Improving performance of blackboard systems

In this thesis, we deal with blackboard system performance issues. We show that blackboard system performance can be improved using parallel processing strategies and a novel blackboard architecture.We study traditional blackboard architectures using a novel performance frame¬ work. This is a useful tool for directing system optimisation efforts. We present the analysis of four blackboard systems present in the literature.nalysis of four blackboard systems present in the literature. Besides localised optimisation efforts, one of the most promising approaches for improving blackboard system performance is the use of parallel processing techniques. However, traditional blackboard architectures present both data and control contention when implemented in parallel.In this thesis we present a novel blackboard architecture, the Active Blackboard Architecture (ABB). We based ABB on a novel variation of the traditional "Blackboard and Experts" metaphor, called "Blackboard, Experts and Desks". This new metaphor introduces a new element, the desks, used by the experts to perform their work.The ABB architecture is based on an active blackboard, capable of processing on its own, and a decentralised control model. This avoids control contention and bottlenecks. We describe this architecture using the Z specification language, and implemented and evaluated in the EPCC Meiko Computing Surface, a multi-transputer distributed memory parallel machine.The ABB Parallel prototype is an object oriented implementation of the ABB model that overcomes both data and control bottlenecks by having a distributed blackboard and using the ABB control model. Based on a series of experiments, we show that the new architecture allows to achieve much greater effective parallelism in a blackboard system. We also present some ways in which the system can be tailored to specific application needs, improving in this way its overall performance

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.

Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Economic and Institutional Determinants in Fiscal Pressure: An Application to the European Case

The objective of this study has been to undertake an analysis of the economic and institutional determining factors of fiscal pressure in a group of European countries with different levels of economic development, recent history, or level of cooperation and integration among them. We have used a panel of data from 40 countries and a time period of eleven years. Apart from the variables generally used, we have introduced additional ones such as governing party ideology, rate of economic freedom of Euro-area countries, together with another set of institutional variables. Results obtained show that the purely economic model improves when institutional and geopolitical variables are included and, in this way, it is possible to see which countries governed by the left, belonging to the Euro-area or having been members of the Soviet block, and with economic freedom, are more liable to increase fiscal pressure

Geografía de la Salud sin fronteras, desde Iberoamérica

Este libro de Geografía sin fronteras, desde Iberoamérica, reúne trabajos de especialistas en materia de Geografía de la salud de países de Iberoamérica, con diversidad de enfoques y métodos, que permitirá al lector tener una visión del estado actual de esta rama holística e integral de la geografía y la importancia que tiene en la solución de problemas que aquejan nuestra sociedad. El libro se estructura en tres partes: la primera aborda aspectos epistemológicos, teórico conceptuales; en la segunda se presentan las aplicaciones de los SIG y aspectos metodológicos para abordar la salud púbica; y en la tercera se presentan estudios de caso. En la primera parte se aborda la epistemología de la Geografía de la salud: retos y convergencias; geografía y salud: integración de conocimientos y prácticas, como un modo de mirar hacia el mundo a partir de la geografía. Se desarrolla la dimensión local de lo cotidiano de la salud en el territorio; se abordan los procesos de urbanización y resultados en salud; se presenta el tema de la planeación estratégica, un nuevo pensamiento hacia la construcción de ciudades saludables; se abordan reflexiones sobre el estado del arte en la gestión municipal del riesgo de desastres en México. El último tema de esta primera parte del libro es sobre “La geografía médica de Jesús Galindo y Villa”, en el que se analizan los elementos que permitieron construir una cartografía desde la perspectiva de la Geografía de la Salud. La segunda parte del libro incluye aplicaciones de los SIG y metodologías. El primer trabajo es la metodología de evaluación multicriterio en el análisis espacial de la salud, cuyo objetivo es brindar elementos para el apoyo a la toma de decisiones que apunten a lograr una mejora en la calidad de vida de la población. Otra temática es la aplicación de las geo-tecnologías en la geografía de la salud, como los sistemas de información geográfica (SIG), los cuales se ha incrementado su uso en el campo de la salud en los últimos años. Las aplicaciones son muy diversas pueden utilizarse para trazar la ruta más efectiva que seguirá una ambulancia, para ubicar los servicios médicos de una ciudad, así como para analizar patrones de distribución de una determinada enfermedad. Se aborda el tema de tendencias y escenario para el 2020 de la diabetes mellitus en el Estado de México con el propósito es incentivar la iniciativa de políticas públicas que incidan en la disminución de esta enfermedad e impulsar estilos de vida más saludables, principalmente en municipios más vulnerables. La tercera parte del libro son estudios de caso de latitudes diferentes: de Puerto Rico, de México y de Chile, en los que se desarrollan las temáticas de riesgos naturales, vulnerabilidad, contaminación en ciudades, estilos de vida, espacios verdes y análisis espacial estadístico y comparativo de la práctica agroecológica. Exhortamos al lector a leer este valioso documento que le permitirá contar con bases teórico conceptuales, conocer algunas aplicaciones y tener una visión del potencial de la geografía de la salud. Agradecemos los valiosos aportes de los colegas participantes en esta obra, como una de las pocas en esta temática en idioma español y portugués, que sin duda seguirá fortaleciendo esta rama de la geografía. También agradecemos a las autoridades de la Facultad de Geografía de la Universidad Autónoma del Estado de México y de la Coordinación para la Innovación y la Aplicación de la Ciencia y la Tecnología de la Universidad Autónoma de San Luis Potosí, por el valioso apoyo brindado para la publicación de este libro