Effective Revenue Diversification Strategies in Nonprofit Organizations

Nonprofit organization leaders increasingly encounter social burdens and financial difficulties, jeopardizing ongoing success and organizational sustainability. The purpose of this single-case study was to explore revenue diversification strategies used by 3 leaders of a small nonprofit organization in the mid-Atlantic region of the United States through the conceptual lens of modern portfolio theory. Data were collected via in-depth semistructured interviews, and member checking was used to facilitate accuracy, consistency, and integrity. Methodological triangulation included a document review and analysis of financial statements, tax returns, strategy objectives, the organizational website, social media, and nonprofit data reports. Data from documents and interviews were manually coded, and themes were identified using thematic analysis. Six themes emerged related to process strengths and opportunities for improvement including capitalizing on a mission-driven workforce; using a systematic strategic planning process; building relationships with partners, suppliers, and collaborators; integrating performance measures to areas of importance; and developing and implanting systematic methods to assess customer satisfaction and workforce engagement. The findings from this study might contribute to positive social change by providing revenue diversification strategies and the supporting processes that leaders of small nonprofit organizations can use to enhance existing services, expand community programs, and create ongoing organizational success

Vincentiana Vol. 36, No. 1-2 [Full Issue]

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Domain analysis of supervillin, an F-actin bundling plasma membrane protein with functional nuclear localization signals

A growing number of actin-associated membrane proteins have been implicated in motile processes, adhesive interactions, and signal transduction to the cell nucleus. We report here that supervillin, an F-actin binding protein originally isolated from bovine neutrophil plasma membranes, contains functional nuclear targeting signals and localizes at or near vinculin-containing focal adhesion plaques in COS7-2 and CV1 cells. Overexpression of full-length supervillin in these cells disrupts the integrity of focal adhesion plaques and results in increased levels of F-actin and vinculin. Localization studies of chimeric proteins containing supervillin sequences fused with the enhanced green fluorescent protein indicate that: (1) the amino terminus promotes F-actin binding, targeting to focal adhesions, and limited nuclear localization; (2) the dominant nuclear targeting signal is in the center of the protein; and (3) the carboxy-terminal villin/gelsolin homology domain of supervillin does not, by itself, bind tightly to the actin cytoskeleton in vivo. Overexpression of chimeras containing both the amino-terminal F-actin binding site(s) and the dominant nuclear targeting signal results in the formation of large nuclear bundles containing F-actin, supervillin, and lamin. These results suggest that supervillin may contribute to cytoarchitecture in the nucleus, as well as at the plasma membrane

Asociacion del APGAR Familiar y los Valores de Hemoglobina Glicosilada en Pacientes Portadores de Diabetes Mellitus Tipo 2 en los Centro de Salud Carlos Llosa - Hunter y Centro de Salud Edificadores Misti, Arequipa 2018

La diabetes mellitus es una enfermedad crónica prevalente ,según la OMS la prevalencia en adultos mayores de 18 años es de 8,5 % para el 2014. (Salud O. M., 2018) En el Perú el INEI en el 2017 se reportó una prevalencia de 3,3 % en la población adulta mayor a 15 años a nivel nacional. (INEI, 2017).Teniendo esto en cuenta se hace importante entender el funcionamiento familiar para apoyar en el control del paciente diabético y así disminuir los niveles de hemoglobina glicosilada en pacientes portadores de Diabetes Mellitus tipo II que pertenecen a los Centros de Salud Carlos Llosa - Hunter y Edificadores Misti. Y así mejorar el nivel de apoyo l control de enfermedad de esos pacientes y apoyar al Programa de Enfermedades no transmisibles del MINSA y evitar complicaciones crónicas a largo plazo que tienen graves consecuencias no solo para la familia ; sino también a los servicios de salud ya que encarecen los costos de salud. Propósito: El APGAR familiar mide la funcionalidad familiar , esta para el médico familiar es un pilar para el control de múltiples patologías, dentro de ellas la Diabetes Mellitus por tener alta prevalencia de complicaciones en la población general encareciendo los costos de los servicios de salud. El presente trabajo pretende demostrar que uno de los factores más importantes para mejorar el control del paciente diabético que se mide por los niveles de hemoglobina glicosilada es la FUNCIONALIDAD FAMILIAR. Métodos: En el presente trabajo se realizaran visitas domiciliarias A LOS PACIENTES DIABETICOS DENTRO DE LA JURISICCION DE LOS los Centros de Salud Carlos Llosa - Hunter y Edificadores Misti EMPADRONADOS EN EL Programa de Daños no Transmisibles (DANT) , luego De firmaran los consentimientos informados Se procederá a la toma de la hemoglobina glicosilada en sangre y a la aplicación de CUESTIONARIO DE APGAR FAMILIAR , luego de unos 3 meses se procederá a una segunda visita domiciliaria con un segunda toma de hemoglobina glicosilada en sangre y se compararan los resultados. los consentimientos informados autorizaron su participación en la investigación, serán incluidos en el presente estudio Análisis estadístico: El presente trabajo es un estudio descriptivo, observacional, correlacional, y prospectivo, de la información obtenida con el cuestionario de APGAR FAMILIAR y el valor de hemoglobina glicosilada obtenida de las visitas domiciliarias a pacientes diabéticos de la JURISICCION DE LOS los Centros de Salud Carlos Llosa - Hunter y Edificadores Misti EMPADRONADOS EN EL Programa de Daños no Transmisibles (DANT) para lo cual se utilizara el estadístico chi - cuadrado y Correlación de Pearson PALABRAS CLAVE: Diabetes Mellitus tipo 2, Apgar familiar, Hemoglobina GlicosiladaTrabajo académic

