Edición de videos digitales en la formación del profesorado

Las nuevas tecnologías están cada vez más presentes en la enseñanza de las Ciencias Experimentales y en la formación del profesorado de Ciencias Experimentales de diferentes niveles educativos. Es por ello, por lo que se ha considerado necesario trabajar y llevar a cabo experiencias apoyadas en las nuevas tecnologías. La finalidad de esta experiencia consiste en fomentar un acercamiento al proceso de enseñanza/aprendizaje de las Ciencias Experimentales a través de la utilización de fotografías y de imágenes editando videos. Además esta actividad sirve como elemento motivador para los futuros maestros y maestras, impulsa la integración de las tecnologías de la información y la comunicación en su competencia profesional, y además, sirven como aprendizaje de estas herramientas como instrumento de evaluación y autoevaluación

Theoretical approach to atomic-scale nanoplasmonics as probed by light and swift electrons

223 P.This thesis tackles the theoretical description of atomic-scale features in plasmonic nanostructures asprobed by light and swift electrons. Plasmonic nanostuctures are known to localize and enhanceelectromagnetic fields in their proximity, and thus serve as building blocks to perform improved andenhanced molecular spectroscopy on them. We focus on the analysis of the effect of atomic-scale featuresin the overall response of plasmonic nanoparticles and nanocavities. We apply ab initio atomisticquantum time-dependent density functional theory (TDDFT) to unveil the near-field distribution aroundmetallic antennas, and describe "classically" various atomic-scale features such as continuous protrusionson the surfaces of the metal using a Boundary Element Method (BEM), providing an extra localization ofthe field. Moreover, we propose an analytical model to address the signal increase observed in surfaceenhancedRaman scattering (SERS) spectra related to local variations of the electron density associated toatomic-scale defects. Last, we identify the excitation of confined bulk plasmons (CBP) within theTDDFT calculations for the electron energy loss (EEL) probability of atomistic clusters, and provide asemi-analytical expression within a Hydrodynamic Model (HDM) to address such excitation

Theoretical approach to atomic-scale nanoplasmonics as probed by light and swift electrons

223 P.This thesis tackles the theoretical description of atomic-scale features in plasmonic nanostructures asprobed by light and swift electrons. Plasmonic nanostuctures are known to localize and enhanceelectromagnetic fields in their proximity, and thus serve as building blocks to perform improved andenhanced molecular spectroscopy on them. We focus on the analysis of the effect of atomic-scale featuresin the overall response of plasmonic nanoparticles and nanocavities. We apply ab initio atomisticquantum time-dependent density functional theory (TDDFT) to unveil the near-field distribution aroundmetallic antennas, and describe "classically" various atomic-scale features such as continuous protrusionson the surfaces of the metal using a Boundary Element Method (BEM), providing an extra localization ofthe field. Moreover, we propose an analytical model to address the signal increase observed in surfaceenhancedRaman scattering (SERS) spectra related to local variations of the electron density associated toatomic-scale defects. Last, we identify the excitation of confined bulk plasmons (CBP) within theTDDFT calculations for the electron energy loss (EEL) probability of atomistic clusters, and provide asemi-analytical expression within a Hydrodynamic Model (HDM) to address such excitation

Detecting Conflicts and Inconsistencies in Web Application Requirements

Web applications evolve fast. One of the main reasons for this evolution is that new requirements emerge and change constantly. These new requirements are posed either by customers or they are the consequence of users’ feedback about the application. One of the main problems when dealing with new requirements is their consistency in relationship with the current version of the application. In this paper we present an effective approach for detecting and solving inconsistencies and conflicts in web software requirements. We first characterize the kind of inconsistencies arising in web applications requirements and then show how to isolate them using a modeldriven approach. With a set of examples we illustrate our approach

Novel mechanisms for regulation of cell survival and migration by ceramide 1-phosphate

201 p. : gráf.Ceramide 1-phosphate is a bioactive sphingolipid that regulates important cell functions, including cell proliferation, apoptosis, migration or inflammation. Cell homeostasis is essential for the normal development of any organism and alteration of any of these pro¬cesses can lead to metabolic dysfunction or cause illnesses such as autoimmune diseases, chronic inflammation, neural degeneration, cardiovascular disorders, or cancer. The molecular mechanisms involved in the regulation of these cell responses by C1P have only begun to be understood. The aim of this Doctoral Thesis was to study the cellular signaling processes involved in C1P-stimulated cell proliferation and migration in immune cells, mainly macrophages. Concerning the regulation of cell proliferation, this Thesis has contributed to the elucidation of three major mechanisms by which C1P exerts its mitogenic actions: 1) Stimulation of vascular endothelial growth factor (VEGF) secretion, an action that involves activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. 2) Induction of translocation and activation of protein kinase C alpha (PKCα). 3) Activation of NADPH oxidase and the subsequent formation of reactive oxygen species (ROS). With regards to cell migration, we have demonstrated that C1P stimulates the release of macrophage chemoattractant protein-1 (MCP-1), which is essential for the induction of macrophage migration. In addition, we have shown that C1P-stimulated cell migration requires the interaction of C1P with a putative C1P receptor, and the subsequent activation of the PI3K/Akt, MAPK/Erk1-2, p38 and JNK signalling pathways. Finally, this Thesis also shows that C1P increases the expression of CD69 in spleenic mononuclear cells, and that it protects these cells from entering apoptosis. A major pathway involved in this action is the mitogen-activated protein kinase kinase (MEK)/ERK1-2/ NF-кB pathway

