Long-term follow-up of dorsal wedge osteotomy for pediatric freiberg disease

Background: Treatment for Freiberg disease has been largely conservative despite availability of various operative options for severe or refractory cases. The aim of this study was to evaluate the long-term results of pediatric patients with symptomatic Freiberg disease treated with intra-articular dorsal wedge osteotomy. Methods: Pediatric patients treated for Freiberg disease with surgery between January 1982 and 1999 were identified and selected for long-term clinical evaluation. Patients were evaluated regarding operative satisfaction and clinical outcome, performed according to the American Orthopaedic Foot & Ankle Society (AOFAS) lesser toe metatarsophalangeal-interphalangeal scale and range of motion (ROM) of metatarsophalangeal (MTP) joint. Patients had radiographic assessment of degenerative joint status with anteroposterior and oblique foot x-ray. Twenty patients (18 female, 2 male; mean age 15.2 years; range 12-17 years) were identified. The mean follow-up period was 23.4 (range 15-32) years. Results: The clinical outcomes of our patients were classified as excellent in 16 (80%) and good in 4 (20%). The AOFAS mean score was 96.8 (range 91-100) points at the last clinical appointment. A negative correlation between AOFAS score and time of follow-up (r's = -0.61, P < .001) was found. Also, a strong negative correlation was found between Smillie classification and AOFAS final score (r's = -0.88, P < .001). Conclusion: The patients were very satisfied with pain and quality of life at a mean follow-up time of 23.4 years. To our knowledge, this is the first long-term follow-up report supporting the procedure described by Gauthier and Elbaz as a good option for operative treatment of Freiberg disease.info:eu-repo/semantics/publishedVersio

Alcohol use in a rural district in Uganda: findings from community-based and facility-based cross-sectional studies

Background Uganda has one of the highest per capita alcohol consumption rates in sub-Saharan Africa. However, the prevalence of alcohol use disorders (AUD) remains unknown in many areas, especially in rural districts. This study aimed to estimate the prevalence of alcohol consumption and of alcohol use disorder among men, and to describe the distribution of drinking intensity, among men in in Kamuli District, Uganda. Methods Men attending primary care clinics in Kamuli District were consecutively interviewed in a facility-based cross-sectional study, and a separate group of men were interviewed in a population-based cross-sectional study. In both studies the men were administered a structured questionnaire, which included the alcohol use disorder identification test (AUDIT) to screen for AUD, as well as sections about demographic characteristics, depression screening, internalized stigma for alcohol problems and treatment-seeking. Results Among the 351 men enrolled in the Community study, 21.8% consumed alcohol in the past 12 months, compared to 39.6% of 778 men in the Facility Survey. The proportion of men who screened positive for AUD was 4.1% in the community study and 5.8% in the facility study. AUDIT scores were higher among older men, men with paid/self-employment status and higher PHQ-9 score (P < 0.05). Nearly half (47.5%) of the men with AUDIT-positive scores reported that alcohol use problems had ruined their lives. A majority (55.0%) of men with AUDIT-positive scores did not seek treatment because they did not think AUD was a problem that could be treated. Conclusions Internalized stigma beliefs among AUDIT-positive men impede treatment-seeking. As part of any efforts to increase detection and treatment services for alcohol use problems, routine screening and brief interventions for internalized stigma must be incorporated within the normal clinical routine of primary health care

Intrinsic and dust-induced polarization in gamma-ray burst afterglows: the case of GRB 021004

Polarization measurements for the optical counterpart to GRB 021004 are presented and discussed. Our observations were performed with the TNG and the VLT-UT3 (Melipal) during the first and fourth night after the gamma-ray burst discovery. We find robust evidence of temporal evolution of the polarization, which is therefore, at least partially, intrinsic to the optical transient. We do not find convincing evidence of wavelength dependence for the intrinsic polarization of the transient, in agreement with current polarization models for optical afterglows. We discuss the role of dust, both in our galaxy and in the host, in modifying the transmitted polarization vector, showing how a sizable fraction of the observed polarized flux is due to Galactic selective extinction, while it is not possible to single out any clear contribution from dust in the host galaxy. We discuss how our data compare to those obtained by different groups showing that a two-component model is required to describe the complete dataset. This is not surprising given the complex lightcurve of GRB 021004.Comment: 9 pages, 6 postscript figures, A&A in pres

Obscured Activity: AGN, Quasars, Starbursts and ULIGs observed by the Infrared Space Observatory

Some of the most active galaxies in the Universe are obscured by large quantities of dust and emit a substantial fraction of their bolometric luminosity in the infrared. Observations of these infrared luminous galaxies with the Infrared Space Observatory (ISO) have provided a relatively unabsorbed view to the sources fuelling this active emission. The improved sensitivity, spatial resolution and spectroscopic capability of ISO over its predecessor Infrared Astronomical Satellite (IRAS), has enabled significant advances in the understanding of the infrared properties of active galaxies. ISO surveyed a wide range of active galaxies which, in the context of this review, includes those powered by intense bursts of star-formation as well as those containing a dominant active galactic nucleus (AGN). Mid infrared imaging resolved for the first time the dust enshrouded nuclei in many nearby galaxies, while a new era in infrared spectroscopy was opened by probing a wealth of atomic, ionic and molecular lines as well as broad band features in the mid and far infrared. This was particularly useful since it resulted in the understanding of the power production, excitation and fuelling mechanisms in the nuclei of active galaxies including the intriguing but so far elusive ultraluminous infrared galaxies. Detailed studies of various classes of AGN and quasars greatly improved our understanding of the unification scenario. Far-infrared imaging and photometry also revealed the presence of a new very cold dust component in galaxies and furthered our knowledge of the far-infrared properties of faint starbursts, ULIGs and quasars. We summarise almost nine years of key results based upon ISO data spanning the full range of luminosity and type of active galaxies.Comment: Accepted for publication in 'ISO science legacy - a compact review of ISO major achievements', Space Science Reviews - dedicated ISO issue. To be published by Springer in 2005. 62 pages (low resolution figures version). Higher resolution PDFs available from http://users.physics.uoc.gr/~vassilis/papers/VermaA.pdf or http://www.iso.vilspa.esa.es/science/SSR/Verma.pd