The use of streambed temperatures to estimate transmission losses on an experimental channel.

Quantifying channel transmission losses in arid environments is important for a variety of reasons, from engineering design of flood control structures to evaluating recharge. To quantify the losses in an alluvial channel, an experiment was performed on a 2-km reach of an alluvial fan located on the Nevada Test Site. The channel was subjected to three separate flow events. Transmission losses were estimated using standard discharge monitoring and subsurface temperature modeling approach. Four stations were equipped to continuously monitor stage, temperature, and water content. Streambed temperatures measured at 0, 30, 50 and 100 cm depths were used to calibrate VS2DH, a two-dimensional, variably saturated flow model. Average losses based on the difference in flow between each station indicate that 21 percent, 27 percent, and 53 percent of the flow was reduced downgradient of the source. Results from the temperature monitoring identified locations with large thermal gradients, suggesting a conduction-dominated heat transfer on streambed sediments where caliche-cemented surfaces were present. Transmission losses at the lowermost segment corresponded to the smallest thermal gradient, suggesting an advection-dominated heat transfer. Losses predicted by VS2DH are within an order of magnitude of the estimated losses based on discharge measurements. The differences in losses are a result of the spatial extent to which the modeling results are applied and lateral subsurface flow

Managed Aquifer Recharge as a Tool to Enhance Sustainable Groundwater Management in California

A growing population and an increased demand for water resources have resulted in a global trend of groundwater depletion. Arid and semi-arid climates are particularly susceptible, often relying on groundwater to support large population centers or irrigated agriculture in the absence of sufficient surface water resources. In an effort to increase the security of groundwater resources, managed aquifer recharge (MAR) programs have been developed and implemented globally. MAR is the approach of intentionally harvesting and infiltrating water to recharge depleted aquifer storage. California is a prime example of this growing problem, with three cities that have over a million residents and an agricultural industry that was valued at 47 billion dollars in 2015. The present-day groundwater overdraft of over 100 km3 (since 1962) indicates a clear disparity between surface water supply and water demand within the state. In the face of groundwater overdraft and the anticipated effects of climate change, many new MAR projects are being constructed or investigated throughout California, adding to those that have existed for decades. Some common MAR types utilized in California include injection wells, infiltration basins (also known as spreading basins, percolation basins, or recharge basins), and low-impact development. An emerging MAR type that is actively being investigated is the winter flooding of agricultural fields using existing irrigation infrastructure and excess surface water resources, known as agricultural MAR. California therefore provides an excellent case study to look at the historical use and performance of MAR, ongoing and emerging challenges, novel MAR applications, and the potential for expansion of MAR. Effective MAR projects are an essential tool for increasing groundwater security, both in California and on a global scale. This chapter aims to provide an overview of the most common MAR types and applications within the State of California and neighboring semi-arid regions