Impulse-control disorders in Parkinson's Disease: development of an animal model

206 p.El objetivo de la presente tesis es el desarrollo de un modelo animal de parkinsonismo e impulsividad inducido por la administración del agonista dopaminérgico pramipexol (PPX).La enfermedad de Párkinson (EP) es una enfermedad neurodegenerativa caracterizada por el desarrollo de alteraciones motoras (temblor, rigidez y bradicinesia) que están asociadas a una progresiva muerte de neuronas dopaminérgicas de la sustancia negra compacta pars compacta (SNc), la consecuente depleción dopaminérgica en el estriado y la aparición de agregados proteicos intracelulares (principalmente de ¿-sinucleína, (¿-syn)). La fisiopatología de la muerte neuronal es aún desconocida en gran medida, y los tratamientos disponibles actualmente están enfocados a mitigar los signos motores de la enfermedad mediante la reposición exógena del déficit dopaminérgico, principalmente mediante la administración de levodopa (precursor de la dopamina) y/o agonistas dopaminérgicos como el PPX. Sin embargo, estos tratamientos promueven un progresivo desarrollo de efectos secundarios motores y no motores a medio-largo plazo, de los que las disquinesias (movimientos involuntarios de tipo coréico) y las complicaciones psiquiátricas como el trastorno de control de impulsos (TCI) (que incluye el juego patológico, las compras compulsivas, la hipersexualidad y la ingesta compulsiva de comida) y otros trastornos impulsivos-compulsivos (síndrome de disregulación dopaminérgica (SDD)), son los más frecuentes e incapacitantes. A pesar de su negativa influencia sobre la vida diaria de los pacientes, la fisiopatología subyacente al TCI en la EP no está bien definida, a lo que contribuye la falta de modelos animales que reflejen lo más fielmente posible las características de este trastorno y se pueden llevar a cabo estudios en ellos.En este sentido, se han realizado diferentes aproximaciones en la literatura, pero se hacen imprescindibles nuevos estudios por diferentes motivos: el análisis de un único rasgo de la impulsividad en los tests conductuales usados o el uso de refuerzos artificiales (como la estimulación eléctrica de la amígdala) en vez de refuerzos naturales como la comida o el sexo, alejándose así del contexto clínico. Por ello, el uso de tests que puedan medir simultáneamente diferentes aspectos de los comportamientos impulsivos-compulsivos y que empleen refuerzos naturales se hace particularmente necesario

The Third Language in English Guidebooks and its Translation into Spanish

This article focuses on a specific feature found in tourist guidebooks –the recurrent use of foreign expressions or “third language”. It presents the findings of a comparative analysis of a parallel corpus made up of twenty guidebooks: ten guidebooks originally written in English and their corresponding translated versions in Spanish, describing different countries and cities (all of them published by Lonely Planet), focusing on those chapters in which the writer includes practical information. The purpose of the study is to analyze the use of the third language in the English and Spanish versions and to determine and identify the translation strategies used by the translators to transfer these linguistic elements from one language to the other. To this aim, a classification of transference strategies is presented, as well as a brief review of the most influential authors who have contributed to this field of study. The results will show the translation tendency regarding the translation of foreign expressions. DOI: 10.1400/22969

Detecting Functional Requirements Inconsistencies within Multi-teams Projects Framed into a Model-based Web Methodology

One of the most essential processes within the software project life cycle is the REP (Requirements Engineering Process) because it allows specifying the software product requirements. This specification should be as consistent as possible because it allows estimating in a suitable manner the effort required to obtain the final product. REP is complex in itself, but this complexity is greatly increased in big, distributed and heterogeneous projects with multiple analyst teams and high integration between functional modules. This paper presents an approach for the systematic conciliation of functional requirements in big projects dealing with a web model-based approach and how this approach may be implemented in the context of the NDT (Navigational Development Techniques): a web methodology. This paper also describes the empirical evaluation in the CALIPSOneo project by analyzing the improvements obtained with our approach.Ministerio de Economía y Competitividad TIN2013-46928-C3-3-RMinisterio de Economía y Competitividad TIN2015-71938-RED