Technology Roadmap for Beyond 5G Wireless Connectivity in D-band

International audienceWireless communication in millimeter wave bands, namely above 20 GHz and up to 300 GHz is foreseen as a key enabler technology for the next generation of wireless systems. The huge available bandwidth is contemplated to achieve high data rate wireless communications, and hence, to fulfill the requirements of future wireless networks. Several Beyond 5G applications are considered for these systems: high capacity back-haul, enhanced hot-spot kiosk as well as short-range Device-to-Device communications. In this paper we propose to discuss the trade-offs between scenario requirements and current silicon technologies limits to draw a technology roadmap for the next generation of wireless connectivity in D-band

Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children

International audienc

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Publisher Copyright: © 2021 The Authors, some rights reserved.Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-alpha and/or IFN-omega are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-alpha and/or IFN-omega (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-beta. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-alpha and/or IFN-omega are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals 80 years. By contrast, auto-Abs neutralizing IFN-beta do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases.Peer reviewe

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

SignificanceThere is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

Enseigner l'Europe

N° 14, automne 2004. ISBN : 2-7475-7060-6. http://www.cairn.info/revue-politique-europeenne-2004-3.ht

An FSK and OOK Compatible RF Demodulator for Wake Up Receivers

This work proposes a novel demodulation circuit to address the implementation of Wake-Up Receivers (Wu-Rx) in Wireless Sensor Nodes (WSN). This RF demodulator, namely Modulated Oscillator for envelOpe Detection (MOOD), is compatible with both FSK and OOK/ASK modulation schemes. The system embeds an LC oscillator, an envelope detector and a base-band amplifier. To optimize the trade-off between RF performances and power consumption, the cross-coupled based oscillator is biased in moderate inversion region. The proof of concept is implemented in a 65 nm CMOS technology and is intended for the 2.4 GHz ISM band. With a supply voltage of 0.5 V, the demodulator consumes 120 μW and demonstrates the demodulation of OOK and FSK at a data rate of 500 kbps

Design Techniques and Modeling for 60GHz Applications With a 65nm-CMOS-RF Technology

International audienceTo exploit the unlicensed band at frequencies around 60GHz, a certain number of design rules is considered. This paper highlights the difficulties to design a millimeter CMOS power amplifier (PA). A model of a compact inductor and interconnect lines is detailed. This model takes into account substrate and resistive parasitic. A 65nm CMOS technology from STMicroelectronics has been used. Innovative techniques are implemented in the design of a power amplifier (PA) which is optimized to deliver the maximum linear output power. To obtain good performances in a small surface of silicon, it has been designed, with both lumped and distributed elements. The PA delivers a linear output power of 8.9dBm with just an area of 0.48mm*0.6mm including pad