Modelo y diseño de interacción basado en confianza para espacios inteligentes orientados a la eSalud

La computación ubicua se ha convertido en un paradigma de referencia para el diseño de espacios inteligentes y los desarrollos actuales en el campo de la inteligencia ambiental están cada vez más relacionados con el concepto de Internet de las Cosas y la Internet del Futuro. A pesar de que este paradigma ofrece soluciones verdaderamente rentables en los ámbitos de la Teleasistencia, la sanidad y Ambient Assisted Living, no proporciona al usuario final un rol claramente defi?nido en el desarrollo de las interacciones dinámicas con el entorno. Por lo tanto, el despliegue de servicios de eSalud inteligentes en un espacio privado, como la casa, está todavía sin resolver. En este artículo se define un modelo de interacción persona-ambiente para fomentar la confianza y aceptación de usuarios en entornos privados mediante la aplicación de los conceptos de seguridad centrada en el usuario, diseño guiado por la actividad y la teoría de la acción

Interaction patterns for smart spaces: a confident interaction design solution for pervasive sensitive IoT services

Smart spaces represent a powerful tool for deploying the new pervasive sensitive services based on Internet of Things products and developed in current Information Society close to users. Researchers have focused their efforts on new techniques to improve systems and products in this area but neglecting the human factors related to psychological aspects of the user and their psycho-social relationship with the deployment space where they live. This research proposes to take into account these cognitive features in early stages of the design of smart spaces by defining a set of interaction patterns. By using this set of interaction patterns it is possible to influence over the confidence that users can develop during the use of IoT products and services based on them. An evaluative verification has been carried out to assess how this design engineering approach provide a real impact on the generation of confidence in the users of this kind of technology

Confidence: dependencies and their critical role in fostering user acceptance in pervasive applications

Pervasive computing offers new scenarios where users are surrounded by invisible and proactive technology making smart spaces. Although the utility and power of solutions developed using this computer paradigm are proved, there are unresolved problems that hinder their acceptance and inclusion in our private life. Users have problems understanding the operations of a pervasive computing solution, and therefore they should trust that the solution works properly and according to their expectations. Nevertheless, the concept of trust is already framed in a specific use within the ecosystem of applications that can populate a smart space. To take this concept of trust to the whole space, we propose to study and define the concept of confidence. In contrast to the concept of trust, confidence has deeper psychological implications

Interaction patterns for smart spaces: a confident interaction design solution for pervasive sensitive IoT services

Smart spaces represent a powerful tool for deploying the new pervasive sensitive services based on Internet of Things products and developed in current Information Society close to users. Researchers have focused their efforts on new techniques to improve systems and products in this area but neglecting the human factors related to psychological aspects of the user and their psycho-social relationship with the deployment space where they live. This research proposes to take into account these cognitive features in early stages of the design of smart spaces by defining a set of interaction patterns. By using this set of interaction patterns it is possible to influence over the confidence that users can develop during the use of IoT products and services based on them. An evaluative verification has been carried out to assess how this design engineering approach provide a real impact on the generation of confidence in the users of this kind of technology

Bluetooth Tracking Approach For User Assistance Based In Sequential Patterns Analysis.

As a civilization, we are drowning in a raging torrent of data, of our own making, that is being harvested by our collective technologies and systems (e.g. Fitbit, phones). However, data itself is of no utility unless it is converted into beneficial knowledge. Design patterns have been shown to be a pragmatic solution to control and manage information flows and provide order and mean-ing to data within a given context. Assisting users within their daily activities has become a key aspect for modern Artificial Intelligence Systems. Neverthe-less, although the GPS technologies work well for outside location, indoor posi-tioning is still problematic, while is a vital awareness component in ambient as-sistance. This paper shows a preliminary Bluetooth tracking system with a focus on the user’s transition between areas of interest. Our work aims to shed light on how the term design patterns can be applied for studying human behavior patterns in the smart environment

Adaptive software architecture based on confident HCI for the deployment of sensitive services in smart homes