The CD85j+ NK Cell Subset Potently Controls HIV-1 Replication in Autologous Dendritic Cells

Natural killer (NK) cells and dendritic cells (DC) are thought to play critical roles in the first phases of HIV infection. In this study, we examined changes in the NK cell repertoire and functions occurring in response to early interaction with HIV-infected DC, using an autologous in vitro NK/DC coculture system. We show that NK cell interaction with HIV-1-infected autologous monocyte-derived DC (MDDC) modulates NK receptor expression. In particular, expression of the CD85j receptor on NK cells was strongly down-regulated upon coculture with HIV-1-infected MDDC. We demonstrate that CD85j+ NK cells exert potent control of HIV-1 replication in single-round and productively HIV-1-infected MDDC, whereas CD85j− NK cells induce a modest and transient decrease of HIV-1 replication. HIV-1 suppression in MDCC by CD85j+ NK cells required cell-to-cell contact and did not appear mediated by cytotoxicity or by soluble factors. HIV-1 inhibition was abolished when NK-MDDC interaction through the CD85j receptor was blocked with a recombinant CD85j molecule, whereas inhibition was only slightly counteracted by blocking HLA class I molecules, which are known CD85j ligands. After masking HLA class I molecules with specific antibodies, a fraction of HIV-1 infected MDDC was still strongly stained by a recombinant CD85j protein. These results suggest that CD85j+ NK cell inhibition of HIV-1 replication in MDDC is mainly mediated by CD85j interaction with an unknown ligand (distinct from HLA class I molecules) preferentially expressed on HIV-1-infected MDDC

The exposure of the hybrid detector of the Pierre Auger Observatory

The Pierre Auger Observatory is a detector for ultra-high energy cosmic rays. It consists of a surface array to measure secondary particles at ground level and a fluorescence detector to measure the development of air showers in the atmosphere above the array. The "hybrid" detection mode combines the information from the two subsystems. We describe the determination of the hybrid exposure for events observed by the fluorescence telescopes in coincidence with at least one water-Cherenkov detector of the surface array. A detailed knowledge of the time dependence of the detection operations is crucial for an accurate evaluation of the exposure. We discuss the relevance of monitoring data collected during operations, such as the status of the fluorescence detector, background light and atmospheric conditions, that are used in both simulation and reconstruction.Comment: Paper accepted by Astroparticle Physic

Leptopirosis canina, equina y humana en un área de alto riesgo por sus características ambientales

La leptospirosis es una zoonosis distribuida por todo el mundo. Los mamíferos cumplen un rol importante dentro de la epidemiología en la transmisión a los humanos. El agente etiológico y zoonótico, de interés patogénico es Leptospira interrogans, que contiene más de 250 serovares o variantes serológicas. La vía más común de infección es a través de aguas, suelos y alimentos contaminados por animales infectados. Nuestro propósito fue determinar la seroprevalencia de Leptospira interrogans en personas y animales (caninos y equinos) de una zona selvático–ribereña del Río de La PlataFacultad de Ciencias Veterinaria

Leptopirosis canina, equina y humana en un área de alto riesgo por sus características ambientales

La leptospirosis es una zoonosis distribuida por todo el mundo. Los mamíferos cumplen un rol importante dentro de la epidemiología en la transmisión a los humanos. El agente etiológico y zoonótico, de interés patogénico es Leptospira interrogans, que contiene más de 250 serovares o variantes serológicas. La vía más común de infección es a través de aguas, suelos y alimentos contaminados por animales infectados. Nuestro propósito fue determinar la seroprevalencia de Leptospira interrogans en personas y animales (caninos y equinos) de una zona selvático–ribereña del Río de La PlataFacultad de Ciencias Veterinaria

Polarimetry of the transient relativistic jet of GRB 110328 / Swift J164449.3+573451

We present deep infrared (Ks band) imaging polarimetry and radio (1.4 and 4.8 GHz) polarimetry of the enigmatic transient Swift J164449.3+573451. This source appears to be a short lived jet phenomenon in a galaxy at redshift z = 0.354, activated by a sudden mass accretion onto the central massive black hole, possibly caused by the tidal disruption of a star. We aim to find evidence for this scenario through linear polarimetry, as linear polarisation is a sensitive probe of jet physics, source geometry and the various mechanisms giving rise to the observed radiation. We find a formal Ks band polarisation measurement of P_lin = 7.4 +/- 3.5 % (including systematic errors). Our radio observations show continuing brightening of the source, which allows sensitive searches for linear polarisation as a function of time. We find no evidence of linear polarisation at radio wavelengths of 1.4 GHz and 4.8 GHz at any epoch, with the most sensitive 3 sigma limits as deep as 2.1%. These upper limits are in agreement with expectations from scenarios in which the radio emission is produced by the interaction of a relativistic jet with a dense circumsource medium. We further demonstrate how the polarisation properties can be used to derive properties of the jet in Swift J164449.3+573451, exploiting the similarities between this source and the afterglows of gamma-ray bursts.Comment: 7 pages, 3 figures. Accepted for publication in MNRA