Sleep deprivation reveals altered brain perfusion patterns in somnambulism

BACKGROUND: Despite its high prevalence, relatively little is known about the pathophysiology of somnambulism. Increasing evidence indicates that somnambulism is associated with functional abnormalities during wakefulness and that sleep deprivation constitutes an important drive that facilitates sleepwalking in predisposed patients. Here, we studied the neural mechanisms associated with somnambulism using Single Photon Emission Computed Tomography (SPECT) with 99mTc-Ethylene Cysteinate Dimer (ECD), during wakefulness and after sleep deprivation. METHODS: Ten adult sleepwalkers and twelve controls with normal sleep were scanned using 99mTc-ECD SPECT in morning wakefulness after a full night of sleep. Eight of the sleepwalkers and nine of the controls were also scanned during wakefulness after a night of total sleep deprivation. Between-group comparisons of regional cerebral blood flow (rCBF) were performed to characterize brain activity patterns during wakefulness in sleepwalkers. RESULTS: During wakefulness following a night of total sleep deprivation, rCBF was decreased bilaterally in the inferior temporal gyrus in sleepwalkers compared to controls. CONCLUSIONS: Functional neural abnormalities can be observed during wakefulness in somnambulism, particularly after sleep deprivation and in the inferior temporal cortex. Sleep deprivation thus not only facilitates the occurrence of sleepwalking episodes, but also uncovers patterns of neural dysfunction that characterize sleepwalkers during wakefulness

Geochemistry and geochronology of the shallow-level La Esperanza magmatic system (Permian-Triassic), Northern Patagonia

The La Esperanza plutonic-volcanic complex is the largest Late Paleozoic-Early Triassic composite magmatic system of northern Patagonia. This paper reports new SHRIMP U-Pb zircon ages and K-Ar muscovite dating as well as whole-rock geochemical data for selected units. In addition, we present some new and reprocessed whole-rock Sr isotopic compositions. On the basis of the new and published data, three compositionally and isotopically distinct high-K magnesian calc-alkaline series were distinguished. Two of these are characterized by high Ba-Sr: (i) biotite and muscovite bearing rhyolites and granites (265 ± 2 Ma; 260 ± 2 Ma) and (ii) metaluminous amphibole-biotite bearing granodiorites (273 ± 2 Ma), monzogranites (255 ± 2 Ma), dacites (253 ± 2 Ma), and slightly peraluminous granites (dated herein as 251 ± 2 Ma). There is also a low Ba-Sr series of high-silica metaluminous rocks (granites and acid dike swarms; 250 ± 2 Ma and ≈244 ± 2 Ma). Geochemistry coupled with geochronology revealed a pulsatory multi-sourced open magmatic system with mafic magma replenishment and reactivation of crystal mushes that occurred before upward migration to upper crustal levels. Mafic magmas alternated with crust-derived magmas incrementally assembled in subvolcanic levels over 30 Ma. Zircon crystallization and mica cooling ages in the granite units allowed detection of two magmatic lulls, between 270 and 265 Ma and between 260 and 255 Ma. Both episodes coincide with a period of exhumation in upper crustal levels. The new temporal and geochemical constraints allow correlation of the La Esperanza plutonic-volcanic complex with the Los Menucos Group (258-248 Ma), encompassing a volume of magmatism comparable to a moderately sized large igneous silicic province. These mid-to-late Permian to Middle Triassic rocks record the transition between subduction-related magmatism (>273 Ma) and post-orogenic extensional magmatism (<250 Ma) in the Gondwana margin. Even though this magmatism would be coeval with the proposed collision of the Patagonia terrane, no expected syn-collisional magmatism or associated deformation were found in upper crustal levels. However, the different nature and melting conditions of the inferred sources of the magmas that crystallized before 270 Ma, between 265 and 260 Ma, and from 255 to 245 Ma, suggest that the La Esperanza plutonic-volcanic complex was assembled during a 30 Ma period of major plate reorganization.Fil: Martínez Dopico, Carmen Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geocronología y Geología Isotópica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geocronología y Geología Isotópica; ArgentinaFil: Lopez, Monica Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geocronología y Geología Isotópica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geocronología y Geología Isotópica; ArgentinaFil: Rapalini, Augusto Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; ArgentinaFil: Fanning, Christopher Mark. The Australian National University; AustraliaFil: Antonio, Paul Yves Jean. Universidade de Sao Paulo; Brasi