Smart spaces foster the development of natural and appropriate forms of human-computer interaction by taking advantage of home customization. The interaction potential of the Smart Home, which is a special type of smart space, is of particular interest in fields in which the acceptance of new technologies is limited and restrictive. The integration of smart home design patterns with sensitive solutions can increase user acceptance. In this paper, we present the main challenges that have been identified in the literature for the successful deployment of sensitive services (e.g., telemedicine and assistive services) in smart spaces and a software architecture that models the functionalities of a Smart Home platform that are required to maintain and support such sensitive services. This architecture emphasizes user interaction as a key concept to facilitate the acceptance of sensitive services by end-users and utilizes activity theory to support its innovative design. The application of activity theory to the architecture eases the handling of novel concepts, such as understanding of the system by patients at home or the affordability of assistive services. Finally, we provide a proof-of-concept implementation of the architecture and compare the results with other architectures from the literature

Frontal and insular input to the dorsolateral temporal pole in primates: Implications for auditory memory

The temporal pole (TP) has been involved in multiple functions from emotional and social behavior, semantic processing,memory, language in humans and epilepsy surgery, to the fronto-temporal neurodegenerative disorder (semantic) dementia. However, the role of the TP subdivisions is still unclear, in part due to the lack of quantitative data about TP connectivity. This study focuses in the dorsolateral subdivision of the TP: area 38DL. Area 38DL main input originates in the auditory processing areas of the rostral superior temporal gyrus. Among other connections, area 38DL conveys this auditory highly processed information to the entorhinal, rostral perirhinal, and posterior parahippocampal cortices, presumably for storage in long-term memory (Muñoz-López et al., 2015). However, the connections of the TP with cortical areas beyond the temporal cortex suggest that this area is part of a wider network. With the aim to quantitatively determine the topographical, laminar pattern and weighting of the lateral TP afferents from the frontal and insular cortices, we placed a total of 11 tracer injections of the fluorescent retrograde neuronal tracers Fast Blue and Diamidino Yellow at different levels of the lateral TP in rhesus monkeys. The results showed that circa 50% of the total cortical input to area 38DL originates in medial frontal areas 14, 25, 32, and 24 (25%); orbitofrontal areas Pro and PAll (15%); and the agranular, parainsular and disgranular insula (10%). This study sets the anatomical bases to better understand the function of the dorsolateral division of the TP. More specifically, these results suggest that area 38DL forms part of the wider limbic circuit that might contribute, among other functions, with an auditory component to multimodal memory processing

A body weight loss- and health-promoting gut microbiota is established after bariatric surgery in individuals with severe obesity

Obesity has reached an epidemic level worldwide, and bariatric surgery (BS) has been proven to be the most efficient therapy to reduce severe obesity-related comorbidities. Given that the gut microbiota plays a causal role in obesity development and that surgery may alter the gut environment, investigating the impact of BS on the microbiota in the context of severe obesity is important. Although, alterations at the level of total gut bacteria, total gene content and total metabolite content have started to be disentangled, a clear deficit exists regarding the analysis of the active fraction of the microbiota, which is the fraction that is most reactive to the BS. Here, active gut microbiota and associated metabolic functions were evaluated using shotgun proteomics and metabolomics in 40 severely obese volunteers. Samples from each volunteer were obtained under basal conditions, after a short high protein and calorie-restricted diet, and 1 and 3 months after BS, including laparoscopic surgery through Roux-en-Y Gastric Bypass or Sleeve Gastrectomy. The results revealed for the first time the most active microbes and metabolic flux distribution pre- and post-surgery and deciphered main differences in the way sugars and short-fatty acids are metabolized, demonstrating that less energy-generating and anaerobic metabolism and detoxification mechanisms are promoted post-surgery. A comparison with non-obese proteome data further signified different ways to metabolize sugars and produce short chain fatty acids and deficiencies in proteins involved in iron transport and metabolism in severely obese individuals compared to lean individuals.This work was funded by grants SAF2015-65878-R, BIO2017-85522-R, PID2019-105969GB-I00 and RTI2018-095166-B-I00 from the Ministry of Science, Innovation and Universities, by the Ministry of Science and Innovation, by the Instituto de Salud Carlos III (projects PIE14/00045 and AC17/00022), Fundación Agencia Española contra el Cáncer and Instituto de Salud Carlos III(projects ERA NET TRANSCAN-2 AC17/00022 and AECC 2017-1485), Generalitat Valenciana (project Prometeo/2018/A/133) and co-financed by the European Regional Development Fund (ERDF). The proteomic analysis was performed in the Proteomics Facility of The Spanish National Center for Biotechnology (CNB-CSIC) that belongs to ProteoRed, PRB3-ISCIII, supported by grant PT17/0019.Peer reviewe

Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach

Systems medicine has a mechanism-based rather than a symptom- or organ-based approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In this work, we apply this to transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2) by cross-validating its position in a protein-protein interaction network (the NRF2 interactome) functionally linked to cytoprotection in low-grade stress, chronic inflammation, metabolic alterations, and reactive oxygen species formation. Multiscale network analysis of these molecular profiles suggests alterations of NRF2 expression and activity as a common mechanism in a subnetwork of diseases (the NRF2 diseasome). This network joins apparently heterogeneous phenotypes such as autoimmune, respiratory, digestive, cardiovascular, metabolic, and neurodegenerative diseases, along with cancer. Importantly, this approach matches and confirms in silico several applications for NRF2-modulating drugs validated in vivo at different phases of clinical development. Pharmacologically, their profile is as diverse as electrophilic dimethyl fumarate, synthetic triterpenoids like bardoxolone methyl and sulforaphane, protein-protein or DNA-protein interaction inhibitors, and even registered drugs such as metformin and statins, which activate NRF2 and may be repurposed for indications within the NRF2 cluster of disease phenotypes. Thus, NRF2 represents one of the first targets fully embraced by classic and systems medicine approaches to facilitate both drug development and drug repurposing by focusing on a set of disease phenotypes that appear to be mechanistically linked. The resulting NRF2 drugome may therefore rapidly advance several surprising clinical options for this subset of chronic diseases

Accessible interaction solution based on confidence for the deployment of pervasive sensitive services in intelligent environments

