Makers against Covid-19: Face shields as the international solidarity KPI

At the first signs of the Covid-19 pandemic, the uncertainty around the global stock of medical supplies sparked a response in the DIY communities around the world. In the case of Spain, a community called Coronavirus Makers (CVM) emerged to supply ventilators and personal protection equipment (PPE) to hospitals and people in need. This paper explores the evolution of this community-driven development, detailing the patterns proposed by members of the group acting as design experts to tackle different problems. More specifically the paper uses face shields, the most produced PPE in Spain, as a boundary object to highlight the relationships amongst individuals, institutions, and companies. The objects of design, since they fall in the specific category of devices for medical use, have to overcome validation at the technical level. Authors will also explore some of the controversies surrounding the transfer of these products from horizontal innovation networks to traditional production companies

Entomological fauna associated with Aguaribay : Mendoza (Argentina)

En los relevamientos de especias dañinas y benéficas presentes en el aguaribay (Schinus molle L. var. Areira), para inventariar su entomofauna se efectuaron observaciones en distintas zonas de Mendoza (Argentina) en 1988/91 y 1994/96, confirmando y actualizando la bibliografía. Se recolectó material a campo para su identificación sistemática. Se evaluaron daños y se los documentó fotográficamente. En el laboratorio se conservaron muestras con parasitoides hasta la aparición de adultos para su clasificación, registrándose 8 especies de Homoptera, 7 de Hymenoptera, 7 de Coleoptera, 5 de Lepidoptera, 4 de Diptera, 4 de Thysanoptera, 2 de Hemiptera y 2 de Neuroptera. Las principales especies que afectan al Aguaribay son Calophya sp. (Homoptera - Psyllidae), Ceroplastes grandis (Homoptera - Coccidae) y Aphis schinifoliae (Homoptera - Aphididae). También cuenta con una importante fauna benéfica: coccinélidos, parasitoides, sírfidos y crisópidos.Pest and beneficial species present in Schinus molle L. var. Areira were monitoring in order to obtain an inventory of its entomological fauna. It was made observations in different zones of Mendoza from 1988 to 1991, and then, between 1994 and 1996, it was confirmed further observations and it was brought up to day bibliographical revisions. It was collected material in field in order to made its systematic identification. Damages were evaluated and documented photographically. Samples with parasitoids were stored in laboratory until the appearance of adults for their classification. It was registered: 8 species of Homoptera, 7 of Hymenoptera, 7 of Coleop-tera, 5 of Lepidoptera, 4 of Diptera, 4 of Thysanoptera, 2 of Hemiptera and 2 of Neuroptera. The main pest are: Calophya sp. (Homoptera - Psyllidae), Ceroplastes grandis (Homoptera - Coccidae) and Aphis schinifoliae (Homoptera - Aphididade). Also, there is an important beneficial fauna: Coccinellidae, parasitoids, Syrphidae and Chrysopidae.Fil: Sáez, César C.. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Departamento de Ciencias BiológicasFil: Mácola, Guido S.. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Departamento de Ciencias BiológicasFil: Holgado, Miriam G.. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Departamento de Ciencias BiológicasFil: García Sáez, José G.. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Departamento de Ciencias Biológica

Gravitational waves from galaxy encounters

We discuss the emission of gravitational radiation produced in encounters of dark matter galactic halos. To this aim we perform a number of numerical simulations of typical galaxy mergers, computing the associated gravitational radiation waveforms as well as the energy released in the processes. Our simulations yield dimensionless gravitational wave amplitudes of the order of $10^{-13}$ and gravitational wave frequencies of the order of $10^{-16}$ Hz, when the galaxies are located at a distance of 10 Mpc. These values are of the same order as those arising in the gravitational radiation originated by strong variations of the gravitational field in the early Universe, and therefore, such gravitational waves cannot be directly observed by ground-based detectors. We discuss the feasibility of an indirect detection by means of the B-mode polarization of the Cosmic Microwave Background (CMB) induced by such waves. Our results show that the gravitational waves from encounters of dark matter galactic halos leave much too small an imprint on the CMB polarization to be actually observed with ongoing and future missions.Comment: 9 pages with revtex style, 3 ps figures; to be published in Physical Review

A feasibility study for implementation 'Health Arcade': a study protocol for prototype of multidomain intervention based on gamification technologies in acutely hospitalized older patients

