one pair of mirrors. One of the mirror pairs was tested in GSFC 600-m long beamline facility and Panter (Neuried, Germay) 120-m long x-ray beamline facility. Both full aperture x-ray tests, Hartmann tests, and focal plane sweeps were completed. In this paper we present the data analysis process and compare the results from our models to measured x-ray centroid data, x-ray performance data, and out of focus images of the mirror pair
The imaging properties of the Gas Pixel Detector as a focal plane polarimeter
X-rays are particularly suited to probe the physics of extreme objects.
However, despite the enormous improvements of X-ray Astronomy in imaging,
spectroscopy and timing, polarimetry remains largely unexplored. We propose the
photoelectric polarimeter Gas Pixel Detector (GPD) as an instrument candidate
to fill the gap of more than thirty years of lack of measurements. The GPD, in
the focus of a telescope, will increase the sensitivity of orders of magnitude.
Moreover, since it can measure the energy, the position, the arrival time and
the polarization angle of every single photon, allows to perform polarimetry of
subsets of data singled out from the spectrum, the light curve or the image of
source. The GPD has an intrinsic very fine imaging capability and in this work
we report on the calibration campaign carried out in 2012 at the PANTER X-ray
test facility of the Max-Planck-Institut f\"ur extraterrestrische Physik of
Garching (Germany) in which, for the first time, we coupled it to a JET-X
optics module with a focal length of 3.5 m and an angular resolution of 18
arcsec at 4.5 keV. This configuration was proposed in 2012 aboard the X-ray
Imaging Polarimetry Explorer (XIPE) in response to the ESA call for a small
mission. We derived the imaging and polarimetric performance for extended
sources like Pulsar Wind Nebulae and Supernova Remnants as case studies for the
XIPE configuration, discussing also possible improvements by coupling the
detector with advanced optics, having finer angular resolution and larger
effective area, to study with more details extended objects.Comment: Accepted for publication in The Astrophysical Journal Supplemen
Rank-(n – 1) convexity and quasiconvexity for divergence free fields
The CAST experiment at CERN (European Organization of Nuclear Research)
searches for axions from the sun. The axion is a pseudoscalar particle that was
motivated by theory thirty years ago, with the intention to solve the strong CP
problem. Together with the neutralino, the axion is one of the most promising
dark matter candidates. The CAST experiment has been taking data during the
last two years, setting an upper limit on the coupling of axions to photons
more restrictive than from any other solar axion search in the mass range below
0.1 eV. In 2005 CAST will enter a new experimental phase extending the
sensitivity of the experiment to higher axion masses. The CAST experiment
strongly profits from technology developed for high energy physics and for
X-ray astronomy: A superconducting prototype LHC magnet is used to convert
potential axions to detectable X-rays in the 1-10 keV range via the inverse
Primakoff effect. The most sensitive detector system of CAST is a spin-off from
space technology, a Wolter I type X-ray optics in combination with a prototype
pn-CCD developed for ESA's XMM-Newton mission. As in other rare event searches,
background suppression and a thorough shielding concept is essential to improve
the sensitivity of the experiment to the best possible. In this context CAST
offers the opportunity to study the background of pn-CCDs and its long term
behavior in a terrestrial environment with possible implications for future
space applications. We will present a systematic study of the detector
background of the pn-CCD of CAST based on the data acquired since 2002
including preliminary results of our background simulations.Comment: 11 pages, 8 figures, to appear in Proc. SPIE 5898, UV, X-Ray, and
Gamma-Ray Space Instrumentation for Astronomy XI
First Light Measurements of Capella with the Low Energy Transmission Grating Spectrometer aboard the Chandra X-ray Observatory
We present the first X-ray spectrum obtained by the Low Energy Transmission
Grating Spectrometer (LETGS) aboard the Chandra X-ray Observatory. The spectrum
is of Capella and covers a wavelength range of 5-175 A (2.5-0.07 keV). The
measured wavelength resolution, which is in good agreement with ground
calibration, is 0.06 A (FWHM). Although in-flight
calibration of the LETGS is in progress, the high spectral resolution and
unique wavelength coverage of the LETGS are well demonstrated by the results
from Capella, a coronal source rich in spectral emission lines. While the
primary purpose of this letter is to demonstrate the spectroscopic potential of
the LETGS, we also briefly present some preliminary astrophysical results. We
discuss plasma parameters derived from line ratios in narrow spectral bands,
such as the electron density diagnostics of the He-like triplets of carbon,
nitrogen, and oxygen, as well as resonance scattering of the strong Fe XVII
line at 15.014 A.Comment: 4 pages (ApJ letter LaTeX), 2 PostScript figures, accepted for
publication in ApJ Letters, 200
RNA editing signature during myeloid leukemia cell differentiation
Adenosine deaminases acting on RNA (ADARs) are key proteins for hematopoietic stem cell self-renewal and for survival of differentiating progenitor cells. However, their specific role in myeloid cell maturation has been poorly investigated. Here we show that ADAR1 is present at basal level in the primary myeloid leukemia cells obtained from patients at diagnosis as well as in myeloid U-937 and THP1 cell lines and its expression correlates with the editing levels. Upon phorbol-myristate acetate or Vitamin D3/granulocyte macrophage colony-stimulating factor (GM-CSF)-driven differentiation, both ADAR1 and ADAR2 enzymes are upregulated, with a concomitant global increase of A-to-I RNA editing. ADAR1 silencing caused an editing decrease at specific ADAR1 target genes, without, however, interfering with cell differentiation or with ADAR2 activity. Remarkably, ADAR2 is absent in the undifferentiated cell stage, due to its elimination through the ubiquitin–proteasome pathway, being strongly upregulated at the end of the differentiation process. Of note, peripheral blood monocytes display editing events at the selected targets similar to those found in differentiated cell lines. Taken together, the data indicate that ADAR enzymes play important and distinct roles in myeloid cells
Hypermethylation and loss of retinoic acid receptor responder 1 expression in human choriocarcinoma
Evading innate immunity in nonviral mRNA delivery : don't shoot the messenger
In de field of non-viral gene therapy, in vitro transcribed (IVT) mRNA has emerged as a promising tool for the delivery of genetic information. Over the past few years it has become widely known the introduction of IVT mRNA into mammalian cells elicits an innate immune response which has favored mRNA use towards immunotherapeutic vaccination strategies. However, for non-immunotherapy related applications this intrinsic immune-stimulatory activity directly interferes with the aimed therapeutic outcome, as it can seriously compromise the expression of the desired protein. This review presents an overview of the immune-related obstacles that limit mRNA advance for non-immunotherapy related applications
Исследование пропускной способности между DDR3 памяти и ПЛИС с использованием Soft контроллера для Altera Cyclone V
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