Transcriar a linguagem rosiana para o francês no conto A hora e a vez de Augusto Matraga

Trabalho de conclusão de curso (graduação)—Universidade de Brasília, Instituto de Letras, Departamento de Línguas Estrangeiras e Tradução, Curso de Letras – Tradução – Francês, 2016.“A hora e a vez de Augusto Matraga” é um conto escrito por João Guimarães Rosa e publicado em Sagarana em 1946. O objetivo desse trabalho é, a partir de nossa tradução para o francês, discutir o processo tradutório e a necessidade de uma transcriação frente a um texto criativo. João Guimarães Rosa vê a linguagem como um meio de transformar o mundo e defende a necessidade de renová-la para que conserve sua força. Ele faz, portanto, um uso singular da língua portuguesa, fora das normas da língua padrão. “A hora e a vez de Augusto Matraga” comporta assim inúmeras inovações de linguagem, tanto no nível lexical que gramático-sintático, que devem ser transpostas para outra língua. As teorias apresentadas por Walter Benjamin em “A tarefa do tradutor” e por Haroldo de Campos em Transcriaçãopermitem encontrar um caminho para chegar uma tradução satisfatória. Assim, o trabalho do tradutor consiste em analisar os processos de escrita a fim de poder recri-alos em francês.“A hora e a vez de Augusto Matraga” est un conte écrit par João Guimarães Rosa et publié dans Sagaranaen 1946. L’objectif de ce travail est de, à partir de notre traduction vers le français, discuter le processus de traduction et la necessite d’une transcriation face à un texte criatif. João Guimarães Rosa voit le langage comme um moyen de transformer le monde et défend la necessite de le renouveler pour qu’il conserve sa force. Il fait donc un usage singulier de la langue portugaise, en dehors des normes du langage écrit. “A hora e a vez de Augusto Matraga” comporte ainsi de nombreuses innovations de langage, tant au niveau lexical que grammatico-syntaxique, qui doivent être transposées vers une autre langue.Les théories présentées par Walter Benjamin dans “La tâche du traducteur” et par Haroldo de Campos dans Transcriação permettent de trouver un chemin pour arriver à une traduction satisfaisante. Ainsi, le travail du traducteur consiste à analyser les processus d’écriture de l’auteur afin de pouvoir les recréer en français

Central activation after chronic vagus nerve stimulation in pigs : contribution of functional imaging

Chronic vagus nerve stimulation (VNS), used to treat refractory epilepsy, has the potential to alter food intake in animals and humans. The aim of our study was to evaluate the impact of VNS on the feeding behaviour of pigs used as a human model, and to investigate the origin of its potential effects. Food intake was significantly decreased after five weeks of chronic VNS. This reduction was not due to stimulation of the vagus efferents as neither gastric compliance nor gastric emptying was altered. VNS triggered a reorganisation of brain activation, probably via subcortical structures involved in the reward mechanism. The activation of the olfactory bulb during VNS is probably one of the mechanisms responsible for the drastic changes in food preference in favour of lipids.La stimulation vagale chronique (VNS), une thérapeutique de l'épilepsie pharmacorésistante, serait capable chez l'animal et chez l'homme de modifier le comportement alimentaire. Le but de notre étude était de préciser l'impact de la VNS sur le comportement alimentaire du porc pris comme modèle de l'homme et d'étudier l'origine de ses effets potentiels. La VNS conduit au bout de cinq semaines à une réduction de la quantité d'aliment ingéré. Cette réduction n'est pas la conséquence de la stimulation des efférences vagales, la compliance ou l'évacuation de l'estomac, n'étant pas modifiée. Par contre, la VNS provoque une réorganisation de l'activation cérébrale mettant vraisemblablement en jeu les structures sous-corticales impliquées dans le processus de récompense. L'activation du bulbe olfactif au cours de la VNS est probablement l'un des éléments à l'origine des modifications drastiques des préférences alimentaires en faveur des lipides