The aim of this article is to present the research protocol for a study that will evaluate the feasibility of implementation of Health Arcade prototype multidomain intervention based on physical and cognitive training using gamification technologies at improving care for older people hospitalized with an acute illness. A total of 40 older people will be recruited in a tertiary public hospital at Pamplona, Spain. The intervention duration will be four to nine consecutive days. Additionally, the patients will receive encouragement for maintaining active during hospital stay and for reducing sedentary time. Primary implementation-related outcomes will be the adherence to treatment (i.e., number of games and days completed during the intervention period), reaction or response time, and number of success and failures in each game per day. Secondary implementation-related outcomes will be self-perceived grade of difficulty, satisfaction, enjoyment per game and session, and self-perceived difficulties in handling the prototype hardware. Other health-related outcomes will also be assessed such as functional capacity in activities of daily living, mood status, quality of life, handgrip strength, physical activity levels, and mobility. The current study will provide additional evidence to support the implementation of multidomain interventions designed to target older persons with an acute illness based on friendly technology. The proposed intervention will increase accessibility of in-clinical geriatrics services, improve function, promote recovery of the health, and reduce economic costs.This study has been funded by a Gobierno de Navarra project grant (Resolucion 81E/2019, de 19 de junio). Expediente: 0011-1365-2019-000139; Sistema piloto de entrenamiento fisico multicomponente basado en tecnologias de gamificacion para la prevencion del deterioro funcional en ancianos hospitalizados 'HEALTH ARCADE'. N.M.-V. received funding from 'la Caixa' Foundation (ID 100010434), under agreement LCF/PR/PR15/51100006. R.R.-V. is funded in part by a Postdoctotal fellowship grant ID 420/2019 of the Universidad Publica de Navarra, Spain. A.G.-H. is a Miguel Servet Fellow (Instituto de Salud Carlos III -FSE, CP18/0150)

Paleopaisajes concretos: polen, suelos y arqueología del yacimiento de As Pontes (Abadín, Lugo)

The field work to assess the archaeological impact of the Gas pipeline in Galicia discovered a site with an interesting archaeological and environmental stratigraphy. Its base is dated lo preneolithic times and offers a small set of lithics related to that period. Then the location was used to establish a neolithic camp with complex firing structures. Once abandoned, the site was covered by a paleosoil that was cultivated in early·medieval times. The most complicated example of plough marks in Galician archeology was found here; they give us good information about agrarian technology. Archaeological interpretations were combined with pollen and soil analytics. The research strategy applied in this site allows us to define the landscape sequence for the period, showing not only the nature but also the land uses and patterns of change of this space. This paper is a good example of what could be called intensive micro-landscape archeology.En el marco de los trabajos de corrección del impacto arqueológico de la red del Gas en Galicia, se descubrió un yacimiento que ofreció una interesante estratigrafía arqueológica y ambiental. La base del mismo es de momentos preneolíticosy presenta industrias líticas. Sobre ese nivel aparece un yacimiento neolítico con interesantes estructuras de combustión. Una vez abandonado el yacimiento se generó sobre él un palesuelo que, en época medieval, fue cultivado con arado, apareciendo un interesante conjunto de huellas de arado que aportan información sobre la tecnología agraria de la época. El análisis arqueológico se combinó con análisis polínicos y edafológicos que, una vez integrados, permiten establecer la secuencia de la naturaleza, uso y cambio de esos paisajes a lo largo de casi ocho mil años. El trabajo es un buen ejemplo de un tipo de investigación de gran escala e hiperintensiva en arqueología del paisaje

Paleoecología y cultura material en el complejo tumular prehistórico de Castillejo del Bonete (Terrinches, Ciudad Real)

Castillejo del Bonete es un complejo tumular situado en el borde meridional de la Meseta Ibérica, ocupado en fechas calcolíticas y de la Edad del Bronce, vinculado a la Cultura de las Motillas. Materiales arqueológicos muy diversos han sido recuperados asociados a las arquitecturas del lugar (túmulos, corredores, potentes muros, etc.). Se presenta un avance de la investigación paleoecológica sobre las colecciones de carbón, polen y microvertebrados. Además se presentan cuentas de piedra y madera, colgantes de concha, material lítico, la colección cerámica, nuevas metalografías e industria metálica y botones de marfil. El conjunto de estas evidencias arqueológicas pone de manifiesto la celebración ritual de banquetes y ofrendas durante la Prehistoria Reciente en una cueva monumentalizada mediante túmulos en el interior de la Península Ibérica

Intermediate Molecular Phenotypes to Identify Genetic Markers of Anthracycline-Induced Cardiotoxicity Risk.