Services based on the Information and Communications Technologies (ICT) are present more and more in the lives of people. The advancement of ICT in technical and social acceptance terms has led the creation of new models of service provision. These provision models involve further integration with people's activities so that are not only present in their professions or civic space but also in a more intimate areas related to their own identity. So it is now common to find services aware of user's health, their domestic habits, ideology, etc. Therefore, the analysis of existing services must be open out to include other aspects related to the way of being and feeling of their members. This way is possible to ensure both the technical correctness of its features as promoting safe and respectful solutions both of civic rights as the way of being and feeling of its members. From the engineering point of view, the user perspective has historically encompassed under the concept of technological acceptance. Within this field can be interpreted as friendly solutions adapted to users will encourage the acceptance by them. Solution acceptance is desirable although it is difficult to ensure. This difficulty is due to the lack of the number of variables that affect the acceptance of technological solutions and the difficulty of optimizing the known variables. In this thesis it is studied and characterized one of the variables that affect the acceptance of existing services: confidence. Confidence is defined in psychological terms, providing its characterization with the aim of be used in typical methods of engineering. Also different tools are proposed to facilitate the optimization of this confidence in services whose complexity establishes this variable in a basic issue to improve acceptance. Health services deployed in a home have been chosen as working context for this thesis. This scenario presents a number of acceptance restrictions on the technology used to create services and how they manage the acquired user information. It comes to highly sensitive and delocalized services that can affect to the user's perception of the environment, the home, and generate fear or rejection to prevent final adoption as a valid solution. Once defined the generic framework, the main objective of this dissertation is focused on promote the acceptance of new pervasive and personalized health services and their deployment in domestic intelligent environments through a layout that promotes a psychological state of confidence in users. To achieve this goal, a set of results, both conceptual, technological and experimental, have been provided. In particular, it has offered a complete characterization of the feeling of confidence from a viewpoint of engineering and a definition of sensitive or delocalized pervasive service. Furthermore, a method for the inclusion of the Interaction Design discipline in engineering processes of such services through a set of patterns of interaction is offered. Finally, this thesis provides the development of a software architecture to ensure proper deployment of these pervasive sensitive services in intelligent environments in a confident way. Discussion of the results suggests the extension of the deployment model to different services of the Information Society that handle sensitive data both in the context of the digital home and other settings where the user perform everyday activities such as work spaces or schools. The future work lines include the imminent need to apply the results to ongoing developments, within research projects in those the author takes part, and the development of new research lines aimed at creating new spaces and interaction technologies as advanced accessible interfaces, toys of the future, confident visualization systems or security systems based on the condition of the user.Tjänster baserade på informations- och kommunikationsteknik (IKT) blir allt mer vanligare i människors liv. För att främja acceptansen för IKT i både tekniska och sociala aspekter av människors liv har nya modeller för dessa tjänster skapats. Dessa modeller har en närmare knytning till människors verksamhet så att de inte bara förekommer i deras yrken eller fritid men också i mer intima områden som anknyter till individens egen identitet. Det är nu därför vanligt att hitta tjänster som tar hänsyn till användarens hälsa, vanor, ideologi, etc.  En analys av befintliga tjänster måste inkludera dessa aspekter men även användarnas känsla av identitet och medlemskap. På detta sätt är det möjligt att säkerställa den tekniska riktigheten hos dessa funktioner som i sin tur borgar för säkra och respektfulla lösningar som tar hänsyn till medlemmarnas medborgerliga rättigheter likväl som deras känsla av identitet och medlemskap. Historiskt sett, och ur ett tekniskt perspektiv, har användarperspektivet omfattats under begreppet teknisk acceptans. Inom detta område har användarvänliga lösningar anpassade till användarna själva uppmuntrat acceptans av dem. Acceptans av lösningar är önskvärt även om det är svårt att säkerställa. Denna svårighet beror på avsaknaden av antalet variabler som påverkar acceptansen av tekniska lösningar och svårigheten att optimera de kända variablerna. I denna avhandling studeras och karaktäriseras en av de variabler som påverkar acceptansen av befintliga tjänster: förtroende. Förtroendet definieras i psykologiska termer med syftet att kunna använda termen i typiska metoder för teknik. Det föreslås också olika verktyg för att underlätta optimering av detta förtroende inom tjänstesektorn. Hälso- och sjukvård i hemmet har valts som scenario för denna avhandling. Detta scenario presenterar ett antal restriktioner med avseende på acceptansen av den teknik som används för att skapa tjänster och hur dessa tjänster hanterar den förvärvade användarinformationen. För användaren är situationen mycket känslig och de erbjudna tjänsterna kan påverka användarens uppfattning av miljön och hemmet och/eller generera rädsla eller avsmak för att acceptera lösningen. När den generiska ramen är etablerad är det huvudsakliga syftet med denna avhandling att främja acceptans av nya tjänster för personlig hälsovård och deras användning i hemmet. Detta skall uppnås genom en layout som främjar ett psykologiskt förtroende hos användarna. För att uppnå detta mål har en uppsättning resultat, både begreppsmässiga, tekniska och experimentella, analyserats. Framför allt har en fullständig karaktärisering gjorts av känslan av förtroende från en teknologisk synvinkel och en definition av en känslig och allomfattande tjänst. Dessutom framläggs en metod för införandet av interaktionsdesign i de aktuella tjänsterna genom ett antal interaktionsmönster. Slutligen behandlar denna avhandling utvecklingen av en mjukvaruarkitektur för att säkerställa en korrekt användning av dessa känsliga tjänster. Resultaten pekar på att distributionsmodellen även kan användas för andra tjänster i informationssamhället där användaren utför vardagliga sysslor, såsom i det digitala hemmet eller andra miljöer (t.ex. skolor och arbetsplatser), där känsliga uppgifter hanteras. De framtida arbetsuppgifterna omfattar det överhängande behovet av att tillämpa resultaten på den pågående utvecklingen av forskningsprojekt som författaren är involverad i. Detta omfattar även utveckling av ny forskning som syftar till att skapa ny interaktionsteknik t.ex. avancerade gränssnitt, framtida leksaker, säkra visualiseringssystem eller säkerhetssystem baserat på användarens hälsa/tillstånd.This PhD research has been conducted under a double PhD agreement degree between the School of Telecommunications Systems and Engineering (ETSIST) at the Technical University of Madrid (UPM) in Spain and the School of Technology and Health (STH) at the Royal Institute of Technology (KTH) in Sweden.QC 20160129</p