Paleomagnetism of the ~860 Ma Manso dyke swarm, West Africa: implications for the assembly of Rodinia

The West African Craton (WAC) is one of the major cratons in the Rodinia jigsaw puzzle (~1000?750Ma). In the Rodinian models, the position of West Africa is mainly constrained by the assumptionthat it had been a partner of Amazonia since the Paleoproterozoic. Unfortunately, nopaleomagnetic data are available for these cratons when the Rodina supercontinent is consideredtectonically stable (~1000-750 Ma). Thus, every new reliable paleomagnetic pole for the WestAfrican Craton during the Neoproterozoic times is of paramount importance to constrain itsposition and testing the Rodinia models. In this study we present a combined paleomagnetic andgeochronological investigation for the Manso dyke swarm in the Leo-Man Shield, southern WestAfrica (Ghana). The ~860 Ma emplacement age for the NNW-trending Manso dykes is thus wellconstrainedby two new U-Pb apatite ages of 857.2 ± 8.5 Ma and 855 ± 16 Ma, in agreement withbaddeleyite data. Remanence of these coarse-to-fine grained dolerite dykes is carried by stablesingle to pseudo-single domain (SD-PSD) magnetite. A positive baked-contact test, associated to apositive reversal test (Class-C), support the primary remanence obtained for these dykes (13 sites).Moreover, our new paleomagnetic dataset satisfy all the seven R-criteria (R=7). The ~860 MaManso pole can thus be considered as the first key Tonian paleomagnetic pole for West Africa. Wepropose that the West Africa-Baltica-Amazonia-Congo-São Francisco were associated in a longlivedWABAMGO juxtaposition (~1100?800 Ma).Fil: Antonio, Paul Yves Jean. National Research Institute of Science and Technology. Centre de Montpellier; FranciaFil: Baratoux, Lenka. Université Paul Sabatier; FranciaFil: Ferreira Trindade, Ricardo Ivan. Universidade de Sao Paulo; BrasilFil: Rousse, Sonia. Université Paul Sabatier; FranciaFil: Ayite, Anani. University Of Ghana; GhanaFil: Lana, Cristiano. Universidade Federal de Ouro Preto; BrasilFil: Macouin, Melina. Université Paul Sabatier; FranciaFil: Kobby Adu, Emmanuel Williams. University Of Ghana; GhanaFil: Sanchez, Caroline. Université Paul Sabatier; FranciaFil: Silva, Marco. Universidade Federal de Ouro Preto; BrasilFil: Firmin, Anne Sophie. Université Paul Sabatier; FranciaFil: Martínez Dopico, Carmen Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geocronología y Geología Isotópica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geocronología y Geología Isotópica; ArgentinaFil: Proietti, Arnaud. Centre de Microcaractérisation Raimond Castaing; FranciaFil: Amponsah, Prince Ofori. University Of Ghana; GhanaFil: Asamoah Sakyi, Patrick. University Of Ghana; GhanaEGU General Assembly 2021ViennaAustriaEuropean Geosciences Unio

2nd ESMO Consensus Conference in Lung Cancer: locally advanced stage III non-small-cell lung cancer

To complement the existing treatment guidelines, ESMO organises consensus conferences to focus on specific issues. The 2nd ESMO Consensus Conference on Lung Cancer included 35 experts who met to address several questions on non-small-cell lung cancer (NSCLC). Recommendations were made with reference to grade of recommendation and level of evidence. This paper focuses on locally advanced diseas