Cardiotoxicity due to anthracyclines (CDA) affects cancer patients, but we cannot predict who may suffer from this complication. CDA is a complex trait with a polygenic component that is mainly unidentified. We propose that levels of intermediate molecular phenotypes (IMPs) in the myocardium associated with histopathological damage could explain CDA susceptibility, so variants of genes encoding these IMPs could identify patients susceptible to this complication. Thus, a genetically heterogeneous cohort of mice (n = 165) generated by backcrossing were treated with doxorubicin and docetaxel. We quantified heart fibrosis using an Ariol slide scanner and intramyocardial levels of IMPs using multiplex bead arrays and QPCR. We identified quantitative trait loci linked to IMPs (ipQTLs) and cdaQTLs via linkage analysis. In three cancer patient cohorts, CDA was quantified using echocardiography or Cardiac Magnetic Resonance. CDA behaves as a complex trait in the mouse cohort. IMP levels in the myocardium were associated with CDA. ipQTLs integrated into genetic models with cdaQTLs account for more CDA phenotypic variation than that explained by cda-QTLs alone. Allelic forms of genes encoding IMPs associated with CDA in mice, including AKT1, MAPK14, MAPK8, STAT3, CAS3, and TP53, are genetic determinants of CDA in patients. Two genetic risk scores for pediatric patients (n = 71) and women with breast cancer (n = 420) were generated using machine-learning Least Absolute Shrinkage and Selection Operator (LASSO) regression. Thus, IMPs associated with heart damage identify genetic markers of CDA risk, thereby allowing more personalized patient management.J.P.L.’s lab is sponsored by Grant PID2020-118527RB-I00 funded by MCIN/AEI/10.13039/ 501100011039; Grant PDC2021-121735-I00 funded by MCIN/AEI/10.13039/501100011039 and by the “European Union Next Generation EU/PRTR”, the Regional Government of Castile and León (CSI144P20). J.P.L. and P.L.S. are supported by the Carlos III Health Institute (PIE14/00066). AGN laboratory and human patients’ studies are supported by an ISCIII project grant (PI18/01242). The Human Genotyping unit is a member of CeGen, PRB3, and is supported by grant PT17/0019 of the PE I + D + i 2013–2016, funded by ISCIII and ERDF. SCLl is supported by MINECO/FEDER research grants (RTI2018-094130-B-100). CH was supported by the Department of Defense (DoD) BCRP, No. BC190820; and the National Cancer Institute (NCI) at the National Institutes of Health (NIH), No. R01CA184476. Lawrence Berkeley National Laboratory (LBNL) is a multi-program national laboratory operated by the University of California for the DOE under contract DE AC02-05CH11231. The Proteomics Unit belongs to ProteoRed, PRB3-ISCIII, supported by grant PT17/0019/0023 of the PE I + D +i, 2017–2020, funded by ISCIII and FEDER. RCC is funded by fellowships from the Spanish Regional Government of Castile and León. NGS is a recipient of an FPU fellowship (MINECO/FEDER). hiPSC-CM studies were funded in part by the “la Caixa” Banking Foundation under the project code HR18-00304 and a Severo Ochoa CNIC Intramural Project (Exp. 12-2016 IGP) to J.J.S

Vegetation and fire dynamics during the last 4000 years in the Cabañeros National Park (central Spain)

The Holocene vegetation dynamics of low- and mid-altitude areas of inland Iberia remain largely unknown, masking possible legacy effects of past land-use on current and future ecosystem trajectories. Here we present a 4000-year long palaeoecological record (pollen, spores, microscopic charcoal) from a mire located in the Cabañeros National Park (Toledo Mountains, central Spain), a region with key conservation challenges due to ongoing land-use changes. We reconstruct late Holocene vegetation history and assess the extent to which climate, land-use and disturbances played a role in the observed changes. Our results show that oak (Quercus) woodlands have been the main forested community of the Toledo Mountains over millennia, with deciduous Quercus pyrenaica and Quercus faginea more abundant than evergreen Quercus ilex and Quercus suber, particularly on the humid soils of the valley bottoms. Deciduous oak woodlands spread during drier periods replacing hygrophilous communities (Betula, Salix, hygrophilous Ericaceae) on the edges of the mire, and could cope with fire disturbance variability under dry conditions (e.g. ca. 3800–3000–1850–1050 BC- and 1300–100 cal BP–AD 650–1850-) as suggested by regional palaeoclimatic reconstructions. Pollen and coprophilous fungi data suggest that enhanced fire occurrence at ca. 1300–100 cal BP (AD 650–1850) was due to deliberate burning by local people to promote pastoral and arable farming at the expense of woodlands/shrublands under dry conditions. While historical archives date the onset of strong human impact on the vegetation of Cabañeros to the period at and after the Ecclesiastical Confiscation (ca. 150–100 cal BP, AD 1800–1850), our palaeoecological data reveal that land-use was already intense during the Arab period (ca. 1250–900 cal BP, AD 700–1050) and particularly marked during the subsequent City of Toledo's rule (ca. 700–150 cal BP, AD 1250–1800). Finally, we hypothesize that persistent groundwater discharge allowed the mires of the Toledo Mountains to act as interglacial hydrologic microrefugia for some hygrophilous woody plants (Betula, Myrica gale, Erica tetralix) during pronounced dry spells over the past millennia