ABOUT INDIGENOUS POETRY

Este artigo nasce a partir de possíveis interpretações do poema “Ay Kakuyri Tama (Eu moro na cidade)”, da autora indígena amazonense Márcia Kambeba. Esta pesquisa se coloca como teórica e de cunho bibliográfico. Julgamos que este tema seja relevante para pensar os diferentes tipos de literaturas emergentes na sociedade atual, assim como a literatura indígena. A poesia indígena de Márcia Kambeba nos revela ter um forte aporte na memória, na oralidade, na afirmação da identidade indígena, entre outros pontos, dando voz às mulheres indígenas e reafirmando a importância de seus territórios sociais.This paper was created from possible interpretations of the poem "Ay Kakuyri Tama (I live in the city)", by the indigenous Amazonian author Márcia Kambeba. This research is presented as a theoretical one and of a bibliographical nature. We believe that this theme is relevant to think about the different types of literatures emerging in today's society, as well as indigenous literature. The indigenous poetry of Márcia Kambeba reveals to us a strong dependency on memory and orality, the affirmation of indigenous identity, among other points, giving voice to indigenous women and reaffirming the importance of their social territories

Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system

The bacterial human pathogen Helicobacter pylori produces a type IV secretion system ( cag T4SS) to inject the oncoprotein CagA into gastric cells. The cag T4SS external pilus mediates attachment of the apparatus to the target cell and the delivery of CagA. While the composition of the pilus is unclear, CagI is present at the surface of the bacterium and required for pilus formation. Here, we have investigated the properties of CagI by an integrative structural biology approach. Using Alpha Fold 2 and Small Angle X-ray scattering, it was found that CagI forms elongated dimers mediated by rod-shape N-terminal domains (CagI N ) prolonged by globular C-terminal domains (CagI C ). Three Designed Ankyrin Repeat Proteins (DARPins) K2, K5 and K8 selected against CagI interacted with CagI C with subnanomolar affinities. The crystal structures of the CagI:K2 and CagI:K5 complexes were solved and identified the interfaces between the molecules, thereby providing a structural explanation for the difference in affinity between the two binders. Purified CagI and CagI C were found to interact with adenocarcinoma gastric (AGS) cells, induced cell spreading and the interaction was inhibited by K2. The same DARPin inhibited CagA translocation by up to 65% in AGS cells while inhibition levels were 40% and 30% with K8 and K5, respectively. Our study suggests that CagI C plays a key role in cag T4SS-mediated CagA translocation and that DARPins targeting CagI represent potent inhibitors of the cag T4SS, a crucial risk factor for gastric cancer development.Bases structurale du système de secretion de type IV d'Helicobacter pyloriBases structurales et moléculaires de l'exploitation de l'integrin a5ß1 par le système de sécrétion de type IV d'Helicobacter pylor

Dipstick Test for Rapid Diagnosis of Shigella dysenteriae 1 in Bacterial Cultures and Its Potential Use on Stool Samples

International audienceBACKGROUND: We describe a test for rapid detection of S. dysenteriae 1 in bacterial cultures and in stools, at the bedside of patients. METHODOLOGY/PRINCIPAL FINDINGS: The test is based on the detection of S. dysenteriae 1 lipopolysaccharide (LPS) using serotype 1-specific monoclonal antibodies coupled to gold particles and displayed on a one-step immunochromatographic dipstick. A concentration as low as 15 ng/ml of LPS was detected in distilled water and in reconstituted stools in 10 minutes. In distilled water and in reconstituted stools, an unequivocal positive reaction was obtained with 1.6×10⁶ CFU/ml and 4.9×10⁶ CFU/ml of S. dysenteriae 1, respectively. Optimal conditions to read the test have been determined to limit the risk of ambiguous results due to appearance of a faint yellow test band in some negative samples. The specificity was 100% when tested with a battery of Shigella and unrelated strains in culture. When tested on 328 clinical samples in India, Vietnam, Senegal and France by laboratory technicians and in Democratic Republic of Congo by a field technician, the specificity (312/316) was 98.7% (95% CI:96.6-99.6%) and the sensitivity (11/12) was 91.7% (95% CI:59.8-99.6%). Stool cultures and the immunochromatographic test showed concordant results in 98.4 % of cases (323/328) in comparative studies. Positive and negative predictive values were 73.3% (95% CI:44.8-91.1%) and 99.7% (95% CI:98-100%). CONCLUSION: The initial findings presented here for a simple dipstick-based test to diagnose S. dysenteriae 1 demonstrates its promising potential to become a powerful tool for case management and epidemiological surveys

Altimetry for the future: Building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the ‘‘Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Altimetry for the future: building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the “Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Gestion, contrôle et maîtrise des Zones à Atmosphère Contrôlée dans le cadre des procédés aseptiques

MONTPELLIER-BU Pharmacie (341722105) / SudocSudocFranceF