Para a noção de transformação curricular

Neste artigo é evidenciada a relação entre currículo e conhecimento, abordando-se o conhecimento escolar na sua seleção, organização e transformação, a partir de uma revisão do conceito de transposição didática e da proposição dos conceitos de transformação curricular e transformação didática. Qualquer debate sobre o currículo exige a dilucidação do conhecimento e uma reflexão sobre os seus diversos significados, sobretudo quando a educação se torna num projeto amplo de questionamento da realidade social. Para além de várias questões colocadas acerca do conhecimento escolar e do modo como a sua organização pode ser realizada, procura-se centrar o debate numa reflexão sobre as fronteiras entre conhecimentos e esclarecer que, sobre essa temática, jamais poderão existir respostas fechadas.This article highlights the link between curriculum and knowledge, the approach of school knowledge’s selection, organization and transformation is based on a revision of the concept of didactic transposition and on the proposal of the concepts of curriculum and didactic transformation. Debates on curriculum demand an explanation and a reflection on the multiple meanings of knowledge mainly when education aims to be a broad project to contest social reality. It aims to focus the discussion on a reflection regarding the borders between knowledges and to show that in this subject there are never closed answers.Dans cet article est mis en évidence le rapport entre le curriculum et la connaissance, en abordant la connaissance scolaire dans sa sélection, son organisation et sa transformation à partir d’une révision du concept de transposition didactique et de la proposition des concepts de transformation du curriculum et de transformation didactique. Toute discussion sur le curriculum exige la dilucidation de la connaissance et une réflexion sur ses plusieurs signifiés, surtout quand l’éducation devient un projet plus large de mise en question de la réalité sociale. Au delà des plusieurs questions posées autour de la connaissance scolaire et de la manière comme son organisation peut être réalisée, on cherche á fixer le débat dans une réflexion sur les frontières entre connaissances et éclaircir que, sur cette thématique jamais ne pourront exister des réponses absolues.En este trabajo se pone en evidencia la relación entre el currículum y el conocimiento, abordándose el conocimiento escolar en su selección, organización y transformación desde una revisión del concepto de transposición didáctica y de la proposición de los conceptos de transformación curricular y transformación didáctica. Cualquier discusión sobre el currículum requiere la aclaración del conocimiento y una reflexión sobre sus diversos significados, especialmente cuando la educación se convierte en un proyecto más amplio de cuestionamiento de la realidad social. Además de varias preguntas sobre el conocimiento escolar y el modo en el que su organización puede tener lugar, se intenta centrar el debate en una reflexión sobre las fronteras entre conocimientos y aclarar que en esta temática jamás podrán existir respuestas cerradas.(undefined

2nd ESMO Consensus Conference on Lung Cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up

This manuscript provides recommendations for the diagnosis, treatment and follow-up of early stage non-small cell lung cancer developed during the 2nd ESMO Consensus Conference on Lung Cancer in May 201

2nd ESMO Consensus Conference on Lung Cancer: non-small-cell lung cancer first-line/second and further lines of treatment in advanced disease

This manuscript provides recommendations for first-line / second and further lines of treatment in advanced disease in non-small cell lung cancer (NSCLC). These recommendations were developed during the 2nd ESMO Consensus Conference on Lung Cancer in May 201

OBEDIS Core Variables Project : European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions

Heterogeneity of interindividual and intraindividual responses to interventions is often observed in randomized, controlled trials for obesity. To address the global epidemic of obesity and move toward more personalized treatment regimens, the global research community must come together to identify factors that may drive these heterogeneous responses to interventions. This project, called OBEDIS (OBEsity Diverse Interventions Sharing - focusing on dietary and other interventions), provides a set of European guidelines for a minimal set of variables to include in future clinical trials on obesity, regardless of the specific endpoints. Broad adoption of these guidelines will enable researchers to harmonize and merge data from multiple intervention studies, allowing stratification of patients according to precise phenotyping criteria which are measured using standardized methods. In this way, studies across Europe may be pooled for better prediction of individuals' responses to an intervention for obesity - ultimately leading to better patient care and improved obesity outcomes.Peer reviewe