The role of clathrin in post-golgi trafficking in toxoplasma gondii

Apicomplexan parasites are single eukaryotic cells with a highly polarised secretory system that contains unique secretory organelles (micronemes and rhoptries) that are required for host cell invasion. In contrast, the role of the endosomal system is poorly understood in these parasites. With many typical endocytic factors missing, we speculated that endocytosis depends exclusively on a clathrin-mediated mechanism. Intriguingly, in Toxoplasma gondii we were only able to observe the endogenous clathrin heavy chain 1 (CHC1) at the Golgi, but not at the parasite surface. For the functional characterisation of Toxoplasma gondii CHC1 we generated parasite mutants conditionally expressing the dominant negative clathrin Hub fragment and demonstrate that CHC1 is essential for vesicle formation at the trans-Golgi network. Consequently, the functional ablation of CHC1 results in Golgi aberrations, a block in the biogenesis of the unique secretory microneme and rhoptry organelles, and of the pellicle. However, we found no morphological evidence for clathrin mediating endocytosis in these parasites and speculate that they remodelled their vesicular trafficking system to adapt to an intracellular lifestyle

Nutrient Processes at the Stream-Lake Interface for a Channelized Versus Unmodified Stream Mouth

Inorganic forms of nitrogen and phosphorous impact freshwater lakes by stimulating primary production and affecting water quality and ecosystem health. Communities around the world are motivated to sustain and restore freshwater resources and are interested in processes controlling nutrient inputs. We studied the environment where streams flow into lakes, referred to as the stream-lake interface (SLI), for a channelized and unmodified stream outlet. Channelization is done to protect infrastructure or recreational beach areas. We collected hydraulic and nutrient data for surface water and shallow groundwater in two SLIs to develop conceptual models that describe characteristics that are representative of these hydrologic features. Water, heat, and solute transport models were used to evaluate hydrologic conceptualizations and estimate mean residence times of water in the sediment. A nutrient mass balance model is developed to estimate net rates of adsorption and desorption, mineralization, and nitrification along subsurface flow paths. Results indicate that SLIs are dynamic sources of nutrients to lakes and that the common practice of channelizing the stream at the SLI decreases nutrient concentrations in pore water discharging along the lakeshore. This is in contrast to the unmodified SLI that forms a barrier beach that disconnects the stream from the lake and results in higher nutrient concentrations in pore water discharging to the lake. These results are significant because nutrient delivery through pore water seepage at the lakebed from the natural SLI contributes to nearshore algal communities and produces elevated concentrations of inorganic nutrients in the benthic zone where attached algae grow

Sistema para el Costeo de las Ordenes de Trabajo en Illary Joste S.R.L. Basado en un Costeo por Actividades como Herramienta para la Estimación de Costos, la Fijación de Precios y la Medición del Impacto en la Toma de Decisiones

En la actualidad la competitividad es un tema de vital importancia para una empresa que quiere desarrollarse. El presente trabajo nace de la aplicación de una metodología de costeo por actividades a la realidad de una empresa textil. Con el paso del tiempo, el mercado ha cambiado el cual demanda que las empresas se vuelvan más competitivas para sobrevivir y un pilar para lograr la competitividad es conocer el costo del proceso productivo. Ya que esto nos permite generar ideas para atacar los generadores de costos con la finalidad de reducir estos mismos. Desarrollar el proceso de costeo también tiene aplicaciones tanto a nivel estratégico como operativo, permitiendo asignar a las personas adecuadas a determinadas tareas o decidiendo volúmenes de producción según la conveniencia de la empresa. En el transcurso del trabajo detallaremos como se logró construir un sistema de costeo y una herramienta practica para el uso del sistema basado en actividades para Illary Joste S.R.L. en el cual las ordenes de trabajo viajan a través de cada actividad, absorbiendo sus costos, esto con dos finalidades: una – finalidad a corto plazo, fijación de precios para producción propia y para terceros (servicio) y dos – finalidad a mediano y largo plazo, la herramienta para decidir en donde invertir y a su vez medir el impacto de las inversiones en nuestros procesos en base a los costos de cada actividad, básicamente estos dos conceptos mencionados ayudaran a mejorar la competitividad de la empresa, ya que la empresa contará con una herramienta que dará el soporte necesario para poder fijar precios en base a nuestros costos y de igual manera plantear mejoras y medir el impacto de estas. El presente trabajo se puede aplicar a otras empresas del rubro que realicen los procesos de acabado y tejido puesto que el proceso productivo suele ser el mismo, con ciertas variaciones que deben ser adecuadas a la realidad de cada empresa. Palabras Clave: Costeo por Actividades, Textil, Tejido Plano, Proceso, AcabadoTesi